The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice

British Journal of Pharmacology

Volumn 165, Issue 1, 2012, Pages 183-196

  Martins, J P ^a   Silva, R B M ^a   Coutinho Silva, R ^b   Takiya, C M ^b   Battastini, A M O ^c   Morrone, F B ^a   Campos, M M ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Instituto de Ciencias Biologicas e da Saude Pontifical Catholic University of Minas Gerais   (Brazil)

Author keywords

A 438079; cyclophosphamide; genetic ablation; haemorrhagic cystitis; mice; P2X7 receptor

Indexed keywords

A 438079; CYCLOPHOSPHAMIDE; INTERLEUKIN 1BETA; MESNA; MYELOPEROXIDASE; PROTEIN C FOS; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DOSE COMPARISON; DRUG MECHANISM; EDEMA; ENZYME INHIBITION; GENE DELETION; HEMORRHAGIC CYSTITIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; KNOCKOUT MOUSE; LUMBAR SPINAL CORD; MACROPHAGE MIGRATION INHIBITION; MALE; MOUSE; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SINGLE DRUG DOSE; TISSUE LEVEL;

ANIMALS; CELL MOVEMENT; CYCLOPHOSPHAMIDE; CYSTITIS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENES, FOS; HEMORRHAGE; INFLAMMATION; MACROPHAGES; MALE; MESNA; MICE; MICE, KNOCKOUT; NOCICEPTION; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIDINES; RECEPTORS, PURINERGIC P2X7; TETRAZOLES; URINARY BLADDER;

EID: 82955173738     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01535.x     Document Type: Article

References (64)

1. Alexander SPH, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164: S1-S324.
2. Basso AM, Bratcher NA, Harris RR, Jarvis MF, Decker MW, Rueter LE, (2009). Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders. Behav Brain Res 198: 83-90.
3. Batista CK, Brito GA, Souza ML, Leitao BT, Cunha FQ, Ribeiro RA, (2006). A model of hemorrhagic cystitis induced with acrolein in mice. Braz J Med Biol Res 39: 1475-1481. (Pubitemid 46357863)
4. Birder LA, Ruan HZ, Chopra B, Xiang Z, Barrick S, Buffington CA, et al,. (2004). Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 287: F1084-F1091. (Pubitemid 39391107)
5. Bon K, Lichtensteiger CA, Wilson SG, Mogil JS, (2003). Characterization of cyclophosphamide cystitis, a model of visceral and referred pain, in the mouse: species and strain differences. J Urol 170: 1008-1012. (Pubitemid 36999622)
6. Burnstock G, (2006). Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol Rev 58: 58-86.
7. Burnstock G, (2007). Purine and pyrimidine receptors. Cell Mol Life Sci 64: 1471-1483. (Pubitemid 46954150)
8. Burnstock G, (2009). Purinergic receptors and pain. Curr Pharm Des 15: 1717-1735.
9. Burnstock G, (2011). Therapeutic potential of purinergic signalling for diseases of the urinary tract. BJU Int 107: 192-204.
10. Chen L, Brosnan CF, (2006). Regulation of immune response by P2X7 receptor. Crit Rev Immunol 26: 499-513.
11. Chen Y, Yao Y, Sumi Y, Li A, To UK, Elkhal A, et al,. (2010). Purinergic signaling: a fundamental mechanism in neutrophil activation. Sci Signal 3: ra45.
12. Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, et al,. (2005). Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114: 386-396. (Pubitemid 40385877)
13. Cheuk DK, Lee TL, Chiang AK, Ha SY, Lau YL, Chan GC, (2007). Risk factors and treatment of hemorrhagic cystitis in children who underwent hematopoietic stem cell transplantation. Transpl Int 20: 73-81.
14. Chow YC, Yang S, Huang CJ, Tzen CY, Huang PL, Su YH, et al,. (2006). Epinephrine promotes hemostasis in rats with cyclophosphamide-induced hemorrhagic cystitis. Urology 67: 636-641. (Pubitemid 43343571)
15. Chow YC, Yang S, Huang CJ, Tzen CY, Su YH, Wang PS, (2007). Prophylactic intravesical instillation of epinephrine prevents cyclophosphamide-induced hemorrhagic cystitis in rats. Exp Biol Med (Maywood) 232: 565-570. (Pubitemid 46524479)
16. Cotrina ML, Nedergaard M, (2009). Physiological and pathological functions of P2X7 receptor in the spinal cord. Purinergic Signal 5: 223-232.
17. Crocitto LE, Simpson JF, Wilson TG, (1996). Bladder augmentation in the prevention of cyclophosphamide-induced haemorrhagic cystitis in the rat model. Br J Urol 78: 530-533.
18. Di Virgilio F, (2007). Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol Sci 28: 465-472.
19. Donnelly-Roberts DL, Jarvis MF, (2007). Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol 151: 571-579. (Pubitemid 47016292)
20. Donnelly-Roberts DL, Namovic MT, Han P, Jarvis MF, (2009). Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol 157: 1203-1214.
21. Dubyak GR, (2007). Go it alone no more-P2X7 joins the society of heteromeric ATP-gated receptor channels. Mol Pharmacol 72: 1402-1405. (Pubitemid 350146076)
22. Fernandes ES, Passos GF, Campos MM, De Souza GE, Fittipaldi JF, Pesquero JL, et al,. (2005). Cytokines and neutrophils as important mediators of platelet-activating factor-induced kinin B1 receptor expression. Br J Pharmacol 146: 209-216. (Pubitemid 43079960)
23. Ferrari D, Chiozzi P, Falzoni S, Dal Susino M, Melchiorri L, Baricordi OR, et al,. (1997). Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J Immunol 159: 1451-1458. (Pubitemid 127484125)
24. Giraud G, Bogdanovic G, Priftakis P, Remberger M, Svahn BM, Barkholt L, et al,. (2006). The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen. Haematologica 91: 401-404.
25. Gonçalves RG, Gabrich L, Rosario A, Jr, Takiya CM, Ferreira ML, Chiarini LB, et al,. (2006). The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice. Kidney Int 70: 1599-1606. (Pubitemid 44606995)
26. Grassi F, (2010). Purinergic control of neutrophil activation. J Mol Cell Biol 2: 176-177.
27. Gray KJ, Engelmann UH, Johnson EH, Fishman IJ, (1986). Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy. J Urol 136: 497-500. (Pubitemid 16070487)
28. Grygorowicz T, Struzynska L, Sulkowski G, Chalimoniuk M, Sulejczak D, (2010). Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis. Neurochem Int 57: 823-829.
29. Honore P, Donnelly-Roberts D, Namovic MT, Hsieh G, Zhu CZ, Mikusa JP, et al,. (2006). A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther 319: 1376-1385.
30. Honore P, Donnelly-Roberts D, Namovic M, Zhong C, Wade C, Chandran P, et al,. (2009). The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice. Behav Brain Res 204: 77-81.
31. Iglesias R, Locovei S, Roque A, Alberto AP, Dahl G, Spray DC, et al,. (2008). P2X7 receptor-Pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol 295: C752-C760.
32. Khazen W, M'bika JP, Tomkiewicz C, Benelli C, Chany C, Achour A, et al,. (2005). Expression of macrophage-selective markers in human and rodent adipocytes. FEBS Lett 579: 5631-5634. (Pubitemid 41455641)
33. King BF, (2007). Novel P2X7 receptor antagonists ease the pain. Br J Pharmacol 151: 565-567. (Pubitemid 47016293)
34. Labasi JM, Petrushova N, Donovan C, Mccurdy S, Lira P, Payette MM, et al,. (2002). Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 168: 6436-6445. (Pubitemid 34620068)
35. Labrousse VF, Costes L, Aubert A, Darnaudery M, Ferreira G, Amedee T, et al,. (2009). Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice. PLoS ONE 4: e6006.
36. Li X, Zhou L, Feng YH, Abdul-Karim FW, Gorodeski GI, (2006). The P2X7 receptor: a novel biomarker of uterine epithelial cancers. Cancer Epidemiol Biomarkers Prev 15: 1906-1913. (Pubitemid 44664267)
37. Mackenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A, (2001). Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15: 825-835. (Pubitemid 34008509)
38. Manikandan R, Kumar S, Dorairajan LN, (2010). Hemorrhagic cystitis: a challenge to the urologist. Indian J Urol 26: 159-166.
39. Marcellino D, Suarez-Boomgaard D, Sanchez-Reina MD, Aguirre JA, Yoshitake T, Yoshitake S, et al,. (2010). On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm 117: 681-687.
40. Maus UA, Janzen S, Wall G, Srivastava M, Blackwell TS, Christman JW, et al,. (2006). Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol 35: 227-235. (Pubitemid 44175323)
41. Mcgaraughty S, Chu KL, Namovic MT, Donnelly-Roberts DL, Harris RR, Zhang XF, et al,. (2007). P2X7-related modulation of pathological nociception in rats. Neuroscience 146: 1817-1828. (Pubitemid 46783230)
42. Morais MM, Belarmino-Filho JN, Brito GA, Ribeiro RA, (1999). Pharmacological and histopathological study of cyclophosphamide-induced hemorrhagic cystitis-comparison of the effects of dexamethasone and Mesna. Braz J Med Biol Res 32: 1211-1215.
43. Namasivayam S, Eardley I, Morrison JF, (1999). Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat. BJU Int 84: 854-860. (Pubitemid 29500056)
44. Neheman A, Nativ O, Moskovitz B, Melamed Y, Stein A, (2005). Hyperbaric oxygen therapy for radiation-induced haemorrhagic cystitis. BJU Int 96: 107-109. (Pubitemid 40942879)
45. Nelson DW, Gregg RJ, Kort ME, Perez-Medrano A, Voight EA, Wang Y, et al,. (2006). Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J Med Chem 49: 3659-3666. (Pubitemid 43902471)
46. Nickel JC, (2002). Interstitial cystitis: characterization and management of an enigmatic urologic syndrome. Rev Urol 4: 112-121.
47. O'reilly BA, Kosaka AH, Chang TK, Ford AP, Popert R, Mcmahon SB, (2001a). A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction. BJU Int 87: 617-622. (Pubitemid 34293751)
48. O'reilly BA, Kosaka AH, Chang TK, Ford AP, Popert R, Rymer JM, et al,. (2001b). A quantitative analysis of purinoceptor expression in human fetal and adult bladders. J Urol 165: 1730-1734. (Pubitemid 32410298)
49. Olivar T, Laird JM, (1999). Cyclophosphamide cystitis in mice: behavioural characterisation and correlation with bladder inflammation. Eur J Pain 3: 141-149. (Pubitemid 29290767)
50. Passos GF, Fernandes ES, Campos MM, Araujo JG, Pesquero JL, Souza GE, et al,. (2004). Kinin B1 receptor up-regulation after lipopolysaccharide administration: role of proinflammatory cytokines and neutrophil influx. J Immunol 172: 1839-1847. (Pubitemid 38116833)
51. Ralevic V, Burnstock G, (1998). Receptors for purines and pyrimidines. Pharmacol Rev 50: 413-492. (Pubitemid 28477681)
52. Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, et al,. (2010). Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med 182: 774-783.
53. Santos AA Jr, Leal PC, Edelweiss MI, Lopes TG, Calixto JB, Morrone FB, et al,. (2010). Effects of the compounds MV8608 and MV8612 obtained from Mandevilla velutina in the model of hemorrhagic cystitis induced by cyclophosphamide in rats. Naunyn Schmiedebergs Arch Pharmacol 382: 399-407.
54. Skaper SD, Debetto P, Giusti P, (2010). The P2X7 purinergic receptor: from physiology to neurological disorders. FASEB J 24: 337-345.
55. Sun Y, Chai TC, (2006). Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis. Am J Physiol Cell Physiol 290: C27-C34.
56. Surprenant A, North RA, (2009). Signaling at purinergic P2X receptors. Annu Rev Physiol 71: 333-359.
57. Teixeira JM, Oliveira MC, Parada CA, Tambeli CH, (2010). Peripheral mechanisms underlying the essential role of P2X7 receptors in the development of inflammatory hyperalgesia. Eur J Pharmacol 644: 55-60.
58. Tempest HV, Dixon AK, Turner WH, Elneil S, Sellers LA, Ferguson DR, (2004). P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis. BJU Int 93: 1344-1348. (Pubitemid 38823965)
59. Traxer O, Desgrandchamps F, Sebe P, Haab F, Le Duc A, Gattegno B, et al,. (2001). [Hemorrhagic cystitis: etiology and treatment]. Prog Urol 11: 591-601.
60. Vizzard MA, (2000a). Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis. Am J Physiol Regul Integr Comp Physiol 278: R1027-R1039. (Pubitemid 30215217)
61. Vizzard MA, (2000b). Increased expression of spinal cord Fos protein induced by bladder stimulation after spinal cord injury. Am J Physiol Regul Integr Comp Physiol 279: R295-R305. (Pubitemid 30625446)
62. Wantuch C, Piesla M, Leventhal L, (2007). Pharmacological validation of a model of cystitis pain in the mouse. Neurosci Lett 421: 250-252. (Pubitemid 46935365)
63. Wong TM, Yeo W, Chan LW, Mok TS, (2000). Hemorrhagic pyelitis, ureteritis, and cystitis secondary to cyclophosphamide: case report and review of the literature. Gynecol Oncol 76: 223-225. (Pubitemid 30067200)
64. Yoon MJ, Lee HJ, Lee YS, Kim JH, Park JK, Chang WK, et al,. (2007). Extracellular ATP is involved in the induction of apoptosis in murine hematopoietic cells. Biol Pharm Bull 30: 671-676.