T helper type 1 and 17 cells determine efficacy of interferon-Β in multiple sclerosis and experimental encephalomyelitis

Nature Medicine

Volumn 16, Issue 4, 2010, Pages 406-412

  Axtell, Robert C ^a   De Jong, Brigit A ^a,b,c   Boniface, Katia ^d   Van Der Voort, Laura F ^c   Bhat, Roopa ^a   De Sarno, Patrizia ^e   Naves, Rodrigo ^f   Han, May ^a   Zhong, Franklin ^a   Castellanos, Jim G ^a   Mair, Robert ^a   Christakos, Athena ^a   Kolkowitz, Ilan ^a   Katz, Liat ^a   Killestein, Joep ^c   Polman, Chris H ^c   De Waal Malefyt, René ^d   Steinman, Lawrence ^a   Raman, Chander ^f  

^a STANFORD UNIVERSITY   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MERCK RESEARCH LABORATORIES   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^f University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 9; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17F; STAT1 PROTEIN; STAT2 PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; HUMAN; HUMAN CELL; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECURRENT DISEASE; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN CELL; TH1 CELL; TH17 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; INTERFERON-BETA; INTERFERON-GAMMA; INTERFERON-STIMULATED GENE FACTOR 3; INTERLEUKIN-10; INTERLEUKIN-17; MICE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS;

EID: 77950534540     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2110     Document Type: Article

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