Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-α inducer in systemic lupus erythematosus

Journal of Immunology

Volumn 163, Issue 11, 1999, Pages 6306-6313

  Vallin, Helena ^a   Perers, Anders ^a   Alm, Gunnar V ^a,c   Rönnblom, Lars ^b  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; BETA INTERFERON; DNA ANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G; INTERFERON INDUCING AGENT; INTERLEUKIN 10; PLASMID DNA;

ADOLESCENT; ADULT; AGED; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DENDRITIC CELL; DNA METHYLATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; MALE; MONONUCLEAR CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANTIGEN-ANTIBODY COMPLEX; AUTOANTIBODIES; CYTOKINES; DENDRITIC CELLS; DNA; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN G; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; PLASMIDS;

EID: 0033485756     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Wallace, D. J., and B. Hahn. 1997. Dubois' Lupus Erythematosus. Williams & Wilkins, Baltimore.
2. Uzé, G., G. Lutfalla, and K. E. Mogensen. 1995. α and β interferons and their receptors and their friends and relations. J. Interferon Cytokine Res. 15:3.
3. De Maeyer, E., and J. De Maeyer-Guignard. 1988. Interferons and Other Regulatory Cytokines. Wiley, New York.
4. Diaz, M. O. 1995. The human type I interferon gene cluster. Semin. Virol. 6:143.
5. Kim, T., Y. Kanayama, N. Negoro, M. Okamura, T. Takeda, and T. Inoue. 1987. Serum levels of interferons in patients with systemic lupus erythematosus. Clin. Exp. Immunol. 70:562.
6. Klippel, J. H., S. Carette, O. T. Preble, R. M. Friedman, and P. M. Grimley. 1985. Serum α interferon and lymphocyte inclusions in systemic lupus erythematosus. Ann. Rheum. Dis. 44:104.
7. Preble, O. T., K. Rothko, J. H. Klippel, R. M. Friedman, and M. I. Johnston. 1983. Interferon-induced 2′-5′ adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon. J. Exp. Med. 157:2140.
8. Strannegard, O., S. Hermodsson, and G. Westberg. 1982. Interferon and natural killer cells in systemic lupus erythematosus. Clin. Exp. Immunol. 50:246.
9. Ytterberg, S. R., and T. J. Schnitzer. 1982. Serum interferon levels in patients with systemic lupus erythematosus. Arthritis Rheum. 25:401.
10. von Wussow, P., D. Jakschies, K. Hartung, and H. Deicher. 1988. Presence of interferon and anti-interferon in patients with systemic lupus erythematosus. Rheumatol. Int. 8:225.
11. von Wussow, P., D. Jakschies, H. Hochkeppel, M. Horisberger, K. Hartung, and H. Deicher. 1989. MX homologous protein in mononuclear cells from patients with systemic lupus erythematosus. Arthritis Rheum. 32:914.
12. Belardelli, F. 1995. Role of interferons and other cytokines in the regulation of the immune response. APMIS 103:161.
13. Rogge, L., L. Barberis-Maino, M. Biffi, N. Passini, D. H. Presky, U. Gubler, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 5:825.
14. Rogge, L., D. D'Ambrosio, M. Biffi, G. Penna, L. J. Minetti, D. H. Presky, L. Adorini, and F. Sinigaglia. 1998. The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J. Immunol. 161:6567.
15. Marrack, P., J. Kappler, and T. Mitchell. 1999. Type I interferons keep activated T cells alive. J. Exp. Med. 189:521.
16. Tough, D. F., and J. Sprent. 1998. Bystander stimulation of T cells in vivo by cytokines. Vet. Immunol. Immunopathol. 63:123.
17. Ronnblom, L. E., G. V. Alm, and K. E. Oberg. 1990. Possible induction of systemic lupus erythematosus by interferon-α treatment in a patient with a malignant carcinoid tumour. J. Intern. Med. 227:207.
18. Ronnblom, L. E., G. V. Alm, and K. E. Oberg. 1991. Autoimmunity after α-interferon therapy for malignant carcinoid tumors. Ann. Intern. Med. 115:178.
19. Fritzler, M. J. 1994. Drugs recently associated with lupus syndromes. Lupus 3:455.
20. Kalkner, K., L. Ronnblom, A. Karlsson Parra, M. Bengtsson, Y. Olsson, and K. Oberg. 1998. Antibodies against double-stranded DNA and development of polymyositis during treatment with interferon. Q. J. Med. 91:393.
21. Ehrenstein, M. R., E. McSweeney, M. Swane, C. P. Worman, A. H. Goldstone, and D. A. Isenberg. 1993. Appearance of anti-DNA antibodies in patients treated with interferon-α. Arthritis Rheum. 36:279.
22. Pitha, P. M., and W.-C. Au. 1995. Induction of interferon α genes expression. Semin. Virol. 6:151.
23. Hiscott, J., H. Nguyen, and R. Lin. 1995. Molecular mechanisms of interferon β gene induction. Semin. Virol. 6:161.
24. Cederblad, B., S. Blomberg, H. Vallin, A. Perers, G. Alm, and L. Ronnblom. 1998. Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-α producing cells. J. Autoimmun. 11:465.
25. Vallin, H., S. Blomberg, G.V. Alm, B. Cederblad, and L. Ronnblom. 1999. Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-α (IFN-α) production acting on leucocytes resembling immature dendritic cells. Clin. Exp. Immunol. 115:196.
26. Tan, E. M., A. S. Cohen, J. F. Fries, A. T. Masi, D. J. McShane, N. F. Rothfield, J. G. Schaller, N. Talal, and R. J. Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25:1271.
27. Bombardier, C., D. D. Gladman, M. B. Urowitz, D. Caron, and C. H. Chang. 1992. Derivation of the SLEDAI: a disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 35:630.
28. Reichlin, M., A. Martin, E. Taylor-Albert, K. Tsuzaka, W. Zhang, M. W. Reichlin, E. Koren, F. M. Ebling, B. Tsao, and B. H. Hahn. 1994. Lupus autoantibodies to native DNA cross-react with the A and D SnRNP polypeptides. J. Clin. Invest. 93:443.
29. Cederblad, B., T. Riesenfeld, and G. V. Alm. 1990. Deficient herpes simplex virus-induced interferon-α production by blood leukocytes of preterm and term newborn infants. Pediatr. Res. 27:7.
30. Svensson, H., A. Johannisson, T. Nikkila, G. V. Alm, and B. Cederblad. 1996. The cell surface phenotype of human natural interferon-α producing cells as determined by flow cytometry. Scand. J. Immunol. 44:164.
31. Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M. Corr, M. D. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352.
32. Yamamoto, S., T. Yamamoto, T. Kataoka, E. Kuramoto, O. Yano, and T. Tokunaga. 1992. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol. 148:4072.
33. Tokunaga, T., O. Yano, E. Kuramoto, Y. Kimura, T. Yamamoto, T. Kataoka, and S. Yamamoto. 1992. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol. Immunol. 36:55.
34. Roman, M., E. Martin-Orozco, J. S. Goodman, M. D. Nguyen, Y. Sato, A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3:849.
35. Sano, H., O. Takai, N. Harata, K. Yoshinaga, I. Kodama-Kanada, and T. Sasaki. 1989. Binding properties of human anti-DNA antibodies to cloned human DNA fragments. Scand. J. Immunol. 30:51.
36. Sato, Y., M. Miyata, T. Nishimaki, H. Kochi, and R. Kasukawa. 1999. CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro. J. Rheumatol. 26:294.
37. Miyata, M., T. Kanno, H. Ishida, H. Kobayashi, Y. Satoh, T. Nishimaki, and R. Kasukawa. 1996. CpG motif in DNA from immune complexes of SLE patients augments expression of intercellular adhesion molecule-1 on endothelial cells. Rinsho Byori 44:1125.
38. Krieg, A. 1995. CpG DNA: a pathogenic factor in systemic lupus erythematosus. J. Clin. Immunol. 15:284.
39. Yamamoto, T., S. Yamamoto, T. Kataoka, and T. Tokunaga. 1994. Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity. Microbiol. Immunol. 38:831.
40. Alarcon-Segovia, D., A. Ruiz-Arguelles, and L. Llorente. 1996. Broken dogma: penetration of autoantibodies into living cells. Immunol. Today 17:163.
41. Golan, T. D., A. E. Gharavi, and K. B. Elkon. 1993. Penetration of autoantibodies into living epithelial cells. J. Invest. Dermatol. 100:316.
42. Vlahakos, D., M. H. Foster, A. A. Ucci, K. J. Barrett, S. K. Datta, and M. P. Madaio. 1992. Murine monoclonal anti-DNA antibodies penetrate cells. bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. J. Am. Soc. Nephrol. 2:1345.
43. Weisbart, R. H., M. Stempniak, S. Harris, D. J. Zack, and K. Ferreri. 1998. An autoantibody is modified for use as a delivery system to target the cell nucleus: therapeutic implications. J. Autoimmun. 11:539.
44. Koutouzov, S., A. Cabrespines, Z. Amoura, H. Chabre, C. Lotton, and J. F. Bach. 1996. Binding of nucleosomes to a cell surface receptor: redistribution and endocytosis in the presence of lupus antibodies. Eur. J. Immunol. 26:472.
45. Zamulaeva, I. A., I. V. Lekakh, V. I. Kiseleva, V. L. Gabai, A. S. Saenko, A. S. Shevchenko, and A. M. Poverenny. 1997. Natural hidden antibodies reacting with DNA or cardiolipin bind to thymocytes and evoke their death. FEBS Lett. 413:231.
46. Krause, I., M. Blank, and Y. Shoenfeld. 1998. Anti-DNA and antiphospholipid antibodies in IVIG preparations: in vivo study in naive mice. J. Clin. Immunol. 18:52.
47. Cederblad, B., and G. V. Alm. 1991. Interferons and the colony-stimulating factors IL-3 and GM-CSF enhance the IFN-α response in human blood leucocytes induced by herpes simplex virus. Scand. J. Immunol. 34:549.
48. Erlandsson, L., R. Blumenthal, M. L. Eloranta, H. Engel, G. Alm, S. Weiss, and T. Leanderson. 1998. Interferon-β is required for interferon-α production in mouse fibroblasts. Curr. Biol. 8:223.
49. Lehtonen, A., S. Matikainen, and I. Julkunen. 1997. Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. J. Immunol. 159:794.
50. Yoneyama, M., W. Suhara, Y. Fukuhara, M. Sato, K. Ozato, and T. Fujita. 1996. Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3). J. Biochem. (Tokyo) 120:160.
51. Hiscott, J., P. Pitha, P. Genin, H. Nguyen, C. Heylbroeck, Y. Mamane, M. Algarte, and R. Lin. 1999. Triggering the interferon response: the role of IRF-3 transcription factor. J. Interferon Cytokine Res. 19:1.
52. Welte, T., F. Koch, G. Schuler, J. Lechner, W. Doppler, and C. Heufler. 1997. Granulocyte-macrophage colony-stimulating factor induces a unique set of STAT factors in murine dendritic cells. Eur. J. Immunol. 27:2737.
53. Payvandi, F., S. Amrute, and P. Fitzgerald-Bocarsly. 1998. Exogenous and endogenous IL-10 regulate IFN-α production by peripheral blood mononuclear cells in response to viral stimulation. J. Immunol. 160:5861.
54. Takeshita, S., J. R. Gage, T. Kishimoto, D. L. Vredevoe, and O. Martinez-Maza. 1996. Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines. J. Immunol. 156:2591.
55. Wang, P., P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah. 1994. IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J. Immunol. 153:811.
56. de Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209.
57. Llorente, L., Y. Richaud-Patin, J. Couderc, D. Alarcon-Segovia, R. Ruiz-Soto, N. Alcocer-Castillejos, J. Alcocer-Varela, J. Granados, S. Bahena, P. Galanaud, and D. Emilie. 1997. Dysregulation of interleukin-10 production in relatives of patients with systemic lupus erythematosus. Arthritis Rheum. 40:1429.
58. Llorente, L., W. Zou, Y. Levy, Y. Richaud-Patin, J. Wijdenes, J. Alcocer-Varela, B. Morel-Fourrier, J. C. Brouet, D. Alarcon-Segovia, P. Galanaud, and D. Emilie. 1995. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med. 181:839.
59. Llorente, L., Y. Richaud-Patin, R. Fior, J. Alcocer-Varela, J. Wijdenes, B. M. Fourrier, P. Galanaud, and D. Emilie. 1994. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus: a potential mechanism of B lymphocyte hyperactivity and autoimmunity. Arthritis Rheum. 37:1647.
60. Georgescu, L., R. K. Vakkalanka, K. B. Elkon, and M. K. Crow. 1997. Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand. J. Clin. Invest. 100:2622.
61. + T cells and monocytes. Blood 87:4731.
62. Hermann, P., M. Rubio, T. Nakajima, G. Delespesse, and M. Sarfati. 1998. IFN-α priming of human monocytes differentially regulates Gram-positive and Gram-negative bacteria-induced IL-10 release and selectively enhances lL-12p70, CD80, and MHC class I expression. J. Immunol. 161:2011.
63. Svensson, H., B. Cederblad, M. Lindahl, and G. V. Alm. 1996. Stimulation of natural interferon-α/β-producing cells by Staphylococcus aureus. J. Interferon Res. 16:7.
64. Feldman, S. B., M. Ferraro, H. M. Zheng, N. Patel, S. Gould-Fogerite, and P. Fitzgerald-Bocarsly. 1994. Viral induction of low frequency interferon-α producing cells. Virology 204:1.
65. Fitzgerald-Bocarsly, P. 1993. Human natural interferon-α producing cells. Pharmacol. Ther. 60:39.
66. Tanaka, N., M. Sato, M. S. Lamphier, H. Nozawa, E. Oda, S. Noguchi, R. D. Schreiber, Y. Tsujimoto, and T. Taniguchi. 1998. Type I interferons are essential mediators of apoptotic death in virally infected cells. Genes Cells 3:29.