Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease

Journal of Molecular Neuroscience

Volumn 17, Issue 2, 2001, Pages 137-145

  Glabe, C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's pathogenesis; Amyloid accumulation; Dense bodies dystrophic neurites; Intracellular amyloid A ; Lysosomes

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; DEGENERATIVE DISEASE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LYSOSOME; NEURITE; NEUROLOGIC DISEASE; NEUROPATHOLOGY; PATHOGENESIS; SENILE PLAQUE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; BRAIN; HUMANS; INTRACELLULAR FLUID; NEURITES; SENILE PLAQUES;

EID: 0035159785     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:17:2:137     Document Type: Article

References (92)

1. Solution structures of beta peptide and its constituent fragments: Relation to amyloid deposition
2. Hydrogen peroxide mediates amyloid beta protein toxicity
3. The retinal pigment epithelium: A versatile partner in vision
4. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
5. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs
6. Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide A beta 1-42, in differentiated PC 12 cells
7. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor
8. Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein
9. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: Evidence for a neuronal origin
10. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
11. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
12. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation
13. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
14. Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease
15. Caspase activation in dystrophic neurites in Alzheimer's Disease and aged HuAPPsw transgenic mice
16. Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease
17. Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease
18. Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
19. Neurochemical studies: An update on Alzheimer's disease
20. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease
21. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
22. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
23. Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease
24. Complement activation in amyloid plaques in Alzheimer's dementia
25. Involvement of free oxygen radicals in beta-amyloidosis: An hypothesis
26. Transmissible and non-transmissible amyloidoses: Autocatalytic post-translational conversion of host precursor proteins to beta-pleated sheet configurations
27. The pathobiology of Alzheimer's disease
28. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
29. Intraneuronal Abeta42 accumulation in human brain
30. Ubiquitin-mediated degradative pathway degrades the extracellular but not the intracellular form of amyloid beta-protein precursor
31. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
32. The risk factors for Alzheimer's disease: A review and a hypothesis
33. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
34. Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease
35. Free radicals and degenerative diseases of the nervous system
36. Hirano bodies and related neuronal inclusions
37. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage
38. Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease
39. Alzheimer's disease or Alzheimer's diseases? Clues from molecular epidemiology
40. Ubiquitin immunocytochemistry in human spongiform encephalopathies
41. Visualization of Abeta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
42. Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques
43. The immunopathology of Alzheimer's disease and some related disorders
44. Are advanced glycation end-products associated with amyloidosis in Alzheimer's disease?
45. Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein
46. The E280A presenilin 1 Alzheimer mutation produces increased Abeta 42 deposition and severe cerebellar pathology
47. Ubiquitin conjugate immunoreactivity in the brains of scrapie infected mice
48. Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease
49. Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise
50. Endosome-lysosomes, ubiquitin and neurodegeneration
51. Immunohistochemical localization of beta-amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy
52. Neuroimmune mechanisms in Alzheimer disease pathogenesis
53. Dystrophic neurites around amyloid plaques of human patients with Gerstmann-Straussler-Scheinker disease contain ubiquitinated inclusions
54. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
55. Racemization: Its biological significance on neuropathogenesis of Alzheimer's disease
56. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene
57. Alzheimer's disease. Beta-amyloid precursor protein expression in the nucleus basalis of Meynert
58. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
59. The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis
60. The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils
61. Acid phosphatase activity in senile plaques and cerebrospinal fluid of patients with Alzheimer's disease
62. Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease
63. Prions causing nervous system degeneration
64. Inflammation as a pathogenic mechanism in Alzheimer's disease
65. beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of alzheimer disease
66. Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease
67. Altered structural proteins in plaques and tangles: What do they tell us about the biology of Alzheimer's disease?
68. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
69. Alzheimer's disease: Genes, proteins, and therapy
70. Neuritic plaque amyloid inAlzheimer's disease is highly racemized
71. Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia
72. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
73. Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease
74. Radical AGEing in Alzheimer's disease
75. The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease
76. Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome
77. Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation
78. Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease
79. An etiological role of amyloidogenic carboxyl-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease
80. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
81. Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles
82. Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis
83. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue
84. Advanced glycation end products contribute to amyloidosis in Alzheimer disease
85. Ultrastructural studies of the cells forming amyloid fibers in classical plaques
86. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins
87. Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes
88. Ultrastructural localization of argyrophilic substances in diffuse plaques of Alzheimer-type dementia demonstrated by methenamine silver staining
89. Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells
90. Loss of endosomal/lysosmal membrane impermeability is an early event in amyloid A β1-42 pathogenesis
91. Two types of dystrophic neurites in senile plaques of Alzheimer disease and elderly non-demented cases
92. Evidence that A beta 42 is the real culprit in Alzheimer's disease