Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins

Journal of Biological Chemistry

Volumn 282, Issue 39, 2007, Pages 28960-28970

  Werneburg, Nathan W ^a   Guicciardi, M Eugenia ^a   Bronk, Steve F ^a   Kaufmann, Scott H ^a   Gores, Gregory J ^a  

^a Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CYTOTOXICITY; ENZYME ACTIVITY; LIGANDS; PROTEINS; RNA;

CLONOGENIC ASSAYS; LYSOSOMAL PERMEABILIZATION; RNA-TARGETED INHIBITION;

CELL DEATH;

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BH3 PROTEIN; BIM PROTEIN; CASPASE 9; CATHEPSIN B; GREEN FLUORESCENT PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN MCL 1; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CELL DEATH; CELL PERMEABILIZATION; CELLULAR DISTRIBUTION; CLONOGENIC ASSAY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LYSOSOME; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STATISTICAL ANALYSIS;

ANTHRACENES; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CATHEPSIN B; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; HUMANS; LYSOSOMES; MAP KINASE KINASE 4; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 35348948380     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705671200     Document Type: Article

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