메뉴 건너뛰기




Volumn 171, Issue 10, 2003, Pages 5233-5243

Timing of IFN-β Exposure during Human Dendritic Cell Maturation and Naive Th Cell Stimulation Has Contrasting Effects on Th1 Subset Generation: A Role for IFN-β-Mediated Regulation of IL-12 Family Cytokines and IL-18 in Naive Th Cell Differentiation

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 23; INTERLEUKIN 27; UNCLASSIFIED DRUG;

EID: 0242412154     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.10.5233     Document Type: Article
Times cited : (96)

References (59)
  • 1
    • 0036604930 scopus 로고    scopus 로고
    • Control of adaptive immune responses by Toll-like receptors
    • Barton, G. M., and R. Medzhitov. 2002. Control of adaptive immune responses by Toll-like receptors. Curr. Opin. Immunol. 14:380.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 380
    • Barton, G.M.1    Medzhitov, R.2
  • 2
    • 0035663922 scopus 로고    scopus 로고
    • Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection
    • Zou, W., J. Borvak, S. Wei, T. Isaeva, D. T. Curiel, and T. J. Curiel. 2001. Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection. Eur. J. Immunol. 31:3833.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3833
    • Zou, W.1    Borvak, J.2    Wei, S.3    Isaeva, T.4    Curiel, D.T.5    Curiel, T.J.6
  • 3
    • 0036668242 scopus 로고    scopus 로고
    • Links between innate and adaptive immunity via type I interferon
    • Le Bon, A., and D. F. Tough. 2002. Links between innate and adaptive immunity via type I interferon. Curr. Opin. Immunol. 14:432.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 432
    • Le Bon, A.1    Tough, D.F.2
  • 4
    • 0034044735 scopus 로고    scopus 로고
    • The function of type I interferons in antimicrobial immunity
    • Bogdan, C. 2000. The function of type I interferons in antimicrobial immunity. Curr. Opin. Immunol. 12:419.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 419
    • Bogdan, C.1
  • 5
    • 0035284744 scopus 로고    scopus 로고
    • Differential regulation of human blood dendritic cell subsets by IFNs
    • Ito, T., R. Amakawa, M. Inaba, S. Ikehara, K. Inaba, and S. Fukuhara. 2001. Differential regulation of human blood dendritic cell subsets by IFNs. J. Immunol. 166:2961.
    • (2001) J. Immunol. , vol.166 , pp. 2961
    • Ito, T.1    Amakawa, R.2    Inaba, M.3    Ikehara, S.4    Inaba, K.5    Fukuhara, S.6
  • 6
    • 0034658658 scopus 로고    scopus 로고
    • Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice
    • Santini, S. M., C. Lapenta, M. Logozzi, S. Parlato, M. Spada, T. Di Pucchio, and F. Belardelli. 2000. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J. Exp. Med. 191:1777.
    • (2000) J. Exp. Med. , vol.191 , pp. 1777
    • Santini, S.M.1    Lapenta, C.2    Logozzi, M.3    Parlato, S.4    Spada, M.5    Di Pucchio, T.6    Belardelli, F.7
  • 7
    • 0036464603 scopus 로고    scopus 로고
    • Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties
    • Buelens, C., E. J. Bartholome, Z. Amraoui, M. Boutriaux, I. Salmon, K. Thielemans, F. Willems, and M. Goldman. 2002. Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties. Blood 99:993.
    • (2002) Blood , vol.99 , pp. 993
    • Buelens, C.1    Bartholome, E.J.2    Amraoui, Z.3    Boutriaux, M.4    Salmon, I.5    Thielemans, K.6    Willems, F.7    Goldman, M.8
  • 9
    • 0034954034 scopus 로고    scopus 로고
    • Interferons α and β as immune regulators: A new look
    • Biron, C. A. 2001. Interferons α and β as immune regulators: a new look. Immunity 14:661.
    • (2001) Immunity , vol.14 , pp. 661
    • Biron, C.A.1
  • 11
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715.
    • (2000) Immunity , vol.13 , pp. 715
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6    Vega, F.7    Yu, N.8    Wang, J.9    Singh, K.10
  • 14
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 133
    • Trinchieri, G.1
  • 15
    • 0037434779 scopus 로고    scopus 로고
    • Autoimmunity: A case of mistaken identity
    • Watford, W. T., and J. J. O'Shea. 2003. Autoimmunity: a case of mistaken identity. Nature 421:706.
    • (2003) Nature , vol.421 , pp. 706
    • Watford, W.T.1    O'Shea, J.J.2
  • 19
    • 0036065808 scopus 로고    scopus 로고
    • Further checkpoints in Th1 development
    • Robinson, D. S., and A. O'Garra. 2002. Further checkpoints in Th1 development. Immunity 16:755.
    • (2002) Immunity , vol.16 , pp. 755
    • Robinson, D.S.1    O'Garra, A.2
  • 21
    • 0032536447 scopus 로고    scopus 로고
    • An interleukin (IL)-10/ IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
    • Segal, B. M., B. K. Dwyer, and E. M. Shevach. 1998. An interleukin (IL)-10/ IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187:537.
    • (1998) J. Exp. Med. , vol.187 , pp. 537
    • Segal, B.M.1    Dwyer, B.K.2    Shevach, E.M.3
  • 22
    • 0032080850 scopus 로고    scopus 로고
    • Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development
    • McRae, B. L., R. T. Semnani, M. P. Hayes, and G. A. van Seventer. 1998. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development. J. Immunol. 160:4298.
    • (1998) J. Immunol. , vol.160 , pp. 4298
    • McRae, B.L.1    Semnani, R.T.2    Hayes, M.P.3    Van Seventer, G.A.4
  • 24
    • 0036154417 scopus 로고    scopus 로고
    • Interferon-β therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production
    • Byrnes, A. A., J. C. McArthur, and C. L. Karp. 2002. Interferon-β therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production. Ann. Neurol. 51:165.
    • (2002) Ann. Neurol. , vol.51 , pp. 165
    • Byrnes, A.A.1    McArthur, J.C.2    Karp, C.L.3
  • 25
    • 0033961721 scopus 로고    scopus 로고
    • IFN-β differentially regulates CD40-induced cytokine secretion by human dendritic cells
    • McRae, B. L., B. A. Beilfuss, and G. A. van Seventer. 2000. IFN-β differentially regulates CD40-induced cytokine secretion by human dendritic cells. J. Immunol. 164:23.
    • (2000) J. Immunol. , vol.164 , pp. 23
    • McRae, B.L.1    Beilfuss, B.A.2    Van Seventer, G.A.3
  • 26
    • 0034333099 scopus 로고    scopus 로고
    • Interferon-β treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-γ and interleukin-4
    • Furlan, R., A. Bergami, R. Lang, E. Brambilla, D. Franciotta, V. Martinelli, G. Comi, P. Panina, and G. Martino. 2000. Interferon-β treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-γ and interleukin-4. J. Neuroimmunol. 111:86.
    • (2000) J. Neuroimmunol. , vol.111 , pp. 86
    • Furlan, R.1    Bergami, A.2    Lang, R.3    Brambilla, E.4    Franciotta, D.5    Martinelli, V.6    Comi, G.7    Panina, P.8    Martino, G.9
  • 27
    • 0035156672 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: Involvement of syncytiotrophoblasts and extravillous trophoblasts
    • Devergne, O., A. Coulomb-L'Hermine, F. Capel, M. Moussa, and F. Capron. 2001. Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts. Am. J. Pathol. 159:1763.
    • (2001) Am. J. Pathol. , vol.159 , pp. 1763
    • Devergne, O.1    Coulomb-L'Hermine, A.2    Capel, F.3    Moussa, M.4    Capron, F.5
  • 28
    • 0036890125 scopus 로고    scopus 로고
    • Interferon-β differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells
    • van Seventer, J. M., T. Nagai, and G. A. van Seventer. 2002. Interferon-β differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells. J. Neuroimmunol. 133:60.
    • (2002) J. Neuroimmunol. , vol.133 , pp. 60
    • Van Seventer, J.M.1    Nagai, T.2    Van Seventer, G.A.3
  • 31
    • 0033047330 scopus 로고    scopus 로고
    • IFN-β interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells: Selective inhibition of CD40-dependent interleukin-12 secretion
    • Bartholome, E. J., F. Willems, A. Crusiaux, K. Thielemans, L. Schandene, and M. Goldman. 1999. IFN-β interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells: selective inhibition of CD40-dependent interleukin-12 secretion. J. Interferon Cytokine Res. 19:471.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 471
    • Bartholome, E.J.1    Willems, F.2    Crusiaux, A.3    Thielemans, K.4    Schandene, L.5    Goldman, M.6
  • 33
    • 0034232036 scopus 로고    scopus 로고
    • Type I IFNs and regulation of TH1 responses: Enigmas both resolved and emerge
    • O'Shea, J. J., and R. Visconti. 2000. Type I IFNs and regulation of TH1 responses: enigmas both resolved and emerge. Nat. Immunol. 1:17.
    • (2000) Nat. Immunol. , vol.1 , pp. 17
    • O'Shea, J.J.1    Visconti, R.2
  • 36
    • 0037438664 scopus 로고    scopus 로고
    • Down-modulation of responses to type I IFN upon T cell activation
    • Dondi, E., L. Rogge, G. Lutfalla, G. Uze, and S. Pellegrini. 2003. Down-modulation of responses to type I IFN upon T cell activation. J. Immunol. 170:749.
    • (2003) J. Immunol. , vol.170 , pp. 749
    • Dondi, E.1    Rogge, L.2    Lutfalla, G.3    Uze, G.4    Pellegrini, S.5
  • 37
    • 0030658048 scopus 로고    scopus 로고
    • Human recombinant IFN-β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors
    • McRae, B. L., L. J. Picker, and G. A. van Seventer. 1997. Human recombinant IFN-β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors. Eur. J. Immunol. 27:2650.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2650
    • McRae, B.L.1    Picker, L.J.2    Van Seventer, G.A.3
  • 38
    • 0030584733 scopus 로고    scopus 로고
    • IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses
    • Meyaard, L., E. Hovenkamp, S. A. Otto, and F. Miedema. 1996. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J. Immunol. 156:2776.
    • (1996) J. Immunol. , vol.156 , pp. 2776
    • Meyaard, L.1    Hovenkamp, E.2    Otto, S.A.3    Miedema, F.4
  • 40
    • 0036886390 scopus 로고    scopus 로고
    • The role of IL-10 and TGF-β in the differentiation and effector function of T regulatory cells
    • Levings, M. K., R. Bacchetta, U. Schulz, and M. G. Roncarolo. 2002. The role of IL-10 and TGF-β in the differentiation and effector function of T regulatory cells. Int. Arch. Allergy Immunol 129:263.
    • (2002) Int. Arch. Allergy Immunol. , vol.129 , pp. 263
    • Levings, M.K.1    Bacchetta, R.2    Schulz, U.3    Roncarolo, M.G.4
  • 42
    • 0030200026 scopus 로고    scopus 로고
    • Recombinant interferon-β blocks proliferation but enhances interleukin-10 secretion by activated human T-cells
    • Rep, M. H., R. Q. Hintzen, C. H. Polman, and R. A. van Lier. 1996. Recombinant interferon-β blocks proliferation but enhances interleukin-10 secretion by activated human T-cells. J. Neuroimmunol. 67:111.
    • (1996) J. Neuroimmunol. , vol.67 , pp. 111
    • Rep, M.H.1    Hintzen, R.Q.2    Polman, C.H.3    Van Lier, R.A.4
  • 43
    • 0036013759 scopus 로고    scopus 로고
    • Type I interferons inhibit interleukin-10 production in activated human monocytes and stimulate IL-10 in T cells: Implications for Th1-mediated diseases
    • Feng, X., D. Yau, C. Holbrook. and A. T. Reder. 2002. Type I interferons inhibit interleukin-10 production in activated human monocytes and stimulate IL-10 in T cells: implications for Th1-mediated diseases. J. Interferon Cytokine Res. 22: 311.
    • (2002) J. Interferon Cytokine Res. , vol.22 , pp. 311
    • Feng, X.1    Yau, D.2    Holbrook, C.3    Reder, A.T.4
  • 44
    • 0034194222 scopus 로고    scopus 로고
    • Biosynthesis and posttranslational regulation of human IL-12
    • Carra, G., F. Gerosa, and G. Trinchieri. 2000. Biosynthesis and posttranslational regulation of human IL-12. J. Immunol. 164:4752.
    • (2000) J. Immunol. , vol.164 , pp. 4752
    • Carra, G.1    Gerosa, F.2    Trinchieri, G.3
  • 45
    • 0034650811 scopus 로고    scopus 로고
    • Disparate intracellular processing of human IL-12 preprotein subunits: Atypical processing of the P35 signal peptide
    • Murphy, F. J., M. P. Hayes, and P. R. Burd. 2000. Disparate intracellular processing of human IL-12 preprotein subunits: atypical processing of the P35 signal peptide. J. Immunol. 164:839.
    • (2000) J. Immunol. , vol.164 , pp. 839
    • Murphy, F.J.1    Hayes, M.P.2    Burd, P.R.3
  • 46
    • 0035156672 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: Involvement of syncytiotrophoblasts and extravillous trophoblasts
    • Devergne, O., A. Coulomb-L'Hermine, F. Capel, M. Moussa, and F. Capron. 2001. Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts. Am. J. Pathol. 159:1763.
    • (2001) Am. J. Pathol. , vol.159 , pp. 1763
    • Devergne, O.1    Coulomb-L'Hermine, A.2    Capel, F.3    Moussa, M.4    Capron, F.5
  • 49
    • 0034144269 scopus 로고    scopus 로고
    • Chemokines: A new classification system and their role in immunity
    • Zlotnik, A., and O. Yoshie. 2000. Chemokines: a new classification system and their role in immunity. Immunity 12:121.
    • (2000) Immunity , vol.12 , pp. 121
    • Zlotnik, A.1    Yoshie, O.2
  • 50
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal, S., N. Ghilardi, M. H. Xie, F. J. de Sauvage, and A. L. Gurney. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278:1910.
    • (2003) J. Biol. Chem. , vol.278 , pp. 1910
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    De Sauvage, F.J.4    Gurney, A.L.5
  • 52
    • 0034232047 scopus 로고    scopus 로고
    • Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox
    • Nguyen, K. B., L. P. Cousens, L. A. Doughty, G. C. Pien, J. E. Durbin, and C. A. Biron. 2000. Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox. Nat. Immunol. 1:70.
    • (2000) Nat. Immunol. , vol.1 , pp. 70
    • Nguyen, K.B.1    Cousens, L.P.2    Doughty, L.A.3    Pien, G.C.4    Durbin, J.E.5    Biron, C.A.6
  • 53
    • 0033081259 scopus 로고    scopus 로고
    • Type I interferons keep activated T cells alive
    • Marrack, P., J. Kappler, and T. Mitchell. 1999. Type I interferons keep activated T cells alive. J. Exp. Med. 189:521.
    • (1999) J. Exp. Med. , vol.189 , pp. 521
    • Marrack, P.1    Kappler, J.2    Mitchell, T.3
  • 54
    • 0037124508 scopus 로고    scopus 로고
    • Use of peginterferon α-2a (40 KD) (Pegasys) for the treatment of hepatitis C
    • Rajender, R. K., M. W. Modi, and S. Pedder. 2002. Use of peginterferon α-2a (40 KD) (Pegasys) for the treatment of hepatitis C. Adv. Drug Deliv. Rev. 54:571.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 571
    • Rajender, R.K.1    Modi, M.W.2    Pedder, S.3
  • 55
    • 0029000750 scopus 로고
    • Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
    • McRae, B. L., C. L. Vanderlugt, M. C. Dal Canto, and S. D. Miller. 1995. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 182:75.
    • (1995) J. Exp. Med. , vol.182 , pp. 75
    • McRae, B.L.1    Vanderlugt, C.L.2    Dal Canto, M.C.3    Miller, S.D.4
  • 56
    • 0029670711 scopus 로고    scopus 로고
    • Interferon-β inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis
    • Yu, M., A. Nishiyama, B. D. Trapp, and V. K. Tuohy. 1996. Interferon-β inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis. J. Neuroimmunol. 64:91.
    • (1996) J. Neuroimmunol. , vol.64 , pp. 91
    • Yu, M.1    Nishiyama, A.2    Trapp, B.D.3    Tuohy, V.K.4
  • 57
    • 0034332949 scopus 로고    scopus 로고
    • Modulation of the IL-10/IL-12 cytokine circuit by interferon-β inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis
    • Tuohy, V. K., M. Yu, L. Yin, P. M. Mathisen, J. M. Johnson, and J. A. Kawczak. 2000. Modulation of the IL-10/IL-12 cytokine circuit by interferon-β inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis. J. Neuroimmunol. 111:55.
    • (2000) J. Neuroimmunol. , vol.111 , pp. 55
    • Tuohy, V.K.1    Yu, M.2    Yin, L.3    Mathisen, P.M.4    Johnson, J.M.5    Kawczak, J.A.6
  • 58
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran, B., G. X. Zhang, S. Yu, J. Li, X. H. Chen, E. S. Ventura, M. Kamoun, and A. Rostami. 2002. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169: 7104.
    • (2002) J. Immunol. , vol.169 , pp. 7104
    • Gran, B.1    Zhang, G.X.2    Yu, S.3    Li, J.4    Chen, X.H.5    Ventura, E.S.6    Kamoun, M.7    Rostami, A.8
  • 59
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher, B., B. G. Durell, and R. J. Noelle. 2002. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110:493.
    • (2002) J. Clin. Invest. , vol.110 , pp. 493
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.