Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

Journal of Experimental Medicine

Volumn 206, Issue 7, 2009, Pages 1589-1602

  Longhi, M Paula ^a   Trumpfheller, Christine ^a   Idoyaga, Juliana ^a   Caskey, Marina ^a   Matos, Ines ^a   Kluger, Courtney ^a   Salazar, Andres M ^b   Colonna, Marco ^c   Steinman, Ralph M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b Oncovir Inc   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON RECEPTOR; GAG PROTEIN; GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERFERON; INTERLEUKIN 12P40; POLYINOSINIC POLYCYTIDYLIC ACID; STAT1 PROTEIN; TOLL LIKE RECEPTOR 3;

ADAPTIVE IMMUNITY; ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL MATURATION; CELLULAR IMMUNITY; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG EFFICACY; HOST CELL; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; STROMA CELL; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CHIMERA; CYTOKINES; DENDRITIC CELLS; IMMUNITY, INNATE; INTERFERON TYPE I; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; POLY I-C; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 67650445798     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20090247     Document Type: Article

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