Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia

Neurobiology of Disease

Volumn 40, Issue 1, 2010, Pages 293-302

  Kilinc, Münire ^a   Gürsoy Özdemir, Yasemin ^b   Gürer, Günfer ^b   Erdener, Sefik Evren ^b   Erdemli, Esra ^c   Can, Alp ^c   Dalkara, Turgay ^b  

^a BASKENT UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c ANKARA UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Caspases; Cathepsins; Focal cerebral ischemia; Necrosis

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CATHEPSIN B; CYSTEINE PROTEINASE; CYTOCHROME C; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ENZYME; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; PROTEIN BID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN TISSUE; CELL INTERACTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOREACTIVITY; ISCHEMIA; LYSOSOME MEMBRANE; LYSOSOME STORAGE DISEASE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN SECRETION; REPERFUSION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BRAIN ISCHEMIA; CELL COMMUNICATION; CYSTEINE PROTEASES; LYSOSOMES; MICE; NECROSIS; NERVE DEGENERATION; NEURONS; RECEPTOR CROSS-TALK;

EID: 77955845955     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.06.003     Document Type: Article

References (38)

1. Asahi M., Hoshimaru M., Uemura Y., Tokime T., Kojima M., Ohtsuka T., Matsuura N., Aoki T., Shibahara K., Kikuchi H. Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. J. Cereb. Blood Flow Metab. 1997, 17:11-18.
2. Benchoua A., Guegan C., Couriaud C., Hosseini H., Sampaio N., Morin D., Onteniente B. Specific caspase pathways are activated in the two stages of cerebral infarction. J. Neurosci. 2001, 21:7127-7134.
3. Benchoua A., Braudeau J., Reis A., Couriaud C., Onteniente B. Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 2004, 24:1272-1279.
4. Brunk U.T., Zhang H., Dalen H., Ollinger K. Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization. Free Radic. Biol. Med. 1995, 19:813-822.
5. Chan P.H. Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia. Neurochem. Res. 2004, 29:1943-1949.
6. Degterev A., Yuan J. Expansion and evolution of cell death programmes. Nat. Rev. Mol. Cell Biol. 2008, 9:378-390.
7. Evans C.J., Aguilera R.J. DNase II: genes, enzymes and function. Gene 2003, 322:1-15.
8. Fujimura M., Morita-Fujimura Y., Noshita N., Sugawara T., Kawase M., Chan P.H. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci. 2000, 20:2817-2824.
9. Guicciardi M.E., Deussing J., Miyoshi H., Bronk S.F., Svingen P.A., Peters C., Kaufmann S.H., Gores G.J. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J. Clin. Invest. 2000, 106:1127-1137.
10. Gurer G., Gursoy-Ozdemir Y., Erdemli E., Can A., Dalkara T. Astrocytes are more resistant to focal cerebral ischemia than neurons and die by a delayed necrosis. Brain Pathol. 2009, 19:630-641.
11. Hill I.E., Preston E., Monette R., MacManus J.P. A comparison of cathepsin B processing and distribution during neuronal death in rats following global ischemia or decapitation necrosis. Brain Res. 1997, 751:206-216.
12. Kalra J., Chaudhary A.K., Prasad K. Role of oxygen free radicals and pH on the release of cardiac lysosomal enzymes. J. Mol. Cell. Cardiol. 1989, 21:1125-1136.
13. Leist M., Jaattela M. Triggering of apoptosis by cathepsins. Cell Death Differ. 2001, 8:324-326.
14. Li W., Yuan X., Nordgren G., Dalen H., Dubowchik G.M., Firestone R.A., Brunk U.T. Induction of cell death by the lysosomotropic detergent MSDH. FEBS Lett. 2000, 470:35-39.
15. Lo E.H., Dalkara T., Moskowitz M.A. Mechanisms, challenges and opportunities in stroke. Nat. Rev. Neurosci. 2003, 4:399-415.
16. Martin L.J., Al-Abdulla N.A., Brambrink A.M., Kirsch J.R., Sieber F.E., Portera-Cailliau C. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis. Brain Res. Bull. 1998, 46:281-309.
17. Martinou J.C., Dubois-Dauphin M., Staple J.K., Rodriguez I., Frankowski H., Missotten M., Albertini P., Talabot D., Catsicas S., Pietra C., et al. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 1994, 13:1017-1030.
18. Mort J.S., Buttle D.J. Cathepsin B. Int. J. Biochem. Cell Biol. 1997, 29:715-720.
19. Namura S., Zhu J., Fink K., Endres M., Srinivasan A., Tomaselli K.J., Yuan J., Moskowitz M.A. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 1998, 18:3659-3668.
20. Nicotera P., Leist M., Manzo L. Neuronal cell death: a demise with different shapes. Trends Pharmacol. Sci. 1999, 20:46-51.
21. Onteniente B., Rasika S., Benchoua A., Guegan C. Molecular pathways in cerebral ischemia: cues to novel therapeutic strategies. Mol. Neurobiol. 2003, 27:33-72.
22. Rami A. Ischemic neuronal death in the rat hippocampus: the calpain-calpastatin-caspase hypothesis. Neurobiol. Dis. 2003, 13:75-88.
23. Schmued L.C., Stowers C.C., Scallet A.C., Xu L. Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res. 2005, 1035:24-31.
24. Seyfried D., Han Y., Zheng Z., Day N., Moin K., Rempel S., Sloane B., Chopp M. Cathepsin B and middle cerebral artery occlusion in the rat. J. Neurosurg. 1997, 87:716-723.
25. Stoka V., Turk B., Schendel S.L., Kim T.H., Cirman T., Snipas S.J., Ellerby L.M., Bredesen D., Freeze H., Abrahamson M., Bromme D., Krajewski S., Reed J.C., Yin X.M., Turk V., Salvesen G.S. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J. Biol. Chem. 2001, 276:3149-3157.
26. Syntichaki P., Tavernarakis N. The biochemistry of neuronal necrosis: rogue biology?. Nat. Rev. Neurosci. 2003, 4:672-684.
27. Turk V., Turk B., Turk D. Lysosomal cysteine proteases: facts and opportunities. EMBO J. 2001, 20:4629-4633.
28. Unal-Cevik I., Kilinc M., Can A., Gursoy-Ozdemir Y., Dalkara T. Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia. Stroke 2004, 35:2189-2194.
29. Uysal H., Cevik I.U., Soylemezoglu F., Elibol B., Ozdemir Y.G., Evrenkaya T., Saygi S., Dalkara T. Is the cell death in mesial temporal sclerosis apoptotic?. Epilepsia 2003, 44:778-784.
30. van Lookeren Campagne M., Gill R. Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat. Neurosci. Lett. 1996, 213:111-114.
31. Velier J.J., Ellison J.A., Kikly K.K., Spera P.A., Barone F.C., Feuerstein G.Z. Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat. J. Neurosci. 1999, 19:5932-5941.
32. Yamashima T. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog. Neurobiol. 2000, 62:273-295.
33. Yamashima T. Ca2+ -dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell Calcium 2004, 36:285-293.
34. Yamashima T., Kohda Y., Tsuchiya K., Ueno T., Yamashita J., Yoshioka T., Kominami E. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur. J. Neurosci. 1998, 10:1723-1733.
35. Yamashima T., Tonchev A.B., Tsukada T., Saido T.C., Imajoh-Ohmi S., Momoi T., Kominami E. Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus 2003, 13:791-800.
36. Yin X.M., Luo Y., Cao G., Bai L., Pei W., Kuharsky D.K., Chen J. Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia. J. Biol. Chem. 2002, 277:42074-42081.
37. Yuan J. Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis 2009, 14:469-477.
38. Yuan X.M., Li W., Dalen H., Lotem J., Kama R., Sachs L., Brunk U.T. Lysosomal destabilization in p53-induced apoptosis. Proc. Natl Acad. Sci. USA 2002, 99:6286-6291.