Structure-activity relationship studies of spinorphin as a potent and selective human P2X3 receptor antagonist

Journal of Medicinal Chemistry

Volumn 50, Issue 18, 2007, Pages 4543-4547

  Jung, Kwan Young ^a   Hyoun, Duk Moon ^a   Ga, Eun Lee ^a   Lim, Hyun Ho ^a   Park, Chul Seung ^a   Kim, Yong Chul ^a,b  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Division of Drug Discovery   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

A 317491; ADENOSINE TRIPHOSPHATE; MRS 2273; PURINE P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; SPINORPHIN; UNCLASSIFIED DRUG;

AGONIST; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; OOCYTE; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP; XENOPUS;

ANIMALS; FEMALE; HUMANS; MICE; OLIGOPEPTIDES; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, PURINERGIC P2; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 34548494816     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070114m     Document Type: Article

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