Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy

Journal of Neuroscience

Volumn 31, Issue 21, 2011, Pages 7817-7830

  Lee, Sooyeon ^a,b   Sato, Yutaka ^b   Nixon, Ralph A ^a,b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CATHEPSIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NEUROFILAMENT PROTEIN; RAB7 PROTEIN; UBIQUITIN;

ACIDIFICATION; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; BRAIN CORTEX; BRAIN NERVE CELL; CELL ORGANELLE; CELL VACUOLE; CONTROLLED STUDY; EMBRYO; ENDOSOME; ENZYME INHIBITION; LYSOSOME; MITOCHONDRION; MOUSE; NERVE FIBER TRANSPORT; NEUROAXONAL DYSTROPHY; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

ALZHEIMER DISEASE; ANIMALS; AXONAL TRANSPORT; AXONS; CELLS, CULTURED; FEMALE; HUMANS; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ORGANELLES; PEPTIDE HYDROLASES; PREGNANCY;

EID: 79957663035     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6412-10.2011     Document Type: Article

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