ATP-activated P2X2 current in mouse spermatozoa

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 34, 2011, Pages 14342-14347

  Navarro, Betsy ^a   Miki, Kiyoshi ^a   Clapham, David E ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Infertility; P2X channel; Purinergic ion channel; Reproduction

Indexed keywords

ION CHANNEL; NEUROTRANSMITTER RECEPTOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PURINERGIC P2X2 RECEPTOR;

ACROSOME REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY DETECTION; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DESENSITIZATION; HETEROLOGOUS EXPRESSION; ION CONDUCTANCE; MALE; MALE FERTILITY; MATING; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERMATOZOON; SPERMATOZOON MOTILITY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CATIONS; CROSSES, GENETIC; FEMALE; FERTILITY; ION CHANNEL GATING; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, PURINERGIC P2X2; SPERM MIDPIECE; SPERMATOZOA;

MUS;

EID: 80052181424     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111695108     Document Type: Article

References (38)

1. 2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci USA 100:14864-14868.
2. 2+ channel. Nature 439:737-740.
3. Qi H, et al. (2007) All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci USA 104:1219-1223. (Pubitemid 46183985)
4. Ren D, et al. (2001) A sperm ion channel required for sperm motility and male fertility. Nature 413:603-609. (Pubitemid 32964054)
5. 2+ channel of human sperm. Nature 471:387-391.
6. 2+ influx in human sperm. Nature 471:382-386.
7. Revelli A, et al. (2009) Follicular fluid content and oocyte quality: From single biochemical markers to metabolomics. Reprod Biol Endocrinol 7:40-53.
8. Harris SE, Gopichandran N, Picton HM, Leese HJ, Orsi NM (2005) Nutrient concentrations in murine follicular fluid and the female reproductive tract. Theriogenology 64:992-1006. (Pubitemid 41065529)
9. Burrello N, et al. (2004) Human follicular fluid stimulates the sperm acrosome reaction by interacting with the gamma-aminobutyric acid receptors. Fertil Steril 82 (Suppl 3): 1086-1090. (Pubitemid 39335921)
10. Meizel S (2004) The sperm, a neuron with a tail: 'Neuronal' receptors in mammalian sperm. Biol Rev Camb Philos Soc 79:713-732.
11. Naz RK, Sellamuthu R (2006) Receptors in spermatozoa: Are they real? J Androl 27:627-636.
12. + current that controls sperm membrane potential. Proc Natl Acad Sci USA 104:7688-7692.
13. Liu J, Xia J, Cho KH, Clapham DE, Ren D (2007) CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem 282:18945-18952. (Pubitemid 47100166)
14. Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE (2011) A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun 2:153-165.
15. Avenarius MR, et al. (2009) Human male infertility caused by mutations in the CATSPER1 channel protein. Am J Hum Genet 84:505-510.
16. Hildebrand MS, et al. (2010) Genetic male infertility and mutation of CATSPER ion channels. Eur J Hum Genet 18:1178-1184.
17. Navarro B, Kirichok Y, Chung JJ, Clapham DE (2008) Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol 52:607-613.
18. Quill TA, Ren D, Clapham DE, Garbers DL (2001) A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci USA 98:12527-12531. (Pubitemid 33019979)
19. Quill TA, et al. (2003) Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci USA 100:14869-14874. (Pubitemid 37517983)
20. Santi CM, et al. (2010) The SLO3 sperm-specific potassium channel plays a vital role in male fertility. FEBS Lett 584:1041-1046.
21. + current in mouse spermatozoa. Proc Natl Acad Sci USA 108:5879-5884.
22. Lishko PV, Kirichok Y (2010) The role of Hv1 and CatSper channels in sperm activation. J Physiol 588:4667-4672.
23. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067.
24. Wildman SS, King BF, Burnstock G (1999) Modulation of ATP-responses at recombinant rP2X4 receptors by extracellular pH and zinc. Br J Pharmacol 126:762-768. (Pubitemid 29087857)
25. 2+ modulation of ATP-responses at recombinant P2X2 receptors and its dependence on extracellular pH. Br J Pharmacol 123:1214-1220.
26. King BF, Wildman SS, Ziganshina LE, Pintor J, Burnstock G (1997) Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor. Br J Pharmacol 121:1445-1453. (Pubitemid 27317559)
27. Koshimizu TA, et al. (2006) Carboxyl-terminal splicing enhances physical interactions between the cytoplasmic tails of purinergic P2X receptors. Mol Pharmacol 69:1588-1598.
28. Torres GE, Egan TM, Voigt MM (1998) N-Linked glycosylation is essential for the functional expression of the recombinant P2X2 receptor. Biochemistry 37:14845-14851. (Pubitemid 28487592)
29. Rodríguez-Miranda E, et al. (2008) Extracellular adenosine 5′-triphosphate alters motility and improves the fertilizing capability of mouse sperm. Biol Reprod 79:164-171. (Pubitemid 351931038)
30. 2+ entry into mouse sperm triggers a tail-to-head propagation. Biol Reprod 77:551-559.
31. Wan B, LaNoue KF, Cheung JY, Scaduto RC, Jr. (1989) Regulation of citric acid cycle by calcium. J Biol Chem 264:13430-13439. (Pubitemid 19198419)
32. Kim YH, et al. (2007) Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece. Dev Biol 302:463-476.
33. Kramer RH (1990) Patch cramming: Monitoring intracellular messengers in intact cells with membrane patches containing detector ion channels. Neuron 4:335-341.
34. Levine N, Kelly H (1978) Measurement of pH in the rat epididymis in vivo. J Reprod Fertil 52:333-335. (Pubitemid 8277389)
35. Mawson CA, Fischer MI (1951) Zinc content of the genital organs of the rat. Nature 167:859.
36. Pastor-Soler N, Piétrement C, Breton S (2005) Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction. Physiology (Bethesda) 20:417-428. (Pubitemid 41812425)
37. Stoltenberg M, Ernst E, Andreasen A, Danscher G (1996) Histochemical localization of zinc ions in the epididymis of the rat. Histochem J 28:173-185. (Pubitemid 26153267)
38. Surprenant A, North RA (2009) Signaling at purinergic P2X receptors. Annu Rev Physiol 71:333-359.