2′,3′-O-(2,4,6,trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X 3 receptor

British Journal of Pharmacology

Volumn 140, Issue 1, 2003, Pages 202-210

  Neelands, Torben R ^a   Burgard, Edward C ^a,b   Uchic, Marie E ^a   McDonald, Heath A ^a   Niforatos, Wende ^a   Faltynek, Connie R ^a   Lynch, Kevin J ^a   Jarvis, Michael F ^a  

^a ABBOTT LABORATORIES   (United States)

^b Dynogen Pharmaceuticals Inc   (United States)

Author keywords

, meATP; Chimeras; Competitive antagonist; Desensitization; P2X 2; P2X 3; Purinergic receptors; TNP ATP

Indexed keywords

2',3' O (2,4,6 TRINITROPHENYL)ADENOSINE TRIPHOSPHATE; A 317491; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; CALCIUM; PURINE P2X 2 3 RECEPTOR; PURINE P2X 3 2 RECEPTOR; PURINE P2X RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; 2',3' O (2,4,6 TRINITRO CYCLOHEXADIENYLIDINE)ADENOSINE 5' TRIPHOSPHATE; 2',3'-O-(2,4,6-TRINITRO-CYCLOHEXADIENYLIDINE)ADENOSINE 5'-TRIPHOSPHATE; A-317491; DRUG DERIVATIVE; PHENOL DERIVATIVE; POLYCYCLIC HYDROCARBON; PURINE P2 RECEPTOR; PURINE P2X3 RECEPTOR;

ARTICLE; ASTROCYTOMA CELL; CARBOXY TERMINAL SEQUENCE; CELL CLONE; CELL LINE; CHIMERA; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG POTENCY; ELECTROPHYSIOLOGY; EXPERIMENTAL DESIGN; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMAGING; NERVE CELL MEMBRANE POTENTIAL; PRIORITY JOURNAL; RECEPTOR BLOCKING; WILD TYPE; BINDING COMPETITION; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; BINDING, COMPETITIVE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PHENOLS; POLYCYCLIC COMPOUNDS; RECEPTORS, PURINERGIC P2;

EID: 0141507009     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705411     Document Type: Article

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