P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease

Journal of Biological Chemistry

Volumn 278, Issue 15, 2003, Pages 13309-13317

  Parvathenani, Lav K ^a   Tertyshnikova, Svetlana ^b   Greco, Corinne R ^b   Roberts, Susan B ^b   Robertson, Barbara ^b   Posmantur, Rand ^b  

^a CURAGEN CORPORATION   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ATTENUATION; CELLS;

NEURODEGENERATION;

DISEASE CONTROL;

3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P44; PURINE P2X RECEPTOR; PURINE P2X7 RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; UNCLASSIFIED DRUG; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 3' O (4 BENZOYL)BENZOYLADENOSINE 5' TRIPHOSPHATE; 3'-O-(4-BENZOYL)BENZOYLADENOSINE 5'-TRIPHOSPHATE; CALCIUM; CHROMONE DERIVATIVE; DRUG DERIVATIVE; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PURINE P2 RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; EXPERIMENTAL MODEL; MICROGLIA; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SENILE PLAQUE; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; BRAIN CORTEX; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; EMBRYO; FEMALE; GENETICS; HUMAN; KINETICS; METABOLISM; NEUTROPHIL; NEWBORN; PHYSIOLOGY; PREGNANCY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALIA; MUS MUSCULUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ALZHEIMER DISEASE; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CEREBRAL CORTEX; CHROMONES; DISEASE MODELS, ANIMAL; EMBRYO; ENZYME INHIBITORS; FEMALE; HUMANS; KINETICS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MICROGLIA; MORPHOLINES; NADPH OXIDASE; NEUTROPHILS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; SUPEROXIDES; UP-REGULATION;

EID: 0038143359     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209478200     Document Type: Article

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