Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression

Biological Psychiatry

Volumn 68, Issue 10, 2010, Pages 885-893

  Ginsberg, Stephen D ^a,b   Alldred, Melissa J ^a   Counts, Scott E ^c   Cataldo, Anne M ^d   Neve, Rachael L ^e   Jiang, Ying ^a   Wuu, Joanne ^f   Chao, Moses V ^a,b   Mufson, Elliott J ^c   Nixon, Ralph A ^a,b   Che, Shaoli ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d MCLEAN HOSPITAL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Laser capture microdissection; mild cognitive impairment; qPCR; rab5; rab7; RNA amplification; siRNA; TrkB

Indexed keywords

BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CALPASTATIN; CATHEPSIN D; EARLY ENDOSOME ANTIGEN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROTROPHIN RECEPTOR; PROTEIN TRKC; RAB PROTEIN; RAB7 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENDOCYTOSIS; ENDOSOME; FIBROBLAST; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LASER CAPTURE MICRODISSECTION; MICROARRAY ANALYSIS; MILD COGNITIVE IMPAIRMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

AGED, 80 AND OVER; ALZHEIMER DISEASE; CA1 REGION, HIPPOCAMPAL; CELL LINE, TRANSFORMED; DISEASE PROGRESSION; DOWN-REGULATION; ENDOSOMES; FEMALE; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RAB GTP-BINDING PROTEINS; RAB5 GTP-BINDING PROTEINS; RECEPTOR, TRKB; RECEPTOR, TRKC; UP-REGULATION;

EID: 78049427173     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.05.030     Document Type: Article

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