IFN-α and IL-18 synergistically enhance IFN-γ production in human NK cells: Differential regulation of Stat4 activation and IFN-γ gene expression by IFN-α and IL-12

European Journal of Immunology

Volumn 31, Issue 7, 2001, Pages 2236-2245

  Matikainen, Sampsa ^a   Paananen, Auli ^a,b   Miettinen, Minja ^a   Kurimoto, Masashi ^b   Timonen, Tuomo ^a   Julkunen, Ilkka ^c   Sareneva, Timo ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

Author keywords

Cytokine; NK cell; Signal transduction; T lymphocyte; Th1

Indexed keywords

ALPHA INTERFERON; APC; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; MESSENGER RNA; STAT4 PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL ACTIVATION; CELL CONTACT; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNITY; INFECTION; INTERFERON PRODUCTION; MACROPHAGE; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL;

CELL LINE; CELLS, CULTURED; CYCLOHEXIMIDE; DNA-BINDING PROTEINS; DRUG SYNERGISM; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; INTERLEUKIN-12; INTERLEUKIN-18; KILLER CELLS, NATURAL; KINETICS; PHOSPHOTYROSINE; PROMOTER REGIONS (GENETICS); PROTEIN SYNTHESIS INHIBITORS; RESPONSE ELEMENTS; RNA, MESSENGER; STAT4 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 0034939227     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200107)31:7<2236::AID-IMMU2236>3.0.CO;2-G     Document Type: Article

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