Essential role for Nix in autophagic maturation of erythroid cells

Nature

Volumn 454, Issue 7201, 2008, Pages 232-235

  Sandoval, Hector ^a   Thiagarajan, Perumal ^a   Dasgupta, Swapan K ^a   Schumacher, Armin ^a   Prchal, Josef T ^b   Chen, Min ^a   Wang, Jin ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN BNIP3;

BLOOD; CYTOLOGY; MATURATION;

ANEMIA; ANIMAL CELL; ARTICLE; AUTOPHAGY; BLOOD; CELL MATURATION; CONTROLLED STUDY; EMBRYO; ERYTHROID CELL; LIFESPAN; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; QUALITY CONTROL; RIBOSOME;

MUS;

EID: 47049100413     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07006     Document Type: Article

References (32)

1. Yoshida, H. et al. Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature 437, 754-758 (2005).
2. Fader, C. M. & Colombo, M. I. Multivesicular bodies and autophagy in erythrocyte maturation. Autophagy 2, 122-125 (2006).
3. Koury, M. J., Koury, S. T., Kopsombut, P. & Bondurant, M. C. In vitro maturation of nascent reticulocytes to erythrocytes. Blood 105, 2168-2174 (2005).
4. Kent, G., Minick, O. T., Volini, F. I. & Orfei, E. Autophagic vacuoles in human red cells. Am. J. Pathol. 48, 831-857 (1966).
5. Heynen, M. J. & Verwilghen, R. L. A quantitative ultrastructural study of normal rat erythroblasts and reticulocytes. Cell Tissue Res. 224, 397-408 (1982).
6. Takano-Ohmuro, H., Mukaida, M., Kominami, E. & Morioka, K. Autophagy in embryonic erythroid cells: its role in maturation. Eur. J. Cell Biol. 79, 759-764 (2000).
7. Chen, G. et al. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J. Biol. Chem. 274, 7-10 (1999).
8. Imazu, T. et al. Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene 18, 4523-4529 (1999).
9. -/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc. Natl Acad. Sci. USA 104, 6794-6799 (2007).
10. Aerbajinai, W., Giattina, M., Lee, Y. T., Raffeld, M. & Miller, J. L. The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. Blood 102, 712-717 (2003).
11. Kina, T. et al. The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br. J. Haematol. 109, 280-287 (2000).
12. Pan, B. T. & Johnstone, R. M. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33, 967-978 (1983).
13. -/- mice due to decreased survival of early erythroblasts. Blood 98, 3261-3273 (2001).
14. Holm, T. M. et al. Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. Blood 99, 1817-1824 (2002).
15. Sivilotti, M. L. Oxidant stress and haemolysis of the human erythrocyte. Toxicol. Rev. 23, 169-188 (2004).
16. Raha, S. & Robinson, B. H. Mitochondria, oxygen free radicals, and apoptosis. Am. J. Med. Genet. 106, 62-70 (2001).
17. Hoffmann-Fezer, G. et al. Biotin labeling as an alternative nonradioactive approach to determination of red cell survival. Ann. Hematol. 67, 81-87 (1993).
18. Levin, J. et al. Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood 94, 3037-3047 (1999).
19. Fadok, V. A., Bratton, D. L., Frasch, S. C., Warner, M. L. & Henson, P. M. The role of phosphatidylserine in recognition of apoptotic cells by phagocytes. Cell Death Differ. 5, 551-562 (1998).
20. Caserta, T. M., Smith, A. N., Gultice, A. D., Reedy, M. A. & Brown, T. L. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 8, 345-352 (2003).
21. low mice). Blood 97, 3040-3050 (2001).
22. Lum, J. J. et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248 (2005).
23. Blommaart, E. F., Krause, U., Schellens, J. P., Vreeling-Sindelarova, H. & Meijer, A. J. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243, 240-246 (1997).
24. Kabeya, Y. et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J. Cell Sci. 117, 2805-2812 (2004).
25. Gottlieb, E., Vander Heiden, M. G. & Thompson, C. B. Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor a-induced apoptosis. Mol. Cell. Biol. 20, 5680-5689 (2000).
26. Oltersdorf, T. et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435, 677-681 (2005).
27. Maiuri, M. C. et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 26, 2527-2539 (2007).
28. Kissova, I., Deffieu, M., Manon, S. & Camougrand, N. Uth1p is involved in the autophagic degradation of mitochondria. J. Biol. Chem. 279, 39068-39074 (2004).
29. Tal, R., Winter, G., Ecker, N., Klionsky, D. J. & Abeliovich, H. Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J. Biol. Chem. 282, 5617-5624 (2007).
30. Tatsuta, T. & Langer, T. Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J. 27, 306-314 (2008).
31. Koury, S. T., Koury, M. J. & Bondurant, M. C. Cytoskeletal distribution and function during the maturation and enucleation of mammalian erythroblasts. J. Cell Biol. 109, 3005-3013 (1989).
32. Mok, H., Mendoza, M., Prchal, J. T., Balogh, P. & Schumacher, A. Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice. Development 131, 4871-4881 (2004).