Interleukin-1 (IL-1): A central regulator of stress responses

Frontiers in Neuroendocrinology

Volumn 30, Issue 1, 2009, Pages 30-45

  Goshen, Inbal ^a   Yirmiya, Raz ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Depression; Glucocorticoids; HPA axis; Interleukin 1; Memory; Neurogenesis; Plasticity; Stress

Indexed keywords

GLUCOCORTICOID; INTERLEUKIN 1;

COPING BEHAVIOR; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MENTAL STRESS; NERVOUS SYSTEM DEVELOPMENT; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRESS;

ANIMALS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INTERLEUKIN-1; MEMORY; NEURONAL PLASTICITY; PITUITARY-ADRENAL SYSTEM; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL;

EID: 58049190133     PISSN: 00913022     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yfrne.2008.10.001     Document Type: Review

References (290)

1. Ackerman K.D., Martino M., Heyman R., Moyna N.M., and Rabin B.S. Stressor-induced alteration of cytokine production in multiple sclerosis patients and controls. Psychosom. Med. 60 (1998) 484-491
2. Aimone J.B., Wiles J., and Gage F.H. Potential role for adult neurogenesis in the encoding of time in new memories. Nat. Neurosci. 9 (2006) 723-727
3. Alonso R., Griebel G., Pavone G., Stemmelin J., Le Fur G., and Soubrie P. Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Mol. Psychiatry 9 (2004) 278-286 224
4. Amano Y., Lee S.W., and Allison A.C. Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: mediation by decreased mRNA stability. Mol. Pharmacol. 43 (1993) 176-182
5. Amit Z., and Galina Z.H. Stress induced analgesia plays an adaptive role in the organization of behavioral responding. Brain Res. Bull. 21 (1988) 955-958
6. Anisman H., Ravindran A.V., Griffiths J., and Merali Z. Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Mol. Psychiatry 4 (1999) 182-188
7. Aubert A., Vega C., Dantzer R., and Goodall G. Pyrogens specifically disrupt the acquisition of a task involving cognitive processing in the rat. Brain Behav. Immun. 9 (1995) 129-148
8. Avital A., Goshen I., Kamsler A., Segal M., Iverfeldt K., Richter-Levin G., and Yirmiya R. Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus 13 (2003) 826-834
9. Avitsur R., and Yirmiya R. The immunobiology of sexual behavior: gender differences in the suppression of sexual activity during illness. Pharmacol. Biochem. Behav. 64 (1999) 787-796
10. Banks W.A., Farr S.A., LaScola M.E., and Morley J.E. Intravenous human interleukin-1alpha impairs memory processing in mice. Dependence on blood-brain barrier transport into posterior division of the septum. J. Pharmacol. Exp. Ther. 299 (2001) 536-541
11. Banks W.A., Farr S.A., and Morley J.E. Entry of blood-borne cytokines into the central nervous system: effects on cognitive processes. Neuroimmunomodulation 10 (2002) 319-327
12. Banks W.A., Kastin A.J., and Broadwell R.D. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 2 (1995) 241-248
13. Barak O., Goshen I., Ben-Hur T., Weidenfeld J., Taylor A.N., and Yirmiya R. Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120. Brain Res. 933 (2002) 98-108
14. Barak O., Weidenfeld J., Goshen I., Ben-Hur T., Taylor A.N., and Yirmiya R. Intracerebral HIV-1 glycoprotein 120 produces sickness behavior and pituitary-adrenal activation in rats: role of prostaglandins. Brain Behav. Immun. 16 (2002) 720-735
15. Barden N., Reul J.M., and Holsboer F. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?. Trends Neurosci. 18 (1995) 6-11
16. Barrientos R.M., Higgins E.A., Sprunger D.B., Watkins L.R., Rudy J.W., and Maier S.F. Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus. Behav. Brain Res. 134 (2002) 291-298
17. Barrientos R.M., Sprunger D.B., Campeau S., Higgins E.A., Watkins L.R., Rudy J.W., and Maier S.F. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience 121 (2003) 847-853
18. Barrientos R.M., Sprunger D.B., Campeau S., Watkins L.R., Rudy J.W., and Maier S.F. BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration. J. Neuroimmunol. 155 (2004) 119-126
19. Bartolomucci A., Palanza P., Parmigiani S., Pederzani T., Merlot E., Neveu P.J., and Dantzer R. Chronic psychosocial stress down-regulates central cytokines mRNA. Brain Res. Bull. 62 (2003) 173-178
20. Beck G., and Habicht G.S. Purification and biochemical characterization of an invertebrate interleukin 1. Mol. Immunol. 28 (1991) 577-584
21. Beishuizen A., and Thijs L.G. Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis. J. Endotoxin Res. 9 (2003) 3-24
22. Bellinger F.P., Madamba S., and Siggins G.R. Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus. Brain Res. 628 (1993) 227-234
23. Ben-Hur T., Cialic R., Itzik A., Barak O., Yirmiya R., and Weidenfeld J. A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis. Neuroscience 108 (2001) 119-127
24. Ben-Hur T., Cialic R., Itzik A., Yirmiya R., and Weidenfeld J. Acute effects of purified and UV-inactivated Herpes simplex virus type 1 on the hypothalamo-pituitary-adrenocortical axis. Neuroendocrinology 74 (2001) 160-166
25. BenMenachem-Zidon O., Goshen I., Kreisel T., BenMenahem Y., Reinhartz E., BenHur T., and Yirmiya R. Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis. Neuropsychopharmacology 5 (2007) 54
26. Berkenbosch F., van Oers J., del Rey A., Tilders F., and Besedovsky H. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238 (1987) 524-526
27. Bernton E.W., Beach J.E., Holaday J.W., Smallridge R.C., and Fein H.G. Release of multiple hormones by a direct action of interleukin-1 on pituitary cells. Science 238 (1987) 519-521
28. Berton O., and Nestler E.J. New approaches to antidepressant drug discovery: beyond monoamines. Nat. Rev. Neurosci. 7 (2006) 137-151
29. Besedovsky H., Sorkin E., Keller M., and Muller J. Changes in blood hormone levels during the immune response. Proc. Soc. Exp. Biol. Med. 150 (1975) 466-470
30. Besedovsky H.O., and del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 17 (1996) 64-102
31. Blandino Jr. P., Barnum C.J., and Deak T. The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress. J. Neuroimmunol. 173 (2006) 87-95
32. Bluthe R.M., Michaud B., Kelley K.W., and Dantzer R. Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally. Neuroreport 7 (1996) 1485-1488
33. Bonaccorso S., Marino V., Biondi M., Grimaldi F., Ippoliti F., and Maes M. Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus. J. Affect. Disord. 72 (2002) 237-241
34. Brambilla F., Monteleone P., and Maj M. Interleukin-1beta and tumor necrosis factor-alpha in children with major depressive disorder or dysthymia. J. Affect. Disord. 78 (2004) 273-277
35. Brebner K., Hayley S., Zacharko R., Merali Z., and Anisman H. Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations. Neuropsychopharmacology 22 (2000) 566-580
36. Brennan F.X., Beck K.D., and Servatius R.J. Low doses of interleukin-1beta improve the leverpress avoidance performance of Sprague-Dawley rats. Neurobiol. Learn. Mem. 80 (2003) 168-171
37. Brennan F.X., Beck K.D., and Servatius R.J. Proinflammatory cytokines differentially affect leverpress avoidance acquisition in rats. Behav. Brain Res. 153 (2004) 351-355
38. Briest W., Elsner C., Hemker J., Muller-Strahl G., and Zimmer H.G. Norepinephrine-induced expression of cytokines in isolated biventricular working rat hearts. Mol. Cell. Biochem. 245 (2003) 69-76
39. Brydon L., Edwards S., Jia H., Mohamed-Ali V., Zachary I., Martin J.F., and Steptoe A. Psychological stress activates interleukin-1beta gene expression in human mononuclear cells. Brain Behav. Immun. 19 (2005) 540-546
40. Buller K., Xu Y., Dayas C., and Day T. Dorsal and ventral medullary catecholamine cell groups contribute differentially to systemic interleukin-1beta-induced hypothalamic pituitary adrenal axis responses. Neuroendocrinology 73 (2001) 129-138
41. Buwalda B., Kole M.H., Veenema A.H., Huininga M., de Boer S.F., Korte S.M., and Koolhaas J.M. Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning. Neurosci. Biobehav. Rev. 29 (2005) 83-97
42. Cameron H.A., and Gould E. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience 61 (1994) 203-209
43. Campbell S., and Macqueen G. The role of the hippocampus in the pathophysiology of major depression. J. Psychiatry Neurosci. 29 (2004) 417-426
44. Capuron L., and Miller A.H. Cytokines and psychopathology: lessons from interferon-alpha. Biol. Psychiatry 56 (2004) 819-824
45. Carroll B.J. The dexamethasone suppression test for melancholia. Br. J. Psychiatry 140 (1982) 292-304
46. Caso J.R., Leza J.C., and Menchen L. The effects of physical and psychological stress on the gastro-intestinal tract: lessons from animal models. Curr. Mol. Med. 8 (2008) 299-312
47. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., and Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
48. Castanon N., Bluthe R.M., and Dantzer R. Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat. Psychopharmacology (Berl.) 154 (2001) 50-60
49. Chuluyan H.E., Saphier D., Rohn W.M., and Dunn A.J. Noradrenergic innervation of the hypothalamus participates in adrenocortical responses to interleukin-1. Neuroendocrinology 56 (1992) 106-111
50. Clatworthy A.L. Neural-immune interactions-an evolutionary perspective. Neuroimmunomodulation 5 (1998) 136-142
51. Cohen O., Reichenberg A., Perry C., Ginzberg D., Pollmacher T., Soreq H., and Yirmiya R. Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase. J. Mol. Neurosci. 21 (2003) 199-212
52. Conrad C.D., Lupien S.J., and McEwen B.S. Support for a bimodal role for type II adrenal steroid receptors in spatial memory. Neurobiol. Learn. Mem. 72 (1999) 39-46
53. Coogan A., and O'Connor J.J. Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1 beta. Neuroreport 8 (1997) 2107-2110
54. Coogan A.N., and O'Connor J.J. Interleukin-1beta inhibits a tetraethylammonium-induced synaptic potentiation in the rat dentate gyrus in vitro. Eur. J. Pharmacol. 374 (1999) 197-206
55. Coogan A.N., O'Neill L.A., and O'Connor J.J. The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro. Neuroscience 93 (1999) 57-69
56. Cunha J.M., Cunha F.Q., Poole S., and Ferreira S.H. Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist. Br. J. Pharmacol. 130 (2000) 1418-1424
57. Cunningham A.J., Murray C.A., O'Neill L.A., Lynch M.A., and O'Connor J.J. Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. Neurosci. Lett. 203 (1996) 17-20
58. Cunningham Jr. E.T., and De Souza E.B. Interleukin 1 receptors in the brain and endocrine tissues. Immunol. Today 14 (1993) 171-176
59. Curran B.P., Murray H.J., and O'Connor J.J. A role for c-Jun N-terminal kinase in the inhibition of long-term potentiation by interleukin-1beta and long-term depression in the rat dentate gyrus in vitro. Neuroscience 118 (2003) 347-357
60. Czeh B., Michaelis T., Watanabe T., Frahm J., de Biurrun G., van Kampen M., Bartolomucci A., and Fuchs E. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc. Natl. Acad. Sci. USA 98 (2001) 12796-12801
61. Dallman M.F., Jones M.T., Vernikos-Danellis J., and Ganong W.F. Corticosteroid feedback control of ACTH secretion: rapid effects of bilateral adrenalectomy on plasma ACTH in the rat. Endocrinology 91 (1972) 961-968
62. Dantzer R. Cytokine-induced sickness behavior: where do we stand?. Brain Behav. Immun. 15 (2001) 7-24
63. Dantzer R. Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur. J. Pharmacol. 500 (2004) 399-411
64. Dantzer R., Wollman E., Vitkovic L., and Yirmiya R. Cytokines and depression: fortuitous or causative association?. Mol. Psychiatry 4 (1999) 328-332
65. de Kloet E.R., Joels M., and Holsboer F. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6 (2005) 463-475
66. de Kloet E.R., Oitzl M.S., and Joels M. Stress and cognition: are corticosteroids good or bad guys?. Trends Neurosci. 22 (1999) 422-426
67. Deak T., Meriwether J.L., Fleshner M., Spencer R.L., Abouhamze A., Moldawer L.L., Grahn R.E., Watkins L.R., and Maier S.F. Evidence that brief stress may induce the acute phase response in rats. Am. J. Physiol. 273 (1997) R1998-2004
68. Deinzer R., Forster P., Fuck L., Herforth A., Stiller-Winkler R., and Idel H. Increase of crevicular interleukin 1beta under academic stress at experimental gingivitis sites and at sites of perfect oral hygiene. J. Clin. Periodontol. 26 (1999) 1-8
69. Deinzer R., Kottmann W., Forster P., Herforth A., Stiller-Winkler R., and Idel H. After-effects of stress on crevicular interleukin-1beta. J. Clin. Periodontol. 27 (2000) 74-77
70. DeKeyser F.G., Leker R.R., and Weidenfeld J. Activation of the adrenocortical axis by surgical stress: involvement of central norepinephrine and interleukin-1. Neuroimmunomodulation 7 (2000) 182-188
71. Del Rey A., Roggero E., Randolf A., Mahuad C., McCann S., Rettori V., and Besedovsky H.O. IL-1 resets glucose homeostasis at central levels. Proc. Natl. Acad. Sci. USA 103 (2006) 16039-16044
72. Depino A.M., Alonso M., Ferrari C., del Rey A., Anthony D., Besedovsky H., Medina J.H., and Pitossi F. Learning modulation by endogenous hippocampal IL-1: blockade of endogenous IL-1 facilitates memory formation. Hippocampus 14 (2004) 526-535
73. Diamond D.M., Bennett M.C., Fleshner M., and Rose G.M. Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus 2 (1992) 421-430
74. Dinarello C.A. Biologic basis for interleukin-1 in disease. Blood 87 (1996) 2095-2147
75. Dranovsky A., and Hen R. Hippocampal neurogenesis: regulation by stress and antidepressants. Biol. Psychiatry 59 (2006) 1136-1143
76. Dubrovsky B. Effects of adrenal cortex hormones on limbic structures: some experimental and clinical correlations related to depression. J. Psychiatry Neurosci. 18 (1993) 4-16
77. Duman R.S. Depression: a case of neuronal life and death?. Biol. Psychiatry 56 (2004) 140-145
78. Duman R.S., and Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 59 (2006) 1116-1127
79. Dunn A.J. Effects of the IL-1 receptor antagonist on the IL-1- and endotoxin-induced activation of the HPA axis and cerebral biogenic amines in mice. Neuroimmunomodulation 7 (2000) 36-45
80. Dunn A.J., and Vickers S.L. Neurochemical and neuroendocrine responses to Newcastle disease virus administration in mice. Brain Res. 645 (1994) 103-112
81. Duval F., Mokrani M.C., Monreal-Ortiz J.A., Fattah S., Champeval C., Schulz P., and Macher J.P. Cortisol hypersecretion in unipolar major depression with melancholic and psychotic features: dopaminergic, noradrenergic and thyroid correlates. Psychoneuroendocrinology 31 (2006) 876-888
82. Ekdahl C.T., Claasen J.H., Bonde S., Kokaia Z., and Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc. Natl. Acad. Sci. USA 100 (2003) 13632-13637
83. Ericsson A., Kovacs K.J., and Sawchenko P.E. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci. 14 (1994) 897-913
84. Eutamene H., Theodorou V., Fioramonti J., and Bueno L. Acute stress modulates the histamine content of mast cells in the gastrointestinal tract through interleukin-1 and corticotropin-releasing factor release in rats. J. Physiol. 553 (2003) 959-966
85. Fanselow M.S. Contextual fear gestalt memories and the hippocampus. Behav. Brain Res. 110 (2000) 73-81
86. Farhadi A., Fields J.Z., and Keshavarzian A. Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation. World J. Gastroenterol. 13 (2007) 3027-3030
87. Ferreira S.H., Lorenzetti B.B., Bristow A.F., and Poole S. Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature 334 (1988) 698-700
88. Fleshner M., Goehler L.E., Hermann J., Relton J.K., Maier S.F., and Watkins L.R. Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated. Brain Res. Bull. 37 (1995) 605-610
89. Fleshner M., Nguyen K.T., Cotter C.S., Watkins L.R., and Maier S.F. Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. Am. J. Physiol. 275 (1998) R870-878
90. Frank M.G., Baratta M.V., Sprunger D.B., Watkins L.R., and Maier S.F. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav. Immun. 21 (2007) 47-59
91. Fuchs E., Czeh B., and Flugge G. Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews. Behav. Pharmacol. 15 (2004) 315-325
92. Fuchs E., Flugge G., and Czeh B. Remodeling of neuronal networks by stress. Front Biosci. 11 (2006) 2746-2758
93. Gaykema R.P., Goehler L.E., Hansen M.K., Maier S.F., and Watkins L.R. Subdiaphragmatic vagotomy blocks interleukin-1beta-induced fever but does not reduce IL-1beta levels in the circulation. Auton Neurosci. 85 (2000) 72-77
94. Gibbons J.L., and Mc H.P. Plasma cortisol in depressive illness. J. Psychiatr. Res. 1 (1962) 162-171
95. Gibertini M. Cytokines and cognitive behavior. Neuroimmunomodulation 5 (1998) 160-165
96. Gibertini M. IL1 beta impairs relational but not procedural rodent learning in a water maze task. Adv. Exp. Med. Biol. 402 (1996) 207-217
97. Gibertini M., Newton C., Friedman H., and Klein T.W. Spatial learning impairment in mice infected with Legionella pneumophila or administered exogenous interleukin-1-beta. Brain Behav. Immun. 9 (1995) 113-128
98. Gibertini M., Newton C., Klein T.W., and Friedman H. Legionella pneumophila-induced visual learning impairment reversed by anti-interleukin-1 beta. Proc. Soc. Exp. Biol. Med. 210 (1995) 7-11
99. Gillespie C.F., and Nemeroff C.B. Hypercortisolemia and depression. Psychosom. Med. 67 Suppl 1 (2005) S26-S28
100. Goshen I., Kreisel T., Ben-Menachem-Zidon O., Licht T., Weidenfeld J., Ben-Hur T., and Yirmiya R. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol. Psychiatry (2007)
101. Goshen I., Kreisel T., Ounallah-Saad H., Renbaum P., Zalzstein Y., Ben-Hur T., Levy-Lahad E., and Yirmiya R. A dual role for interleukin-1 in hippocampal-dependent memory processes. Psychoneuroendocrinology 32 (2007) 1106-1115
102. Goshen I., and Yirmiya R. The role of pro-inflammatory cytokines in memory processes and neural plasticity. In: Ader R. (Ed). Psychoneuroimmunology. 4 ed. (2007), Elsevier, Academic press, Amsterdam 337-377
103. Goshen I., Yirmiya R., Iverfeldt K., and Weidenfeld J. The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretion. Endocrinology 144 (2003) 4453-4458
104. Goujon E., Parnet P., Aubert A., Goodall G., and Dantzer R. Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice. Am. J. Physiol. 269 (1995) R154-R159
105. Goujon E., Parnet P., Cremona S., and Dantzer R. Endogenous glucocorticoids down regulate central effects of interleukin-1 beta on body temperature and behaviour in mice. Brain Res. 702 (1995) 173-180
106. Goujon E., Parnet P., Laye S., Combe C., and Dantzer R. Adrenalectomy enhances pro-inflammatory cytokines gene expression in the spleen, pituitary and brain of mice in response to lipopolysaccharide. Brain Res. Mol. Brain Res. 36 (1996) 53-62
107. Goujon E., Parnet P., Laye S., Combe C., Kelley K.W., and Dantzer R. Stress downregulates lipopolysaccharide-induced expression of proinflammatory cytokines in the spleen, pituitary, and brain of mice. Brain Behav. Immun. 9 (1995) 292-303
108. Gould E., and Tanapat P. Stress and hippocampal neurogenesis. Biol. Psychiatry 46 (1999) 1472-1479
109. Gould E., Tanapat P., Rydel T., and Hastings N. Regulation of hippocampal neurogenesis in adulthood. Biol. Psychiatry 48 (2000) 715-720
110. Grippo A.J., Francis J., Beltz T.G., Felder R.B., and Johnson A.K. Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia. Physiol. Behav. 84 (2005) 697-706
111. Gross C.G. Neurogenesis in the adult brain: death of a dogma. Nat. Rev. Neurosci. 1 (2000) 67-73
112. Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12 (1988) 123-137
113. Hayley S., Poulter M.O., Merali Z., and Anisman H. The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity. Neuroscience 135 (2005) 659-678
114. He S.H. Key role of mast cells and their major secretory products in inflammatory bowel disease. World J. Gastroenterol. 10 (2004) 309-318
115. Heinz A., Hermann D., Smolka M.N., Rieks M., Graf K.J., Pohlau D., Kuhn W., and Bauer M. Effects of acute psychological stress on adhesion molecules interleukins and sex hormones: implications for coronary heart disease. Psychopharmacology (Berl.) 165 (2003) 111-117
116. Holsboer F., Liebl R., and Hofschuster E. Repeated dexamethasone suppression test during depressive illness. Normalisation of test result compared with clinical improvement. J. Affect. Disord. 4 (1982) 93-101
117. Horai R., Asano M., Sudo K., Kanuka H., Suzuki M., Nishihara M., Takahashi M., and Iwakura Y. Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J. Exp. Med. 187 (1998) 1463-1475
118. Hosoi T., Okuma Y., and Nomura Y. Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 (2000) R141-R147
119. Hughes Jr. T.K., Smith E.M., Leung M.K., and Stefano G.B. Evidence for the conservation of an immunoreactive monokine network in invertebrates. Ann. NY Acad. Sci. 650 (1992) 74-80
120. Jacobs B.L., Praag H., and Gage F.H. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol. Psychiatry 5 (2000) 262-269
121. Jacobson L., and Sapolsky R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr. Rev. 12 (1991) 118-134
122. Jayatissa M.N., Bisgaard C., Tingstrom A., Papp M., and Wiborg O. Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression. Neuropsychopharmacology 31 (2006) 2395-2404
123. Joels M. Role of corticosteroid hormones in the dentate gyrus. Prog. Brain Res. 163 (2007) 355-370
124. Johnson J.D., Campisi J., Sharkey C.M., Kennedy S.L., Nickerson M., Greenwood B.N., and Fleshner M. Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines. Neuroscience 135 (2005) 1295-1307
125. Johnson J.D., O'Connor K.A., Hansen M.K., Watkins L.R., and Maier S.F. Effects of prior stress on LPS-induced cytokine and sickness responses. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 (2003) R422-R432
126. Kapcala L.P., He J.R., Gao Y., Pieper J.O., and DeTolla L.J. Subdiaphragmatic vagotomy inhibits intra-abdominal interleukin-1 beta stimulation of adrenocorticotropin secretion. Brain Res. 728 (1996) 247-254
127. Katsuki H., Nakai S., Hirai Y., Akaji K., Kiso Y., and Satoh M. Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. Eur. J. Pharmacol. 181 (1990) 323-326
128. Kaufer D., Friedman A., Seidman S., and Soreq H. Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 393 (1998) 373-377
129. Keller-Wood M.E., and Dallman M.F. Corticosteroid inhibition of ACTH secretion. Endocr. Rev. 5 (1984) 1-24
130. Kelly A., Vereker E., Nolan Y., Brady M., Barry C., Loscher C.E., Mills K.H., and Lynch M.A. Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus. J. Biol. Chem. 278 (2003) 19453-19462
131. Kempermann G., and Neumann H. Neuroscience. Microglia: the enemy within?. Science 302 (2003) 1689-1690
132. Kempermann G., Wiskott L., and Gage F.H. Functional significance of adult neurogenesis. Curr. Opin. Neurobiol. 14 (2004) 186-191
133. Kendler K.S., Karkowski L.M., and Prescott C.A. Causal relationship between stressful life events and the onset of major depression. Am. J. Psychiatry 156 (1999) 837-841
134. Kent S., Bluthe R.M., Kelley K.W., and Dantzer R. Sickness behavior as a new target for drug development. Trends Pharmacol. Sci. 13 (1992) 24-28
135. Kern J.A., Lamb R.J., Reed J.C., Daniele R.P., and Nowell P.C. Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms. J. Clin. Invest. 81 (1988) 237-244
136. Kessler R.C. The effects of stressful life events on depression. Annu. Rev. Psychol. 48 (1997) 191-214
137. Kim J.J., and Diamond D.M. The stressed hippocampus, synaptic plasticity and lost memories. Nat. Rev. Neurosci. 3 (2002) 453-462
138. Kim J.J., Song E.Y., and Kosten T.A. Stress effects in the hippocampus: synaptic plasticity and memory. Stress 9 (2006) 1-11
139. Knudsen P.J., Dinarello C.A., and Strom T.B. Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J. Immunol. 139 (1987) 4129-4134
140. Kodama M., Fujioka T., and Duman R.S. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol. Psychiatry 56 (2004) 570-580
141. Koo J.W., and Duman R.S. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc. Natl. Acad. Sci. USA 105 (2008) 751-756
142. Krueger J.M., Obal F.J., Fang J., Kubota T., and Taishi P. The role of cytokines in physiological sleep regulation. Ann. NY Acad. Sci. 933 (2001) 211-221
143. Krugers H.J., van der Linden S., van Olst E., Alfarez D.N., Maslam S., Lucassen P.J., and Joels M. Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats. Synapse 61 (2007) 221-230
144. Kwon M.S., Seo Y.J., Lee J.K., Lee H.K., Jung J.S., Jang J.E., Park S.H., and Suh H.W. The repeated immobilization stress increases IL-1beta immunoreactivities in only neuron but not astrocyte or microglia in hippocampal CA1 region striatum and paraventricular nucleus. Neurosci. Lett. 430 (2008) 258-263
145. Labow M., Shuster D., Zetterstrom M., Nunes P., Terry R., Cullinan E.B., Bartfai T., Solorzano C., Moldawer L.L., Chizzonite R., and McIntyre K.W. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J. Immunol. 159 (1997) 2452-2461
146. Landgraf R., Neumann I., Holsboer F., and Pittman Q.J. Interleukin-1 beta stimulates both central and peripheral release of vasopressin and oxytocin in the rat. Eur. J. Neurosci. 7 (1995) 592-598
147. Larson S.J., and Dunn A.J. Behavioral effects of cytokines. Brain Behav. Immun. 15 (2001) 371-387
148. Lee S.W., Tsou A.P., Chan H., Thomas J., Petrie K., Eugui E.M., and Allison A.C. Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA. Proc. Natl. Acad. Sci. USA 85 (1988) 1204-1208
149. LeMay L.G., Vander A.J., and Kluger M.J. The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol. Behav. 47 (1990) 957-961
150. Levine J., Barak Y., Chengappa K.N., Rapoport A., Rebey M., and Barak V. Cerebrospinal cytokine levels in patients with acute depression. Neuropsychobiology 40 (1999) 171-176
151. Li Y., Liu L., Kang J., Sheng J.G., Barger S.W., Mrak R.E., and Griffin W.S. Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. J. Neurosci. 20 (2000) 149-155
152. Lipton J.M., and Catania A. Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH. Immunol. Today 18 (1997) 140-145
153. Loddick S.A., Liu C., Takao T., Hashimoto K., and De Souza E.B. Interleukin-1 receptors: cloning studies and role in central nervous system disorders. Brain Res. Brain Res. Rev. 26 (1998) 306-319
154. Loscher C.E., Mills K.H., and Lynch M.A. Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor. J. Neuroimmunol. 137 (2003) 117-124
155. Lundkvist J., Sundgren-Andersson A.K., Tingsborg S., Ostlund P., Engfors C., Alheim K., Bartfai T., Iverfeldt K., and Schultzberg M. Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist. Am. J. Physiol. 276 (1999) R644-R651
156. Lynch M.A. Interleukin-1 beta exerts a myriad of effects in the brain and in particular in the hippocampus: analysis of some of these actions. Vitam. Horm. 64 (2002) 185-219
157. Maes M., Bosmans E., Meltzer H.Y., Scharpe S., and Suy E. Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?. Am. J. Psychiatry 150 (1993) 1189-1193
158. Maes M., Smith R., and Scharpe S. The monocyte-T-lymphocyte hypothesis of major depression. Psychoneuroendocrinology 20 (1995) 111-116
159. Maes M., Song C., Lin A., De Jongh R., Van Gastel A., Kenis G., Bosmans E., De Meester I., Benoy I., Neels H., Demedts P., Janca A., Scharpe S., and Smith R.S. The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 10 (1998) 313-318
160. Maier S.F. Bi-directional immune-brain communication: implications for understanding stress, pain, and cognition. Brain Behav. Immun. 17 (2003) 69-85
161. Maier S.F. Role of fear in mediating shuttle escape learning deficit produced by inescapable shock. J. Exp. Psychol. Anim. Behav. Process. 16 (1990) 137-149
162. Maier S.F., and Watkins L.R. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior mood, and cognition. Psychol. Rev. 105 (1998) 83-107
163. Maier S.F., and Watkins L.R. Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock. Brain Res. 695 (1995) 279-282
164. Maier S.F., Wiertelak E.P., Martin D., and Watkins L.R. Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res. 623 (1993) 321-324
165. Malberg J.E. Implications of adult hippocampal neurogenesis in antidepressant action. J. Psychiatry Neurosci. 29 (2004) 196-205
166. Malberg J.E., Eisch A.J., Nestler E.J., and Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20 (2000) 9104-9110
167. Maren S. Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci. 24 (2001) 897-931
168. Maren S., and Holt W. The hippocampus and contextual memory retrieval in Pavlovian conditioning. Behav. Brain Res. 110 (2000) 97-108
169. Martin P., Soubrie P., and Puech A.J. Reversal of helpless behavior by serotonin uptake blockers in rats. Psychopharmacology (Berl.) 101 (1990) 403-407
170. Matsumoto Y., Yamaguchi T., Watanabe S., and Yamamoto T. Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta. Neuropharmacology 46 (2004) 1195-1200
171. Matsumoto Y., Yoshida M., Watanabe S., and Yamamoto T. Involvement of cholinergic and glutamatergic functions in working memory impairment induced by interleukin-1beta in rats. Eur. J. Pharmacol. 430 (2001) 283-288
172. McCulloch C.A., Downey G.P., and El-Gabalawy H. Signalling platforms that modulate the inflammatory response: new targets for drug development. Nat. Rev. Drug Discov. 5 (2006) 864-876
173. McEwen B.S., and Sapolsky R.M. Stress and cognitive function. Curr. Opin. Neurobiol. 5 (1995) 205-216
174. Mekaouche M., Givalois L., Barbanel G., Siaud P., Maurel D., Malaval F., Bristow A.F., Boissin J., Assenmacher I., and Ixart G. Chronic restraint enhances interleukin-1-beta release in the basal state and after an endotoxin challenge, independently of adrenocorticotropin and corticosterone release. Neuroimmunomodulation 1 (1994) 292-299
175. Merali Z., Brennan K., Brau P., and Anisman H. Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake. Psychopharmacology (Berl.) 165 (2003) 413-418
176. Meshorer E., Erb C., Gazit R., Pavlovsky L., Kaufer D., Friedman A., Glick D., Ben-Arie N., and Soreq H. Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science 295 (2002) 508-512
177. Miller A.H., Pariante C.M., and Pearce B.D. Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression. Adv. Exp. Med. Biol. 461 (1999) 107-116
178. Milligan E.D., Nguyen K.T., Deak T., Hinde J.L., Fleshner M., Watkins L.R., and Maier S.F. The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone. Brain Res. 810 (1998) 48-58
179. Minami M., Kuraishi Y., Yamaguchi T., Nakai S., Hirai Y., and Satoh M. Immobilization stress induces interleukin-1 beta mRNA in the rat hypothalamus. Neurosci. Lett. 123 (1991) 254-256
180. Mirescu C., and Gould E. Stress and adult neurogenesis. Hippocampus 16 (2006) 233-238
181. Monje M.L., Toda H., and Palmer T.D. Inflammatory blockade restores adult hippocampal neurogenesis. Science 302 (2003) 1760-1765
182. Morag M., Yirmiya R., Lerer B., and Morag A. Influence of socioeconomic status on behavioral, emotional and cognitive effects of rubella vaccination: a prospective, double blind study. Psychoneuroendocrinology 23 (1998) 337-351
183. Moraska A., Campisi J., Nguyen K.T., Maier S.F., Watkins L.R., and Fleshner M. Elevated IL-1beta contributes to antibody suppression produced by stress. J. Appl. Physiol. 93 (2002) 207-215
184. Mormede C., Castanon N., Medina C., Moze E., Lestage J., Neveu P.J., and Dantzer R. Chronic mild stress in mice decreases peripheral cytokine and increases central cytokine expression independently of IL-10 regulation of the cytokine network. Neuroimmunomodulation 10 (2002) 359-366
185. Musselman D.L., Lawson D.H., Gumnick J.F., Manatunga A.K., Penna S., Goodkin R.S., Greiner K., Nemeroff C.B., and Miller A.H. Paroxetine for the prevention of depression induced by high-dose interferon alfa. N. Engl. J. Med. 344 (2001) 961-966
186. Nair A., and Bonneau R.H. Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J. Neuroimmunol. 171 (2006) 72-85
187. Nance D.M., and Sanders V.M. Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav. Immun. 21 (2007) 736-745
188. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., and Monteggia L.M. Neurobiology of depression. Neuron 34 (2002) 13-25
189. Nguyen K.T., Deak T., Owens S.M., Kohno T., Fleshner M., Watkins L.R., and Maier S.F. Exposure to acute stress induces brain interleukin-1beta protein in the rat. J. Neurosci. 18 (1998) 2239-2246
190. Nguyen K.T., Deak T., Will M.J., Hansen M.K., Hunsaker B.N., Fleshner M., Watkins L.R., and Maier S.F. Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress. Brain Res. 859 (2000) 193-201
191. O'Connor J.J., and Coogan A.N. Actions of the pro-inflammatory cytokine IL-1 beta on central synaptic transmission. Exp. Physiol. 84 (1999) 601-614
192. O'Connor K.A., Johnson J.D., Hansen M.K., Wieseler Frank J.L., Maksimova E., Watkins L.R., and Maier S.F. Peripheral and central proinflammatory cytokine response to a severe acute stressor. Brain Res. 991 (2003) 123-132
193. O'Donnell E., Vereker E., and Lynch M.A. Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms. Eur. J. Neurosci. 12 (2000) 345-352
194. Oitzl M.S., van Oers H., Schobitz B., and de Kloet E.R. Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning. Brain Res. 613 (1993) 160-163
195. Oka T., Aou S., and Hori T. Intracerebroventricular injection of interleukin-1 beta induces hyperalgesia in rats. Brain Res. 624 (1993) 61-68
196. Ottaviani E., and Franceschi C. The neuroimmunology of stress from invertebrates to man. Prog. Neurobiol. 48 (1996) 421-440
197. Ottaviani E., Franchini A., and Franceschi C. Presence of several cytokine-like molecules in molluscan hemocytes. Biochem. Biophys. Res. Commun. 195 (1993) 984-988
198. Overmier J.B., and Seligman M.E. Effects of inescapable shock upon subsequent escape and avoidance responding. J. Comp. Physiol. Psychol. 63 (1967) 28-33
199. Owen B.M., Eccleston D., Ferrier I.N., and Young A.H. Raised levels of plasma interleukin-1beta in major and postviral depression. Acta Psychiatr. Scand. 103 (2001) 226-228
200. Palin K., Bluthe R.M., Verrier D., Tridon V., Dantzer R., and Lestage J. Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guerin in the rat hippocampus. Brain Behav. Immun. 18 (2004) 223-230
201. Parsadaniantz S.M., Gaillet S., Malaval F., Lenoir V., Batsche E., Barbanel G., Gardier A., Terlain B., Jacquot C., Szafarczyk A., et al. Lesions of the afferent catecholaminergic pathways inhibit the temporal activation of the CRH and POMC gene expression and ACTH release induced by human interleukin-1beta in the male rat. Neuroendocrinology 62 (1995) 586-595
202. Plata-Salaman C.R., Ilyin S.E., Turrin N.P., Gayle D., Flynn M.C., Bedard T., Merali Z., and Anisman H. Neither acute nor chronic exposure to a naturalistic (predator) stressor influences the interleukin-1beta system, tumor necrosis factor-alpha, transforming growth factor-beta1, and neuropeptide mRNAs in specific brain regions. Brain Res. Bull. 51 (2000) 187-193
203. Pollak Y., Gilboa A., Ben-Menachem O., Ben-Hur T., Soreq H., and Yirmiya R. Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production. Ann. Neurol. 57 (2005) 741-745
204. Pollak Y., and Yirmiya R. Cytokine-induced changes in mood and behaviour: implications for 'depression due to a general medical condition', immunotherapy and antidepressive treatment. Int. J. Neuropsychopharmacol. 5 (2002) 389-399
205. Porsolt R.D. Animal models of depression: utility for transgenic research. Rev. Neurosci. 11 (2000) 53-58
206. Porsolt R.D., Le Pichon M., and Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 266 (1977) 730-732
207. Propes M.J., and Johnson R.W. Role of corticosterone in the behavioral effects of central interleukin-1 beta. Physiol. Behav. 61 (1997) 7-13
208. Pugh C.R., Johnson J.D., Martin D., Rudy J.W., Maier S.F., and Watkins L.R. Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments. Brain Res. 861 (2000) 8-15
209. Pugh C.R., Kumagawa K., Fleshner M., Watkins L.R., Maier S.F., and Rudy J.W. Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain Behav. Immun. 12 (1998) 212-229
210. Pugh C.R., Nguyen K.T., Gonyea J.L., Fleshner M., Wakins L.R., Maier S.F., and Rudy J.W. Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation. Behav. Brain Res. 106 (1999) 109-118
211. Qiu B.S., Vallance B.A., Blennerhassett P.A., and Collins S.M. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis. Nat. Med. 5 (1999) 1178-1182
212. Rachal Pugh C., Fleshner M., Watkins L.R., Maier S.F., and Rudy J.W. The immune system and memory consolidation: a role for the cytokine IL-1beta. Neurosci. Biobehav. Rev. 25 (2001) 29-41
213. Reichenberg A., Yirmiya R., Schuld A., Kraus T., Haack M., Morag A., and Pollmacher T. Cytokine-associated emotional and cognitive disturbances in humans. Arch. Gen. Psychiatry 58 (2001) 445-452
214. Reul J.M., Stec I., Soder M., and Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology 133 (1993) 312-320
215. Rivier C., and Vale W. In the rat interleukin-1 alpha acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion. Endocrinology 124 (1989) 2105-2109
216. Rohleder N., Wolf J.M., Herpfer I., Fiebich B.L., Kirschbaum C., and Lieb K. No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress. Life Sci. 78 (2006) 3082-3089
217. Ross F.M., Allan S.M., Rothwell N.J., and Verkhratsky A. A dual role for interleukin-1 in LTP in mouse hippocampal slices. J. Neuroimmunol. 144 (2003) 61-67
218. Rothwell N.J., and Luheshi G.N. Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci. 23 (2000) 618-625
219. Sachar E.J., Hellman L., Fukushima D.K., and Gallagher T.F. Cortisol production in depressive illness. A clinical and biochemical clarification. Arch. Gen. Psychiatry 23 (1970) 289-298
220. Safieh-Garabedian B., Poole S., Allchorne A., Winter J., and Woolf C.J. Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br. J. Pharmacol. 115 (1995) 1265-1275
221. Sahay A., and Hen R. Adult hippocampal neurogenesis in depression. Nat. Neurosci. 10 (2007) 1110-1115
222. Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., Weisstaub N., Lee J., Duman R., Arancio O., Belzung C., and Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301 (2003) 805-809
223. Santos J., Alonso C., Vicario M., Ramos L., Lobo B., and Malagelada J.R. Neuropharmacology of stress-induced mucosal inflammation: implications for inflammatory bowel disease and irritable bowel syndrome. Curr. Mol. Med. 8 (2008) 258-273
224. Sapolsky R., Rivier C., Yamamoto G., Plotsky P., and Vale W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238 (1987) 522-524
225. Sapolsky R.M., Romero L.M., and Munck A.U. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21 (2000) 55-89
226. Schiepers O.J., Wichers M.C., and Maes M. Cytokines and major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 29 (2005) 201-217
227. Schiltz J.C., and Sawchenko P.E. Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults. J. Comp. Neurol. 502 (2007) 455-467
228. Schmid D.A., Wichniak A., Uhr M., Ising M., Brunner H., Held K., Weikel J.C., Sonntag A., and Steiger A. Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine. Neuropsychopharmacology 31 (2006) 832-844
229. Schmidt E.D., Janszen A.W., Wouterlood F.G., and Tilders F.J. Interleukin-1-induced long-lasting changes in hypothalamic corticotropin-releasing hormone (CRH)--neurons and hyperresponsiveness of the hypothalamus-pituitary-adrenal axis. J. Neurosci. 15 (1995) 7417-7426
230. Schneider H., Pitossi F., Balschun D., Wagner A., del Rey A., and Besedovsky H.O. A neuromodulatory role of interleukin-1beta in the hippocampus. Proc. Natl. Acad. Sci. USA 95 (1998) 7778-7783
231. Seligman M.E., and Maier S.F. Failure to escape traumatic shock. J. Exp. Psychol. 74 (1967) 1-9
232. Shapira-Lichter I., Beilin B., Ofek K., Bessler H., Gruberger M., Shavit Y., Seror D., Grinevich G., Posner E., Reichenberg A., Soreq H., and Yirmiya R. Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory. Brain Behav. Immun. 22 (2008) 388-398
233. Shavit Y., Wolf G., Goshen I., Livshits D., and Yirmiya R. Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance. Pain 115 (2005) 50-59
234. Shavit Y., Wolf G., Johnston I.N., Westbrook F.R., Watkins L.R., and Yirmiya R. Proinflammatory cytokines modulate neuropathic pain, opioid analgesia, and opioid tolerance. In: DeLeo J., Sorkin L., and Watkins L. (Eds). Immune and Glial Regulation of Pain (2007), IASP Press, Seattle 361-382
235. Sheline Y.I. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol. Psychiatry 48 (2000) 791-800
236. Sherman A.D., and Petty F. Additivity of neurochemical changes in learned helplessness and imipramine. Behav. Neural. Biol. 35 (1982) 344-353
237. Shintani F., Nakaki T., Kanba S., Sato K., Yagi G., Shiozawa M., Aiso S., Kato R., and Asai M. Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat. J. Neurosci. 15 (1995) 1961-1970
238. Shors T.J., Miesegaes G., Beylin A., Zhao M., Rydel T., and Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature 410 (2001) 372-376
239. Sims J.E. IL-1 and IL-18 receptors, and their extended family. Curr. Opin. Immunol. 14 (2002) 117-122
240. Singer R., Harker C.T., Vander A.J., and Kluger M.J. Hyperthermia induced by open-field stress is blocked by salicylate. Physiol. Behav. 36 (1986) 1179-1182
241. Smagin G.N., Swiergiel A.H., and Dunn A.J. Peripheral administration of interleukin-1 increases extracellular concentrations of norepinephrine in rat hypothalamus: comparison with plasma corticosterone. Psychoneuroendocrinology 21 (1996) 83-93
242. Sommer C., Petrausch S., Lindenlaub T., and Toyka K.V. Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy. Neurosci. Lett. 270 (1999) 25-28
243. Song C., and Horrobin D. Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration. J. Lipid Res. 45 (2004) 1112-1121
244. Song C., Leonard B.E., and Horrobin D.F. Dietary ethyl-eicosapentaenoic acid but not soybean oil reverses central interleukin-1-induced changes in behavior corticosterone and immune response in rats. Stress 7 (2004) 43-54
245. Song C., Phillips A.G., and Leonard B. Interleukin 1 beta enhances conditioned fear memory in rats: possible involvement of glucocorticoids. Eur. J. Neurosci. 18 (2003) 1739-1743
246. Song C., Phillips A.G., Leonard B.E., and Horrobin D.F. Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats. Mol. Psychiatry 9 (2004) 630-638
247. Soreq H., Yirmiya R., Cohen O., and Glick D. Acetylcholinesterase as a window onto stress responses. In: Steckler T., Kalin N.H., and Reul J.M.H.M. (Eds). Handbook of Stress and the Brain (2005), Elsevier, Amsterdam 585-608
248. Spivak B., Shohat B., Mester R., Avraham S., Gil-Ad I., Bleich A., Valevski A., and Weizman A. Elevated levels of serum interleukin-1 beta in combat-related posttraumatic stress disorder. Biol. Psychiatry 42 (1997) 345-348
249. Steptoe A., Hamer M., and Chida Y. The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav. Immun. 21 (2007) 901-912
250. Steptoe A., Willemsen G., Owen N., Flower L., and Mohamed-Ali V. Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels. Clin. Sci. (Lond.) 101 (2001) 185-192
251. Sundar S.K., Cierpial M.A., Kamaraju L.S., Long S., Hsieh S., Lorenz C., Aaron M., Ritchie J.C., and Weiss J.M. Human immunodeficiency virus glycoprotein (gp120) infused into rat brain induces interleukin 1 to elevate pituitary-adrenal activity and decrease peripheral cellular immune responses. Proc. Natl. Acad. Sci. USA 88 (1991) 11246-11250
252. Suzuki E., Shintani F., Kanba S., Asai M., and Nakaki T. Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions. Cell. Mol. Neurobiol. 17 (1997) 557-562
253. Tanebe K., Nishijo H., Muraguchi A., and Ono T. Effects of chronic stress on hypothalamic lnterleukin-1beta, interleukin-2, and gonadotrophin-releasing hormone gene expression in ovariectomized rats. J. Neuroendocrinol. 12 (2000) 13-21
254. Tannenbaum B., Tannenbaum G.S., Sudom K., and Anisman H. Neurochemical and behavioral alterations elicited by a chronic intermittent stressor regimen: implications for allostatic load. Brain Res. 953 (2002) 82-92
255. Thomas A.J., Davis S., Morris C., Jackson E., Harrison R., and O'Brien J.T. Increase in interleukin-1beta in late-life depression. Am. J. Psychiatry 162 (2005) 175-177
256. Tilders F.J., DeRijk R.H., Van Dam A.M., Vincent V.A., Schotanus K., and Persoons J.H. Activation of the hypothalamus-pituitary-adrenal axis by bacterial endotoxins: routes and intermediate signals. Psychoneuroendocrinology 19 (1994) 209-232
257. Tracey K.J. The inflammatory reflex. Nature 420 (2002) 853-859
258. Tucker P., Ruwe W.D., Masters B., Parker D.E., Hossain A., Trautman R.P., and Wyatt D.B. Neuroimmune and cortisol changes in selective serotonin reuptake inhibitor and placebo treatment of chronic posttraumatic stress disorder. Biol. Psychiatry 56 (2004) 121-128
259. Turnbull A.V., and Rivier C.L. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol. Rev. 79 (1999) 1-71
260. Vereker E., O'Donnell E., Lynch A., Kelly A., Nolan Y., and Lynch M.A. Evidence that interleukin-1beta and reactive oxygen species production play a pivotal role in stress-induced impairment of LTP in the rat dentate gyrus. Eur. J. Neurosci. 14 (2001) 1809-1819
261. Vereker E., O'Donnell E., and Lynch M.A. The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases. J. Neurosci. 20 (2000) 6811-6819
262. Vermetten E., Vythilingam M., Southwick S.M., Charney D.S., and Bremner J.D. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol. Psychiatry 54 (2003) 693-702
263. Vitkovic L., Bockaert J., and Jacque C. "Inflammatory" cytokines: neuromodulators in normal brain?. J. Neurochem. 74 (2000) 457-471
264. Watanobe H., and Takebe K. Effects of intravenous administration of interleukin-1-beta on the release of prostaglandin E2, corticotropin-releasing factor, and arginine vasopressin in several hypothalamic areas of freely moving rats: estimation by push-pull perfusion. Neuroendocrinology 60 (1994) 8-15
265. Watkins L.R., Hutchinson M.R., Johnston I.N., and Maier S.F. Glia: novel counter-regulators of opioid analgesia. Trends Neurosci. 28 (2005) 661-669
266. Watkins L.R., Maier S.F., and Goehler L.E. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci. 57 (1995) 1011-1026
267. Watkins L.R., Wiertelak E.P., Goehler L.E., Smith K.P., Martin D., and Maier S.F. Characterization of cytokine-induced hyperalgesia. Brain Res. 654 (1994) 15-26
268. Weidenfeld J., Abramsky O., and Ovadia H. Effect of interleukin-1 on ACTH and corticosterone secretion in dexamethasone and adrenalectomized pretreated male rats. Neuroendocrinology 50 (1989) 650-654
269. Weidenfeld J., Corcos A.P., Wohlman A., and Feldman S. Characterization of the 2-deoxyglucose effect on the adrenocortical axis. Endocrinology 134 (1994) 1924-1931
270. Whitnall M.H., Mezey E., and Gainer H. Co-localization of corticotropin-releasing factor and vasopressin in median eminence neurosecretory vesicles. Nature 317 (1985) 248-250
271. Wieczorek M., and Dunn A.J. Relationships among the behavioral, noradrenergic, and pituitary-adrenal responses to interleukin-1 and the effects of indomethacin. Brain Behav. Immun. 20 (2006) 477-487
272. Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52 (2005) 90-110
273. Willner P. Validity reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl.) 134 (1997) 319-329
274. Wittwer D., Franchini A., Ottaviani E., and Wiesner A. Presence of IL-1- and TNF-like molecules in Galleria mellonella (Lepidoptera) haemocytes and in an insect cell line Fromestigmene acraea (Lepidoptera). Cytokine 11 (1999) 637-642
275. Wolf G., Gabay E., Tal M., Yirmiya R., and Shavit Y. Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice. Pain 120 (2006) 315-324
276. Wolf G., Yirmiya R., Goshen I., Iverfeldt K., Holmlund L., Takeda K., and Shavit Y. Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects. Pain 104 (2003) 471-480
277. Wolf G., Yirmiya R., Kreisel T., Goshen I., Weidenfeld J., Poole S., and Shavit Y. Interleukin-1 signaling modulates stress-induced analgesia. Brain Behav. Immun. 21 (2007) 652-659
278. Wong E.Y., and Herbert J. Raised circulating corticosterone inhibits neuronal differentiation of progenitor cells in the adult hippocampus. Neuroscience 137 (2006) 83-92
279. Wu L.M., Han H., Wang Q.N., Hou H.L., Tong H., Yan X.B., and Zhou J.N. Mifepristone repairs region-dependent alteration of synapsin I in hippocampus in rat model of depression. Neuropsychopharmacology 32 (2007) 2500-2510
280. Yirmiya R. Behavioral and psychological effects of immune activation: implications for 'depression due to a general medical condition'. Curr. Opin. Psychiatry 10 (1997) 470-476
281. Yirmiya R. Endotoxin produces a depressive-like episode in rats. Brain Res. 711 (1996) 163-174
282. Yirmiya R., Pollak Y., Barak O., Avitsur R., Ovadia H., Bette M., Weihe E., and Weidenfeld J. Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents. Neuropsychopharmacology 24 (2001) 531-544
283. Yirmiya R., Weidenfeld J., Barak O., Avitsur R., Pollak Y., Gallily R., Wohlman A., Ovadia H., and Ben-Hur T. The role of brain cytokines in mediating the behavioral and neuroendocrine effects of intracerebral mycoplasma fermentans. Brain Res. 829 (1999) 28-38
284. Yirmiya R., Weidenfeld J., Pollak Y., Morag M., Morag A., Avitsur R., Barak O., Reichenberg A., Cohen E., Shavit Y., and Ovadia H. Cytokines, "depression due to a general medical condition," and antidepressant drugs. Adv. Exp. Med. Biol. 461 (1999) 283-316
285. Yirmiya R., Winocur G., and Goshen I. Brain interleukin-1 is involved in spatial memory and passive avoidance conditioning. Neurobiol. Learn. Mem. 78 (2002) 379-389
286. Young E.A., Altemus M., Lopez J.F., Kocsis J.H., Schatzberg A.F., DeBattista C., and Zubieta J.K. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 29 (2004) 1198-1204
287. Yu Y.W., Chen T.J., Hong C.J., Chen H.M., and Tsai S.J. Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response. Neuropsychopharmacology 28 (2003) 1182-1185
288. Zhou D., Kusnecov A.W., Shurin M.R., DePaoli M., and Rabin B.S. Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 133 (1993) 2523-2530
289. Zhou M., Das P., Simms H.H., and Wang P. Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10. Biochim. Biophys. Acta 1740 (2005) 446-452
290. Zou C.J., Liu J.D., and Zhou Y.C. Roles of central interleukin-1 on stress-induced-hypertension and footshock-induced-analgesia in rats. Neurosci. Lett. 311 (2001) 41-44