Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Nature Cell Biology

Volumn 8, Issue 10, 2006, Pages 1124-1132

  Yousefi, Shida ^a   Perozzo, Remo ^a   Schmid, Inès ^a   Ziemiecki, Andrew ^a   Schaffner, Thomas ^a   Scapozza, Leonardo ^b   Brunner, Thomas ^a   Simon, Hans Uwe ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AUTOPHAGY RELATED GENE PROTEIN 5; CALPAIN; CYCLOHEXIMIDE; CYTOCHROME C; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; GENE PRODUCT; LENTIVIRUS VECTOR; PROTEIN ATG5; PROTEIN BCL XL; SMALL INTERFERING RNA; STAUROSPORINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL TYPE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENE TRANSFER; GENE TRANSLOCATION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL LINE; MITOCHONDRION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; TUMOR XENOGRAFT;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CALPAIN; CASPASES; CYTOCHROMES C; CYTOSOL; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; ENZYME INHIBITORS; ETOPOSIDE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HELA CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; STAUROSPORINE;

EID: 33749162486     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1482     Document Type: Article

References (35)

1. Levine, B. & Klionsky, D. J. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477 (2004).
2. Gozuacik, D. & Kimchi, A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23, 2891-2906 (2004).
3. Blommaart, E. F., Luiken, J. J. & Meijer, A. J. Autophagic proteolysis: control and specificity. Histochem. J. 29, 365-385 (1997).
4. Yu, L. et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304, 1500-1502 (2004).
5. Shimizu, S. et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nature Cell Biol. 6, 1221-1228 (2004).
6. Mizushima, N. et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J. Cell. Biol. 152, 657-667 (2001).
7. Qu, X. et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 gene. J. Clin. Invest. 112, 1809-1820 (2003).
8. Yue, Z., Jin, S., Yang, C., Levine, A. J. & Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA 100, 15077-15082 (2003).
9. Goldstein, J. C., Waterhouse, N. J., Juin, P., Evan, G. I. & Green, D. R. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nature Cell Biol. 2, 156-162 (2000).
10. Simon, H.-U. Neutrophil apoptosis pathways and their modifications in inflammation. Immunol. Rev. 193, 101-110 (2003).
11. Gao, G. & Dou, Q. P. N-terminal cleavage of Bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes Bcl-2-independent cytochrome c release and apoptotic cell death. J. Cell Biochem. 80, 53-72 (2000).
12. Altznauer, F., Conus, S., Cavalli, A., Folkers, G. & Simon, H.-U. Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis. J. Biol. Chem. 279, 5947-5957 (2004).
13. Arthur, J. S., Elce, J. S., Hegadorn, C., Williams, K. & Greer, P. A. Disruption of the murine calpain small subunit gene, Capn4: Calpain is essential for embryonic development but not for cell growth and division. Mol. Cell. Biol. 20, 4474-4481 (2000).
14. Martin, S. J. et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182, 1545-1556 (1995).
15. Strasser, A. The role of BH3-only proteins in the immune system. Nature Rev. Immunol. 5, 189-200 (2005).
16. Marchenko, N. D., Zaika, A. & Moll, U. M. Death signal-induced localization of p53 protein to mitochondria: A potential role in apoptotic signaling. J. Biol. Chem. 275, 16202-16212 (2000).
17. Mihara, M. et al. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 11, 577-590 (2003).
18. Chipuk, J. E. et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303, 1010-1014 (2004).
19. Leu, J. I., Dumont, P., Haley, M., Murphy, M. E. & George, D. L. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nature Cell Biol. 6, 443-450 (2004).
20. Li, H. et al. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science 289, 1159-1164 (2000).
21. Karuman, P. et al. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol. Cell 7, 1307-1319 (2001).
22. Chua, B. T. et al. Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nature Cell Biol. 5, 1083-1089 (2003).
23. Daigle, I., Yousefi, S., Colonna, M., Green, D. R. & Simon, H.-U. Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nature Med. 8, 61-67 (2002).
24. Simon, H.-U. et al. Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. J. Immunol. 165, 4069-4075 (2000).
25. Altznauer, F. et al. Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J. Exp. Med. 199, 1343-1354 (2004).
26. Martinelli, S. et al. Induction of genes mediating interferon-dependent extracellular trap formation during neutrophil differentiation. J. Biol. Chem. 279, 44123-44132 (2004).
27. Adrain, C., Creagh, E. M. & Martin, S. J. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J. 20, 6627-6636 (2001).
28. Yousefi, S., Green, D. R., Blaser, K. & Simon, H.-U. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc. Natl Acad. Sci. USA 91, 10868-10872 (1994).
29. von Gunten, S. et al. Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment. Blood 106, 1423-1431 (2005).
30. Takeuchi, H., Kanzawa, T., Kondo, Y. & Kondo, S. Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells. Br. J. Cancer 90, 1069-1075 (2004).
31. Wolf, B. B. et al. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood 94, 1683-1692 (1999).
32. Bovia, F. et al. Efficient transduction of primary human B lymphocytes and nondividing myeloma B cells with HIV-1-derived lentiviral vectors. Blood 101, 1727-1733 (2003).
33. Wiznerowicz, M. & Trono D. Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J. Virol. 77, 8957-8961 (2003).
34. Costes, S. V. et al. Automatic and quantitative measurement of protein-protein colocalization in live cells. Biophys. J. 86, 3993-4003 (2004).
35. Uren, R. T. et al. Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes. J. Biol. Chem. 280, 2266-2274 (2005).