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Volumn 69, Issue 20, 2012, Pages 3395-3418

Type I IFN-mediated regulation of IL-1 production in inflammatory disorders

Author keywords

Anti IL 1 therapy; Autoimmunity; IL 1; Inflammasome; Inflammatory disorders; Multiple sclerosis; Type I IFN

Indexed keywords

ADAPTOR PROTEIN; AIM2 PROTEIN; ALPHA INTERFERON; ASC PROTEIN; BETA INTERFERON; BETA1A INTERFERON; CRYOPYRIN; EXTRACHROMOSOMAL DNA; GAMMA INTERFERON; HELICASE; INFLAMMASOME; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON STIMULATED GENE FACTOR 3; INTERFERON TYPE III; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MELANOMA DIFFERENTIATION ASSOCIATED GENE 5 PROTEIN; NLRC4 PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; STAT PROTEIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

EID: 84867574317     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-0989-2     Document Type: Review
Times cited : (33)

References (347)
  • 1
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454(7203):428-435
    • (2008) Nature , vol.454 , Issue.7203 , pp. 428-435
    • Medzhitov, R.1
  • 2
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34(5):637-650
    • (2011) Immunity , vol.34 , Issue.5 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 3
    • 79956292569 scopus 로고    scopus 로고
    • Reis e Sousa C (2011) Myeloid C-type lectin receptors in pathogen recognition and host defense
    • Osorio F, Reis e Sousa C (2011) Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 34(5): 651-664
    • Immunity , vol.34 , Issue.5 , pp. 651-664
    • Osorio, F.1
  • 4
    • 79956303498 scopus 로고    scopus 로고
    • Regulation of the antimicrobial response by NLR proteins
    • Elinav E et al (2011) Regulation of the antimicrobial response by NLR proteins. Immunity 34(5):665-679
    • (2011) Immunity , vol.34 , Issue.5 , pp. 665-679
    • Elinav, E.1
  • 5
    • 79956314622 scopus 로고    scopus 로고
    • Immune signaling by RIG-I-like receptors
    • Loo YM, Gale M Jr (2011) Immune signaling by RIG-I-like receptors. Immunity 34(5):680-692
    • (2011) Immunity , vol.34 , Issue.5 , pp. 680-692
    • Loo, Y.M.1    Gale Jr., M.2
  • 6
    • 58049190133 scopus 로고    scopus 로고
    • Interleukin-1 (IL-1): A central regulator of stress responses
    • Goshen I, Yirmiya R (2009) Interleukin-1 (IL-1): A central regulator of stress responses. Front Neuroendocrinol 30(1): 30-45
    • (2009) Front Neuroendocrinol , vol.30 , Issue.1 , pp. 30-45
    • Goshen, I.1    Yirmiya, R.2
  • 7
    • 8344261590 scopus 로고    scopus 로고
    • Infection, fever, and exogenous and endogenous pyrogens: Some concepts have changed
    • Dinarello CA (2004) Infection, fever, and exogenous and endogenous pyrogens: Some concepts have changed. J Endotoxin Res 10(4):201-222
    • (2004) J Endotoxin Res , vol.10 , Issue.4 , pp. 201-222
    • Dinarello, C.A.1
  • 9
    • 0023028213 scopus 로고
    • The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical
    • Dower SK et al (1986) The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. Nature 324(6094): 266-268
    • (1986) Nature , vol.324 , Issue.6094 , pp. 266-268
    • Dower, S.K.1
  • 10
    • 0026694674 scopus 로고
    • Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes
    • Stylianou E et al (1992) Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes. J Biol Chem 267(22):15836-15841
    • (1992) J Biol Chem , vol.267 , Issue.22 , pp. 15836-15841
    • Stylianou, E.1
  • 11
    • 0027976653 scopus 로고
    • The cytoplasmic domain of the interleukin-1 receptor is required for nuclear factor-kappa B signal transduction
    • Leung K et al (1994) The cytoplasmic domain of the interleukin-1 receptor is required for nuclear factor-kappa B signal transduction. J Biol Chem 269(3):1579-1582
    • (1994) J Biol Chem , vol.269 , Issue.3 , pp. 1579-1582
    • Leung, K.1
  • 12
    • 0028982919 scopus 로고
    • NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity
    • Croston GE, Cao Z, Goeddel DV (1995) NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity. J Biol Chem 270(28):16514-16517
    • (1995) J Biol Chem , vol.270 , Issue.28 , pp. 16514-16517
    • Croston, G.E.1    Cao, Z.2    Goeddel, D.V.3
  • 13
    • 55149105005 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
    • O'Neill LA (2008) The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol Rev 226:10-18
    • (2008) Immunol Rev , vol.226 , pp. 10-18
    • O'Neill, L.A.1
  • 14
    • 79955148909 scopus 로고    scopus 로고
    • A clinical perspective of IL-1 beta as the gatekeeper of inflammation
    • Dinarello CA (2011) A clinical perspective of IL-1 beta as the gatekeeper of inflammation. Eur J Immunol 41(5):1203-1217
    • (2011) Eur J Immunol , vol.41 , Issue.5 , pp. 1203-1217
    • Dinarello, C.A.1
  • 15
    • 0029979369 scopus 로고    scopus 로고
    • Biologic basis for interleukin-1 in disease
    • Dinarello CA (1996) Biologic basis for interleukin-1 in disease. Blood 87(6):2095-2147
    • (1996) Blood , vol.87 , Issue.6 , pp. 2095-2147
    • Dinarello, C.A.1
  • 16
    • 0030013088 scopus 로고    scopus 로고
    • The inflammatory response in interleukin-1 beta-deficient mice: Comparison with other cytokine-related knock-out mice
    • Fantuzzi G, Dinarello CA (1996) The inflammatory response in interleukin-1 beta-deficient mice: Comparison with other cytokine-related knock-out mice. J Leukoc Biol 59(4):489-493
    • (1996) J Leukoc Biol , vol.59 , Issue.4 , pp. 489-493
    • Fantuzzi, G.1    Dinarello, C.A.2
  • 17
    • 78650610580 scopus 로고    scopus 로고
    • Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1 alpha and IL-1 beta
    • Yazdi AS et al (2010) Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1 alpha and IL-1 beta. Proc Natl Acad Sci USA 107(45):19449-19454
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.45 , pp. 19449-19454
    • Yazdi, A.S.1
  • 18
    • 33746747096 scopus 로고    scopus 로고
    • MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
    • Chen CJ et al (2006) MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest 116(8):2262-2271
    • (2006) J Clin Invest , vol.116 , Issue.8 , pp. 2262-2271
    • Chen, C.J.1
  • 19
    • 0019197783 scopus 로고
    • Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells
    • Smith KA, Gilbride KJ, Favata MF (1980) Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells. Nature 287(5785):853-855
    • (1980) Nature , vol.287 , Issue.5785 , pp. 853-855
    • Smith, K.A.1    Gilbride, K.J.2    Favata, M.F.3
  • 20
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C et al (2006) A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203(7):1685-1691
    • (2006) J Exp Med , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1
  • 21
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1 beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez EV et al (2007) Interleukins 1 beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8(9):942-949
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 942-949
    • Acosta-Rodriguez, E.V.1
  • 22
    • 33744921639 scopus 로고    scopus 로고
    • IL-1 beta breaks tolerance through expansion of CD25? effector T cells
    • O'Sullivan BJ et al (2006) IL-1 beta breaks tolerance through expansion of CD25? effector T cells. J Immunol 176(12): 7278-7287
    • (2006) J Immunol , vol.176 , Issue.12 , pp. 7278-7287
    • O'Sullivan, B.J.1
  • 23
    • 0025713953 scopus 로고
    • Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
    • Hannum CH et al (1990) Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343(6256): 336-340
    • (1990) Nature , vol.343 , Issue.6256 , pp. 336-340
    • Hannum, C.H.1
  • 24
    • 0025321201 scopus 로고
    • Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein
    • Carter DB et al (1990) Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344(6267):633-638
    • (1990) Nature , vol.344 , Issue.6267 , pp. 633-638
    • Carter, D.B.1
  • 25
    • 66649121678 scopus 로고    scopus 로고
    • An auto inflammatory disease with deficiency of the interleukin-1- receptor antagonist
    • Aksentijevich I et al (2009) An auto inflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med 360(23):2426-2437
    • (2009) N Engl J Med , vol.360 , Issue.23 , pp. 2426-2437
    • Aksentijevich, I.1
  • 26
    • 66649113371 scopus 로고    scopus 로고
    • An auto inflammatory disease due to homozygous deletion of the IL1RN locus
    • Reddy S et al (2009) An auto inflammatory disease due to homozygous deletion of the IL1RN locus. N Engl J Med 360(23):2438-2444
    • (2009) N Engl J Med , vol.360 , Issue.23 , pp. 2438-2444
    • Reddy, S.1
  • 27
    • 67650736238 scopus 로고    scopus 로고
    • Horror autoinflammaticus: The molecular pathophysiology of auto inflammatory disease
    • Masters SL et al (2009) Horror autoinflammaticus: The molecular pathophysiology of auto inflammatory disease. Annu Rev Immunol 27:621-668
    • (2009) Annu Rev Immunol , vol.27 , pp. 621-668
    • Masters, S.L.1
  • 28
    • 64049084303 scopus 로고    scopus 로고
    • Differential requirement for the activation of the inflammasome for processing and release of IL-1 beta in monocytes and macrophages
    • Netea MG et al (2009) Differential requirement for the activation of the inflammasome for processing and release of IL-1 beta in monocytes and macrophages. Blood 113(10):2324-2335
    • (2009) Blood , vol.113 , Issue.10 , pp. 2324-2335
    • Netea, M.G.1
  • 29
    • 12044259166 scopus 로고
    • Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: Evidence for a positive autoregulatory loop
    • Hiscott J et al (1993) Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: Evidence for a positive autoregulatory loop. Mol Cell Biol 13(10):6231-6240
    • (1993) Mol Cell Biol , vol.13 , Issue.10 , pp. 6231-6240
    • Hiscott, J.1
  • 30
    • 70249138036 scopus 로고    scopus 로고
    • Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    • Bauernfeind FG et al (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183(2):787-791
    • (2009) J Immunol , vol.183 , Issue.2 , pp. 787-791
    • Bauernfeind, F.G.1
  • 31
    • 79951578449 scopus 로고    scopus 로고
    • Inflammasomes: Current understanding and open questions
    • Bauernfeind F et al (2011) Inflammasomes: Current understanding and open questions. Cell Mol Life Sci 68(5):765-783
    • (2011) Cell Mol Life Sci , vol.68 , Issue.5 , pp. 765-783
    • Bauernfeind, F.1
  • 32
    • 79951818190 scopus 로고    scopus 로고
    • Differential expression of NLRP3 among hematopoietic cells
    • Guarda G et al (2011) Differential expression of NLRP3 among hematopoietic cells. J Immunol 186(4):2529-2534
    • (2011) J Immunol , vol.186 , Issue.4 , pp. 2529-2534
    • Guarda, G.1
  • 33
    • 33751257755 scopus 로고    scopus 로고
    • Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs
    • Lu JY, Sadri N, Schneider RJ (2006) Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Genes Dev 20(22):3174-3184
    • (2006) Genes Dev , vol.20 , Issue.22 , pp. 3174-3184
    • Lu, J.Y.1    Sadri, N.2    Schneider, R.J.3
  • 34
    • 0023261032 scopus 로고
    • Transcriptional regulation of the human prointerleukin 1 beta gene
    • Fenton MJ et al (1987) Transcriptional regulation of the human prointerleukin 1 beta gene. J Immunol 138(11):3972-3979
    • (1987) J Immunol , vol.138 , Issue.11 , pp. 3972-3979
    • Fenton, M.J.1
  • 35
    • 0025302145 scopus 로고
    • Dissociation between interleukin-1 betamRNAand protein synthesis in human peripheral blood mononuclear cells
    • Schindler R, Clark BD, Dinarello CA (1990) Dissociation between interleukin-1 betamRNAand protein synthesis in human peripheral blood mononuclear cells. J Biol Chem 265(18): 10232-10237
    • (1990) J Biol Chem , vol.265 , Issue.18 , pp. 10232-10237
    • Schindler, R.1    Clark, B.D.2    Dinarello, C.A.3
  • 36
    • 0025094641 scopus 로고
    • Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: Translational signal provided by lipopolysaccharide or IL-1 itself
    • Schindler R, Gelfand JA, Dinarello CA (1990) Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: Translational signal provided by lipopolysaccharide or IL-1 itself. Blood 76(8): 1631-1638
    • (1990) Blood , vol.76 , Issue.8 , pp. 1631-1638
    • Schindler, R.1    Gelfand, J.A.2    Dinarello, C.A.3
  • 37
    • 0028341028 scopus 로고
    • Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles
    • Kaspar RL, Gehrke L (1994) Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles. J Immunol 153(1):277-286
    • (1994) J Immunol , vol.153 , Issue.1 , pp. 277-286
    • Kaspar, R.L.1    Gehrke, L.2
  • 38
    • 0023165175 scopus 로고
    • The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor
    • Mosley B et al (1987) The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem 262(7):2941-2944
    • (1987) J Biol Chem , vol.262 , Issue.7 , pp. 2941-2944
    • Mosley, B.1
  • 39
    • 0026507126 scopus 로고
    • A novel hetero dimeric cysteine protease is required for interleukin-1 beta processing in monocytes
    • Thornberry NA et al (1992) A novel hetero dimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356(6372):768-774
    • (1992) Nature , vol.356 , Issue.6372 , pp. 768-774
    • Thornberry, N.A.1
  • 40
    • 0028920863 scopus 로고
    • Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
    • Kuida K et al (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267(5206):2000-2003
    • (1995) Science , vol.267 , Issue.5206 , pp. 2000-2003
    • Kuida, K.1
  • 41
    • 0028984948 scopus 로고
    • Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
    • Li P et al (1995) Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80(3):401-411
    • (1995) Cell , vol.80 , Issue.3 , pp. 401-411
    • Li, P.1
  • 42
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J (2002) The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10(2):417-426
    • (2002) Mol Cell , vol.10 , Issue.2 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 43
    • 79551662979 scopus 로고    scopus 로고
    • Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice
    • Narayan S et al (2011) Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice. Arthritis Rheum 63(2): 422-433
    • (2011) Arthritis Rheum , vol.63 , Issue.2 , pp. 422-433
    • Narayan, S.1
  • 44
    • 81055145409 scopus 로고    scopus 로고
    • Inflammasome activation and IL-1beta target IL-1alpha for secretion as opposed to surface expression
    • Fettelschoss A et al (2011) Inflammasome activation and IL-1beta target IL-1alpha for secretion as opposed to surface expression. Proc Natl Acad Sci USA 108(44):18055-18060
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.44 , pp. 18055-18060
    • Fettelschoss, A.1
  • 45
  • 46
    • 79953046719 scopus 로고    scopus 로고
    • The inflammasome NLRs in immunity, inflammation, and associated diseases
    • Davis BK, Wen H, Ting JP (2011) The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol 29:707-735
    • (2011) Annu Rev Immunol , vol.29 , pp. 707-735
    • Davis, B.K.1    Wen, H.2    Ting, J.P.3
  • 47
    • 34548434775 scopus 로고    scopus 로고
    • Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigellainfected macrophages
    • Suzuki T et al (2007) Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigellainfected macrophages. PLoS Pathog 3(8):e111
    • (2007) PLoS Pathog , vol.3 , Issue.8
    • Suzuki, T.1
  • 48
    • 52549099416 scopus 로고    scopus 로고
    • Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
    • Lightfield KL et al (2008) Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol 9(10):1171-1178
    • (2008) Nat Immunol , vol.9 , Issue.10 , pp. 1171-1178
    • Lightfield, K.L.1
  • 49
    • 80053379974 scopus 로고    scopus 로고
    • Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
    • Kofoed EM, Vance RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477(7366):592-595
    • (2011) Nature , vol.477 , Issue.7366 , pp. 592-595
    • Kofoed, E.M.1    Vance, R.E.2
  • 50
    • 3142654767 scopus 로고    scopus 로고
    • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    • Mariathasan S et al (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430(6996):213-218
    • (2004) Nature , vol.430 , Issue.6996 , pp. 213-218
    • Mariathasan, S.1
  • 51
    • 31744441475 scopus 로고    scopus 로고
    • Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
    • Boyden ED, Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38(2): 240-244
    • (2006) Nat Genet , vol.38 , Issue.2 , pp. 240-244
    • Boyden, E.D.1    Dietrich, W.F.2
  • 52
    • 80052626087 scopus 로고    scopus 로고
    • The NLRP3 inflammasome in health and disease: The good, the bad and the ugly
    • Menu P, Vince JE (2011) The NLRP3 inflammasome in health and disease: The good, the bad and the ugly. Clin Exp Immunol 166(1):1-15
    • (2011) Clin Exp Immunol , vol.166 , Issue.1 , pp. 1-15
    • Menu, P.1    Vince, J.E.2
  • 53
    • 77649179433 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
    • Tschopp J, Schroder K (2010) NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10(3):210-215
    • (2010) Nat Rev Immunol , vol.10 , Issue.3 , pp. 210-215
    • Tschopp, J.1    Schroder, K.2
  • 54
    • 66149086936 scopus 로고    scopus 로고
    • NOD-like receptors: Role in innate immunity and inflammatory disease
    • Chen G et al (2009) NOD-like receptors: Role in innate immunity and inflammatory disease. Annu Rev Pathol 4:365-398
    • (2009) Annu Rev Pathol , vol.4 , pp. 365-398
    • Chen, G.1
  • 55
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E et al (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145(5):745-757
    • (2011) Cell , vol.145 , Issue.5 , pp. 745-757
    • Elinav, E.1
  • 56
    • 79955566751 scopus 로고    scopus 로고
    • Identification and functional consequences of a recurrent NLRP12 missense mutation in periodic fever syndromes
    • Jeru I et al (2011) Identification and functional consequences of a recurrent NLRP12 missense mutation in periodic fever syndromes. Arthritis Rheum 63(5):1459-1464
    • (2011) Arthritis Rheum , vol.63 , Issue.5 , pp. 1459-1464
    • Jeru, I.1
  • 57
    • 79953702540 scopus 로고    scopus 로고
    • Clinical presentation and pathogenesis of cold-induced auto inflammatory disease in a family with recurrence of an NLRP12 mutation
    • Borghini S et al (2011) Clinical presentation and pathogenesis of cold-induced auto inflammatory disease in a family with recurrence of an NLRP12 mutation. Arthritis Rheum 63(3):830-839
    • (2011) Arthritis Rheum , vol.63 , Issue.3 , pp. 830-839
    • Borghini, S.1
  • 58
    • 80052152283 scopus 로고    scopus 로고
    • The PYHIN protein family as mediators of host defenses
    • Schattgen SA, Fitzgerald KA (2011) The PYHIN protein family as mediators of host defenses. Immunol Rev 243(1):109-118
    • (2011) Immunol Rev , vol.243 , Issue.1 , pp. 109-118
    • Schattgen, S.A.1    Fitzgerald, K.A.2
  • 59
    • 33747115709 scopus 로고    scopus 로고
    • Anti-inflammatory properties of type I interferons
    • Billiau A (2006) Anti-inflammatory properties of type I interferons. Antivir Res 71(2-3):108-116
    • (2006) Antivir Res , vol.71 , Issue.2-3 , pp. 108-116
    • Billiau, A.1
  • 60
    • 0037147337 scopus 로고    scopus 로고
    • Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays
    • Schlaak JF et al (2002) Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays. J Biol Chem 277(51):49428-49437
    • (2002) J Biol Chem , vol.277 , Issue.51 , pp. 49428-49437
    • Schlaak, J.F.1
  • 61
    • 33748051738 scopus 로고    scopus 로고
    • IRFs: Master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
    • Honda K, Taniguchi T (2006) IRFs: Master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 6(9):644-658
    • (2006) Nat Rev Immunol , vol.6 , Issue.9 , pp. 644-658
    • Honda, K.1    Taniguchi, T.2
  • 62
    • 0033795196 scopus 로고    scopus 로고
    • Interferons: Cell signalling, immune modulation, antiviral response and virus countermeasures
    • Goodbourn S, Didcock L, Randall RE (2000) Interferons: Cell signalling, immune modulation, antiviral response and virus countermeasures. J Gen Virol 81(Pt 10):2341-2364
    • (2000) J Gen Virol , vol.81 , Issue.PART 10 , pp. 2341-2364
    • Goodbourn, S.1    Didcock, L.2    Randall, R.E.3
  • 63
    • 0036628966 scopus 로고    scopus 로고
    • Viruses and the type I interferon antiviral system: Induction and evasion
    • Basler CF, Garcia-Sastre A (2002) Viruses and the type I interferon antiviral system: Induction and evasion. Int Rev Immunol 21(4-5):305-337
    • (2002) Int Rev Immunol , vol.21 , Issue.4-5 , pp. 305-337
    • Basler, C.F.1    Garcia-Sastre, A.2
  • 64
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I-and type-II-interferon-mediated signalling
    • Platanias LC (2005) Mechanisms of type-I-and type-II-interferon-mediated signalling. Nat Rev Immunol 5(5):375-386
    • (2005) Nat Rev Immunol , vol.5 , Issue.5 , pp. 375-386
    • Platanias, L.C.1
  • 65
    • 38449105556 scopus 로고    scopus 로고
    • IFN-gamma: Recent advances in understanding regulation of expression, biological functions, and clinical applications
    • Young HA, Bream JH (2007) IFN-gamma: Recent advances in understanding regulation of expression, biological functions, and clinical applications. Curr Top Microbiol Immunol 316: 97-117
    • (2007) Curr Top Microbiol Immunol , vol.316 , pp. 97-117
    • Young, H.A.1    Bream, J.H.2
  • 66
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations
    • Zhu J, Yamane H, Paul WE (2010) Differentiation of effector CD4 T cell populations. Annu Rev Immunol 28:445-489
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 67
    • 77956215618 scopus 로고    scopus 로고
    • Transcriptional regulation of T helper 17 cell differentiation
    • Hwang ES (2010) Transcriptional regulation of T helper 17 cell differentiation. Yonsei Med J 51(4):484-491
    • (2010) Yonsei Med J , vol.51 , Issue.4 , pp. 484-491
    • Hwang, E.S.1
  • 68
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: An overview of signals, mechanisms and functions
    • Schroder K et al (2004) Interferon-gamma: An overview of signals, mechanisms and functions. J Leukoc Biol 75(2):163-189
    • (2004) J Leukoc Biol , vol.75 , Issue.2 , pp. 163-189
    • Schroder, K.1
  • 69
    • 1642370060 scopus 로고    scopus 로고
    • Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells
    • Coccia EM et al (2004) Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells. Eur J Immunol 34(3):796-805
    • (2004) Eur J Immunol , vol.34 , Issue.3 , pp. 796-805
    • Coccia, E.M.1
  • 70
    • 77955860021 scopus 로고    scopus 로고
    • IL-28A, IL-28B, and IL-29: Promising cytokines with type I interferon-like properties
    • Witte K et al (2010) IL-28A, IL-28B, and IL-29: Promising cytokines with type I interferon-like properties. Cytokine Growth Factor Rev 21(4):237-251
    • (2010) Cytokine Growth Factor Rev , vol.21 , Issue.4 , pp. 237-251
    • Witte, K.1
  • 71
    • 0037236826 scopus 로고    scopus 로고
    • IL-28, IL-29 and their class II cytokine receptor IL-28R
    • Sheppard P et al (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 4(1):63-68
    • (2003) Nat Immunol , vol.4 , Issue.1 , pp. 63-68
    • Sheppard, P.1
  • 72
    • 0037243222 scopus 로고    scopus 로고
    • IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    • Kotenko SV et al (2003) IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 4(1):69-77
    • (2003) Nat Immunol , vol.4 , Issue.1 , pp. 69-77
    • Kotenko, S.V.1
  • 73
    • 34347259525 scopus 로고    scopus 로고
    • IL-28 and IL-29: Newcomers to the interferon family
    • Uze G, Monneron D (2007) IL-28 and IL-29: Newcomers to the interferon family. Biochimie 89(6-7):729-734
    • (2007) Biochimie , vol.89 , Issue.6-7 , pp. 729-734
    • Uze, G.1    Monneron, D.2
  • 74
    • 0028093580 scopus 로고
    • Inhibition by interleukin-4 of constitutive beta interferon synthesis in mouse macrophages
    • Nickolaus P, Zawatzky R (1994) Inhibition by interleukin-4 of constitutive beta interferon synthesis in mouse macrophages. J Virol 68(10):6763-6766
    • (1994) J Virol , vol.68 , Issue.10 , pp. 6763-6766
    • Nickolaus, P.1    Zawatzky, R.2
  • 75
    • 16244372726 scopus 로고    scopus 로고
    • Constitutive expression of alpha interferon by skin dendritic cells confers resistance to infection by foot-and-mouth disease virus
    • Bautista EM et al (2005) Constitutive expression of alpha interferon by skin dendritic cells confers resistance to infection by foot-and-mouth disease virus. J Virol 79(8):4838-4847
    • (2005) J Virol , vol.79 , Issue.8 , pp. 4838-4847
    • Bautista, E.M.1
  • 76
    • 70349260311 scopus 로고    scopus 로고
    • Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo
    • Lienenklaus S et al (2009) Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. J Immunol 183(5):3229-3236
    • (2009) J Immunol , vol.183 , Issue.5 , pp. 3229-3236
    • Lienenklaus, S.1
  • 77
    • 77956643985 scopus 로고    scopus 로고
    • Temporal and spatial resolution of type I and III interferon responses in vivo
    • Pulverer JE et al (2010) Temporal and spatial resolution of type I and III interferon responses in vivo. J Virol 84(17):8626-8638
    • (2010) J Virol , vol.84 , Issue.17 , pp. 8626-8638
    • Pulverer, J.E.1
  • 78
    • 0035344461 scopus 로고    scopus 로고
    • A weak signal for strong responses: Interferon-alpha/beta revisited
    • Taniguchi T, Takaoka A (2001) A weak signal for strong responses: Interferon-alpha/beta revisited. Nat Rev Mol Cell Biol 2(5):378-386
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.5 , pp. 378-386
    • Taniguchi, T.1    Takaoka, A.2
  • 79
    • 33646453915 scopus 로고    scopus 로고
    • Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    • Weber F et al (2006) Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J Virol 80(10):5059-5064
    • (2006) J Virol , vol.80 , Issue.10 , pp. 5059-5064
    • Weber, F.1
  • 80
    • 58049202928 scopus 로고    scopus 로고
    • Viral sensors: Diversity in pathogen recognition
    • McCartney SA, Colonna M (2009) Viral sensors: Diversity in pathogen recognition. Immunol Rev 227(1):87-94
    • (2009) Immunol Rev , vol.227 , Issue.1 , pp. 87-94
    • McCartney, S.A.1    Colonna, M.2
  • 81
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan E et al (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437(7062):1167-1172
    • (2005) Nature , vol.437 , Issue.7062 , pp. 1167-1172
    • Meylan, E.1
  • 83
    • 0032579369 scopus 로고    scopus 로고
    • Regulation of type I interferon gene expression by interferon regulatory factor-3
    • Schafer SL et al (1998) Regulation of type I interferon gene expression by interferon regulatory factor-3. J Biol Chem 273(5):2714-2720
    • (1998) J Biol Chem , vol.273 , Issue.5 , pp. 2714-2720
    • Schafer, S.L.1
  • 84
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator of type-I interferon-dependent immune responses
    • Honda K et al (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434(7034):772-777
    • (2005) Nature , vol.434 , Issue.7034 , pp. 772-777
    • Honda, K.1
  • 85
    • 79952073161 scopus 로고    scopus 로고
    • Innate immune sensing of DNA viruses
    • Rathinam VA, Fitzgerald KA (2011) Innate immune sensing of DNA viruses. Virology 411(2):153-162
    • (2011) Virology , vol.411 , Issue.2 , pp. 153-162
    • Rathinam, V.A.1    Fitzgerald, K.A.2
  • 86
    • 79953705058 scopus 로고    scopus 로고
    • The STING pathway and regulation of innate immune signaling in response to DNA pathogens
    • Ishikawa H, Barber GN (2011) The STING pathway and regulation of innate immune signaling in response to DNA pathogens. Cell Mol Life Sci 68(7):1157-1165
    • (2011) Cell Mol Life Sci , vol.68 , Issue.7 , pp. 1157-1165
    • Ishikawa, H.1    Barber, G.N.2
  • 87
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V et al (2002) Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168(9):4531-4537
    • (2002) J Immunol , vol.168 , Issue.9 , pp. 4531-4537
    • Hornung, V.1
  • 89
    • 58049202272 scopus 로고    scopus 로고
    • Innate immunity to virus infection
    • Takeuchi O, Akira S (2009) Innate immunity to virus infection. Immunol Rev 227(1):75-86
    • (2009) Immunol Rev , vol.227 , Issue.1 , pp. 75-86
    • Takeuchi, O.1    Akira, S.2
  • 90
    • 15244349785 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in immunity
    • Colonna M, Trinchieri G, Liu YJ (2004) Plasmacytoid dendritic cells in immunity. Nat Immunol 5(12):1219-1226
    • (2004) Nat Immunol , vol.5 , Issue.12 , pp. 1219-1226
    • Colonna, M.1    Trinchieri, G.2    Liu, Y.J.3
  • 91
    • 0036604972 scopus 로고    scopus 로고
    • Interferon-producing cells: On the front line in immune responses against pathogens
    • Colonna M, Krug A, Cella M (2002) Interferon-producing cells: On the front line in immune responses against pathogens. Curr Opin Immunol 14(3):373-379
    • (2002) Curr Opin Immunol , vol.14 , Issue.3 , pp. 373-379
    • Colonna, M.1    Krug, A.2    Cella, M.3
  • 92
    • 0027742729 scopus 로고
    • Interferon-induced nuclear signalling by Jak protein tyrosine kinases
    • Silvennoinen O et al (1993) Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature 366(6455):583-585
    • (1993) Nature , vol.366 , Issue.6455 , pp. 583-585
    • Silvennoinen, O.1
  • 93
    • 36749069393 scopus 로고    scopus 로고
    • Interferons at age 50: Past, current and future impact on biomedicine
    • Borden EC et al (2007) Interferons at age 50: Past, current and future impact on biomedicine. Nat Rev Drug Discov 6(12):975-990
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.12 , pp. 975-990
    • Borden, E.C.1
  • 94
    • 0034977353 scopus 로고    scopus 로고
    • Functional classification of interferonstimulated genes identified using microarrays
    • de Veer MJ et al (2001) Functional classification of interferonstimulated genes identified using microarrays. J Leukoc Biol 69(6):912-920
    • (2001) J Leukoc Biol , vol.69 , Issue.6 , pp. 912-920
    • De Veer, M.J.1
  • 95
    • 0032130972 scopus 로고    scopus 로고
    • The role of interferon regulatory factors in the interferon system and cell growth control
    • Harada H, Taniguchi T, Tanaka N (1998) The role of interferon regulatory factors in the interferon system and cell growth control. Biochimie 80(8-9):641-650
    • (1998) Biochimie , vol.80 , Issue.8-9 , pp. 641-650
    • Harada, H.1    Taniguchi, T.2    Tanaka, N.3
  • 96
    • 78249277326 scopus 로고    scopus 로고
    • Mechanisms of mRNA translation of interferon stimulated genes
    • Joshi S et al (2010) Mechanisms of mRNA translation of interferon stimulated genes. Cytokine 52(1-2):123-127
    • (2010) Cytokine , vol.52 , Issue.1-2 , pp. 123-127
    • Joshi, S.1
  • 97
    • 79955694610 scopus 로고    scopus 로고
    • Type I interferon in organ-targeted autoimmune and inflammatory diseases
    • CrowMK(2010) Type I interferon in organ-targeted autoimmune and inflammatory diseases. Arthritis Res Ther 12(Suppl 1):S5
    • (2010) Arthritis Res Ther , vol.12 , Issue.SUPPL. 1
    • Crow, M.K.1
  • 98
    • 83455213857 scopus 로고    scopus 로고
    • Interferons in autoimmune and inflammatory diseases: Regulation and roles
    • Choubey D, Moudgil KD (2011) Interferons in autoimmune and inflammatory diseases: Regulation and roles. J Interferon Cytokine Res 31(12):857-865
    • (2011) J Interferon Cytokine Res , vol.31 , Issue.12 , pp. 857-865
    • Choubey, D.1    Moudgil, K.D.2
  • 99
    • 57749092917 scopus 로고    scopus 로고
    • The stability of the ternary interferonreceptor complex rather than the affinity to the individual subunits dictates differential biological activities
    • Kalie E et al (2008) The stability of the ternary interferonreceptor complex rather than the affinity to the individual subunits dictates differential biological activities. J Biol Chem 283(47):32925-32936
    • (2008) J Biol Chem , vol.283 , Issue.47 , pp. 32925-32936
    • Kalie, E.1
  • 100
    • 56749133272 scopus 로고    scopus 로고
    • Viral evasion and subversion of pattern-recognition receptor signalling
    • Bowie AG, Unterholzner L (2008) Viral evasion and subversion of pattern-recognition receptor signalling. Nat Rev Immunol 8(12):911-922
    • (2008) Nat Rev Immunol , vol.8 , Issue.12 , pp. 911-922
    • Bowie, A.G.1    Unterholzner, L.2
  • 101
    • 34347225099 scopus 로고    scopus 로고
    • The ds RNA protein kinase PKR: Virus and cell control
    • Garcia MA, Meurs EF, Esteban M (2007) The ds RNA protein kinase PKR: Virus and cell control. Biochimie 89(6-7):799-811
    • (2007) Biochimie , vol.89 , Issue.6-7 , pp. 799-811
    • Garcia, M.A.1    Meurs, E.F.2    Esteban, M.3
  • 102
    • 34548137353 scopus 로고    scopus 로고
    • On the discovery of interferon-inducible, double-stranded RNA activated enzymes: The 20-50oligoadenylate synthetases and the protein kinase PKR
    • Hovanessian AG (2007) On the discovery of interferon-inducible, double-stranded RNA activated enzymes: The 20-50oligoadenylate synthetases and the protein kinase PKR. Cytokine Growth Factor Rev 18(5-6):351-361
    • (2007) Cytokine Growth Factor Rev , vol.18 , Issue.5-6 , pp. 351-361
    • Hovanessian, A.G.1
  • 103
    • 36348940608 scopus 로고    scopus 로고
    • Interferons and viruses: An inter play between induction, signalling, antiviral responses and virus countermeasures
    • Randall RE, Goodbourn S (2008) Interferons and viruses: An inter play between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89(Pt 1):1-47
    • (2008) J Gen Virol , vol.89 , Issue.PART 1 , pp. 1-47
    • Randall, R.E.1    Goodbourn, S.2
  • 104
    • 46249115827 scopus 로고    scopus 로고
    • Interferon-inducible antiviral effectors
    • Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8(7):559-568
    • (2008) Nat Rev Immunol , vol.8 , Issue.7 , pp. 559-568
    • Sadler, A.J.1    Williams, B.R.2
  • 105
    • 77956406173 scopus 로고    scopus 로고
    • Regulation of immune cell homeostasis by type I interferons
    • Mattei F, Schiavoni G, Tough DF (2010) Regulation of immune cell homeostasis by type I interferons. Cytokine Growth Factor Rev 21(4):227-236
    • (2010) Cytokine Growth Factor Rev , vol.21 , Issue.4 , pp. 227-236
    • Mattei, F.1    Schiavoni, G.2    Tough, D.F.3
  • 106
    • 67650445798 scopus 로고    scopus 로고
    • Dendritic cells require a systemic type I interferon response to mature and induce CD4? Th1 immunity with poly IC as adjuvant
    • Longhi MP et al (2009) Dendritic cells require a systemic type I interferon response to mature and induce CD4? Th1 immunity with poly IC as adjuvant. J Exp Med 206(7):1589-1602
    • (2009) J Exp Med , vol.206 , Issue.7 , pp. 1589-1602
    • Longhi, M.P.1
  • 107
    • 0142092614 scopus 로고    scopus 로고
    • Cross-priming of CD8? T cells stimulated by virus-induced type I interferon
    • Le Bon A et al (2003) Cross-priming of CD8? T cells stimulated by virus-induced type I interferon. Nat Immunol 4(10): 1009-1015
    • (2003) Nat Immunol , vol.4 , Issue.10 , pp. 1009-1015
    • Le Bon, A.1
  • 108
    • 17644402442 scopus 로고    scopus 로고
    • Type I interferons (alpha/beta) in immunity and autoimmunity
    • Theofilopoulos AN et al (2005) Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol 23:307-336
    • (2005) Annu Rev Immunol , vol.23 , pp. 307-336
    • Theofilopoulos, A.N.1
  • 109
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci S, Lolkema M, Matzinger P (1999) Natural adjuvants: Endogenous activators of dendritic cells. Nat Med 5(11):1249-1255
    • (1999) Nat Med , vol.5 , Issue.11 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 110
    • 0027433104 scopus 로고
    • Interferon alpha increases the frequency of interferon gamma-producing human CD4? T cells
    • Brinkmann V et al (1993) Interferon alpha increases the frequency of interferon gamma-producing human CD4? T cells. J Exp Med 178(5):1655-1663
    • (1993) J Exp Med , vol.178 , Issue.5 , pp. 1655-1663
    • Brinkmann, V.1
  • 111
    • 0037377990 scopus 로고    scopus 로고
    • CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells
    • Krug A et al (2003) CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. J Immunol 170(7):3468-3477
    • (2003) J Immunol , vol.170 , Issue.7 , pp. 3468-3477
    • Krug, A.1
  • 112
    • 10844291719 scopus 로고    scopus 로고
    • IL-12, but not IFNalpha, promotes STAT4 activation and Th1 development in murine CD4? T cells expressing a chimeric murine/human Stat2 gene
    • Persky ME, Murphy KM, Farrar JD (2005) IL-12, but not IFNalpha, promotes STAT4 activation and Th1 development in murine CD4? T cells expressing a chimeric murine/human Stat2 gene. J Immunol 174(1):294-301
    • (2005) J Immunol , vol.174 , Issue.1 , pp. 294-301
    • Persky, M.E.1    Murphy, K.M.2    Farrar, J.D.3
  • 113
    • 33749521701 scopus 로고    scopus 로고
    • Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha
    • Berenson LS et al (2006) Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha. J Immunol 177(8):5195-5203
    • (2006) J Immunol , vol.177 , Issue.8 , pp. 5195-5203
    • Berenson, L.S.1
  • 114
    • 0034939227 scopus 로고    scopus 로고
    • IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: Differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12
    • Matikainen S et al (2001) IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: Differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12. Eur J Immunol 31(7):2236-2245
    • (2001) Eur J Immunol , vol.31 , Issue.7 , pp. 2236-2245
    • Matikainen, S.1
  • 115
    • 0030892136 scopus 로고    scopus 로고
    • Selective expression of an interleukin-12 receptor component by human T helper 1 cells
    • Rogge L et al (1997) Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 185(5):825-831
    • (1997) J Exp Med , vol.185 , Issue.5 , pp. 825-831
    • Rogge, L.1
  • 116
    • 77955503273 scopus 로고    scopus 로고
    • Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3
    • Huber JP et al (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J Immunol 185(2):813-817
    • (2010) J Immunol , vol.185 , Issue.2 , pp. 813-817
    • Huber, J.P.1
  • 117
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4? effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE et al (2005) Interleukin 17-producing CD4? effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-1132
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1
  • 118
    • 52749084284 scopus 로고    scopus 로고
    • Interferon-alpha controls IL-17 expression in vitro and in vivo
    • Moschen AR et al (2008) Interferon-alpha controls IL-17 expression in vitro and in vivo. Immunobiology 213(9-10): 779-787
    • (2008) Immunobiology , vol.213 , Issue.9-10 , pp. 779-787
    • Moschen, A.R.1
  • 119
    • 79960219135 scopus 로고    scopus 로고
    • IL-27 mediates the response to IFNbeta therapy in multiple sclerosis patients by inhibiting Th17 cells
    • Sweeney CM et al (2011) IL-27 mediates the response to IFNbeta therapy in multiple sclerosis patients by inhibiting Th17 cells. Brain Behav Immun 25(6):1170-1181
    • (2011) Brain Behav Immun , vol.25 , Issue.6 , pp. 1170-1181
    • Sweeney, C.M.1
  • 120
    • 77950526192 scopus 로고    scopus 로고
    • IFN-beta inhibits human Th17 cell differentiation
    • Ramgolam VS et al (2009) IFN-beta inhibits human Th17 cell differentiation. J Immunol 183(8):5418-5427
    • (2009) J Immunol , vol.183 , Issue.8 , pp. 5418-5427
    • Ramgolam, V.S.1
  • 121
    • 0029614679 scopus 로고
    • Tumor suppressor activity of the human consensus type I interferon gene
    • Geng Y et al (1995) Tumor suppressor activity of the human consensus type I interferon gene. Cytokines Mol Ther 1(4):289-300
    • (1995) Cytokines Mol Ther , vol.1 , Issue.4 , pp. 289-300
    • Geng, Y.1
  • 122
    • 0031925470 scopus 로고    scopus 로고
    • Type I interferons are essential mediators of apoptotic death in virally infected cells
    • TanakaNet al (1998) Type I interferons are essential mediators of apoptotic death in virally infected cells. Genes Cells 3(1):29-37
    • (1998) Genes Cells , vol.3 , Issue.1 , pp. 29-37
    • Tanaka, N.1
  • 123
    • 0033081259 scopus 로고    scopus 로고
    • Type I interferons keep activated T cells alive
    • Marrack P, Kappler J, Mitchell T (1999) Type I interferons keep activated T cells alive. J Exp Med 189(3):521-530
    • (1999) J Exp Med , vol.189 , Issue.3 , pp. 521-530
    • Marrack, P.1    Kappler, J.2    Mitchell, T.3
  • 124
    • 58849086312 scopus 로고    scopus 로고
    • Cutting edge: A T-bet-independent role for IFN-alpha/beta in regulating IL-2 secretion in human CD4? central memory T cells
    • Davis AM et al (2008) Cutting edge: A T-bet-independent role for IFN-alpha/beta in regulating IL-2 secretion in human CD4? central memory T cells. J Immunol 181(12):8204-8208
    • (2008) J Immunol , vol.181 , Issue.12 , pp. 8204-8208
    • Davis, A.M.1
  • 125
    • 18344362061 scopus 로고    scopus 로고
    • Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
    • Curtsinger JM et al (2005) Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol 174(8):4465-4469
    • (2005) J Immunol , vol.174 , Issue.8 , pp. 4465-4469
    • Curtsinger, J.M.1
  • 126
    • 33645775256 scopus 로고    scopus 로고
    • Direct stimulation of T cells by type I IFN enhances the CD8? T cell response during cross-priming
    • Le Bon A et al (2006) Direct stimulation of T cells by type I IFN enhances the CD8? T cell response during cross-priming. J Immunol 176(8):4682-4689
    • (2006) J Immunol , vol.176 , Issue.8 , pp. 4682-4689
    • Le Bon, A.1
  • 128
    • 0032076635 scopus 로고    scopus 로고
    • Potent and selective stimulation of memory-phenotype CD8? T cells in vivo by IL-15
    • Zhang X et al (1998) Potent and selective stimulation of memory-phenotype CD8? T cells in vivo by IL-15. Immunity 8(5):591-599
    • (1998) Immunity , vol.8 , Issue.5 , pp. 591-599
    • Zhang, X.1
  • 129
    • 0035423390 scopus 로고    scopus 로고
    • IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation
    • Mattei F et al (2001) IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J Immunol 167(3):1179-1187
    • (2001) J Immunol , vol.167 , Issue.3 , pp. 1179-1187
    • Mattei, F.1
  • 130
    • 79952246247 scopus 로고    scopus 로고
    • Role of IL-15 in immune-mediated and infectious diseases
    • Di Sabatino A et al (2011) Role of IL-15 in immune-mediated and infectious diseases. Cytokine Growth Factor Rev 22(1): 19-33
    • (2011) Cytokine Growth Factor Rev , vol.22 , Issue.1 , pp. 19-33
    • Di Sabatino, A.1
  • 131
    • 79951944636 scopus 로고    scopus 로고
    • CXCR3 ligands: Redundant, collaborative and antagonistic functions
    • Groom JR, Luster AD (2011) CXCR3 ligands: Redundant, collaborative and antagonistic functions. Immunol Cell Biol 89(2):207-215
    • (2011) Immunol Cell Biol , vol.89 , Issue.2 , pp. 207-215
    • Groom, J.R.1    Luster, A.D.2
  • 132
    • 0035030376 scopus 로고    scopus 로고
    • Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo
    • Le Bon A et al (2001) Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14(4):461-470
    • (2001) Immunity , vol.14 , Issue.4 , pp. 461-470
    • Le Bon, A.1
  • 133
    • 0041429619 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    • Jego G et al (2003) Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19(2):225-234
    • (2003) Immunity , vol.19 , Issue.2 , pp. 225-234
    • Jego, G.1
  • 134
    • 77952546595 scopus 로고    scopus 로고
    • Type I interferon (IFN-alpha/beta) rescues B-lymphocytes from apoptosis via PI3Kdelta/Akt, Rho-A, NFkappaB and Bcl-2/Bcl(XL)
    • Badr G et al (2010) Type I interferon (IFN-alpha/beta) rescues B-lymphocytes from apoptosis via PI3Kdelta/Akt, Rho-A, NFkappaB and Bcl-2/Bcl(XL). Cell Immunol 263(1):31-40
    • (2010) Cell Immunol , vol.263 , Issue.1 , pp. 31-40
    • Badr, G.1
  • 135
    • 77952214698 scopus 로고    scopus 로고
    • Antiproliferative properties of type I and type II interferon
    • Bekisz J et al (2010) Antiproliferative properties of type I and type II interferon. Pharmaceuticals 3(4):994-1015
    • (2010) Pharmaceuticals , vol.3 , Issue.4 , pp. 994-1015
    • Bekisz, J.1
  • 136
    • 0034827441 scopus 로고    scopus 로고
    • Antiproliferative effects of IFNalpha correlate with the downregulation of nuclear factor-kappa B in human Burkitt lymphoma Daudi cells
    • Rath PC, Aggarwal BB (2001) Antiproliferative effects of IFNalpha correlate with the downregulation of nuclear factor-kappa B in human Burkitt lymphoma Daudi cells. J Interferon Cytokine Res 21(7):523-528
    • (2001) J Interferon Cytokine Res , vol.21 , Issue.7 , pp. 523-528
    • Rath, P.C.1    Aggarwal, B.B.2
  • 137
    • 0041662272 scopus 로고    scopus 로고
    • Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence
    • Takaoka A et al (2003) Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 424(6948):516-523
    • (2003) Nature , vol.424 , Issue.6948 , pp. 516-523
    • Takaoka, A.1
  • 138
    • 80053354500 scopus 로고    scopus 로고
    • Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by Poly IC in vivo
    • Fuertes Marraco SA et al (2011) Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by Poly IC in vivo. PLoS ONE 6(6):e20189
    • (2011) PLoS ONE , vol.6 , Issue.6
    • Fuertes Marraco, S.A.1
  • 139
    • 79959838502 scopus 로고    scopus 로고
    • Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-beta-dependent induction of pro-apoptotic Noxa
    • Eitz Ferrer P et al (2011) Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-beta-dependent induction of pro-apoptotic Noxa. PLoS Pathog 7(6):e1002083
    • (2011) PLoS Pathog , vol.7 , Issue.6
    • Eitz Ferrer, P.1
  • 140
    • 0028290902 scopus 로고
    • The interferon-induced doublestranded RNA-activated protein kinase induces apoptosis
    • Lee SB, Esteban M (1994) The interferon-induced doublestranded RNA-activated protein kinase induces apoptosis. Virology 199(2):491-496
    • (1994) Virology , vol.199 , Issue.2 , pp. 491-496
    • Lee, S.B.1    Esteban, M.2
  • 141
    • 0034721082 scopus 로고    scopus 로고
    • The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors
    • Gil J, Esteban M (2000) The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors. Oncogene 19(32):3665-3674
    • (2000) Oncogene , vol.19 , Issue.32 , pp. 3665-3674
    • Gil, J.1    Esteban, M.2
  • 142
    • 1642617628 scopus 로고    scopus 로고
    • The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
    • Hsu LC et al (2004) The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428(6980):341-345
    • (2004) Nature , vol.428 , Issue.6980 , pp. 341-345
    • Hsu, L.C.1
  • 143
    • 0037790592 scopus 로고    scopus 로고
    • Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis
    • Chawla-Sarkar M et al (2003) Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 8(3):237-249
    • (2003) Apoptosis , vol.8 , Issue.3 , pp. 237-249
    • Chawla-Sarkar, M.1
  • 144
    • 37549058765 scopus 로고    scopus 로고
    • Toll-like receptors' two-edged sword: When immunity meets apoptosis
    • Salaun B, Romero P, Lebecque S (2007) Toll-like receptors' two-edged sword: When immunity meets apoptosis. Eur J Immunol 37(12):3311-3318
    • (2007) Eur J Immunol , vol.37 , Issue.12 , pp. 3311-3318
    • Salaun, B.1    Romero, P.2    Lebecque, S.3
  • 145
    • 29144501207 scopus 로고    scopus 로고
    • The interferon response circuit: Induction and suppression by pathogenic viruses
    • Haller O, Kochs G, Weber F (2006) The interferon response circuit: Induction and suppression by pathogenic viruses. Virology 344(1):119-130
    • (2006) Virology , vol.344 , Issue.1 , pp. 119-130
    • Haller, O.1    Kochs, G.2    Weber, F.3
  • 146
    • 68849096790 scopus 로고    scopus 로고
    • Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells
    • Besch R et al (2009) Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest 119(8):2399-2411
    • (2009) J Clin Invest , vol.119 , Issue.8 , pp. 2399-2411
    • Besch, R.1
  • 147
    • 34249940441 scopus 로고    scopus 로고
    • Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs
    • Hasan UA et al (2007) Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs. Proc Natl Acad Sci USA 104(19):8047-8052
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.19 , pp. 8047-8052
    • Hasan, U.A.1
  • 148
    • 33748306209 scopus 로고    scopus 로고
    • Toll-like receptors and IFN-alpha: Partners in autoimmunity
    • Colonna M (2006) Toll-like receptors and IFN-alpha: Partners in autoimmunity. J Clin Invest 116(9):2319-2322
    • (2006) J Clin Invest , vol.116 , Issue.9 , pp. 2319-2322
    • Colonna, M.1
  • 149
    • 75149189005 scopus 로고    scopus 로고
    • Type I interferons: Crucial participants in disease amplification in autoimmunity
    • Hall JC, Rosen A (2010) Type I interferons: Crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol 6(1):40-49
    • (2010) Nat Rev Rheumatol , vol.6 , Issue.1 , pp. 40-49
    • Hall, J.C.1    Rosen, A.2
  • 150
    • 79954992665 scopus 로고    scopus 로고
    • IFN-alpha mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms
    • Akeno N et al (2011) IFN-alpha mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms. J Immunol 186(8):4693-4706
    • (2011) J Immunol , vol.186 , Issue.8 , pp. 4693-4706
    • Akeno, N.1
  • 151
    • 33845357261 scopus 로고    scopus 로고
    • Syndromes and complications of interferon therapy
    • Borg FA, Isenberg DA (2007) Syndromes and complications of interferon therapy. Curr Opin Rheumatol 19(1):61-66
    • (2007) Curr Opin Rheumatol , vol.19 , Issue.1 , pp. 61-66
    • Borg, F.A.1    Isenberg, D.A.2
  • 152
    • 0033485756 scopus 로고    scopus 로고
    • Anti-double-stranded DNA antibodies and immuno stimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus
    • Vallin H et al (1999) Anti-double-stranded DNA antibodies and immuno stimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus. J Immunol 163(11):6306-6313
    • (1999) J Immunol , vol.163 , Issue.11 , pp. 6306-6313
    • Vallin, H.1
  • 153
    • 0041832267 scopus 로고    scopus 로고
    • Fc gamma RIIa is expressed on natural IFNalpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG
    • Bave U et al (2003) Fc gamma RIIa is expressed on natural IFNalpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG. J Immunol 171(6):3296-3302
    • (2003) J Immunol , vol.171 , Issue.6 , pp. 3296-3302
    • Bave, U.1
  • 154
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • Means TK et al (2005) Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 115(2):407-417
    • (2005) J Clin Invest , vol.115 , Issue.2 , pp. 407-417
    • Means, T.K.1
  • 155
    • 82755162135 scopus 로고    scopus 로고
    • Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus
    • Kahlenberg JM et al (2011) Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. J Immunol 187(11):6143-6156
    • (2011) J Immunol , vol.187 , Issue.11 , pp. 6143-6156
    • Kahlenberg, J.M.1
  • 156
    • 78650674088 scopus 로고    scopus 로고
    • Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus
    • Panchanathan R et al (2010) Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. J Immunol 185(12):7385-7393
    • (2010) J Immunol , vol.185 , Issue.12 , pp. 7385-7393
    • Panchanathan, R.1
  • 157
    • 70350630253 scopus 로고    scopus 로고
    • An extensive screen of the HLA region reveals an independent association of HLA class I and class II with susceptibility for systemic lupus erythematosus
    • Martens HA et al (2009) An extensive screen of the HLA region reveals an independent association of HLA class I and class II with susceptibility for systemic lupus erythematosus. Scand J Rheumatol 38(4):256-262
    • (2009) Scand J Rheumatol , vol.38 , Issue.4 , pp. 256-262
    • Martens, H.A.1
  • 158
    • 13844292408 scopus 로고    scopus 로고
    • Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
    • Sigurdsson S et al (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 76(3):528-537
    • (2005) Am J Hum Genet , vol.76 , Issue.3 , pp. 528-537
    • Sigurdsson, S.1
  • 159
    • 0037451124 scopus 로고    scopus 로고
    • Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    • Santiago-Raber ML et al (2003) Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med 197(6):777-788
    • (2003) J Exp Med , vol.197 , Issue.6 , pp. 777-788
    • Santiago-Raber, M.L.1
  • 160
    • 0037320208 scopus 로고    scopus 로고
    • Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice
    • Braun D, Geraldes P, Demengeot J (2003) Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice. J Autoimmun 20(1):15-25
    • (2003) J Autoimmun , vol.20 , Issue.1 , pp. 15-25
    • Braun, D.1    Geraldes, P.2    Demengeot, J.3
  • 161
    • 3242805826 scopus 로고    scopus 로고
    • Type I IFN protects against murine lupus
    • Hron JD, Peng SL (2004) Type I IFN protects against murine lupus. J Immunol 173(3):2134-2142
    • (2004) J Immunol , vol.173 , Issue.3 , pp. 2134-2142
    • Hron, J.D.1    Peng, S.L.2
  • 162
    • 31044440025 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling protects against murine lupus
    • Wu X, Peng SL (2006) Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum 54(1):336-342
    • (2006) Arthritis Rheum , vol.54 , Issue.1 , pp. 336-342
    • Wu, X.1    Peng, S.L.2
  • 163
    • 80052025961 scopus 로고    scopus 로고
    • Activation of the type I interferon pathway in primary Sjogren's syndrome: An update
    • Vakaloglou KM, Mavragani CP (2011) Activation of the type I interferon pathway in primary Sjogren's syndrome: An update. Curr Opin Rheumatol 23(5):459-464
    • (2011) Curr Opin Rheumatol , vol.23 , Issue.5 , pp. 459-464
    • Vakaloglou, K.M.1    Mavragani, C.P.2
  • 164
    • 34249712937 scopus 로고    scopus 로고
    • Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type I interferon signature in a subpopulation of patients
    • van der Pouw Kraan TC et al (2007) Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type I interferon signature in a subpopulation of patients. Ann Rheum Dis 66(8):1008-1014
    • (2007) Ann Rheum Dis , vol.66 , Issue.8 , pp. 1008-1014
    • Van Der Pouw Kraan, T.C.1
  • 165
    • 72649094481 scopus 로고    scopus 로고
    • Fatigue in primary Sjogren's syndrome-A link to sickness behaviour in animals?
    • Harboe E et al (2009) Fatigue in primary Sjogren's syndrome-a link to sickness behaviour in animals? Brain Behav Immun 23(8):1104-1108
    • (2009) Brain Behav Immun , vol.23 , Issue.8 , pp. 1104-1108
    • Harboe, E.1
  • 166
    • 36949034505 scopus 로고    scopus 로고
    • The future of biologic agents in the treatment of Sjogren's syndrome
    • Meijer JM et al (2007) The future of biologic agents in the treatment of Sjogren's syndrome. Clin Rev Allergy Immunol 32(3):292-297
    • (2007) Clin Rev Allergy Immunol , vol.32 , Issue.3 , pp. 292-297
    • Meijer, J.M.1
  • 167
    • 27944449008 scopus 로고    scopus 로고
    • IFN-beta in rheumatoid arthritis
    • Tak PP (2004) IFN-beta in rheumatoid arthritis. Front Biosci 9:3242-3247
    • (2004) Front Biosci , vol.9 , pp. 3242-3247
    • Tak, P.P.1
  • 168
    • 79957551873 scopus 로고    scopus 로고
    • Type I IFN protects against antigen-induced arthritis
    • Ying F et al (2011) Type I IFN protects against antigen-induced arthritis. Eur J Immunol 41(6):1687-1695
    • (2011) Eur J Immunol , vol.41 , Issue.6 , pp. 1687-1695
    • Ying, F.1
  • 169
    • 17644372231 scopus 로고    scopus 로고
    • Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis
    • van Holten J et al (2004) Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther 6(3):R239-R249
    • (2004) Arthritis Res Ther , vol.6 , Issue.3
    • Van Holten, J.1
  • 170
    • 0032752786 scopus 로고    scopus 로고
    • The effects of interferon beta treatment on arthritis
    • Tak PP et al (1999) The effects of interferon beta treatment on arthritis. Rheumatology (Oxford) 38(4):362-369
    • (1999) Rheumatology (Oxford , vol.38 , Issue.4 , pp. 362-369
    • Tak, P.P.1
  • 171
    • 58849134282 scopus 로고    scopus 로고
    • Interferon beta for rheumatoid arthritis: New clothes for an old kid on the block
    • Vervoordeldonk MJ, Aalbers CJ, Tak PP (2009) Interferon beta for rheumatoid arthritis: New clothes for an old kid on the block. Ann Rheum Dis 68(2):157-158
    • (2009) Ann Rheum Dis , vol.68 , Issue.2 , pp. 157-158
    • Vervoordeldonk, M.J.1    Aalbers, C.J.2    Tak, P.P.3
  • 172
    • 0015815123 scopus 로고
    • Inhibition of the acute inflammatory response by interferon inducers
    • Koltai M, Meos E (1973) Inhibition of the acute inflammatory response by interferon inducers. Nature 242(5399):525-526
    • (1973) Nature , vol.242 , Issue.5399 , pp. 525-526
    • Koltai, M.1    Meos, E.2
  • 173
    • 0032922277 scopus 로고    scopus 로고
    • Amelioration of collageninduced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy
    • Triantaphyllopoulos KA et al (1999) Amelioration of collageninduced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy. Arthritis Rheum 42(1):90-99
    • (1999) Arthritis Rheum , vol.42 , Issue.1 , pp. 90-99
    • Triantaphyllopoulos, K.A.1
  • 174
    • 0016030217 scopus 로고
    • Immunosuppressive effects of an interferon preparation in vivo
    • Hirsch MS et al (1974) Immunosuppressive effects of an interferon preparation in vivo. Transplantation 17(2):234-236
    • (1974) Transplantation , vol.17 , Issue.2 , pp. 234-236
    • Hirsch, M.S.1
  • 175
    • 0042838032 scopus 로고    scopus 로고
    • Interferon-beta prevents cytokineinduced neutrophil infiltration and attenuates blood-brain barrier disruption
    • Veldhuis WB et al (2003) Interferon-beta prevents cytokineinduced neutrophil infiltration and attenuates blood-brain barrier disruption. J Cereb Blood Flow Metab 23(9):1060-1069
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.9 , pp. 1060-1069
    • Veldhuis, W.B.1
  • 176
    • 0029670711 scopus 로고    scopus 로고
    • Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis
    • Yu M et al (1996) Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis. J Neuroimmunol 64(1):91-100
    • (1996) J Neuroimmunol , vol.64 , Issue.1 , pp. 91-100
    • Yu, M.1
  • 177
    • 3843101531 scopus 로고    scopus 로고
    • Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro
    • Kraus J et al (2004) Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro. Ann Neurol 56(2): 192-205
    • (2004) Ann Neurol , vol.56 , Issue.2 , pp. 192-205
    • Kraus, J.1
  • 178
    • 77957745555 scopus 로고    scopus 로고
    • Type I interferon: Friend or foe?
    • Trinchieri G (2010) Type I interferon: Friend or foe? J Exp Med 207(10):2053-2063
    • (2010) J Exp Med , vol.207 , Issue.10 , pp. 2053-2063
    • Trinchieri, G.1
  • 179
    • 80051880722 scopus 로고    scopus 로고
    • Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
    • Sharma S et al (2011) Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity 35(2):194-207
    • (2011) Immunity , vol.35 , Issue.2 , pp. 194-207
    • Sharma, S.1
  • 180
    • 77951626413 scopus 로고    scopus 로고
    • Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections
    • Henry T et al (2010) Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections. J Immunol 184(7):3755-3767
    • (2010) J Immunol , vol.184 , Issue.7 , pp. 3755-3767
    • Henry, T.1
  • 181
    • 4344601300 scopus 로고    scopus 로고
    • Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes
    • Auerbuch V et al (2004) Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes. J Exp Med 200(4):527-533
    • (2004) J Exp Med , vol.200 , Issue.4 , pp. 527-533
    • Auerbuch, V.1
  • 182
    • 4344627833 scopus 로고    scopus 로고
    • Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    • O'Connell RM et al (2004) Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med 200(4):437-445
    • (2004) J Exp Med , vol.200 , Issue.4 , pp. 437-445
    • O'Connell, R.M.1
  • 183
    • 77953633983 scopus 로고    scopus 로고
    • Type I IFN receptor regulates neutrophil functions and innate immunity to Leishmania parasites
    • Xin L et al (2010) Type I IFN receptor regulates neutrophil functions and innate immunity to Leishmania parasites. J Immunol 184(12):7047-7056
    • (2010) J Immunol , vol.184 , Issue.12 , pp. 7047-7056
    • Xin, L.1
  • 184
    • 84255162073 scopus 로고    scopus 로고
    • Innate and adaptive interferons suppress IL-1 alpha and IL-1 beta production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection
    • Mayer-Barber KD et al (2011) Innate and adaptive interferons suppress IL-1 alpha and IL-1 beta production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity 35(6):1023-1034
    • (2011) Immunity , vol.35 , Issue.6 , pp. 1023-1034
    • Mayer-Barber, K.D.1
  • 185
    • 29444432905 scopus 로고    scopus 로고
    • Hypervirulent M. Tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway
    • Manca C et al (2005) Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res 25(11):694-701
    • (2005) J Interferon Cytokine Res , vol.25 , Issue.11 , pp. 694-701
    • Manca, C.1
  • 186
    • 77955894773 scopus 로고    scopus 로고
    • An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    • Berry MP et al (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466(7309):973-977
    • (2010) Nature , vol.466 , Issue.7309 , pp. 973-977
    • Berry, M.P.1
  • 187
    • 68849124811 scopus 로고    scopus 로고
    • Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
    • Shahangian A et al (2009) Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest 119(7):1910-1920
    • (2009) J Clin Invest , vol.119 , Issue.7 , pp. 1910-1920
    • Shahangian, A.1
  • 188
    • 79951740151 scopus 로고    scopus 로고
    • Type I interferon inhibits interleukin-1 production and inflammasome activation
    • Guarda G et al (2011) Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2): 213-223
    • (2011) Immunity , vol.34 , Issue.2 , pp. 213-223
    • Guarda, G.1
  • 189
    • 0015291918 scopus 로고
    • Effect of an interferon stimulator, polyinosinic: Polycytidylic acid, on experimental fungus infections
    • Worthington M, Hasenclever HF (1972) Effect of an interferon stimulator, polyinosinic: Polycytidylic acid, on experimental fungus infections. Infect Immun 5(2):199-202
    • (1972) Infect Immun , vol.5 , Issue.2 , pp. 199-202
    • Worthington, M.1    Hasenclever, H.F.2
  • 190
    • 0026613519 scopus 로고
    • Poly (I. C)-induced interferons enhance susceptibility of SCID mice to systemic candidiasis
    • Jensen J, Vazquez-Torres A, Balish E (1992) Poly (I. C)-induced interferons enhance susceptibility of SCID mice to systemic candidiasis. Infect Immun 60(11):4549-4557
    • (1992) Infect Immun , vol.60 , Issue.11 , pp. 4549-4557
    • Jensen, J.1    Vazquez-Torres, A.2    Balish, E.3
  • 191
    • 0031740883 scopus 로고    scopus 로고
    • Spontaneous and inducible cytokine responses in healthy humans receiving a single dose of IFNalpha2b: Increased production of interleukin-1 receptor antagonist and suppression of IL-1-induced IL-8
    • Reznikov LL et al (1998) Spontaneous and inducible cytokine responses in healthy humans receiving a single dose of IFNalpha2b: Increased production of interleukin-1 receptor antagonist and suppression of IL-1-induced IL-8. J Interferon Cytokine Res 18(10):897-903
    • (1998) J Interferon Cytokine Res , vol.18 , Issue.10 , pp. 897-903
    • Reznikov, L.L.1
  • 192
    • 0025707532 scopus 로고
    • IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharideinduced transcription of IL-1
    • Schindler R, Ghezzi P, Dinarello CA (1990) IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharideinduced transcription of IL-1. J Immunol 144(6):2216-2222
    • (1990) J Immunol , vol.144 , Issue.6 , pp. 2216-2222
    • Schindler, R.1    Ghezzi, P.2    Dinarello, C.A.3
  • 193
    • 77953488157 scopus 로고    scopus 로고
    • Regulation of inflammasome activity
    • Guarda G, So A (2010) Regulation of inflammasome activity. Immunology 130(3):329-336
    • (2010) Immunology , vol.130 , Issue.3 , pp. 329-336
    • Guarda, G.1    So, A.2
  • 194
    • 0028901912 scopus 로고
    • Type 1 interferon as an antiinflammatory agent: Inhibition of lipopolysaccharideinduced interleukin-1 beta and induction of interleukin-1 receptor antagonist
    • Huang Y, Blatt LM, Taylor MW (1995) Type 1 interferon as an antiinflammatory agent: Inhibition of lipopolysaccharideinduced interleukin-1 beta and induction of interleukin-1 receptor antagonist. J Interferon Cytokine Res 15(4):317-321
    • (1995) J Interferon Cytokine Res , vol.15 , Issue.4 , pp. 317-321
    • Huang, Y.1    Blatt, L.M.2    Taylor, M.W.3
  • 195
    • 0031463988 scopus 로고    scopus 로고
    • Interferon-beta not only inhibits interleukin-1 beta and tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells
    • Coclet-Ninin J, Dayer JM, Burger D (1997) Interferon-beta not only inhibits interleukin-1 beta and tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells. Eur Cytokine Netw 8(4):345-349
    • (1997) Eur Cytokine Netw , vol.8 , Issue.4 , pp. 345-349
    • Coclet-Ninin, J.1    Dayer, J.M.2    Burger, D.3
  • 196
    • 4444298256 scopus 로고    scopus 로고
    • Regulation of differentiation and functional properties of monocytes and monocyte-derived dendritic cells by interferon beta in multiple sclerosis
    • Zang YC et al (2004) Regulation of differentiation and functional properties of monocytes and monocyte-derived dendritic cells by interferon beta in multiple sclerosis. Mult Scler 10(5): 499-506
    • (2004) Mult Scler , vol.10 , Issue.5 , pp. 499-506
    • Zang, Y.C.1
  • 197
    • 0034944385 scopus 로고    scopus 로고
    • Type I interferons and IL-12: Convergence and cross-regulation among mediators of cellular immunity
    • Byrnes AA et al (2001) Type I interferons and IL-12: Convergence and cross-regulation among mediators of cellular immunity. Eur J Immunol 31(7):2026-2034
    • (2001) Eur J Immunol , vol.31 , Issue.7 , pp. 2026-2034
    • Byrnes, A.A.1
  • 198
    • 0242412154 scopus 로고    scopus 로고
    • Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: A role for IFNbeta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation
    • Nagai T et al (2003) Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: A role for IFNbeta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. J Immunol 171(10):5233-5243
    • (2003) J Immunol , vol.171 , Issue.10 , pp. 5233-5243
    • Nagai, T.1
  • 199
    • 80052669048 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1{beta} production in human macrophages
    • Novikov A et al (2011) Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1{beta} production in human macrophages. J Immunol 187(5):2540-2547
    • (2011) J Immunol , vol.187 , Issue.5 , pp. 2540-2547
    • Novikov, A.1
  • 200
    • 78649865005 scopus 로고    scopus 로고
    • Tyrosine kinase 2 controls IL-1 beta production at the translational level
    • Radwan M et al (2010) Tyrosine kinase 2 controls IL-1 beta production at the translational level. J Immunol 185(6):3544-3553
    • (2010) J Immunol , vol.185 , Issue.6 , pp. 3544-3553
    • Radwan, M.1
  • 201
    • 10744221913 scopus 로고    scopus 로고
    • The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo
    • Bellocchio S et al (2004) The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 172(5):3059-3069
    • (2004) J Immunol , vol.172 , Issue.5 , pp. 3059-3069
    • Bellocchio, S.1
  • 202
    • 33646363575 scopus 로고    scopus 로고
    • Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis
    • Vonk AG et al (2006) Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis. J Infect Dis 193(10):1419-1426
    • (2006) J Infect Dis , vol.193 , Issue.10 , pp. 1419-1426
    • Vonk, A.G.1
  • 203
    • 34548704962 scopus 로고    scopus 로고
    • IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacteriumtuberculosis infection
    • Fremond CM et al (2007) IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacteriumtuberculosis infection. J Immunol 179(2):1178-1189
    • (2007) J Immunol , vol.179 , Issue.2 , pp. 1178-1189
    • Fremond, C.M.1
  • 204
    • 77951628300 scopus 로고    scopus 로고
    • Caspase-1 independent IL-1 beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
    • Mayer-Barber KD et al (2010) Caspase-1 independent IL-1 beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol 184(7):3326-3330
    • (2010) J Immunol , vol.184 , Issue.7 , pp. 3326-3330
    • Mayer-Barber, K.D.1
  • 205
    • 77955055799 scopus 로고    scopus 로고
    • Regulation of interleukin-1 beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    • Masters SL et al (2010) Regulation of interleukin-1 beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production. EMBO Rep 11(8):640-646
    • (2010) EMBO Rep , vol.11 , Issue.8 , pp. 640-646
    • Masters, S.L.1
  • 206
    • 0028067822 scopus 로고
    • Regulation of cytokine expression by interferon-alpha in human bone marrow stromal cells: Inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist
    • Aman MJ et al (1994) Regulation of cytokine expression by interferon-alpha in human bone marrow stromal cells: Inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist. Blood 84(12):4142-4150
    • (1994) Blood , vol.84 , Issue.12 , pp. 4142-4150
    • Aman, M.J.1
  • 207
    • 34249826961 scopus 로고    scopus 로고
    • Cutting edge: Involvement of the type I IFN production and signaling pathway in lipopolysaccharideinduced IL-10 production
    • Chang EY et al (2007) Cutting edge: Involvement of the type I IFN production and signaling pathway in lipopolysaccharideinduced IL-10 production. J Immunol 178(11):6705-6709
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 6705-6709
    • Chang, E.Y.1
  • 208
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R et al (1991) Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med 174(5):1209-1220
    • (1991) J Exp Med , vol.174 , Issue.5 , pp. 1209-1220
    • De Waal Malefyt, R.1
  • 209
    • 0025889028 scopus 로고
    • IL-10 inhibits cytokine production by activated macrophages
    • Fiorentino DF et al (1991) IL-10 inhibits cytokine production by activated macrophages. J Immunol 147(11):3815-3822
    • (1991) J Immunol , vol.147 , Issue.11 , pp. 3815-3822
    • Fiorentino, D.F.1
  • 210
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(?) Th1-like responses
    • Berg DJ et al (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(?) Th1-like responses. J Clin Invest 98(4):1010-1020
    • (1996) J Clin Invest , vol.98 , Issue.4 , pp. 1010-1020
    • Berg, D.J.1
  • 211
    • 79251589064 scopus 로고    scopus 로고
    • The role of glycogen synthase kinase 3 in regulating IFN-beta-mediated IL-10 production
    • Wang H et al (2011) The role of glycogen synthase kinase 3 in regulating IFN-beta-mediated IL-10 production. J Immunol 186(2):675-684
    • (2011) J Immunol , vol.186 , Issue.2 , pp. 675-684
    • Wang, H.1
  • 212
    • 0038544646 scopus 로고    scopus 로고
    • IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3
    • Ziegler-Heitbrock L et al (2003) IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3. J Immunol 171(1):285-290
    • (2003) J Immunol , vol.171 , Issue.1 , pp. 285-290
    • Ziegler-Heitbrock, L.1
  • 213
    • 0028365152 scopus 로고
    • IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells
    • Wang P et al (1994) IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J Immunol 153(2):811-816
    • (1994) J Immunol , vol.153 , Issue.2 , pp. 811-816
    • Wang, P.1
  • 214
    • 0028261520 scopus 로고
    • The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils
    • Jenkins JK, Malyak M, Arend WP (1994) The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils. Lymphokine Cytokine Res 13(1):47-54
    • (1994) Lymphokine Cytokine Res , vol.13 , Issue.1 , pp. 47-54
    • Jenkins, J.K.1    Malyak, M.2    Arend, W.P.3
  • 215
    • 77951263260 scopus 로고    scopus 로고
    • The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    • Fernandes-Alnemri T et al (2010) The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol 11(5):385-393
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 385-393
    • Fernandes-Alnemri, T.1
  • 216
    • 77951269392 scopus 로고    scopus 로고
    • The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    • Rathinam VA et al (2010) The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 11(5):395-402
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 395-402
    • Rathinam, V.A.1
  • 217
    • 44849103483 scopus 로고    scopus 로고
    • IFN-beta increases listeriolysin O-induced membrane permeabilization and death of macrophages
    • Zwaferink H et al (2008) IFN-beta increases listeriolysin O-induced membrane permeabilization and death of macrophages. J Immunol 180(6):4116-4123
    • (2008) J Immunol , vol.180 , Issue.6 , pp. 4116-4123
    • Zwaferink, H.1
  • 218
    • 80055045773 scopus 로고    scopus 로고
    • IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes
    • Veeranki S et al (2011) IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PLoS ONE 6(10): E27040
    • (2011) PLoS ONE , vol.6 , Issue.10
    • Veeranki, S.1
  • 219
    • 54849146600 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Dienstag JL (2008) Hepatitis B virus infection. N Engl J Med 359(14):1486-1500
    • (2008) N Engl J Med , vol.359 , Issue.14 , pp. 1486-1500
    • Dienstag, J.L.1
  • 220
    • 75749146715 scopus 로고    scopus 로고
    • Pegylated interferons for the treatment of chronic hepatitis C: Pharmacological and clinical differences between peginterferon-alpha-2a and peginterferon-alpha-2b
    • Foster GR (2010) Pegylated interferons for the treatment of chronic hepatitis C: Pharmacological and clinical differences between peginterferon-alpha-2a and peginterferon-alpha-2b. Drugs 70(2):147-165
    • (2010) Drugs , vol.70 , Issue.2 , pp. 147-165
    • Foster, G.R.1
  • 221
    • 80052309181 scopus 로고    scopus 로고
    • Does interferon therapy prevent hepatocellular carcinoma in patients with chronic viral hepatitis?
    • Vezali E et al (2011) Does interferon therapy prevent hepatocellular carcinoma in patients with chronic viral hepatitis? Clin Res Hepatol Gastroenterol 35(6-7):455-464
    • (2011) Clin Res Hepatol Gastroenterol , vol.35 , Issue.6-7 , pp. 455-464
    • Vezali, E.1
  • 222
    • 70449435585 scopus 로고    scopus 로고
    • Interferon for the treatment of genital warts: A systematic review
    • Yang J et al (2009) Interferon for the treatment of genital warts: A systematic review. BMC Infect Dis 9:156
    • (2009) BMC Infect Dis , vol.9 , pp. 156
    • Yang, J.1
  • 223
    • 34548132435 scopus 로고    scopus 로고
    • AIDS-associated Kaposi's sarcoma: Is there still a role for interferon alfa?
    • Krown SE (2007) AIDS-associated Kaposi's sarcoma: Is there still a role for interferon alfa? Cytokine Growth Factor Rev 18(5-6):395-402
    • (2007) Cytokine Growth Factor Rev , vol.18 , Issue.5-6 , pp. 395-402
    • Krown, S.E.1
  • 224
    • 79955947379 scopus 로고    scopus 로고
    • The renaissance of interferon therapy for the treatment of myeloid malignancies
    • Kiladjian JJ, Mesa RA, Hoffman R (2011) The renaissance of interferon therapy for the treatment of myeloid malignancies. Blood 117(18):4706-4715
    • (2011) Blood , vol.117 , Issue.18 , pp. 4706-4715
    • Kiladjian, J.J.1    Mesa, R.A.2    Hoffman, R.3
  • 225
    • 79957512995 scopus 로고    scopus 로고
    • Historical treatments of in hairy cell leukemia, splenectomy and interferon: Past and current uses
    • Habermann TM, Rai K (2011) Historical treatments of in hairy cell leukemia, splenectomy and interferon: Past and current uses. Leuk Lymphoma 52(Suppl 2):18-20
    • (2011) Leuk Lymphoma , vol.52 , Issue.SUPPL. 2 , pp. 18-20
    • Habermann, T.M.1    Rai, K.2
  • 226
    • 84655168007 scopus 로고    scopus 로고
    • Ulceration and stage are predictive of interferon efficacy in melanoma: Results of the phase III adjuvant trials EORTC 18952 and EORTC 18991
    • Eggermont AM et al (2012) Ulceration and stage are predictive of interferon efficacy in melanoma: Results of the phase III adjuvant trials EORTC 18952 and EORTC 18991. Eur J Cancer 48(2):218-25
    • (2012) Eur J Cancer , vol.48 , Issue.2 , pp. 218-25
    • Eggermont, A.M.1
  • 227
    • 0026532880 scopus 로고
    • Revised estimate of the prevalence of multiple sclerosis in the United States
    • Anderson DW et al (1992) Revised estimate of the prevalence of multiple sclerosis in the United States. AnnNeurol 31(3):333-336
    • (1992) AnnNeurol , vol.31 , Issue.3 , pp. 333-336
    • Anderson, D.W.1
  • 228
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A (2008) Multiple sclerosis. Lancet 372(9648):1502-1517
    • (2008) Lancet , vol.372 , Issue.9648 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 229
    • 34547497820 scopus 로고    scopus 로고
    • Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: A 3-year follow-up analysis of the BENEFIT study
    • Kappos L et al (2007) Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: A 3-year follow-up analysis of the BENEFIT study. Lancet 370(9585):389-397
    • (2007) Lancet , vol.370 , Issue.9585 , pp. 389-397
    • Kappos, L.1
  • 230
    • 0028348216 scopus 로고
    • Chronic systemic high-dose recombinant interferon alfa-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon gamma production in relapsing-remitting multiple sclerosis
    • Durelli L et al (1994) Chronic systemic high-dose recombinant interferon alfa-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon gamma production in relapsing-remitting multiple sclerosis. Neurology 44(3 Pt 1): 406-413
    • (1994) Neurology , vol.44 , Issue.3 PART 1 , pp. 406-413
    • Durelli, L.1
  • 231
    • 0029887146 scopus 로고    scopus 로고
    • Natural alpha interferon in multiple sclerosis: Results of three preliminary series
    • Squillacote D, Martinez M, Sheremata W (1996) Natural alpha interferon in multiple sclerosis: Results of three preliminary series. J Int Med Res 24(3):246-257
    • (1996) J Int Med Res , vol.24 , Issue.3 , pp. 246-257
    • Squillacote, D.1    Martinez, M.2    Sheremata, W.3
  • 232
    • 0027156946 scopus 로고
    • Effects of recombinant alpha-2binterferon therapy in patients with progressive MS
    • Kinnunen E et al (1993) Effects of recombinant alpha-2binterferon therapy in patients with progressive MS. Acta Neurol Scand 87(6):457-460
    • (1993) Acta Neurol Scand , vol.87 , Issue.6 , pp. 457-460
    • Kinnunen, E.1
  • 233
    • 0024582741 scopus 로고
    • Exacerbation of multiple sclerosis after the administration of recombinant human interferon alfa
    • Larrey D et al (1989) Exacerbation of multiple sclerosis after the administration of recombinant human interferon alfa. JAMA 261(14):2065
    • (1989) JAMA , vol.261 , Issue.14 , pp. 2065
    • Larrey, D.1
  • 234
    • 0036105496 scopus 로고    scopus 로고
    • Multiple sclerosis associated with interferon-alpha therapy for chronic myelogenous leukemia
    • Kataoka I et al (2002) Multiple sclerosis associated with interferon-alpha therapy for chronic myelogenous leukemia. Am J Hematol 70(2):149-153
    • (2002) Am J Hematol , vol.70 , Issue.2 , pp. 149-153
    • Kataoka, I.1
  • 235
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • Ben-Nun A, Wekerle H, Cohen IR (1981) The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 11(3):195-199
    • (1981) Eur J Immunol , vol.11 , Issue.3 , pp. 195-199
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 236
    • 84882496518 scopus 로고    scopus 로고
    • The pathology of multiple sclerosis
    • Compston A (ed) Elsevier, London
    • Lassmann H, Wekerle H (2006) The pathology of multiple sclerosis. In: Compston A (ed) Mc Alpine's multiple sclerosis. Elsevier, London, pp 557-599
    • (2006) Mc Alpine's Multiple Sclerosis. , pp. 557-599
    • Lassmann, H.1    Wekerle, H.2
  • 237
    • 0034618094 scopus 로고    scopus 로고
    • Clonal expansions of CD8(?) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • Babbe H et al (2000) Clonal expansions of CD8(?) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 192(3):393-404
    • (2000) J Exp Med , vol.192 , Issue.3 , pp. 393-404
    • Babbe, H.1
  • 238
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C et al (2000) Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol 47(6):707-717
    • (2000) Ann Neurol , vol.47 , Issue.6 , pp. 707-717
    • Lucchinetti, C.1
  • 239
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass CK et al (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140(6):918-934
    • (2010) Cell , vol.140 , Issue.6 , pp. 918-934
    • Glass, C.K.1
  • 240
    • 77955664480 scopus 로고    scopus 로고
    • Orchestrating innate immune responses in multiple sclerosis: Molecular players
    • Fernandez M, Montalban X, Comabella M (2010) Orchestrating innate immune responses in multiple sclerosis: Molecular players. J Neuroimmunol 225(1-2):5-12
    • (2010) J Neuroimmunol , vol.225 , Issue.1-2 , pp. 5-12
    • Fernandez, M.1    Montalban, X.2    Comabella, M.3
  • 241
    • 0033198269 scopus 로고    scopus 로고
    • Caspase-1 regulates the inflammatory process leading to autoimmune demyelination
    • Furlan R et al (1999) Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol 163(5):2403-2409
    • (1999) J Immunol , vol.163 , Issue.5 , pp. 2403-2409
    • Furlan, R.1
  • 242
    • 77954478334 scopus 로고    scopus 로고
    • Cutting edge: Critical role for PYCARD/ ASC in the development of experimental autoimmune encephalomyelitis
    • Shaw PJ et al (2010) Cutting edge: Critical role for PYCARD/ ASC in the development of experimental autoimmune encephalomyelitis. J Immunol 184(9):4610-4614
    • (2010) J Immunol , vol.184 , Issue.9 , pp. 4610-4614
    • Shaw, P.J.1
  • 243
    • 77955475968 scopus 로고    scopus 로고
    • NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses
    • Gris D et al (2010) NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol 185(2):974-981
    • (2010) J Immunol , vol.185 , Issue.2 , pp. 974-981
    • Gris, D.1
  • 244
    • 31544441415 scopus 로고    scopus 로고
    • Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
    • Matsuki T et al (2006) Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis. Int Immunol 18(2):399-407
    • (2006) Int Immunol , vol.18 , Issue.2 , pp. 399-407
    • Matsuki, T.1
  • 245
    • 70349794459 scopus 로고    scopus 로고
    • Innate and adaptive autoimmunity directed to the central nervous system
    • Bhat R, Steinman L (2009) Innate and adaptive autoimmunity directed to the central nervous system. Neuron 64(1):123-132
    • (2009) Neuron , vol.64 , Issue.1 , pp. 123-132
    • Bhat, R.1    Steinman, L.2
  • 246
    • 0033599730 scopus 로고    scopus 로고
    • Interferon-beta 1b augments activationinduced T-cell death in multiple sclerosis patients
    • Kaser A et al (1999) Interferon-beta 1b augments activationinduced T-cell death in multiple sclerosis patients. Lancet 353(9162):1413-1414
    • (1999) Lancet , vol.353 , Issue.9162 , pp. 1413-1414
    • Kaser, A.1
  • 247
    • 39749116126 scopus 로고    scopus 로고
    • SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients
    • Christophi GP et al (2008) SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients. Lab Invest 88(3):243-255
    • (2008) Lab Invest , vol.88 , Issue.3 , pp. 243-255
    • Christophi, G.P.1
  • 248
    • 69949158153 scopus 로고    scopus 로고
    • Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1
    • Christophi GP et al (2009) Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin Immunol 133(1):27-44
    • (2009) Clin Immunol , vol.133 , Issue.1 , pp. 27-44
    • Christophi, G.P.1
  • 249
    • 0032850616 scopus 로고    scopus 로고
    • Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression
    • Dickensheets HL et al (1999) Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Proc Natl Acad Sci USA 96(19):10800-10805
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.19 , pp. 10800-10805
    • Dickensheets, H.L.1
  • 250
    • 33645289121 scopus 로고    scopus 로고
    • CD69 acts downstream of interferonalpha/ beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    • Shiow LR et al (2006) CD69 acts downstream of interferonalpha/ beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440(7083):540-544
    • (2006) Nature , vol.440 , Issue.7083 , pp. 540-544
    • Shiow, L.R.1
  • 251
    • 2942622588 scopus 로고    scopus 로고
    • Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases
    • Kieseier BC, Archelos JJ, Hartung HP (2004) Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases. Arch Neurol 61(6):929-932
    • (2004) Arch Neurol , vol.61 , Issue.6 , pp. 929-932
    • Kieseier, B.C.1    Archelos, J.J.2    Hartung, H.P.3
  • 252
    • 10744229980 scopus 로고    scopus 로고
    • Neutralizing antibodies against IFN-beta in multiple sclerosis: Antagonization of IFN-beta mediated suppression of MMPs
    • Gilli F et al (2004) Neutralizing antibodies against IFN-beta in multiple sclerosis: Antagonization of IFN-beta mediated suppression of MMPs. Brain 127(Pt 2):259-268
    • (2004) Brain , vol.127 , Issue.PART 2 , pp. 259-268
    • Gilli, F.1
  • 253
    • 0034333256 scopus 로고    scopus 로고
    • VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis
    • Muraro PA et al (2000) VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis. J Neuroimmunol 111(1-2):186-194
    • (2000) J Neuroimmunol , vol.111 , Issue.1-2 , pp. 186-194
    • Muraro, P.A.1
  • 254
    • 11144357349 scopus 로고    scopus 로고
    • Decreased integrin gene expression in patients with MS responding to interferon-beta treatment
    • Muraro PA et al (2004) Decreased integrin gene expression in patients with MS responding to interferon-beta treatment. J Neuroimmunol 150(1-2):123-131
    • (2004) J Neuroimmunol , vol.150 , Issue.1-2 , pp. 123-131
    • Muraro, P.A.1
  • 255
    • 82955228112 scopus 로고    scopus 로고
    • Th17 cytokines in autoimmune neuro-inflammation
    • Becher B, Segal BM (2011) Th17 cytokines in autoimmune neuro-inflammation. Curr Opin Immunol 26:707-712
    • (2011) Curr Opin Immunol , vol.26 , pp. 707-712
    • Becher, B.1    Segal, B.M.2
  • 256
    • 0033017354 scopus 로고    scopus 로고
    • Immunologic therapy of multiple sclerosis
    • Arnason BG (1999) Immunologic therapy of multiple sclerosis. Annu Rev Med 50:291-302
    • (1999) Annu Rev Med , vol.50 , pp. 291-302
    • Arnason, B.G.1
  • 257
    • 0038692013 scopus 로고    scopus 로고
    • Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis
    • Sturzebecher S et al (2003) Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis. Brain 126(Pt 6):1419-1429
    • (2003) Brain , vol.126 , Issue.PART 6 , pp. 1419-1429
    • Sturzebecher, S.1
  • 258
    • 77950534540 scopus 로고    scopus 로고
    • T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
    • Axtell RC et al (2010) T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med 16(4):406-412
    • (2010) Nat Med , vol.16 , Issue.4 , pp. 406-412
    • Axtell, R.C.1
  • 259
    • 33845783410 scopus 로고    scopus 로고
    • Early relapse in multiple sclerosisassociated optic neuritis following the use of interferon beta-1a in Chinese patients
    • Wang AG et al (2006) Early relapse in multiple sclerosisassociated optic neuritis following the use of interferon beta-1a in Chinese patients. Jpn J Ophthalmol 50(6):537-542
    • (2006) Jpn J Ophthalmol , vol.50 , Issue.6 , pp. 537-542
    • Wang, A.G.1
  • 260
    • 0033544299 scopus 로고    scopus 로고
    • Multiple sclerosis: Side effects of interferon beta therapy and their management
    • Walther EU, Hohlfeld R (1999) Multiple sclerosis: Side effects of interferon beta therapy and their management. Neurology 53(8):1622-1627
    • (1999) Neurology , vol.53 , Issue.8 , pp. 1622-1627
    • Walther, E.U.1    Hohlfeld, R.2
  • 261
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group.
    • The IFNB Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43(4):655-661
    • (1993) Neurology , vol.43 , Issue.4 , pp. 655-661
  • 262
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
    • The IFNB Multiple Sclerosis Study Group, The University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group, The University of British Columbia MS/MRI Analysis Group (1995) Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial. Neurology 45(7):1277-1285
    • (1995) Neurology , vol.45 , Issue.7 , pp. 1277-1285
  • 263
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
    • UBC MS/MRI Study Group, The IFNB Multiple Sclerosis Study Group
    • Paty DW, Li DK, UBC MS/MRI Study Group, The IFNB Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43(4):662-667
    • (1993) Neurology , vol.43 , Issue.4 , pp. 662-667
    • Paty, D.W.1    Li, D.K.2
  • 264
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
    • The Multiple Sclerosis Collaborative Research Group (MSCRG) et al.
    • Jacobs LD, The Multiple Sclerosis Collaborative Research Group (MSCRG) et al (1996) Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol 39(3):285-294
    • (1996) Ann Neurol , vol.39 , Issue.3 , pp. 285-294
    • Jacobs, L.D.1
  • 265
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group (1998) Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 352(9139):1498-1504
    • (1998) Lancet , vol.352 , Issue.9139 , pp. 1498-1504
  • 266
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis
    • European Study Group
    • European Study Group (1998) Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet 352(9139):1491-1497
    • (1998) Lancet , vol.352 , Issue.9139 , pp. 1491-1497
  • 267
    • 77953353229 scopus 로고    scopus 로고
    • Cross-sectional study assessing long-term safety of interferon-beta-1b for relapsing-remitting MS
    • Reder AT et al (2010) Cross-sectional study assessing long-term safety of interferon-beta-1b for relapsing-remitting MS. Neurology 74(23):1877-1885
    • (2010) Neurology , vol.74 , Issue.23 , pp. 1877-1885
    • Reder, A.T.1
  • 268
    • 3042599922 scopus 로고    scopus 로고
    • Elevated aminotransferases during treatment with interferon-beta for multiple sclerosis: Actions and outcomes
    • Tremlett HL, Oger J (2004) Elevated aminotransferases during treatment with interferon-beta for multiple sclerosis: Actions and outcomes. Mult Scler 10(3):298-301
    • (2004) Mult Scler , vol.10 , Issue.3 , pp. 298-301
    • Tremlett, H.L.1    Oger, J.2
  • 269
    • 0035933123 scopus 로고    scopus 로고
    • Fulminant liver failure during interferon beta treatment of multiple sclerosis
    • Yoshida EM et al (2001) Fulminant liver failure during interferon beta treatment of multiple sclerosis. Neurology 56(10):1416
    • (2001) Neurology , vol.56 , Issue.10 , pp. 1416
    • Yoshida, E.M.1
  • 270
    • 33745897603 scopus 로고    scopus 로고
    • Unmasking of autoimmune hepatitis in a patient with MS following interferon beta therapy
    • Pulicken M et al (2006) Unmasking of autoimmune hepatitis in a patient with MS following interferon beta therapy. Neurology 66(12):1954-1955
    • (2006) Neurology , vol.66 , Issue.12 , pp. 1954-1955
    • Pulicken, M.1
  • 271
    • 78649390621 scopus 로고    scopus 로고
    • Severe depression, suicide attempts, and ideation during the use of interferon beta by patients with multiple sclerosis
    • Fragoso YD et al (2010) Severe depression, suicide attempts, and ideation during the use of interferon beta by patients with multiple sclerosis. Clin Neuropharmacol 33(6):312-316
    • (2010) Clin Neuropharmacol , vol.33 , Issue.6 , pp. 312-316
    • Fragoso, Y.D.1
  • 272
    • 0344780900 scopus 로고    scopus 로고
    • Emotional state of patients with relapsingremitting MS treated with interferon beta-1b
    • Borras C et al (1999) Emotional state of patients with relapsingremitting MS treated with interferon beta-1b. Neurology 52(8):1636-1639
    • (1999) Neurology , vol.52 , Issue.8 , pp. 1636-1639
    • Borras, C.1
  • 273
    • 0030823454 scopus 로고    scopus 로고
    • Incidence of antibodies to interferon-beta in patients treated with recombinant human interferon-beta 1a from mammalian cells
    • Abdul-Ahad AK et al (1997) Incidence of antibodies to interferon-beta in patients treated with recombinant human interferon-beta 1a from mammalian cells. Cytokines Cell Mol Ther 3(1):27-32
    • (1997) Cytokines Cell Mol Ther , vol.3 , Issue.1 , pp. 27-32
    • Abdul-Ahad, A.K.1
  • 274
    • 0031841745 scopus 로고    scopus 로고
    • Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis
    • Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Rudick RA, Multiple Sclerosis Collaborative Research Group (MSCRG) et al (1998) Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Neurology 50(5):1266-1272
    • (1998) Neurology , vol.50 , Issue.5 , pp. 1266-1272
    • Rudick, R.A.1
  • 275
    • 0005489101 scopus 로고    scopus 로고
    • Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: Experience during the first three years
    • The IFNB Multiple Sclerosis Study Group, The University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group, The University of British Columbia MS/MRI Analysis Group (1996) Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: Experience during the first three years. Neurology 47(4):889-894
    • (1996) Neurology , vol.47 , Issue.4 , pp. 889-894
  • 276
    • 0033763507 scopus 로고    scopus 로고
    • Immunogenicity of interferon-beta in multiple sclerosis patients: Influence of preparation, dosage, dose frequency, and route of administration
    • Danish Multiple Sclerosis Study Group
    • Ross C, Danish Multiple Sclerosis Study Group et al (2000) Immunogenicity of interferon-beta in multiple sclerosis patients: Influence of preparation, dosage, dose frequency, and route of administration. Ann Neurol 48(5):706-712
    • (2000) Ann Neurol , vol.48 , Issue.5 , pp. 706-712
    • Ross, C.1
  • 277
    • 10744225329 scopus 로고    scopus 로고
    • Clinical importance of neutralising antibodies against interferon beta in patients with relapsingremitting multiple sclerosis
    • Sorensen PS et al (2003) Clinical importance of neutralising antibodies against interferon beta in patients with relapsingremitting multiple sclerosis. Lancet 362(9391):1184-1191
    • (2003) Lancet , vol.362 , Issue.9391 , pp. 1184-1191
    • Sorensen, P.S.1
  • 278
    • 33748367018 scopus 로고    scopus 로고
    • A proposed classification of the immunological diseases
    • McGonagle D, McDermott MF (2006) A proposed classification of the immunological diseases. PLoS Med 3(8):e297
    • (2006) PLoS Med , vol.3 , Issue.8
    • McGonagle, D.1    McDermott, M.F.2
  • 279
    • 0035179970 scopus 로고    scopus 로고
    • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome andMuckle-Wells syndrome
    • Hoffman HM et al (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome andMuckle-Wells syndrome. Nat Genet 29(3):301-305
    • (2001) Nat Genet , vol.29 , Issue.3 , pp. 301-305
    • Hoffman, H.M.1
  • 280
    • 1042290321 scopus 로고    scopus 로고
    • Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra
    • Hawkins PN et al (2004) Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 50(2):607-612
    • (2004) Arthritis Rheum , vol.50 , Issue.2 , pp. 607-612
    • Hawkins, P.N.1
  • 281
    • 33746876396 scopus 로고    scopus 로고
    • Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition
    • Goldbach-Mansky R et al (2006) Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med 355(6):581-592
    • (2006) N Engl J Med , vol.355 , Issue.6 , pp. 581-592
    • Goldbach-Mansky, R.1
  • 282
    • 66649102432 scopus 로고    scopus 로고
    • Use of canakinumab in the cryopyrinassociated periodic syndrome
    • Lachmann HJ et al (2009) Use of canakinumab in the cryopyrinassociated periodic syndrome. N Engl J Med 360(23): 2416-2425
    • (2009) N Engl J Med , vol.360 , Issue.23 , pp. 2416-2425
    • Lachmann, H.J.1
  • 283
    • 77955291693 scopus 로고    scopus 로고
    • Follow-up and quality of life of patients with cryopyrin-associated periodic syndromes treated with Anakinra
    • Lepore L et al (2010) Follow-up and quality of life of patients with cryopyrin-associated periodic syndromes treated with Anakinra. J Pediatr 157(2):310-315e1
    • (2010) J Pediatr , vol.157 , Issue.2
    • Lepore, L.1
  • 284
    • 74849115591 scopus 로고    scopus 로고
    • Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome
    • Neven B et al (2010) Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome. Arthritis Rheum 62(1):258-267
    • (2010) Arthritis Rheum , vol.62 , Issue.1 , pp. 258-267
    • Neven, B.1
  • 285
    • 79953677480 scopus 로고    scopus 로고
    • Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome
    • Kuemmerle-Deschner JB et al (2011) Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome. Arthritis Rheum 63(3):840-849
    • (2011) Arthritis Rheum , vol.63 , Issue.3 , pp. 840-849
    • Kuemmerle-Deschner, J.B.1
  • 286
    • 0030745449 scopus 로고
    • Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever
    • The International FMF Consortium.
    • The International FMF Consortium (1947) Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90(4):797-807
    • (1947) Cell , vol.90 , Issue.4 , pp. 797-807
  • 287
    • 16944365196 scopus 로고    scopus 로고
    • A candidate gene for familial Mediterranean fever
    • French Familial Mediterranean Fever Consortium.
    • French Familial Mediterranean fever Consortium (1997) A candidate gene for familial Mediterranean fever. Nat Genet 17(1):25-31
    • (1997) Nat Genet , vol.17 , Issue.1 , pp. 25-31
  • 288
    • 0026528553 scopus 로고
    • Decreased interleukin 1 activity released from circulating monocytes of patients with familial Mediterranean fever during in vitro stimulation by lipopolysaccharide
    • Rozenbaum M et al (1992) Decreased interleukin 1 activity released from circulating monocytes of patients with familial Mediterranean fever during in vitro stimulation by lipopolysaccharide. J Rheumatol 19(3):416-418
    • (1992) J Rheumatol , vol.19 , Issue.3 , pp. 416-418
    • Rozenbaum, M.1
  • 289
    • 34547138176 scopus 로고    scopus 로고
    • The SPRY domain of pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing
    • Papin S et al (2007) The SPRY domain of pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ 14(8):1457-1466
    • (2007) Cell Death Differ , vol.14 , Issue.8 , pp. 1457-1466
    • Papin, S.1
  • 290
    • 79956299492 scopus 로고    scopus 로고
    • Gain-of-function pyrin mutations induce NLRP3 protein-independent interleukin-1beta activation and severe autoinflammation in mice
    • Chae JJ et al (2011) Gain-of-function pyrin mutations induce NLRP3 protein-independent interleukin-1beta activation and severe autoinflammation in mice. Immunity 34(5):755-768
    • (2011) Immunity , vol.34 , Issue.5 , pp. 755-768
    • Chae, J.J.1
  • 291
    • 57849127198 scopus 로고    scopus 로고
    • Anakinra suppresses familial Mediterranean fever crises in a colchicine-resistant patient
    • Mitroulis I et al (2008) Anakinra suppresses familial Mediterranean fever crises in a colchicine-resistant patient. Neth J Med 66(11):489-491
    • (2008) Neth J Med , vol.66 , Issue.11 , pp. 489-491
    • Mitroulis, I.1
  • 292
    • 41849105723 scopus 로고    scopus 로고
    • The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever
    • Calligaris L et al (2008) The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever. Eur J Pediatr 167(6):695-696
    • (2008) Eur J Pediatr , vol.167 , Issue.6 , pp. 695-696
    • Calligaris, L.1
  • 293
    • 79952425658 scopus 로고    scopus 로고
    • Anti-interleukin 1 treatment for patients with familial Mediterranean fever resistant to colchicine
    • Ozen S et al (2011) Anti-interleukin 1 treatment for patients with familial Mediterranean fever resistant to colchicine. J Rheumatol 38(3):516-518
    • (2011) J Rheumatol , vol.38 , Issue.3 , pp. 516-518
    • Ozen, S.1
  • 294
    • 79955138270 scopus 로고    scopus 로고
    • Interleukin-1 targeting drugs in familial Mediterranean fever: A case series and a review of the literature
    • Meinzer U et al (2011) Interleukin-1 targeting drugs in familial Mediterranean fever: A case series and a review of the literature. Semin Arthritis Rheum 65(2):265-271
    • (2011) Semin Arthritis Rheum , vol.65 , Issue.2 , pp. 265-271
    • Meinzer, U.1
  • 295
    • 77949884645 scopus 로고    scopus 로고
    • Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behcet's disease
    • Bilginer Y, Ayaz NA, Ozen S (2010) Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behcet's disease. Clin Rheumatol 29(2):209-210
    • (2010) Clin Rheumatol , vol.29 , Issue.2 , pp. 209-210
    • Bilginer, Y.1    Ayaz, N.A.2    Ozen, S.3
  • 296
    • 47349101976 scopus 로고    scopus 로고
    • Interferon-alpha as a treatment modality for colchicine-resistant familial Mediterranean fever
    • Tweezer-Zaks N et al (2008) Interferon-alpha as a treatment modality for colchicine-resistant familial Mediterranean fever. J Rheumatol 35(7):1362-1365
    • (2008) J Rheumatol , vol.35 , Issue.7 , pp. 1362-1365
    • Tweezer-Zaks, N.1
  • 297
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP et al (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411(6837): 599-603
    • (2001) Nature , vol.411 , Issue.6837 , pp. 599-603
    • Hugot, J.P.1
  • 298
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y et al (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411(6837): 603-606
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1
  • 299
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC et al (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40(8):955-962
    • (2008) Nat Genet , vol.40 , Issue.8 , pp. 955-962
    • Barrett, J.C.1
  • 300
    • 44349136821 scopus 로고    scopus 로고
    • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    • Fisher SA et al (2008) Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet 40(6):710-712
    • (2008) Nat Genet , vol.40 , Issue.6 , pp. 710-712
    • Fisher, S.A.1
  • 301
    • 44349173654 scopus 로고    scopus 로고
    • Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
    • Franke A et al (2008) Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet 40(6):713-715
    • (2008) Nat Genet , vol.40 , Issue.6 , pp. 713-715
    • Franke, A.1
  • 302
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • Cho JH (2008) The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 8(6):458-466
    • (2008) Nat Rev Immunol , vol.8 , Issue.6 , pp. 458-466
    • Cho, J.H.1
  • 303
    • 35848970794 scopus 로고    scopus 로고
    • Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease
    • Massey DC, Parkes M (2007) Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease. Autophagy 3(6):649-651
    • (2007) Autophagy , vol.3 , Issue.6 , pp. 649-651
    • Massey, D.C.1    Parkes, M.2
  • 304
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh T et al (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456(7219):264-268
    • (2008) Nature , vol.456 , Issue.7219 , pp. 264-268
    • Saitoh, T.1
  • 305
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH et al (2010) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 11(1):55-62
    • (2010) Nat Immunol , vol.11 , Issue.1 , pp. 55-62
    • Travassos, L.H.1
  • 306
    • 13244277880 scopus 로고    scopus 로고
    • Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    • Maeda S et al (2005) Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 307(5710):734-738
    • (2005) Science , vol.307 , Issue.5710 , pp. 734-738
    • Maeda, S.1
  • 307
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke A et al (2008) Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 40(11):1319-1323
    • (2008) Nat Genet , vol.40 , Issue.11 , pp. 1319-1323
    • Franke, A.1
  • 308
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker EO et al (2009) Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 361(21):2033-2045
    • (2009) N Engl J Med , vol.361 , Issue.21 , pp. 2033-2045
    • Glocker, E.O.1
  • 309
    • 77950791967 scopus 로고    scopus 로고
    • Efficacy of TNF antagonists beyond one year in adult and pediatric inflammatory bowel diseases: A systematic review
    • Oussalah A, Danese S, Peyrin-Biroulet L (2010) Efficacy of TNF antagonists beyond one year in adult and pediatric inflammatory bowel diseases: A systematic review. Curr Drug Targets 11(2):156-175
    • (2010) Curr Drug Targets , vol.11 , Issue.2 , pp. 156-175
    • Oussalah, A.1    Danese, S.2    Peyrin-Biroulet, L.3
  • 310
    • 0029151725 scopus 로고
    • Induction of remission by interferon-alpha in patients with chronic active ulcerative colitis
    • Sumer N, Palabiyikoglu M (1995) Induction of remission by interferon-alpha in patients with chronic active ulcerative colitis. Eur J Gastroenterol Hepatol 7(7):597-602
    • (1995) Eur J Gastroenterol Hepatol , vol.7 , Issue.7 , pp. 597-602
    • Sumer, N.1    Palabiyikoglu, M.2
  • 311
    • 0042386679 scopus 로고    scopus 로고
    • Interferon beta-1a in ulcerative colitis: A placebo controlled, randomised, dose escalating study
    • Nikolaus S et al (2003) Interferon beta-1a in ulcerative colitis: A placebo controlled, randomised, dose escalating study. Gut 52(9):1286-1290
    • (2003) Gut , vol.52 , Issue.9 , pp. 1286-1290
    • Nikolaus, S.1
  • 312
    • 1842734289 scopus 로고    scopus 로고
    • Type I interferons and their therapeutic role in Th2-regulated inflammatory disorders
    • Tilg H, Kaser A (2004) Type I interferons and their therapeutic role in Th2-regulated inflammatory disorders. Expert Opin Biol Ther 4(4):469-481
    • (2004) Expert Opin Biol Ther , vol.4 , Issue.4 , pp. 469-481
    • Tilg, H.1    Kaser, A.2
  • 313
    • 70349768117 scopus 로고    scopus 로고
    • HLA-B51/B5 and the risk of Behcet's disease: A systematic review and meta-analysis of case-control genetic association studies
    • de Menthon M et al (2009) HLA-B51/B5 and the risk of Behcet's disease: A systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum 61(10):1287-1296
    • (2009) Arthritis Rheum , vol.61 , Issue.10 , pp. 1287-1296
    • De Menthon, M.1
  • 314
    • 77955087288 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants in the MHC class I, IL10, and IL23RIL12RB2 regions associated with Behcet's disease
    • Remmers EF et al (2010) Genome-wide association study identifies variants in the MHC class I, IL10, and IL23RIL12RB2 regions associated with Behcet's disease. Nat Genet 42(8):698-702
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 698-702
    • Remmers, E.F.1
  • 316
    • 34347212190 scopus 로고    scopus 로고
    • Anti-TNF therapy in the management of Behcet's disease-review and basis for recommendations
    • Sfikakis PP et al (2007) Anti-TNF therapy in the management of Behcet's disease-review and basis for recommendations. Rheumatology (Oxford) 46(5):736-741
    • (2007) Rheumatology (Oxford , vol.46 , Issue.5 , pp. 736-741
    • Sfikakis, P.P.1
  • 317
    • 11844283956 scopus 로고    scopus 로고
    • Short-term trial of etanercept in Behcet's disease: A double blind, placebo controlled study
    • Melikoglu M et al (2005) Short-term trial of etanercept in Behcet's disease: A double blind, placebo controlled study. J Rheumatol 32(1):98-105
    • (2005) J Rheumatol , vol.32 , Issue.1 , pp. 98-105
    • Melikoglu, M.1
  • 318
    • 49849103750 scopus 로고    scopus 로고
    • Resistant Behcet disease responsive to anakinra
    • Botsios C et al (2008) Resistant Behcet disease responsive to anakinra. Ann Intern Med 149(4):284-286
    • (2008) Ann Intern Med , vol.149 , Issue.4 , pp. 284-286
    • Botsios, C.1
  • 319
    • 11144355802 scopus 로고    scopus 로고
    • The use of interferon alpha in Behcet disease: Review of the literature
    • Kotter I et al (2004) The use of interferon alpha in Behcet disease: Review of the literature. Semin Arthritis Rheum 33(5):320-335
    • (2004) Semin Arthritis Rheum , vol.33 , Issue.5 , pp. 320-335
    • Kotter, I.1
  • 321
    • 40049088465 scopus 로고    scopus 로고
    • Dendritic cells and epithelial cells: Linking innate and adaptive immunity in asthma
    • Hammad H, Lambrecht BN (2008) Dendritic cells and epithelial cells: Linking innate and adaptive immunity in asthma. Nat Rev Immunol 8(3):193-204
    • (2008) Nat Rev Immunol , vol.8 , Issue.3 , pp. 193-204
    • Hammad, H.1    Lambrecht, B.N.2
  • 322
    • 33846512988 scopus 로고    scopus 로고
    • Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB
    • Lee HC, Ziegler SF (2007) Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc Natl Acad Sci USA 104(3):914-919
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.3 , pp. 914-919
    • Lee, H.C.1    Ziegler, S.F.2
  • 323
    • 33847134006 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
    • Allakhverdi Z et al (2007) Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 204(2):253-258
    • (2007) J Exp Med , vol.204 , Issue.2 , pp. 253-258
    • Allakhverdi, Z.1
  • 324
    • 0035084249 scopus 로고    scopus 로고
    • Interaction of cigarette smoke and house dust mite allergens on inflammatory mediator release from primary cultures of human bronchial epithelial cells
    • Rusznak C et al (2001) Interaction of cigarette smoke and house dust mite allergens on inflammatory mediator release from primary cultures of human bronchial epithelial cells. Clin Exp Allergy 31(2):226-238
    • (2001) Clin Exp Allergy , vol.31 , Issue.2 , pp. 226-238
    • Rusznak, C.1
  • 325
    • 66049134994 scopus 로고    scopus 로고
    • Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
    • Nakamura Y et al (2009) Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med 206(5):1037-1046
    • (2009) J Exp Med , vol.206 , Issue.5 , pp. 1037-1046
    • Nakamura, Y.1
  • 326
    • 0029032712 scopus 로고
    • Potential role of interleukin-1 in allergeninduced late asthmatic reactions in guinea pigs: Suppressive effect of interleukin-1 receptor antagonist on late asthmatic reaction
    • Okada S et al (1995) Potential role of interleukin-1 in allergeninduced late asthmatic reactions in guinea pigs: Suppressive effect of interleukin-1 receptor antagonist on late asthmatic reaction. J Allergy Clin Immunol 95(6):1236-1245
    • (1995) J Allergy Clin Immunol , vol.95 , Issue.6 , pp. 1236-1245
    • Okada, S.1
  • 327
    • 0038744514 scopus 로고    scopus 로고
    • The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model
    • Schmitz N, Kurrer M, Kopf M (2003) The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model. Eur J Immunol 33(4):991-1000
    • (2003) Eur J Immunol , vol.33 , Issue.4 , pp. 991-1000
    • Schmitz, N.1    Kurrer, M.2    Kopf, M.3
  • 328
    • 0037385617 scopus 로고    scopus 로고
    • IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response
    • Nakae S et al (2003) IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int Immunol 15(4):483-490
    • (2003) Int Immunol , vol.15 , Issue.4 , pp. 483-490
    • Nakae, S.1
  • 329
    • 25844527139 scopus 로고    scopus 로고
    • Prevention of IL-1 signaling attenuates airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma
    • Johnson VJ, Yucesoy B, Luster MI (2005) Prevention of IL-1 signaling attenuates airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma. J Allergy Clin Immunol 116(4):851-858
    • (2005) J Allergy Clin Immunol , vol.116 , Issue.4 , pp. 851-858
    • Johnson, V.J.1    Yucesoy, B.2    Luster, M.I.3
  • 330
    • 33751227870 scopus 로고    scopus 로고
    • Pharmacokinetics and anti-asthmatic potential of non-parenterally administered recombinant human interleukin-1 receptor antagonist in animal models
    • Li T et al (2006) Pharmacokinetics and anti-asthmatic potential of non-parenterally administered recombinant human interleukin-1 receptor antagonist in animal models. J Pharmacol Sci 102(3):321-330
    • (2006) J Pharmacol Sci , vol.102 , Issue.3 , pp. 321-330
    • Li, T.1
  • 331
    • 33748879109 scopus 로고    scopus 로고
    • Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma
    • Wang CC et al (2006) Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Gene Ther 13(19):1414-1421
    • (2006) Gene Ther , vol.13 , Issue.19 , pp. 1414-1421
    • Wang, C.C.1
  • 332
    • 34547655975 scopus 로고    scopus 로고
    • Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
    • Idzko M et al (2007) Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 13(8):913-919
    • (2007) Nat Med , vol.13 , Issue.8 , pp. 913-919
    • Idzko, M.1
  • 333
    • 45749111446 scopus 로고    scopus 로고
    • Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    • Eisenbarth SC et al (2008) Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453(7198):1122-1126
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1122-1126
    • Eisenbarth, S.C.1
  • 334
    • 56149119563 scopus 로고    scopus 로고
    • Cutting edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
    • Kool M et al (2008) Cutting edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol 181(6):3755-3759
    • (2008) J Immunol , vol.181 , Issue.6 , pp. 3755-3759
    • Kool, M.1
  • 335
    • 79954597670 scopus 로고    scopus 로고
    • An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma
    • KoolMet al (2011) An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 34(4):527-540
    • (2011) Immunity , vol.34 , Issue.4 , pp. 527-540
    • Kool, M.1
  • 336
    • 0344393717 scopus 로고    scopus 로고
    • Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroidresistant asthma
    • Simon HU et al (2003) Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroidresistant asthma. Allergy 58(12):1250-1255
    • (2003) Allergy , vol.58 , Issue.12 , pp. 1250-1255
    • Simon, H.U.1
  • 337
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: The next generation. Cell 144(5):646-674
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 338
    • 33845546703 scopus 로고    scopus 로고
    • The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions
    • Apte RN et al (2006) The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev 25(3):387-408
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.3 , pp. 387-408
    • Apte, R.N.1
  • 339
    • 0023160237 scopus 로고
    • Inhibition of angiogenesis by interferons: Effects on tumor-and lymphocyte-induced vascular responses
    • Sidky YA, Borden EC (1987) Inhibition of angiogenesis by interferons: Effects on tumor-and lymphocyte-induced vascular responses. Cancer Res 47(19):5155-5161
    • (1987) Cancer Res , vol.47 , Issue.19 , pp. 5155-5161
    • Sidky, Y.A.1    Borden, E.C.2
  • 340
    • 0033739097 scopus 로고    scopus 로고
    • Induction ofVEGFgene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes
    • Tanaka T et al (2000) Induction ofVEGFgene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes. J Mol Cell Cardiol 32(11):1955-1967
    • (2000) J Mol Cell Cardiol , vol.32 , Issue.11 , pp. 1955-1967
    • Tanaka, T.1
  • 341
    • 0033623788 scopus 로고    scopus 로고
    • Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells
    • El Awad B et al (2000) Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells. Kidney Int 58(1):43-50
    • (2000) Kidney Int , vol.58 , Issue.1 , pp. 43-50
    • El Awad, B.1
  • 342
    • 0035677777 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
    • Jung YD et al (2001) Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway. Angiogenesis 4(2):155-162
    • (2001) Angiogenesis , vol.4 , Issue.2 , pp. 155-162
    • Jung, Y.D.1
  • 343
    • 34848903024 scopus 로고    scopus 로고
    • Role of IL-1-mediated inflammation in tumor angiogenesis
    • Voronov E, Carmi Y, Apte RN (2007) Role of IL-1-mediated inflammation in tumor angiogenesis. Adv Exp Med Biol 601:265-270
    • (2007) Adv Exp Med Biol , vol.601 , pp. 265-270
    • Voronov, E.1    Carmi, Y.2    Apte, R.N.3
  • 344
    • 4344643654 scopus 로고    scopus 로고
    • IL-1RA in refractory systemic lupus erythematosus
    • Moosig F et al (2004) IL-1RA in refractory systemic lupus erythematosus. Lupus 13(8):605-606
    • (2004) Lupus , vol.13 , Issue.8 , pp. 605-606
    • Moosig, F.1
  • 345
    • 16344374294 scopus 로고    scopus 로고
    • Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis
    • Ostendorf B et al (2005) Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis. Ann Rheum Dis 64(4):630-633
    • (2005) Ann Rheum Dis , vol.64 , Issue.4 , pp. 630-633
    • Ostendorf, B.1
  • 346
    • 33747512850 scopus 로고    scopus 로고
    • IL-1 beta-deficient mice are resistant to induction of experimentalSLE
    • Voronov E et al (2006) IL-1 beta-deficient mice are resistant to induction of experimentalSLE. Eur Cytokine Netw17(2):109-116
    • (2006) Eur Cytokine Netw , vol.17 , Issue.2 , pp. 109-116
    • Voronov, E.1
  • 347
    • 80054709328 scopus 로고    scopus 로고
    • The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus
    • Davis LS, Hutcheson J, Mohan C (2011) The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus. J Interferon Cytokine Res 31(10):781-789
    • (2011) J Interferon Cytokine Res , vol.31 , Issue.10 , pp. 781-789
    • Davis, L.S.1    Hutcheson, J.2    Mohan, C.3


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