메뉴 건너뛰기




Volumn 243, Issue 1, 2011, Pages 109-118

The PYHIN protein family as mediators of host defenses

Author keywords

DNA; Inflammasomes; Innate immunity; Interferon; PYHINs

Indexed keywords

AIM2 PROTEIN; CRYOPYRIN; I KAPPA B; IFI16 PROTEIN; INFLAMMASOME; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LISTERIOLYSIN O; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; P202 PROTEIN; P204 PROTEIN; PROTEIN; PYHIN PROTEIN; STAT1 PROTEIN; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 80052152283     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2011.01053.x     Document Type: Review
Times cited : (183)

References (74)
  • 1
    • 75649106430 scopus 로고    scopus 로고
    • Intracellular DNA recognition
    • Hornung V, Latz E. Intracellular DNA recognition. Nat Rev Immunol 2010;10:123-130.
    • (2010) Nat Rev Immunol , vol.10 , pp. 123-130
    • Hornung, V.1    Latz, E.2
  • 2
    • 79959377900 scopus 로고    scopus 로고
    • IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA
    • Pichlmair A, et al. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol 2011;12:624-630.
    • (2011) Nat Immunol , vol.12 , pp. 624-630
    • Pichlmair, A.1
  • 3
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 4
    • 34547143110 scopus 로고    scopus 로고
    • DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    • Takaoka A, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007;448:501-505.
    • (2007) Nature , vol.448 , pp. 501-505
    • Takaoka, A.1
  • 5
    • 60749104535 scopus 로고    scopus 로고
    • HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    • Roberts TL, et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 2009;323:1057-1060.
    • (2009) Science , vol.323 , pp. 1057-1060
    • Roberts, T.L.1
  • 6
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri T, Yu J-W, Datta P, Wu J, Alnemri ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009;458:509-513.
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.-W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 7
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    • Hornung V, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009;458:514-518.
    • (2009) Nature , vol.458 , pp. 514-518
    • Hornung, V.1
  • 8
    • 60749136484 scopus 로고    scopus 로고
    • An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
    • Bürckstümmer T, et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 2009;10:266-272.
    • (2009) Nat Immunol , vol.10 , pp. 266-272
    • Bürckstümmer, T.1
  • 9
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
    • Chiu Y-H, MacMillan JB, Chen ZJ. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009;138:576-591.
    • (2009) Cell , vol.138 , pp. 576-591
    • Chiu, Y.-H.1    MacMillan, J.B.2    Chen, Z.J.3
  • 10
    • 70349459734 scopus 로고    scopus 로고
    • RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    • Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009;10:1065-1072.
    • (2009) Nat Immunol , vol.10 , pp. 1065-1072
    • Ablasser, A.1    Bauernfeind, F.2    Hartmann, G.3    Latz, E.4    Fitzgerald, K.A.5    Hornung, V.6
  • 11
    • 77952566304 scopus 로고    scopus 로고
    • The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
    • Yang P, et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 2010;11:487-494.
    • (2010) Nat Immunol , vol.11 , pp. 487-494
    • Yang, P.1
  • 12
    • 77957009390 scopus 로고    scopus 로고
    • Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
    • Kim T, et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci USA 2010;107:15181-15186.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15181-15186
    • Kim, T.1
  • 13
    • 79955004696 scopus 로고    scopus 로고
    • Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN
    • Zhang X, et al. Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN. J Immunol 2011;186:4541-4545.
    • (2011) J Immunol , vol.186 , pp. 4541-4545
    • Zhang, X.1
  • 14
    • 77958140656 scopus 로고    scopus 로고
    • IFI16 is an innate immune sensor for intracellular DNA
    • Unterholzner L, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010;11:997-1004.
    • (2010) Nat Immunol , vol.11 , pp. 997-1004
    • Unterholzner, L.1
  • 15
    • 22144490446 scopus 로고    scopus 로고
    • The HIN-200 family: more than interferon-inducible genes?
    • Ludlow LEA, Johnstone RW, Clarke CJP. The HIN-200 family: more than interferon-inducible genes? Exp Cell Res 2005;308:1-17.
    • (2005) Exp Cell Res , vol.308 , pp. 1-17
    • Ludlow, L.E.A.1    Johnstone, R.W.2    Clarke, C.J.P.3
  • 16
    • 34247842740 scopus 로고    scopus 로고
    • The death domain superfamily in intracellular signaling of apoptosis and inflammation
    • Park HH, Lo Y-C, Lin S-C, Wang L, Yang JK, Wu H. The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu Rev Immunol 2007;25:561-586.
    • (2007) Annu Rev Immunol , vol.25 , pp. 561-586
    • Park, H.H.1    Lo, Y.-C.2    Lin, S.-C.3    Wang, L.4    Yang, J.K.5    Wu, H.6
  • 17
  • 18
    • 79952468076 scopus 로고    scopus 로고
    • Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
    • Liao JCC, et al. Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Structure 2011;19:418-429.
    • (2011) Structure , vol.19 , pp. 418-429
    • Liao, J.C.C.1
  • 20
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002;10:417-426.
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 21
    • 33746028777 scopus 로고    scopus 로고
    • Intracellular pattern recognition receptors in the host response
    • Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature 2006;442:39-44.
    • (2006) Nature , vol.442 , pp. 39-44
    • Meylan, E.1    Tschopp, J.2    Karin, M.3
  • 22
    • 58049200723 scopus 로고    scopus 로고
    • Function of Nod-like receptors in microbial recognition and host defense
    • Franchi L, Warner N, Viani K, Nunez G. Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev 2009;227:106-128.
    • (2009) Immunol Rev , vol.227 , pp. 106-128
    • Franchi, L.1    Warner, N.2    Viani, K.3    Nunez, G.4
  • 24
    • 0036398446 scopus 로고    scopus 로고
    • The IL-1 family and inflammatory diseases
    • Dinarello CA. The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 2002;20:S1-S13.
    • (2002) Clin Exp Rheumatol , vol.20
    • Dinarello, C.A.1
  • 25
    • 22444433175 scopus 로고    scopus 로고
    • NLRs join TLRs as innate sensors of pathogens
    • Martinon F, Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005;26:447-454.
    • (2005) Trends Immunol , vol.26 , pp. 447-454
    • Martinon, F.1    Tschopp, J.2
  • 26
    • 0037679086 scopus 로고    scopus 로고
    • Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure
    • Dinarello CA, Novick D, Rubinstein M, Lonnemann G. Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure. Blood Purif 2003;21:258-270.
    • (2003) Blood Purif , vol.21 , pp. 258-270
    • Dinarello, C.A.1    Novick, D.2    Rubinstein, M.3    Lonnemann, G.4
  • 27
    • 77249118801 scopus 로고    scopus 로고
    • The inflammasomes: mechanisms of activation and function
    • Latz E. The inflammasomes: mechanisms of activation and function. Curr Opin Immunol 2010;22:28-33.
    • (2010) Curr Opin Immunol , vol.22 , pp. 28-33
    • Latz, E.1
  • 28
    • 40449097257 scopus 로고    scopus 로고
    • The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    • Muruve DA, et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008;452:103-107.
    • (2008) Nature , vol.452 , pp. 103-107
    • Muruve, D.A.1
  • 29
    • 77951263260 scopus 로고    scopus 로고
    • The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    • Fernandes-Alnemri T, et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol 2010;11:385-393.
    • (2010) Nat Immunol , vol.11 , pp. 385-393
    • Fernandes-Alnemri, T.1
  • 30
    • 77951269392 scopus 로고    scopus 로고
    • The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    • Rathinam VAK, et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 2010;11:395-402.
    • (2010) Nat Immunol , vol.11 , pp. 395-402
    • Rathinam, V.A.K.1
  • 32
    • 0034327172 scopus 로고    scopus 로고
    • Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection
    • Pien GC, Satoskar AR, Takeda K, Akira S, Biron CA. Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection. J Immunol 2000;165:4787-4791.
    • (2000) J Immunol , vol.165 , pp. 4787-4791
    • Pien, G.C.1    Satoskar, A.R.2    Takeda, K.3    Akira, S.4    Biron, C.A.5
  • 33
    • 26844452231 scopus 로고    scopus 로고
    • Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
    • Mariathasan S, Weiss DS, Dixit VM, Monack DM. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med 2005;202:1043-1049.
    • (2005) J Exp Med , vol.202 , pp. 1043-1049
    • Mariathasan, S.1    Weiss, D.S.2    Dixit, V.M.3    Monack, D.M.4
  • 34
    • 34249044447 scopus 로고    scopus 로고
    • Type I interferon signaling is required for activation of the inflammasome during Francisella infection
    • Henry T, Brotcke A, Weiss DS, Thompson LJ, Monack DM. Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J Exp Med 2007;204:987-994.
    • (2007) J Exp Med , vol.204 , pp. 987-994
    • Henry, T.1    Brotcke, A.2    Weiss, D.S.3    Thompson, L.J.4    Monack, D.M.5
  • 35
    • 78049394393 scopus 로고    scopus 로고
    • Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
    • Ulland TK, et al. Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. J Immunol 2010;185:2670-2674.
    • (2010) J Immunol , vol.185 , pp. 2670-2674
    • Ulland, T.K.1
  • 36
    • 1042292574 scopus 로고    scopus 로고
    • Roles of caspase-1 in Listeria infection in mice
    • Tsuji NM, et al. Roles of caspase-1 in Listeria infection in mice. Int Immunol 2004;16:335-343.
    • (2004) Int Immunol , vol.16 , pp. 335-343
    • Tsuji, N.M.1
  • 37
    • 34547101484 scopus 로고    scopus 로고
    • Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria
    • Franchi L, Kanneganti TD, Dubyak GR, Nunez G. Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem 2007;282:18810-18818.
    • (2007) J Biol Chem , vol.282 , pp. 18810-18818
    • Franchi, L.1    Kanneganti, T.D.2    Dubyak, G.R.3    Nunez, G.4
  • 38
    • 32944470765 scopus 로고    scopus 로고
    • Cryopyrin activates the inflammasome in response to toxins and ATP
    • Mariathasan S, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006;440:228-232.
    • (2006) Nature , vol.440 , pp. 228-232
    • Mariathasan, S.1
  • 39
    • 47249095738 scopus 로고    scopus 로고
    • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection
    • Warren SE, Mao DP, Rodriguez AE, Miao EA, Aderem A. Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J Immunol 2008;180:7558-7564.
    • (2008) J Immunol , vol.180 , pp. 7558-7564
    • Warren, S.E.1    Mao, D.P.2    Rodriguez, A.E.3    Miao, E.A.4    Aderem, A.5
  • 40
    • 77953305895 scopus 로고    scopus 로고
    • Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
    • Kim S, et al. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur J Immunol 2010;40:1545-1551.
    • (2010) Eur J Immunol , vol.40 , pp. 1545-1551
    • Kim, S.1
  • 41
    • 77955501642 scopus 로고    scopus 로고
    • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2
    • Warren SE, et al. Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. J Immunol 2010;185:818-821.
    • (2010) J Immunol , vol.185 , pp. 818-821
    • Warren, S.E.1
  • 42
    • 77955294800 scopus 로고    scopus 로고
    • Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol
    • Sauer JD, Witte CE, Zemansky J, Hanson B, Lauer P, Portnoy DA. Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. Cell Host Microb 2010;7:412-419.
    • (2010) Cell Host Microb , vol.7 , pp. 412-419
    • Sauer, J.D.1    Witte, C.E.2    Zemansky, J.3    Hanson, B.4    Lauer, P.5    Portnoy, D.A.6
  • 43
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • Ishii KJ, et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2005;7:40-48.
    • (2005) Nat Immunol , vol.7 , pp. 40-48
    • Ishii, K.J.1
  • 44
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006;24:93-103.
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 45
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • Ishikawa H, Barber GN. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008;455:674-678.
    • (2008) Nature , vol.455 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 46
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009;461:788-792.
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 47
    • 67651125824 scopus 로고    scopus 로고
    • A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
    • McWhirter SM, et al. A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med 2009;206:1899-1911.
    • (2009) J Exp Med , vol.206 , pp. 1899-1911
    • McWhirter, S.M.1
  • 48
    • 79251506939 scopus 로고    scopus 로고
    • The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides
    • Sauer J-D, et al. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun 2011;79:688-694.
    • (2011) Infect Immun , vol.79 , pp. 688-694
    • Sauer, J.-D.1
  • 49
    • 49149114140 scopus 로고    scopus 로고
    • The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
    • Soulat D, et al. The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J 2008;27:2135-2146.
    • (2008) EMBO J , vol.27 , pp. 2135-2146
    • Soulat, D.1
  • 50
    • 49149113373 scopus 로고    scopus 로고
    • Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
    • Schroder M, Baran M, Bowie AG. Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. EMBO J 2008;27:2147-2157.
    • (2008) EMBO J , vol.27 , pp. 2147-2157
    • Schroder, M.1    Baran, M.2    Bowie, A.G.3
  • 51
    • 0033568734 scopus 로고    scopus 로고
    • The interferon-inducible 204 gene, a member of the Ifi 200 family, is not involved in the antiviral state induction by IFN-α, but is required by the mouse Cytomegalovirus for its replication
    • Hertel L, De Andrea M, Azzimonti B, Rolle A. The interferon-inducible 204 gene, a member of the Ifi 200 family, is not involved in the antiviral state induction by IFN-α, but is required by the mouse Cytomegalovirus for its replication. Virology 1999;262:1-8.
    • (1999) Virology , vol.262 , pp. 1-8
    • Hertel, L.1    De Andrea, M.2    Azzimonti, B.3    Rolle, A.4
  • 52
    • 0035422753 scopus 로고    scopus 로고
    • The interferon-inducible 204 gene is transcriptionally activated by mouse cytomegalovirus and is required for its replication
    • Rolle S, et al. The interferon-inducible 204 gene is transcriptionally activated by mouse cytomegalovirus and is required for its replication. Virology 2001;286:249-255.
    • (2001) Virology , vol.286 , pp. 249-255
    • Rolle, S.1
  • 53
    • 77954485440 scopus 로고    scopus 로고
    • Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein
    • Cristea IM, et al. Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol 2010;84:7803-7814.
    • (2010) J Virol , vol.84 , pp. 7803-7814
    • Cristea, I.M.1
  • 54
    • 79956061094 scopus 로고    scopus 로고
    • IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
    • Kerur N, et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 2011;9:363-375.
    • (2011) Cell Host Microbe , vol.9 , pp. 363-375
    • Kerur, N.1
  • 55
    • 0033568547 scopus 로고    scopus 로고
    • Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster
    • Wang H, et al. Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster. Genomics 1999;60:281-294.
    • (1999) Genomics , vol.60 , pp. 281-294
    • Wang, H.1
  • 56
    • 0037927519 scopus 로고    scopus 로고
    • The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers
    • Ma X-Y, Wang H, Ding B, Zhong H, Ghosh S, Lengyel P. The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. J Biol Chem 2003;278:23008-23019.
    • (2003) J Biol Chem , vol.278 , pp. 23008-23019
    • Ma, X.-Y.1    Wang, H.2    Ding, B.3    Zhong, H.4    Ghosh, S.5    Lengyel, P.6
  • 57
    • 0029656068 scopus 로고    scopus 로고
    • The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities
    • Min W, Ghosh S, Lengyel P. The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities. Mol Cell Biol 1996;16:359-368.
    • (1996) Mol Cell Biol , vol.16 , pp. 359-368
    • Min, W.1    Ghosh, S.2    Lengyel, P.3
  • 58
    • 0031882131 scopus 로고    scopus 로고
    • Increase in p202 expression during skeletal muscle differentiation: inhibition of MyoD protein expression and activity by p202
    • Datta B, Min W, Burma S, Lengyel P. Increase in p202 expression during skeletal muscle differentiation: inhibition of MyoD protein expression and activity by p202. Mol Cell Biol 1998;18:1074-1083.
    • (1998) Mol Cell Biol , vol.18 , pp. 1074-1083
    • Datta, B.1    Min, W.2    Burma, S.3    Lengyel, P.4
  • 59
    • 0032963397 scopus 로고    scopus 로고
    • Retardation of cell proliferation after expression of p202 accompanies an increase in p21(WAF1/CIP1)
    • Gutterman JU, Choubey D. Retardation of cell proliferation after expression of p202 accompanies an increase in p21(WAF1/CIP1). Cell Growth Differ 1999;10:93-100.
    • (1999) Cell Growth Differ , vol.10 , pp. 93-100
    • Gutterman, J.U.1    Choubey, D.2
  • 60
    • 0042567245 scopus 로고    scopus 로고
    • Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence
    • Xin H, Curry J, Johnstone RW, Nickoloff BJ, Choubey D. Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene 2003;22:4831-4840.
    • (2003) Oncogene , vol.22 , pp. 4831-4840
    • Xin, H.1    Curry, J.2    Johnstone, R.W.3    Nickoloff, B.J.4    Choubey, D.5
  • 62
    • 0030750887 scopus 로고    scopus 로고
    • Inhibition of E2F-4/DP-1-stimulated transcription by p202
    • Choubey D, Gutterman JU. Inhibition of E2F-4/DP-1-stimulated transcription by p202. Oncogene 1997;15:291-301.
    • (1997) Oncogene , vol.15 , pp. 291-301
    • Choubey, D.1    Gutterman, J.U.2
  • 63
    • 0035909526 scopus 로고    scopus 로고
    • p202, an interferon-inducible negative regulator of cell growth, is a target of the adenovirus E1A protein
    • Xin H, D'Souza S, Fang L, Lengyel P, Choubey D. p202, an interferon-inducible negative regulator of cell growth, is a target of the adenovirus E1A protein. Oncogene 2001;20:6828-6839.
    • (2001) Oncogene , vol.20 , pp. 6828-6839
    • Xin, H.1    D'Souza, S.2    Fang, L.3    Lengyel, P.4    Choubey, D.5
  • 64
    • 0035808387 scopus 로고    scopus 로고
    • The gene encoding p202, an interferon-inducible negative regulator of the p53 tumor suppressor, is a target of p53-mediated transcriptional repression
    • D'Souza S, Xin H, Walter S, Choubey D. The gene encoding p202, an interferon-inducible negative regulator of the p53 tumor suppressor, is a target of p53-mediated transcriptional repression. J Biol Chem 2001; 276:298-305.
    • (2001) J Biol Chem , vol.276 , pp. 298-305
    • D'Souza, S.1    Xin, H.2    Walter, S.3    Choubey, D.4
  • 65
    • 0029861053 scopus 로고    scopus 로고
    • p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition
    • Datta B, Li B, Choubey D, Nallur G, Lengyel P. p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J Biol Chem 1996;271:27544-27555.
    • (1996) J Biol Chem , vol.271 , pp. 27544-27555
    • Datta, B.1    Li, B.2    Choubey, D.3    Nallur, G.4    Lengyel, P.5
  • 66
    • 77955853897 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins
    • Veeranki S, Choubey D. Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins. Immunol Lett 2010;133:1-5.
    • (2010) Immunol Lett , vol.133 , pp. 1-5
    • Veeranki, S.1    Choubey, D.2
  • 67
    • 0034814052 scopus 로고    scopus 로고
    • Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus
    • Rozzo SJ, et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity 2001;15:435-443.
    • (2001) Immunity , vol.15 , pp. 435-443
    • Rozzo, S.J.1
  • 68
    • 33646475561 scopus 로고    scopus 로고
    • Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis
    • Xin H, et al. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol 2006;176:5863-5870.
    • (2006) J Immunol , vol.176 , pp. 5863-5870
    • Xin, H.1
  • 69
    • 78650674088 scopus 로고    scopus 로고
    • AIM2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus
    • Panchanathan R, et al. AIM2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. J Immunol 2010;185:7385-7393.
    • (2010) J Immunol , vol.185 , pp. 7385-7393
    • Panchanathan, R.1
  • 70
    • 79959564985 scopus 로고    scopus 로고
    • AIM2 deficiency in mice suppresses the expression of the inhibitory Fcγ receptor (FcγRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein
    • Panchanathan R, et al. AIM2 deficiency in mice suppresses the expression of the inhibitory Fcγ receptor (FcγRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein. J Immunol 2011; 186:6762-6770.
    • (2011) J Immunol , vol.186 , pp. 6762-6770
    • Panchanathan, R.1
  • 71
    • 77957951602 scopus 로고    scopus 로고
    • Genomes in conflict: maintaining genome integrity during virus infection
    • Weitzman MD, Lilley CE, Chaurushiya MS. Genomes in conflict: maintaining genome integrity during virus infection. Annu Rev Microbiol 2010;64:61-81.
    • (2010) Annu Rev Microbiol , vol.64 , pp. 61-81
    • Weitzman, M.D.1    Lilley, C.E.2    Chaurushiya, M.S.3
  • 72
    • 33847686708 scopus 로고    scopus 로고
    • Using or abusing: viruses and the cellular DNA damage response
    • Lilley CE, Schwartz RA, Weitzman MD. Using or abusing: viruses and the cellular DNA damage response. Trends Microbiol 2007;15:119-126.
    • (2007) Trends Microbiol , vol.15 , pp. 119-126
    • Lilley, C.E.1    Schwartz, R.A.2    Weitzman, M.D.3
  • 73
    • 9144269673 scopus 로고    scopus 로고
    • A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway
    • Aglipay JA, et al. A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 2003;22:8931-8938.
    • (2003) Oncogene , vol.22 , pp. 8931-8938
    • Aglipay, J.A.1
  • 74
    • 79551502554 scopus 로고    scopus 로고
    • Redistribution of the nuclear protein IFI16 into the cytoplasm of UVB-exposed keratinocytes as a mechanism of autoantigen processing
    • Costa S, et al. Redistribution of the nuclear protein IFI16 into the cytoplasm of UVB-exposed keratinocytes as a mechanism of autoantigen processing. Br J Dermatol 2010;164:282-290.
    • (2010) Br J Dermatol , vol.164 , pp. 282-290
    • Costa, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.