Negative and positive allosteric modulators of the P2X 7 receptor

British Journal of Pharmacology

Volumn 153, Issue 4, 2008, Pages 737-750

  Michel, A D ^a   Chambers, L J ^a   Walter, D S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Allosteric modulator; ATP; BzATP; Non competitive antagonist; P2X 7 receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; ETHIDIUM; GW 791343; N 2 (3,4 DIFLUOROPHENYL) N 1 [2 METHYL 5 (1 PIPERAZINYLMETHYL)PHENYL]GLYCINAMIDE; N [2 [[2 [(2 HYDROXYETHYL)AMINO]ETHYL]AMINO] 5 QUINOLINYL] 2 TRICYCLO[3.3.1.1 3,7]DEC 1 YLACETAMIDE; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHIDIUM; GLYCINE; HUMANS; MOLECULAR STRUCTURE; PIPERAZINES; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; QUINOLINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, PURINERGIC P2; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; TIME FACTORS; TRANSFECTION; VANADATES;

EID: 39449124756     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707625     Document Type: Article

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