The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

Cell Death and Differentiation

Volumn 17, Issue 6, 2010, Pages 962-974

  Michiorri, S ^a,b   Gelmetti, V ^a   Giarda, E ^c   Lombardi, F ^a   Romano, F ^a,b   Marongiu, R ^a   Nerini Molteni, S ^c   Sale, P ^d   Vago, R ^c   Arena, G ^a   Torosantucci, L ^a   Cassina, L ^c   Russo, M A ^b   Dallapiccola, B ^a   Valente, E M ^a,e   Casari, G ^c,f,g  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d IRCCS SAN RAFFAELE PISANA   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

^f VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^g National Institute of Neuroscience   (Italy)

Author keywords

Autophagy; Beclin1; Mitochondria; Parkinson's disease; PINK1

Indexed keywords

BECLIN 1; MITOCHONDRIAL ENZYME; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE INDUCED PUTATIVE KINASE 1; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHAGY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STARVATION;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MITOCHONDRIA; MUTATION; PROTEIN KINASES; SEQUENCE DELETION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 77952242572     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.200     Document Type: Article

References (44)

1. Gasser T. Mendelian forms of Parkinson's disease. Biochim Biophys Acta 2009; 1792: 587-596.
2. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004; 304: 1158-1160. (Pubitemid 38661852)
3. Tan EK, Skipper LM. Pathogenic mutations in Parkinson disease. Hum Mutat 2007; 28: 641-653.
4. Petit A, Kawarai T, Paitel E, Sanjo N, Maj M, Scheid M et al. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J Biol Chem 2005; 280: 34025-34032. (Pubitemid 41443124)
5. Wang HL, Chou AH, Yeh TH, Li AH, Chen YL, Kuo YL et al. PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c. Neurobiol Dis 2007; 28: 216-226.
6. Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AS, Miljan EA, Keen G et al. PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE 2008; 3: e2455.
7. Deng H, Jankovic J, Guo Y, Xie W, Le W. Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. Biochem Biophys Res Commun 2005; 337: 1133-1138. (Pubitemid 41505244)
8. Sandebring A, Thomas KJ, Beilina A, van der BM, Cleland MM, Ahmad R et al. Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS ONE 2009; 4: e5701.
9. Pridgeon JW, Olzmann JA, Chin LS, Li L. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol 2007; 5: e172. (Pubitemid 47105341)
10. Haque ME, Thomas KJ, D'Souza C, Callaghan S, Kitada T, Slack RS et al. Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc Natl Acad Sci USA 2008; 105: 1716-1721. (Pubitemid 351346580)
11. Lin W, Kang UJ. Characterization of PINK1 processing, stability, and subcellular localization. J Neurochem 2008; 106: 464-474. (Pubitemid 351840220)
12. Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. Hum Mol Genet 2008; 17: 602-616. (Pubitemid 351201772)
13. Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C et al. The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci USA 2008; 105: 12022-12027.
14. Tan JM, Dawson TM. Parkin blushed by PINK1. Neuron 2006; 50: 527-529.
15. Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, Gispert S et al. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 2007; 27: 12413-12418. (Pubitemid 350085485)
16. Yang Y, Ouyang Y, Yang L, Beal MF, McQuibban A, Vogel H et al. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci USA 2008; 105: 7070-7075. (Pubitemid 351754531)
17. Park J, Lee G, Chung J. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochem Biophys Res Commun 2009; 378: 518-523.
18. Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Laemmermann K et al. Loss of parkin or PINK1 function increases DRP1-dependent mitochondrial fragmentation. J Biol Chem 2009; 284: 22938-22951.
19. Dagda RK, Cherra III SJ, Kulich SM, Tandon A, Park D, Chu CT. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 2009; 284: 13843-13855.
20. Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183: 795-803.
21. Kim I, Rodriguez-Enriquez S, Lemasters JJ. Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 2007; 462: 245-253. (Pubitemid 46876640)
22. Komatsu M, Ueno T, Waguri S, Uchiyama Y, Kominami E, Tanaka K. Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons. Cell Death Differ 2007; 14: 887-894. (Pubitemid 46629828)
23. Martinez-Vicente M, Cuervo AM. Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol 2007; 6: 352-361. (Pubitemid 46367949)
24. Winslow AR, Rubinsztein DC. Autophagy in neurodegeneration and development. Biochim Biophys Acta 2008; 1782: 723-729.
25. Gomes LC, Scorrano L. High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta 2008; 1777: 860-866.
26. Twig G, Hyde B, Shirihai OS. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta 2008; 1777: 1092-1097.
27. Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ. Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking (dagger). Biochemistry 2009; 48: 2045-2052.
28. Silvestri L, Caputo V, Bellacchio E, Atorino L, Dallapiccola B, Valente EM et al. Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive Parkinsonism. Hum Mol Genet 2005; 14: 3477-3492. (Pubitemid 41672130)
29. Cao Y, Klionsky DJ. Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res 2007; 17: 839-849. (Pubitemid 47585112)
30. Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol 2009; 11: 385-396.
31. Gimenez-Xavier P, Francisco R, Santidrian AF, Gil J, Ambrosio S. Effects of dopamine on LC3-II activation as a marker of autophagy in a neuroblastoma cell model. Neurotoxicology 2009; 30: 658-665.
32. Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3: 542-545. (Pubitemid 350060049)
33. Klionsky DJ, Cuervo AM, Seglen PO. Methods for monitoring autophagy from yeast to human. Autophagy 2007; 3: 181-206.
34. Cipolat S, Martins de BO, Dal ZB, Scorrano L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci USA 2004; 101: 15927-15932. (Pubitemid 39507904)
35. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-939. (Pubitemid 41345209)
36. Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008; 118: 2190-2199. (Pubitemid 351872337)
37. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T et al. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 2006; 281: 14474-14485. (Pubitemid 43848378)
38. Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007; 3: 374-376. (Pubitemid 46986348)
39. Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-X(L) and induction of autophagy. EMBO Rep 2009; 10: 285-292.
40. Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000; 275: 992-998. (Pubitemid 30051145)
41. Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T et al. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 2009; 461: 654-658.
42. Chu CT, Zhu J, Dagda R. Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy 2007; 3: 663-666. (Pubitemid 350060074)
43. Semple JI, Prime G, Wallis LJ, Sanderson CM, Markie D. Two-hybrid reporter vectors for gap repair cloning. Biotechniques 2005; 38: 927-934. (Pubitemid 41724851)
44. Hallworth R, Currall B, Nichols MG, Wu X, Zuo J. Studying inner ear protein-protein interactions using FRET and FLIM. Brain Res 2006; 1091: 122-131. (Pubitemid 43993901)