A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury

Experimental Neurology

Volumn 233, Issue 2, 2012, Pages 687-692

  Marcillo, Alexander ^a   Frydel, Beata ^a   Bramlett, Helen M ^a   Dietrich, W Dalton ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Neuroprotection; Purinergic signaling; Spinal cord injury

Indexed keywords

BRILLIANT BLUE G; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; FEMALE; FUNCTIONAL ASSESSMENT; HISTOPATHOLOGY; LOCOMOTION; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; OPEN FIELD BEHAVIOR; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BLOCKING; SPINAL CORD INJURY; TREATMENT DURATION;

ANIMALS; CONTUSIONS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; NEUROPROTECTIVE AGENTS; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIDOXAL PHOSPHATE; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X7; ROSANILINE DYES; SPINAL CORD INJURIES;

EID: 84856533787     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.06.008     Document Type: Article

References (30)

1. Anderson D.K., Hall E.D. Pathophysiology of spinal cord trauma. Ann. Emerg. Med. 1993, 22:987-992.
2. Baptiste D.C., Fehlings M.G. Update on the treatment of spinal cord injury. Prog. Brain Res. 2007, 161:217-233.
3. Basso D.M., Beattie M.S., Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 1995, 12:1-21.
4. Bianchi D.M., Lynch K.J., Touma E., Niforatos W., Burgard E.C., Alexander K.M., Park H.S., Yu H., Metzger R., Kowaluk E., Jarvis M.F., van Biesen T. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur. J. Pharmacol. 1999, 376:127-138.
5. Borzelleca J.F., Depukat K., Hallagan J.B. Lifetime toxicity/carcinogenicity studies of FD & C Blue No. 1 (Brilliant Blue FCF) in rats and mice. Food Chem. Toxicol. 1990, 28:221-234.
6. Bracken M.B., Shepard M.J., Holford T.R. Administration of methylprednisolone for 24 or 48hours or tirilazad mesylate for 48hours in the treatment of acute spinal cord injury. Results of the third National Acute Spinal Cord Injury randomized controlled trial. National Acute Spinal Cord Injury Study. JAMA 1997, 277:1597-1604.
7. Collo G., Neidhart S., Kawashima E., Kosco-Vilbois M., North R.A., Buell G. Tissue distribution of the P2X7 receptor. Neuropharmacology 1997, 36:1277-1283.
8. Cotrina M.L., Nedergaard M. Physiological and pathological functions of P2X7 receptor in the spinal cord. Purinergic Signal 2009, 5:223-232.
9. Davalos D., Grutzendler J., Yang G., Kim J.V., Zuo Y., Jung S., Littman D.R., Dustin M.L., Gan W.B. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 2005, 8:752-758.
10. Deuchars S.A., Atkinson L., Brooke R.E., Musa H., Milligan C.J., Batten T.F., Buckley N.J., Parson S.H., Deuchars J. Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems. J. Neurosci. 2001, 21:7143-7152.
11. Duan S., Anderson C.M., Keung E.C., Chen Y., Chen Y., Swanson R.A. P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J. Neurosci. 2003, 23:1320-1328.
12. Franke H., Günther A., Grosche J., Schmidt R., Rossner S., Reinhardt R., Faber-Zuschratter H., Schneider D., Illes P. P2X7 receptor expression after ischemia in the cerebral cortex of rats. J. Neuropathol. Exp. Neurol. 2004, 63:686-699.
13. Gruner J.A. A monitored contusion model of spinal cord injury in the rat. J. Neurotrauma 1992, 9:123-128.
14. 2+ signaling in glial cell pathology in the central nervous system. Eur. J. Pharmacol. 2002, 447:247-260.
15. Jiang L.H., Mackenzie A.B., North R.A., Surprenant A. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol. Pharmacol. 2000, 58:82-88.
16. Khakh B.S., North R.A. P2X receptors as cell-surface ATP sensors in health and disease. Nature 2006, 442:527-532.
17. Kimelberg H.K., Nedergaard M. Functions of astrocytes and their potential as therapeutic targets. Neurotherapeutics 2010, 7:338-353.
18. Le Feuvre R., Brough D., Rothwell N. Extracellular ATP and P2X7 receptors in neurodegeneration. Eur. J. Pharmacol. 2002, 447:261-269.
19. Le Feuvre R.A., Brough D., Touzani O., Rothwell N.J. Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo. J. Cereb. Blood Flow Metab. 2003, 23:381-384.
20. Melani A., Amadio S., Gianfriddo M., Vannucchi M.G., Volontè C., Bernardi G., Pedata F., Sancesario G. P2X7 receptor modulation on microglial cells and reduction of brain infarct caused by middle cerebral artery occlusion in rat. J. Cereb. Blood Flow Metab. 2006, 26:974-982.
21. Neary J.T., Kang Y., Willoughby K.A., Ellis E.F. Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J. Neurosci. 2003, 23:2348-2356.
22. North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 2002, 32:1013-1067.
23. Parvathenani L.K., Tertyshnikova S., Greco C.R., Roberts S.B., Robertson B., Posmantur R. P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J. Biol. Chem. 2003, 278:13309-13317.
24. Peng W., Cotrina M.L., Han X., Yu H., Bekar L., Blum L., Takano T., Tian G.F., Goldman S.A., Nedergaard M. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:12489-12493.
25. Pinzon A., Marcillo A., Pabon D., Bramlett H.M., Bunge M.B., Dietrich W.D. A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury. Exp. Neurol. 2008, 213:129-136.
26. Popovich P.G., Wei P., Stokes B.T. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J. Comp. Neurol. 1997, 377:443-464.
27. Remy M., Thaler S., Schumann R.G., May C.A., Fiedorowicz M., Schuettauf F., Grüterich M., Priglinger S.G., Nentwich M.M., Kampik A., Haritoglou C. An in vivo evaluation of Brilliant Blue G in animals and humans. Br. J. Ophthalmol. 2008, 92:1142-1147.
28. Sperlágh B., Vizi E.S., Wirkner K., Illes P. P2X7 receptors in the nervous system. Prog. Neurobiol. 2006, 78:327-346.
29. Suzuki T., Hide I., Ido K., Kohsaka S., Inoue K., Nakata Y. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J. Neurosci. 2004, 24:1-7.
30. Wang X., Arcuino G., Takano T., Lin J., Peng W.G., Wan P., Li P., Xu Q., Liu Q.S., Goldman S.A., Nedergaard M. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat. Med. 2004, 10:821-827.