Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: Chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors

Journal of Biological Chemistry

Volumn 285, Issue 43, 2010, Pages 32770-32777

  Allsopp, Rebecca C ^a   Lalo, Ulyana ^a   Evans, Richard J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO-TERMINAL REGION; CELL SURFACE EXPRESSION; CHIMERIC RECEPTORS; CHOLESTEROL DEPLETION; CONSERVED PROTEINS; HEK293 CELLS; ION CHANNEL; LIPID RAFT; LIPID RAFT ASSOCIATION; MICRO-DOMAINS; MOLECULAR BASIS; P2X RECEPTORS; PATCH-CLAMP STUDIES; RECEPTOR CHANNELS; TERMINAL RESIDUES; TRANSMEMBRANE SEGMENTS; TRITON X-100;

AMINO ACIDS; CELL MEMBRANES; ENZYME ACTIVITY;

CHOLESTEROL;

ADENOSINE TRIPHOSPHATE; CHOLESTEROL; FILIPIN; FLOTILLIN; MEMBRANE PROTEIN; METHYL BETA CYCLODEXTRIN; PROTEIN KINASE C; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X4 RECEPTOR; RECOMBINANT RECEPTOR; TRITON X 100; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL STRAIN HEK293; CELL SURFACE; CHIMERA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPLETION; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPID RAFT; MUTATIONAL ANALYSIS; PATCH CLAMP; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; CELL LINE; CHOLESTEROL; HUMANS; ION CHANNEL GATING; MEMBRANE MICRODOMAINS; MEMBRANE POTENTIALS; MUTATION; RECEPTORS, PURINERGIC P2X1; RECEPTORS, PURINERGIC P2X2; RECEPTORS, PURINERGIC P2X3; RECEPTORS, PURINERGIC P2X4; RECOMBINANT FUSION PROTEINS;

EID: 77958471651     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.148940     Document Type: Article

References (47)

1. Burnstock, G. (2006) Trends Pharmacol. Sci. 27, 166-176
2. Ralevic, V., and Burnstock, G. (1998) Pharmacol. Rev. 50, 413-492
3. North, R. A. (2002) Physiol. Rev. 82, 1013-1067
4. Roberts, J. A., Vial, C., Digby, H. R., Agboh, K. C., Wen, H., Atterbury-Thomas, A., and Evans, R. J. (2006) Pflugers Arch. 452, 486-500
5. Surprenant, A., and North, R. A. (2009) Annu. Rev. Physiol. 71, 333-359
6. Khakh, B. S., and North, R. A. (2006) Nature 442, 527-532
7. Burnstock, G. (2006) Pharmacol. Rev. 58, 58-86
8. Kim, M., Jiang, L. H., Wilson, H. L., North, R. A., and Surprenant, A. (2001) EMBO J. 20, 6347-6358
9. Chaumont, S., Compan, V., Toulme, E., Richler, E., Housley, G. D., Rassendren, F., and Khakh, B. S. (2008) Sci. Signal. 1, ra8
10. Vial, C., and Evans, R. J. (2005) J. Biol. Chem. 280, 30705-30711
11. Vial, C., Fung, C. Y., Goodall, A. H., Mahaut-Smith, M. P., and Evans, R. J. (2006) Biochem. Biophys. Res. Commun. 343, 415-419
12. Pike, L. J. (2004) Biochem. J. 378, 281-292
13. Xia, F., Gao, X., Kwan, E., Lam, P. P., Chan, L., Sy, K., Sheu, L., Wheeler, M. B., Gaisano, H. Y., and Tsushima, R. G. (2004) J. Biol. Chem. 279, 24685-24691
14. Vacca, F., Amadio, S., Sancesario, G., Bernardi, G., and Volonté, C. (2004) J. Neurosci. Res. 76, 653-661
15. Liu, M., Huang, W., Wu, D., and Priestley, J. V. (2006) Eur. J. Neurosci. 24, 1-6
16. Vacca, F., Giustizieri, M., Ciotti, M. T., Mercuri, N. B., and Volonté, C. (2009) J. Neurochem. 109, 1031-1041
17. Garcia-Marcos, M., Pérez-Andrés, E., Tandel, S., Fontanils, U., Kumps, A., Kabré, E., Gómez-Muñoz, A., Marino, A., Dehaye, J. P., and Pochet, S. (2006) J. Lipid Res. 47, 705-714
18. Barth, K., Weinhold, K., Guenther, A., Young, M. T., Schnittler, H., and Kasper, M. (2007) FEBS J. 274, 3021-3033
19. Gonnord, P., Delarasse, C., Auger, R., Benihoud, K., Prigent, M., Cuif, M. H., Lamaze, C., and Kanellopoulos, J. M. (2009) FASEB J. 23, 795-805
20. Bickel, P. E., Scherer, P. E., Schnitzer, J. E., Oh, P., Lisanti, M. P., and Lodish, H. F. (1997) J. Biol. Chem. 272, 13793-13802
21. Ostrom, R. S. (2002) Mol. Pharmacol. 61, 473-476
22. Jacobs, C., Onnockx, S., Vandenbroere, I., and Pirson, I. (2004) FEBS Lett. 565, 70-74
23. Pagano, M., Clynes, M. A., Masada, N., Ciruela, A., Ayling, L. J., Wachten, S., and Cooper, D. M. (2009) Am. J. Physiol. Cell Physiol. 296, C607-C619
24. Qureshi, O. S., Paramasivam, A., Yu, J. C., and Murrell-Lagnado, R. D. (2007) J. Cell Sci. 120, 3838-3849
25. Rybin, V. O., Xu, X., Lisanti, M. P., and Steinberg, S. F. (2000) J. Biol. Chem. 275, 41447-41457
26. Ostrom, R. S., Gregorian, C., Drenan, R. M., Xiang, Y., Regan, J. W., and Insel, P. A. (2001) J. Biol. Chem. 276, 42063-42069
27. Toulme, E., Garcia, A., Samways, D., Egan, T. M., Carson, M. J., and Khakh, B. S. (2010) J. Gen Physiol. 135, 333-353
28. Wen, H., and Evans, R. J. (2009) J. Neurochem. 108, 331-340
29. Werner, P., Seward, E. P., Buell, G. N., and North, R. A. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 15485-15490
30. Janes, P. W., Ley, S. C., and Magee, A. I. (1999) J. Cell Biol. 147, 447-461
31. Boué-Grabot, E., Archambault, V., and Séguéla, P. (2000) J. Biol. Chem. 275, 10190-10195
32. Paukert, M., Osteroth, R., Geisler, H. S., Brandle, U., Glowatzki, E., Ruppersberg, J. P., and Gründer, S. (2001) J. Biol. Chem. 276, 21077-21082
33. Bernier, L. P., Ase, A. R., Chevallier, S., Blais, D., Zhao, Q., Boué-Grabot, E., Logothetis, D., and Séguéla, P. (2008) J. Neurosci. 28, 12938-12945
34. Fragoso, R., Ren, D., Zhang, X., Su, M. W., Burakoff, S. J., and Jin, Y. J. (2003) J. Immunol. 170, 913-921
35. Mukherjee, A., Arnaud, L., and Cooper, J. A. (2003) J. Biol. Chem. 278, 40806-40814
36. Couet, J., Li, S., Okamoto, T., Ikezu, T., and Lisanti, M. P. (1997) J. Biol. Chem. 272, 6525-6533
37. Waheed, A. A., and Jones, T. L. (2002) J. Biol. Chem. 277, 32409-32412
38. Adinolfi, E., Kim, M., Young, M. T., Di Virgilio, F., and Surprenant, A. (2003) J. Biol. Chem. 278, 37344-37351
39. Hiller, S., Garces, R. G., Malia, T. J., Orekhov, V. Y., Colombini, M., and Wagner, G. (2008) Science 321, 1206-1210
40. Dalziel, A. W., Rollins, E. S., and McNamee, M. G. (1980) FEBS Lett. 122, 193-196
41. Hanson, M. A., Cherezov, V., Griffith, M. T., Roth, C. B., Jaakola, V. P., Chien, E. Y., Velasquez, J., Kuhn, P., and Stevens, R. C. (2008) Structure 16, 897-905
42. Jindrichova, M., Vavra, V., Obsil, T., Stojilkovic, S. S., and Zemkova, H. (2009) J. Neurochem. 109, 923-934
43. Epshtein, Y., Chopra, A. P., Rosenhouse-Dantsker, A., Kowalsky, G. B., Logothetis, D. E., and Levitan, I. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 8055-8060
44. Bernier, L. P., Ase, A. R., Tong, X., Hamel, E., Blais, D., Zhao, Q., Logothetis, D. E., and Séguéla, P. (2008) Mol. Pharmacol. 74, 785-792
45. Fujiwara, Y., and Kubo, Y. (2006) J. Physiol. 576, 135-149
46. Fountain, S. J., Parkinson, K., Young, M. T., Cao, L., Thompson, C. R., and North, R. A. (2007) Nature 448, 200-203
47. Kawate, T., Michel, J. C., Birdsong, W. T., and Gouaux, E. (2009) Nature 460, 592-598