Selective expression of an interleukin-12 receptor component by human T helper 1 cells

Journal of Experimental Medicine

Volumn 185, Issue 5, 1997, Pages 825-831

  Rogge, Lars ^a   Barberis Maino, Luisella ^a,c   Biffi, Mauro ^a   Passini, Nadia ^a   Presky, David H ^b   Gubler, Ueli ^b   Sinigaglia, Francesco ^a  

^a ROCHE MILANO RICERCHE   (Italy)

^b HOFFMANN LA ROCHE INC   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12 RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; RECEPTOR SUBUNIT;

ARTICLE; AUTOIMMUNITY; CELL DIFFERENTIATION; DIAGNOSIS; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOLOGY; NEWBORN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

CELL DIFFERENTIATION; CLONE CELLS; DNA-BINDING PROTEINS; FETAL BLOOD; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; INTERLEUKIN-12; INTERLEUKIN-4; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; TH1 CELLS; TH2 CELLS; TRANS-ACTIVATORS;

EID: 0030892136     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.5.825     Document Type: Article

References (38)

1. Coffman, R.L., D.A. Lebman, and P. Rothman. 1993. The mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54:228-269.
2. + T cells. Annu. Rev. Immunol. 12:635-673.
3. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227-257.
4. Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature (Lond.). 383:787-793.
5. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176: 1091-1098.
6. Hsieh, C.S., A.B. Heimberger, J.S. Gold, A. O'Garra, and K.M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA. 89:6065-6069.
7. + T cells through IL-12 produced by Listeria-induced macrophages. Science (Wash. DC). 260:547-549.
8. Manetti, R., P. Parronchi, M.G. Giudizi, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper 1 type (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199-1204.
9. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:10188- 10192.
10. Magram, J., S.E. Connaughton, R.R. Warrier, D.M. Carvajal, C.-Y. Wu, J. Ferrante, C. Stewart, U. Sarimiento, D.A. Faherty, and M.K. Gately. 1996. IL-12 deficient mice are defective in IFNγ production and type I cytokine responses. Immunity. 4:471-481.
11. Kühn, R., K. Rajewsky, and W. Müller. 1991. Generation and analysis of interleukin-4-deficient mice. Science (Wash. DC). 254:707-710.
12. Kopf, M., G. Le Gros, M. Bachmann, M.C. Lamers, H. Bluethmann, and G. Köhler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature (Lond.). 362: 245-248.
13. Kaplan, M.H., U. Schindler, S.T. Smiley, and M.J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity. 4:313-319.
14. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S.-I. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature (Lond.). 380:627-630.
15. Shimoda, K., J. van Deursen, M.Y. Sangster, S.R. Sarawar, R.T. Carson, R.A. Tripp, C. Chu, F.W. Quelle, T. Nosaka, D.A.A. Vignalli, et al. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature (Lond.). 380:630-633.
16. Thierfelder, W.E., J.M. van Deursen, K. Yamamoto, R.A. Tripp, S.R. Sarawar, R.T. Carson, M.Y. Sangster, D.A.A. Vignali, P.C. Doherty, G.C. Grosveld, and J.N. Ihle. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature (Lond.). 382:171-174.
17. Kaplan, M.H., Y.-L. Sun, T. Hoey, and M.J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature (Lond.). 382:174-177.
18. Coligan, J.E., A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober. 1991. Current Protocols in Immunology. 1st ed. Greene & Wiley, New York, 7.1-7.8.
19. Lanzavecchia, A., and D. Scheidegger. 1987. The use of hybrid hybridomas to target human cytotoxic T lymphocytes. Eur. J. Immunol. 17:105-111.
20. Gallati, H., I. Pracht, J. Schmidt, P. Häring, and G. Garotta. 1987. A simple, rapid and large capacity ELISA for biologically active native and recombinant human IFN-γ. J. Biol. Regul. Homeostatic Agents. 1:109-118.
21. Perussia, B., S. Starr, S. Abraham, V. Fanning, and G. Trinchieri. 1983. Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1 J. Immunol. 130:2133-2139.
22. Norton, A.J., A.D. Ramsay, S.H. Smith, P.C.L. Beverly, and P.G. Isaacson. 1986. Monoclonal antibody (UCHL-1) that recognizes normal and neoplastic T cells in fixed tissues. J. Clin. Pathol. (Lond.). 39:399-405.
23. 2 domain of HLA-DR molecules. Nature (Lond.). 356:799-801.
24. Sinigaglia, F., P. Romagnoli, M. Guttinger, B. Takacs, and J.R.P. Pink. 1991. Selection of T cell epitopes and vaccine engineering. Methods Enzymol. 203:370-386.
25. Presky, D.H., H. Yang, L.J. Minetti, A.O. Chua, N. Nabavi, C.-Y. Wu, M.K. Gately, and U. Gubler. 1996. A functional interleukin-12 receptor complex is composed of two β type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA. 93: 14002-14007.
26. Chua, A.O., R. Chizzonite, B.B. Desai, T.P. Truitt, P. Nunes, L.J. Minetti, R.R. Warrier, D.H. Presky, J.F. Levine, M.K. Gately, and U. Gubler. 1994. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 153:128-136.
27. Passini, N., J.D. Larigan, S. Genovese, E. Appella, F. Sinigaglia, and L. Rogge. 1995. The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc. Natl. Acad. Sci. USA. 92:9412-9416.
28. Chizzonite, R., T. Truitt, B.B. Desai, P. Nunes, F.J. Podlaski, A.S. Stern, and M.K. Gately. 1992. IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin- activated human lymphoblasts. J. Immunol. 148:3117-3124.
29. McPherson, G.A. 1985. Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. J. Pharmacol. Methods. 14:213-228.
30. Szabo, S.J., N.G. Jacobson, A.S. Dighe, U. Gubler, and K.M. Murphy. 1995. Developmental commitment to the Th2 lin eage by extinction of IL-12 signaling. Immunity. 2:665-675.
31. Bacon, C.M., E.F. Petricoin III, J.R. Ortaldo, R.C. Rees, A.C. Larner, J.A. Johnston, and J.J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA. 92:7307-7311.
32. Jacobson, N.G., S.J. Szabo, R.N. Weber-Nordt, Z. Zhong, R.D. Schreiber, J.E. Darnell, and K.M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat) 3 and 4. J. Exp. Med. 181:1755-1762.
33. Bacon, C.M., D.W. McVicar, J.R. Ortaldo, R.C. Rees, J.J. O'Shea, and J.A. Johnston. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of Jak2 and Tyk2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399-404.
34. Chua, A.O., V.L. Wilkinson, D.H. Presky, and U. Gubler. 1995. Cloning and characterization of a mouse IL-12 receptor-beta component. J. Immunol. 155:4286-4294.
35. Manetti, R., F. Gerosa, M.G. Giudizi, R. Biagiotti, P. Parronchi, M.-P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179: 1273-1283.
36. + allergen-specific Th2 T cell clones. Int. Immunol. 6:1091-1096.
37. Parronchi, P., S. Mohapatra, S. Sampognaro, L. Giannarini, U. Wahn, P. Chong, S. Mohapatra, E. Maggi, H. Renz, and S. Romagnani. 1996. Effects of interferon-α on cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T cells. Eur. J. Immunol. 26:697-703.
38. Wenner, C.A., M.L. Güler, S.E. Macatonia, A. O'Garra, and K.M. Murphy. 1996. Roles of IFN-γ and IFN-α in IL-12 induced T helper cell-1 development. J. Immunol. 1156:1442- 1447.