Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis

Nature Medicine

Volumn 18, Issue 4, 2012, Pages 600-604

  Gulbransen, Brian D ^a,b   Bashashati, Mohammad ^a,b   Hirota, Simon A ^b,c   Gui, Xianyong ^b   Roberts, Jane A ^d   MacDonald, Justin A ^b,c   Muruve, Daniel A ^b,c   McKay, Derek M ^b   Beck, Paul L ^b,c   Mawe, Gary M ^d   Thompson, Roger J ^a,b   Sharkey, Keith A ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CRYOPYRIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; PANNEXIN 1; PROTEIN; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DENSITY; CELL SURVIVAL; COLITIS; CONTROLLED STUDY; CROHN DISEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INFLAMMATION; INTESTINE CONTRACTION; INTESTINE MOTILITY; MALE; MOUSE; NERVE CELL NECROSIS; NEUROMUSCULAR TRANSMISSION; NEUROPROTECTION; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYMPATHETIC INNERVATION; ULCERATIVE COLITIS;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMALS; CALCIUM; CARRIER PROTEINS; CASPASES; CELL DEATH; COLITIS; CONNEXINS; CYTOSKELETAL PROTEINS; DINITROFLUOROBENZENE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRENES; GASTROINTESTINAL MOTILITY; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYENTERIC PLEXUS; NERVE TISSUE PROTEINS; NEURONS; NITRIC OXIDE SYNTHASE TYPE I; PHOSPHODIESTERASE INHIBITORS; PURINERGIC P2X RECEPTOR AGONISTS; PYRROLIDINONES; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84863393008     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2679     Document Type: Article

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