A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 26, 2002, Pages 17179-17184

  Jarvis, Michael F ^a   Burgard, Edward C ^a   McGaraughty, Steve ^a   Honore, Prisca ^a   Lynch, Kevin ^a   Brennan, Timothy J ^b   Subieta, Alberto ^b   Van Biesen, Tim ^a   Cartmell, Jayne ^a   Bianchi, Bruce ^a   Niforatos, Wende ^a   Kage, Karen ^a   Yu, Haixia ^a   Mikusa, Joe ^a   Wismer, Carol T ^a   Zhu, Chang Z ^a   Chu, Katharine ^a   Lee, Chih Hung ^a   Stewart, Andrew O ^a   Polakowski, James ^a   Cox, Bryan F ^a   Kowaluk, Elizabeth ^a   Williams, Michael ^a   Sullivan, James ^a   Faltynek, Connie ^a   more..

^a ABBOTT LABORATORIES   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 317344; A 317491; PURINE ANTAGONIST; PURINE P2X RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CHRONIC INFLAMMATION; CHRONIC PAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; ENANTIOMER; HUMAN; HUMAN CELL; HYPERALGESIA; IC 50; MALE; NERVE COMPRESSION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY; TREATMENT OUTCOME; VISCERAL PAIN;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMODYNAMIC PROCESSES; MALE; MOTOR ACTIVITY; PHENOLS; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2;

ANIMALIA;

EID: 0037168683     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.252537299     Document Type: Article

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