IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation

Journal of Immunology

Volumn 167, Issue 3, 2001, Pages 1179-1187

  Mattei, F ^a   Schiavoni, G ^a   Belardelli, F ^a   Tough, D F ^a  

^a EDWARD JENNER INST FOR VACC RES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; DOUBLE STRANDED RNA; INTERFERON; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE EXPRESSION; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 0035423390     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.3.1179     Document Type: Article

References (70)

1. Immunobiology of dendritic cells
2. Dendritic cell regulation of Th1-Th2 development
3. Natural adjuvants: Endogenous activators of dendritic cells
4. Coordinated events during bacteria-induced DC maturation
5. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
6. Virus interactions with dendritic cells
7. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
8. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
9. Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming
10. Interferons, a group of multiple lymphokines
11. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
12. Injection of mice with antibody to mouse interferon α/β decreases the level of 2′-5′ oligoadenylate synthetase in peritoneal macrophages
13. The function of type I interferons in antimicrobial immunity
14. Production of interferon-α/β by murine dendritic cell lines stimulated by virus and bacteria
15. Natural interferon α/β-producing cells link innate and adaptive immunity
16. Type I IFNs enhance the terminal differentiation of dendritic cells
17. Interferon-α and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells
18. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice
19. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo
20. The neglected role of type I interferon in the T cell-response: Implications for its clinical use
21. Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor
22. The pleiotropic functions of interleukin 15: Not so interleukin 2-like after all
23. Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor
24. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15
25. Induction and regulation of IL-15 expression in murine macrophages
26. IL-15 is a novel growth factor for murine γδ T cells induced by Salmonella infection
27. Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans
28. IL-15, an immunomodulator of T cell responses in intracellular infection
29. + T cells in vivo by IL-15
30. Functional role of type I and type II interferons in antiviral defense
31. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
32. lo thymocytes in vivo
33. A method for the large scale production of potent interferon preparations
34. The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells
35. Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone
36. Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA
37. Transfer of proteins from SDS-polyacrylamide gels to solid supports: Immunological detection of immobilized proteins (Western blotting)
38. Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes
39. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo
40. Studies on the expression of spontaneous and induced interferons in mouse peritoneal macrophages by means of monoclonal antibodies to mouse interferons
41. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
42. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo
43. + lymphoid dendritic cells
44. Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms
45. IL-15 is produced by a subset of human melanomas, and is involved in the regulation of markers of melanoma progression through juxtacrine loops
46. Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-upregulated interleukin-15
47. Differences in interleukin-12 and -15 production by dendritic cells at the early stage of Listeria monocytogenes infection between BALB/c and C57 BL/6 mice
48. Viral activation of interleukin-15 (IL-15): Characterization of a virus-inducible element in the IL-15 promoter region
49. + T-helper and a T-killer cell
50. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
51. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
52. Maturation of human monocyte-derived dendritic cells studied by microarray hybridization
53. IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production
54. IL-15/IL-15Rα intracellular trafficking in human melanoma cells and signal transduction through the IL-15Rα
55. Expression of functional IL-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma
56. Chemoattraction of human blood T lymphocytes by interleukin-15
57. + T cells for IFN-γ but have differential effects on priming for IL-4
58. IL-15 stimulates the expansion of AIDS virus-specific CTL
59. Interleukin-15 induces the expression of mRNAs of cytolytic mediators and augments cytotoxic activities in primary murine lymphocytes
60. Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells
61. + T cell-mediated immunity against Toxoplasma gondii infection in mice
62. Interleukin-15 acts as an immunological co-adjuvant for liposomal antigen in vivo
63. Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fcγ2a protein blocks delayed-type hypersensitivity
64. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine
65. Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology
66. Selective blockade of IL-15 by soluble IL-15 receptor α-chain enhances cardiac allograft survival
67. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells
68. CD8 T-cell infiltration in extravascular tissues of patients with human immunodeficiency virus infection: Interleukin-15 upmodulates costimulatory pathways involved in the antigen-presenting cells-T-cell interaction
69. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens
70. In vivo modulation of vaccine-induced immune responses toward a Th1 phenotype increases potency and vaccine effectiveness in a herpes simplex virus type 2 mouse model