Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Pain

Volumn 114, Issue 3, 2005, Pages 386-396

  Chessell, Iain P ^a   Hatcher, Jonathan P ^a   Bountra, Chas ^a   Michel, Anton D ^a   Hughes, Jane P ^a   Green, Paula ^a   Egerton, Julie ^a   Murfin, Melanie ^a   Richardson, Jill ^a   Peck, Wendy L ^a   Grahames, Caroline B A ^a,e   Casula, Maria Anna ^b   Yiangou, Yiangos ^b   Birch, Rolfe ^c   Anand, Praveen ^b   Buell, Gary N ^d,f  

^a GLAXOSMITHKLINE   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c ROYAL NATIONAL ORTHOPAEDIC HOSPITAL   (United Kingdom)

^d GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

^e ASTRAZENECA   (United Kingdom)

^f Serono International SA   (Switzerland)

Author keywords

Interleukin 1 beta; Neuropathic; P2X7; Purinoceptor; Taqman

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PURINE P2X7 RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 1 PRECURSOR; PROTEIN PRECURSOR; PURINE P2 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOMETRY; FEMALE; GENE DELETION; GENE DISRUPTION; KNOCKOUT MOUSE; MALE; MECHANICAL STIMULATION; MOUSE; NERVE INJURY; NERVE LIGATION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINAL GANGLION; THERMAL STIMULATION; UPREGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL COUNT; CHRONIC DISEASE; CYTOLOGY; DBA MOUSE; GENE EXPRESSION; GENETICS; HUMAN; HYPERALGESIA; IMMUNOLOGY; LIGATION; METABOLISM; MOUSE MUTANT; NEURALGIA; NOCICEPTIVE RECEPTOR; PATHOPHYSIOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL COUNT; CHRONIC DISEASE; FEMALE; GANGLIA, SPINAL; GENE EXPRESSION; HUMANS; HYPERALGESIA; INTERLEUKIN-1; LIGATION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; NEURALGIA; NOCICEPTORS; PROTEIN PRECURSORS; RECEPTORS, PURINERGIC P2;

EID: 20144375454     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2005.01.002     Document Type: Article

References (39)

1. 7 receptor antagonists Bioorg Med Chem Lett 13 2004 4043 4046
2. K.O. Aley, G. McCarter, and J.D. Levine Nitric oxide signaling in pain and nociceptor sensitization in the rat J Neurosci 18 1998 7008 7014
3. M. Budzinski, K. Misterek, W. Gumulka, and A. Dorociak Inhibition of inducible nitric oxide synthase in persistant pain Life Sci 66 2000 301 305
4. 7 receptor function with a monoclonal antibody Blood 92 1998 3521 3528
5. 7 receptor Fed Eur Biolchem Soc Lett 439 1998 26 30
6. J.D. Clark Chronic pain prevalence and analgesic prescribing in a general medical population J Pain Sympt Manage 23 2003 131 137
7. N.M. Clayton, I. Oakley, S. Thompson, A. Wheeldon, R.S. Sargent, and C. Bountra Validation of the dual channel weight averager as an instrument for the measurement of inflammatory pain Br J Pharmacol 120 1997 219
8. 7 receptor Neuropharmacology 36 1997 1277 1283
9. 7 receptors J Biol Chem 278 2003 30732 30740
10. F. Conquet Inactivation in vivo of metabotropic glutamate receptor 1 by specific chromosomal insertion of a reported gene lacZ Neuropharmacology 34 1995 865 870
11. D. Ferrari, P. Chiozzi, S. Falzoni, S. Hanau, and F. Di Virgilio Purinergic modulation of interleukin-1-beta release from microglial cells stimulated with bacterial endotoxin J Exp Med 185 1997 579 582
12. C.R. Flannery, C.B. Little, B. Caterson, and C.E. Hughes Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes Matrix Biol 18 2003 225 237
13. R.T. Gazinelli, M. Wysocka, S. Hieny, T. Scharton-Kersten, A. Cheever, R. Kuhn, W. Muller, G. Trinchieri, and A. Sher In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha J Immunol 157 2004 798 805
14. R. Glass, and G. Burnstock Immunohistological identification of cells expressing ATP-gated cation channels (P2X receptors) in the adult rat thyroid J Anat 198 2001 569 579
15. C.B.A. Grahames, A.D. Michel, I.P. Chessell, and P.P.A. Humphrey Pharmacological characterization of ATP- and LPS-induced IL-1β release in human monocytes Br J Pharmacol 127 1999 1915 1921
16. i/o-coupled P2Y receptors J Neurosci 21 2001 1975 1982
17. K.K. Jain A guide to drug evaluation for chronic pain Emerg Drugs 5 2000 241 257
18. M. Kim, V. Spelta, R.A. North, and A. Surprenant Differential assembly of rat purinergic P2X7 receptor in immune cells of the brain and periphery J Biol Chem 276 2001 23232 23267
19. 7 receptor agonist 2′-3′-O-(4- benzoylbenzoyl)-ATP J Neurosci 24 2004 7128 7139
20. 7 receptor alters leukocyte function and attenuates an inflammatory response J Immunol 168 2002 6436 6445
21. H. Le Mouellic, Y. Lallemand, and P. Brulet Targeted replacement of the homeobox gene hox-3.1 by the escherichia-coli lacZ in mouse chimeric embryos Proc Natl Acad Sci USA 87 1990 4712 4716
22. R. MacDonald, S. Bingham, B.C. Bond, A.A. Parsons, and K.L. Philpott Determination of changes in mRNA expression in a rat model of neuropathic pain by Taqman quantitative RT-PCR Brain Res 90 2001 48 56
23. V.B. Mehta, J. Hart, and M.D. Wewers ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage J Biol Chem 276 2004 3820 3826
24. 7 receptor function N-S Arch Pharmacol 359 1999 102 109
25. 7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease J Biol Chem 278 2003 13309 13317
26. D.G. Perregaux, and C.A. Gabel Interleukin-1β maturation and release in response to ATP and nigericin J Biol Chem 269 1994 15195 15203
27. T.A. Samad, K.A. Moore, A. Sapirstein, S. Billet, A. Allchorne, S. Poole, J.V. Bonventre, and C.J. Woolf Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity Nature 410 2001 471 475
28. Z. Seltzer, R. Dubner, and Y. Shir A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury Pain 43 2000 205 218
29. S.Y. Shu, G. Ju, and L.Z. Fan The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system Neurosci Lett 85 1988 169 171
30. A. Sica, J.M. Wang, F. Colotta, E. Dejana, A. Mantovani, J.J. Oppenheim, C.G. Larsen, C.O. Zachariae, and K. Matsushima Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor J Immunol 144 1990 3034 3038
31. 7 receptor expression in rodent brain J Neurosci 24 2004 6307 6314
32. 7 receptors J Biol Chem 276 2001 125 132
33. 4- permeabilizes the plasma membrane of mouse macrophages to flourescent dyes J Biol Chem 262 1987 8884 8888
34. 7) Science 272 1996 735 738
35. C. Verderio, and M. Matteoli ATP mediates calcium signalling between astrocytes and microglia cells: modulation by IFN-γ J Immunol 166 2001 6383 6391
36. M.S. Wallace Emerging drugs for neuropathic pain Expert Opin Emerg Drugs 6 2001 249 259
37. C.J. Woolf, Q. Ma, A. Allchorne, and S. Poole Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation J Neurosci 16 1996 2716 2723
38. C.J. Woolf, A. Allchorne, B. Safieh-Garabedian, and S. Poole Cytokines, nerve growth factor and inflammatory hyperlagesia: the contribution of tumour necrosis factor α Br J Pharmacol 121 1997 417 424
39. Y. Yiangou, P. Facer, N.H. Dyer, C.L. Chan, C. Knowles, N.S. Williams, and P. Anand Vannilloid receptor 1 immunoreactivity in inflammed human bowel Lancet 357 2001 1338 1339