An extensive screen of the HLA region reveals an independent association of HLA class i and class II with susceptibility for systemic lupus erythematosus

Scandinavian Journal of Rheumatology

Volumn 38, Issue 4, 2009, Pages 256-262

  Martens, H A ^a   Nolte, I M ^a   Van Der Steege, G ^a   Schipper, M ^a   Kallenberg, C G M ^a   Te Meerman, G J ^a   Bijl, M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGE OF ONSET; AGED; ALLELES; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-D ANTIGENS; HUMANS; INCIDENCE; LINKAGE DISEQUILIBRIUM; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; NETHERLANDS; PEDIGREE; POLYMERASE CHAIN REACTION; PROBABILITY; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 70350630253     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.1080/03009740802552469     Document Type: Article

References (28)

1. Tsao BP. Update on human systemic lupus erythematosus genetics. Curr Opin Rheumatol 2004;16:513-521
2. Kelly JA, Moser KL, Harley JB. The genetics of systemic lupus erythematosus: Putting the pieces together. Genes Immun 2002;3(Suppl 1):S71-S85.
3. Croker JA, Kimberly RP. Genetics of susceptibility and severity in systemic lupus erythematosus. Curr Opin Rheumatol 2005;17:529-537
4. Graham RR, Ortmann WA, Langefeld CD, Jawaheer D, Selby SA, Rodine PR, et al. Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet 2002;71:543-553
5. Smerdel-Ramoya A, Finholt C, Lilleby V, Gilboe IM, Harbo HF, Maslinski S, et al. Systemic lupus erythematosus and the extended major histocompatibility complex - evidence for several predisposing loci. Rheumatology (Oxford) 2005;44:1368-1373
6. Rood MJ, van Krugten MV, Zanelli E, van der Linden MW, Keijsers V, Schreuder GM, et al. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. Arthritis Rheum 2000;43:129-134
7. Tsuchiya N, Kawasaki A, Tsao BP, Komata T, Grossman JM, Tokunaga K. Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun 2001;2:317-322
8. International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN) , Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008;40:204-210
9. Fernando MM, Stevens CR, Sabeti PC, Walsh EC, McWhinnie AJ, Shah A, et al. Identification of two independent risk factors for lupus within the MHC in United Kingdom families. PLoS Genet 2007;3:e192.
10. Wallace DJ, Hahn BH. Dubois' lupus erythematosus. 6th edn, Philadelphia: Lippincott Williams & Wilkins, 2002.
11. Lee YH, Nath SK. Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Genet 2005;118:434-443
12. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-1277
13. Beckmann L, Fischer C, Deck KG, Nolte IM, te Meerman G, Chang-Claude J. Exploring haplotype sharing methods in general and isolated populations to detect gene(s) of a complex genetic trait. Genet Epidemiol 2001;21(Suppl 1):S554-S559.
14. Boon M, Nolte IM, Bruinenberg M, Spijker GT, Terpstra P, Raelson J, et al. Mapping of a susceptibility gene for multiple sclerosis to the 51 kb interval between G511525 and D6S1666 using a new method of haplotype sharing analysis. Neurogenetics 2001;3:221-230
15. Levinson DF, Kirby A, Slepner S, Nolte I, Spijker GT, te Meerman G. Simulation studies of detection of a complex disease in a partially isolated population. Am J Med Genet 2001;105:65-70.
16. Martens HA, Nolte IM, Van der Steege G, Schipper M, Kallenberg CG, Te Meerman GJ, et al. Association of poly(ADP-ribose) polymerase 1 and a novel candidate locus, LOC127086, with systemic lupus erythematosus. Ann Rheum Dis 2007;66:424-425
17. Sham PC, Curtis D. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 1995;59(Pt 3):323-336
18. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: The insulin gene region and insulindependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-516
19. Spijker GT, Nolte IM, Jansen RC, te Meerman GJ. Genetic association studies in complex disease: Disentangling additional predisposing loci from associated neutral loci using a constrained-permutation approach. Ann Hum Genet 2005;69(Pt 1):90-101.
20. McHugh NJ, Owen P, Cox B, Dunphy J, Welsh K. MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus. Ann Rheum Dis 2006;65:488-494
21. Diamond B, Katz JB, Paul E, Aranow C, Lustgarten D, Scharff MD. The role of somatic mutation in the pathogenic anti-DNA response. Annu Rev Immunol 1992;10:731-757
22. Graham RR, Ortmann W, Rodine P, Espe K, Langefeld C, Lange E, et al. Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE. Eur J Hum Genet 2007;15:823-830
23. Gambelunghe G, Gerli R, Bocci EB, Del Sindaco P, Ghaderi M, Sanjeevi CB, et al. Contribution of MHC class I chain-related A (MICA) gene polymorphism to genetic susceptibility for systemic lupus erythematosus. Rheumatology (Oxford) 2005;44:287-292
24. Morgan BP, Walport MJ. Complement deficiency and disease. Immunol Today 1991;12:301-306
25. Pickering MC, Walport MJ. Links between complement abnormalities and systemic lupus erythematosus. Rheumatology (Oxford) 2000;39:133-141
26. Studnicka-Benke A, Steiner G, Petera P, Smolen JS. Tumour necrosis factor alpha and its soluble receptors parallel clinical disease and autoimmune activity in systemic lupus erythematosus. Br J Rheumatol 1996;35:1067-1074
27. Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet 2006;14:364-371
28. Diepstra A, Niens M, Vellenga E, van Imhoff GW, Nolte IM, Schaapveld M, et al. Association with HLA class I in Epstein- Barr-virus-positive and with HLA class III in Epstein- Barr-virus-negative Hodgkin's lymphoma. Lancet 2005;365: 2216-2224