Effects of A-317491, a novel and selective P2X 3/P2X 2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

British Journal of Pharmacology

Volumn 140, Issue 8, 2003, Pages 1381-1388

  McGaraughty, Steve ^a   Wismer, Carol T ^a   Zhu, Chang Z ^a   Mikusa, Joseph ^a   Honore, Prisca ^a   Chu, Katharine L ^a   Lee, Chih Hung ^a   Faltynek, Connie R ^a   Jarvis, Michael F ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Allodynia; ATP; Formalin; Hyperalgesia; Inflammation; Intraplantar; Intrathecal; Neuropathic; P2X 3

Indexed keywords

A 317491; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; ANTINOCICEPTIVE AGENT; CARRAGEENAN; FORMALDEHYDE; PURINE P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; HYPERALGESIA; INFLAMMATION; LOCOMOTION; MALE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REDUCTION; SPINE;

ACUTE DISEASE; ADENOSINE TRIPHOSPHATE; ANALGESICS, NON-NARCOTIC; ANIMALS; CARRAGEENAN; CHRONIC DISEASE; HEAT; HINDLIMB; INFLAMMATION; INJECTIONS, SPINAL; MALE; MOTOR ACTIVITY; NEUROPEPTIDES; PAIN; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; PHENOLS; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2;

EID: 0347949526     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705574     Document Type: Article

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