Interferons: Cell signalling, immune modulation, antiviral responses and virus countermeasures

Journal of General Virology

Volumn 81, Issue 10, 2000, Pages 2341-2364

  Goodbourn, S ^a   Didcock, L ^a   Randall, R E ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ADENOSINE TRIPHOSPHATE; ALPHA INTERFERON; BETA INTERFERON; CD4 ANTIGEN; CD8 ANTIGEN; DOUBLE STRANDED RNA; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OLIGOMER; PROTEIN KINASE; STAT1 PROTEIN; STAT2 PROTEIN; VIRUS VACCINE;

ANTIVIRAL ACTIVITY; APOPTOSIS; BUNYAVIRUS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENCEPHALOMYOCARDITIS VIRUS; ENZYME ACTIVATION; ENZYME INHIBITION; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; ORTHOMYXOVIRUS; PARAMYXOVIRUS; PRIORITY JOURNAL; REOVIRUS; REVIEW; RHABDOVIRUS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TOGAVIRUS; VACCINIA VIRUS; VIRUS INFECTION; VIRUS PATHOGENESIS; VIRUS REPLICATION;

CYTOMEGALOVIRUS; ENCEPHALOMYOCARDITIS VIRUS; ORTHOBUNYAVIRUS; ORTHOMYXOVIRIDAE; PARAMYXOVIRIDAE; REOVIRUS SP.; RHABDOVIRIDAE; TOGAVIRIDAE; VACCINIA; VACCINIA VIRUS;

EID: 0033795196     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-81-10-2341     Document Type: Review

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237. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)
238. Function of Stat2 protein in transcriptional activation by alpha interferon
239. Expression of mutant eukaryotic initiation factor 2α subunit (eIF-2α) reduces inhibition of guanine nucleotide exchange activity of eIF-2β mediated by eIF-2α phosphorylation
240. Regulation of c-myc expression by IFN-gamma through Stat 1-dependent and -Independent pathways
241. Critical role of a common transcription factor, IRF-1, in the regulation of IFN-β and IFN-inducible genes
242. Interferon-major regulator of natural killer cell-mediated cytotoxicity
243. Inhibition of nuclear factor κB activation by a virus-encoded IκB-like protein
244. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
245. Vaccinia virus E3L protein is an inhibitor of the interferon (IFN)-induced 2-5A synthetase enzyme
246. The regulation of the protein kinase PKR by RNA
247. Inhibition of apoptotic cell death in B-CLL by interferon gamma correlates with clinical stage
248. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity
249. Inhibition of interferon-inducible MxA protein expression by hepatitis B virus capsid protein
250. Antiviral activity of autocrine interferon-beta requires the presence of a functional interferon type I receptor
251. Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product
252. Constitutive expression of a 2',5'-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression
253. The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors
254. IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice
255. Reoviruses and the interferon system
256. Molecular mechanisms underlying interferon-α-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins
257. Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene
258. Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
259. A ribonuclease specific for inosine-containing RNA: A potential role in antiviral defence?
260. Regulation of type I interferon gene expression by interferon regulatory factor-3
261. STATs as activators of apoptosis
262. Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84-kDa proteins that are activated by interferon α
263. Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells
264. Interferon-gamma-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4
265. Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA
266. The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: Implications for PKR autoregulation
267. Activation of the interferon-inducible (2'-5') oligoadenylate synthetase by the Epstein-Barr virus RNA, EBER-1
268. Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site
269. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma
270. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
271. 2-5A-dependent RNase L: A regulated endoribonuclease in the interferon system
272. RNA decay by the interferon-regulated 2-5A system as a host defense against viruses
273. Augmentation by interleukin-18 of MHC-nonrestricted killer activity of human peripheral blood mononuclear cells in response to interleukin-12
274. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
275. IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide
276. Induction of IgG3 secretion by interferon gamma: A model for T cell-independent class switching in response to T cell-independent type 2 antigens
277. T-cell turnover in vivo and the role of cytokines
278. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase
279. Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus
280. Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation
281. Mx proteins: GTPases with antiviral activity
282. How cells respond to interferons
283. Negative regulation of the JAK/STAT pathway
284. A family of cytokine-inducible inhibitors of signalling
285. Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice
286. Function of the mouse Mx1 protein is inhibited by overexpression of the PB2 protein of influenza virus
287. A role for the cyclin-dependent kinase inhibitor p21 in the G1 cell cycle arrest mediated by the type I interferons
288. Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line
289. Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity
290. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
291. Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling
292. Activation of the apoptotic Fas antigen-encoding gene upon influenza virus infection involving spontaneously produced beta-interferon
293. Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection
294. Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase
295. The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: A new face of death?
296. Type I interferons are essential mediators of apoptotic death in virally infected cells
297. The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections
298. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
299. Mechanisms of transcriptional synergism of eukaryotic genes. The interferon-beta paradigm
300. IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells
301. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
302. Stimulation of naive and memory T cells by cytokines
303. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
304. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters
305. Transcription of the human beta interferon gene is inhibited by hepatitis B virus
306. Encoding of a homolog of the IFN-γ receptor by myxoma virus
307. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
308. Inhibition of TNF-induced apoptosis by NF-kappa B
309. Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors
310. Immune defence in mice lacking type I and/or type II interferon receptors
311. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins
312. Interferons and other cytokines
313. Double-stranded RNA activates binding of NF-κB to an inducible element in the human β-interferon promoter
314. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
315. Activation of IFN-β element by IRF-1 requires a post-translational
316. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo
317. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
318. The polyoma virus T antigen interferes with interferon-inducible gene expression
319. Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosphorylation
320. Identification of the hepatitis B virus factor that inhibits expression of the beta interferon gene
321. PKR; a sentinel kinase for cellular stress
322. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
323. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells
324. IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: Requirement of STAT1 protein for up-regulation of Fas and FasL expression
325. Phosphorylated interferon-α receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein
326. Deficient signalling in mice devoid of double-stranded RNA-dependent protein kinase, PKR
327. Differentiation of CD4 + T cells to Th1 cells requires MAP kinase JNK2
328. Antiviral activities of individual murine IFN-alpha subtypes in vivo: Intramuscular injection of IFN expression constructs reduces cytomegalovirus replication
329. Reconstitution of virus-mediated expression of interferon-alpha genes in human fibroblast cells by ectopic interferon regulatory factor-7
330. An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells
331. Replication-incompetent Sendai virus can suppress the antiviral action of type I interferon
332. Poor induction of interferon-induced 2',5'-oligoadenylate synthetase (2-5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1α
333. Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3)
334. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
335. Antigen processing and presentation by the class I major histocompatibility complex
336. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production
337. Regulation of interferon-gamma gene expression
338. Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon response
339. Double-stranded RNA-dependent protein kinase (PKR) is regulated by reovirus structural proteins
340. NF-κB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-κB-inducing kinase and IκB kinase
341. Interferon regulatory factor 7 is induced by Epstein-Barr virus latent membrane protein 1
342. Two contact regions between Stat1 and CBP/p300 in interferon-γ signaling
343. Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation
344. Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation
345. Potent and selective stimulation of memory-phenotype CD8 + T cells in vivo by IL-15
346. Inhibition of human parainfluenza virus-3 replication by interferon and human MxA
347. Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L
348. Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways
349. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling
350. Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription