Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

Journal of Neuroscience

Volumn 20, Issue 18, 2000, Pages 6898-6906

  Koike, Masato ^a   Nakanishi, Hiroshi ^b   Saftig, Paul ^c   Ezaki, Junji ^d   Isahara, Kyoko ^a   Ohsawa, Yoshiyuki ^a   Schulz Schaeffer, Walter ^c   Watanabe, Tsuyoshi ^a   Waguri, Satoshi ^a   Kametaka, Satoshi ^a   Shibata, Masahiro ^a   Yamamoto, Kenji ^b   Kominami, Eiki ^d   Peters, Christoph ^e,f   Von Figura, Kurt ^c   Uchiyama, Yasuo ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF FREIBURG   (Germany)

^f UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Cathepsin D; Cerold lipofuscin; CNS neurons; Knockout mouse; Lysosomal storage; Neuronal ceroid lipofuscinosis; Subunit c of mitochondrial F1FOATPase

Indexed keywords

CATHEPSIN D; CEROID; LIPOFUSCIN; PEPTIDASE; PROTEIN; PROTEINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; CENTRAL NERVOUS SYSTEM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LIPOFUSCINOSIS; LYSOSOME STORAGE DISEASE; MORPHOLOGY; MOUSE; NEWBORN; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY;

EID: 0034666116     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-18-06898.2000     Document Type: Article

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