Isoquinolines as antagonists of the P2X7 nucleotide receptor: High selectivity for the human versus rat receptor homologues

Molecular Pharmacology

Volumn 54, Issue 1, 1998, Pages 22-32

  Humphreys, Benjamin D ^a   Virginio, Caterina ^b   Surprenant, Annmarie ^b   Rice, Janet ^a   Dubyak, George R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; AMINO ACID; CALCIUM ION; CATION CHANNEL; ETHIDIUM; ISOQUINOLINE DERIVATIVE; MESSENGER RNA; N [1 [N METHYL 4 (5 ISOQUINOLINESULFONYL)BENZYL] 2 (4 PHENYLPIPERAZINE)ETHYL] 5 ISOQUINOLINESULFONAMIDE; RECEPTOR; UNCLASSIFIED DRUG; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; DRUG DERIVATIVE; ENZYME INHIBITOR; FLUORESCENT DYE; N [1 [4 (5 ISOQUINOLINESULFONYL) ALPHA METHYLBENZYL] 2 (4 PHENYL 1 PIPERAZINYL)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PURINE P2 RECEPTOR; PURINE P2X7 RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG SELECTIVITY; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; ANIMAL; CELL CULTURE; CHIMERA; DRUG ANTAGONISM; DRUG EFFECT; ION TRANSPORT; LEUKOCYTE; METABOLISM; PHYSIOLOGY; RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; CHIMERA; ENZYME INHIBITORS; ETHIDIUM; FLUORESCENT DYES; HUMANS; ION TRANSPORT; ISOQUINOLINES; LEUKOCYTES; RATS; RECEPTORS, PURINERGIC P2;

EID: 0031595744     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.1.22     Document Type: Article

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