MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

Journal of Clinical Investigation

Volumn 116, Issue 8, 2006, Pages 2262-2271

  Chen, Chun Jen ^a   Shi, Yan ^a,c   Hearn, Arron ^a   Fitzgerald, Kate ^a   Golenbock, Douglas ^a   Reed, George ^a   Akira, Shizuo ^b   Rock, Kenneth L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN RECEPTOR; MYD88 ADAPTOR LIKE PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; TIR DOMAIN CONTAINING ADAPTOR INDUCING INTERFERON BETA; TIR DOMAIN CONTAINING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRIF RELATED ADAPTOR MOLECULE; UNCLASSIFIED DRUG; URATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GOUT; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; GOUT; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; URIC ACID;

EID: 33746747096     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI28075     Document Type: Article

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