메뉴 건너뛰기




Volumn 8, Issue 1-2, 2006, Pages 197-204

Oxidative stress, accumulation of biological 'garbage', and aging

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; IRON CHELATE; LIPOFUSCIN;

EID: 33644641768     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2006.8.197     Document Type: Review
Times cited : (320)

References (93)
  • 1
    • 0028007092 scopus 로고
    • DNA oxidative damage and life expectancy in houseflies
    • Agarval S and Sohal RS. DNA oxidative damage and life expectancy in houseflies. Proc Natl Acad Sci USA 91: 12332-12335, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12332-12335
    • Agarval, S.1    Sohal, R.S.2
  • 2
    • 0037009120 scopus 로고    scopus 로고
    • Membrane protein degradation by AAA proteases in mitochondria
    • Arnold I and Langer T. Membrane protein degradation by AAA proteases in mitochondria. Biochim Biophys Acta 1592: 89-96, 2002.
    • (2002) Biochim Biophys Acta , vol.1592 , pp. 89-96
    • Arnold, I.1    Langer, T.2
  • 3
    • 0037517056 scopus 로고    scopus 로고
    • Changes in rat liver mitochondria with aging. Lon protease-like reactivity and N(epsilon)-carboxymethyllysine accumulation in the matrix
    • Bakala H, Delaval E, Hamelin M, Bismuth J, Borot-Laloi C, Corman B, and Friguet B. Changes in rat liver mitochondria with aging. Lon protease-like reactivity and N(epsilon)-carboxymethyllysine accumulation in the matrix. Eur J Biochem 270: 2295-2302, 2003.
    • (2003) Eur J Biochem , vol.270 , pp. 2295-2302
    • Bakala, H.1    Delaval, E.2    Hamelin, M.3    Bismuth, J.4    Borot-Laloi, C.5    Corman, B.6    Friguet, B.7
  • 4
    • 0036596625 scopus 로고    scopus 로고
    • Endogenous oxidative stress: Relationship to aging, longevity and caloric restriction
    • Barja G. Endogenous oxidative stress: relationship to aging, longevity and caloric restriction. Ageing Res Rev 1: 397: 411, 2002.
    • (2002) Ageing Res Rev , vol.1 , Issue.397 , pp. 411
    • Barja, G.1
  • 5
    • 0036829433 scopus 로고    scopus 로고
    • Rate of generation of oxidative stress-related damage and animal longevity
    • Barja G. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic Biol Med 33: 1167-1172, 2002.
    • (2002) Free Radic Biol Med , vol.33 , pp. 1167-1172
    • Barja, G.1
  • 6
    • 2542446099 scopus 로고    scopus 로고
    • Aging in vertebrates, and the effect of caloric restriction: A mitochondrial free radical production-DNA damage mechanism?
    • Barja G. Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism? Biol Rev Camb Philos Soc 79: 235-251, 2004.
    • (2004) Biol Rev Camb Philos Soc , vol.79 , pp. 235-251
    • Barja, G.1
  • 7
    • 0022894660 scopus 로고
    • Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins
    • Barriocanal JG, Bonifacino JS, Yuan L, and Sandoval IV. Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins. J Biol Chem 261: 16755-16763, 1986.
    • (1986) J Biol Chem , vol.261 , pp. 16755-16763
    • Barriocanal, J.G.1    Bonifacino, J.S.2    Yuan, L.3    Sandoval, I.V.4
  • 8
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman KB and Ames BN. The free radical theory of aging matures. Physiol Rev 78: 547-581, 1998.
    • (1998) Physiol Rev , vol.78 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 10
    • 14344263884 scopus 로고    scopus 로고
    • The role of alpha-synuclein in neurodegenerative diseases
    • Bennett MC. The role of alpha-synuclein in neurodegenerative diseases. Pharmacol Ther 105: 311-331, 2005.
    • (2005) Pharmacol Ther , vol.105 , pp. 311-331
    • Bennett, M.C.1
  • 12
    • 0043204997 scopus 로고    scopus 로고
    • The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically
    • Bergamini E, Cavallini G, Donati A, and Gori Z. The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically. Biomed Pharmacother 57: 203-208, 2003.
    • (2003) Biomed Pharmacother , vol.57 , pp. 203-208
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 13
    • 0028908348 scopus 로고
    • Advanced protein glycosylation in diabetes and aging
    • Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu Rev Med 46: 223-234, 1995.
    • (1995) Annu Rev Med , vol.46 , pp. 223-234
    • Brownlee, M.1
  • 14
    • 0015264490 scopus 로고
    • Electron microscopical studies of rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies
    • Brunk U and Ericsson JLE. Electron microscopical studies of rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies. J Ultrastruct Res 38: 1-15, 1972.
    • (1972) J Ultrastruct Res , vol.38 , pp. 1-15
    • Brunk, U.1    Ericsson, J.L.E.2
  • 15
    • 0026663037 scopus 로고
    • A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis
    • Brunk UT, Jones CB, and Sohal RS. A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat Res 275: 395-403, 1992.
    • (1992) Mutat Res , vol.275 , pp. 395-403
    • Brunk, U.T.1    Jones, C.B.2    Sohal, R.S.3
  • 16
    • 0034983544 scopus 로고    scopus 로고
    • Lysosomal involvement in apoptosis
    • Brunk UT, Neuzil J, and Eaton JW. Lysosomal involvement in apoptosis. Redox Rep 6: 91-97, 2001.
    • (2001) Redox Rep , vol.6 , pp. 91-97
    • Brunk, U.T.1    Neuzil, J.2    Eaton, J.W.3
  • 17
    • 0031749350 scopus 로고    scopus 로고
    • Autofluorescent inclusions in long-term postconfluent cultures of retinal pigment epithelium
    • Burke JM and Skumatz CM. Autofluorescent inclusions in long-term postconfluent cultures of retinal pigment epithelium. Invest Ophthalmol Vis Sci 39: 1478-1486, 1998.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1478-1486
    • Burke, J.M.1    Skumatz, C.M.2
  • 18
    • 0015965272 scopus 로고
    • Intrinsic mutagenesis: A genetic basis of ageing
    • Burnet FM. Intrinsic mutagenesis: a genetic basis of ageing. Pathology 6: 1-11, 1974.
    • (1974) Pathology , vol.6 , pp. 1-11
    • Burnet, F.M.1
  • 19
    • 1842519391 scopus 로고    scopus 로고
    • Alzheimer's amyloid beta-peptide (1-42): Involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide
    • Butterfield DA and Bush AI. Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide. Neurobiol Aging 25: 563-568, 2004.
    • (2004) Neurobiol Aging , vol.25 , pp. 563-568
    • Butterfield, D.A.1    Bush, A.I.2
  • 20
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E and Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29: 222-230, 2000.
    • (2000) Free Radic Biol Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 21
    • 0034069237 scopus 로고    scopus 로고
    • Cancer, aging and cellular senescence
    • Campisi J. Cancer, aging and cellular senescence. In Vivo 14: 183-188, 2000.
    • (2000) In Vivo , vol.14 , pp. 183-188
    • Campisi, J.1
  • 22
    • 0038049143 scopus 로고    scopus 로고
    • Cancer and ageing: Rival demons?
    • Campisi J. Cancer and ageing: rival demons? Nat Rev Cancer 3: 339-349, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 339-349
    • Campisi, J.1
  • 23
    • 0035504933 scopus 로고    scopus 로고
    • Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection
    • Cao Z, Wanagat J, McKiernan SH, and Aiken JM. Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res 29: 4502-4508, 2001.
    • (2001) Nucleic Acids Res , vol.29 , pp. 4502-4508
    • Cao, Z.1    Wanagat, J.2    McKiernan, S.H.3    Aiken, J.M.4
  • 24
    • 0031669208 scopus 로고    scopus 로고
    • Effect of a continuous gamma irradiation at a very low dose on the life span of mice
    • Caratero A, Courtade M, Bonnet L, Planel H, and Caratero C. Effect of a continuous gamma irradiation at a very low dose on the life span of mice. Gerontology 44: 272-276, 1998.
    • (1998) Gerontology , vol.44 , pp. 272-276
    • Caratero, A.1    Courtade, M.2    Bonnet, L.3    Planel, H.4    Caratero, C.5
  • 25
    • 4544385218 scopus 로고    scopus 로고
    • Autophagy: Many paths to the same end
    • Cuervo AM. Autophagy: many paths to the same end. Mol Cell Biochem 263: 55-72, 2004.
    • (2004) Mol Cell Biochem , vol.263 , pp. 55-72
    • Cuervo, A.M.1
  • 26
    • 0031081410 scopus 로고    scopus 로고
    • A proposed refinement of the mitochondrial free radical theory of aging
    • de Grey AD. A proposed refinement of the mitochondrial free radical theory of aging. BioEssays 19: 161-166, 1997.
    • (1997) BioEssays , vol.19 , pp. 161-166
    • Grey, A.D.1
  • 27
    • 0036843801 scopus 로고    scopus 로고
    • Bioremediation meets biomedicine: Therapeutic translation of microbial catabolism to the lysosome
    • de Grey AD. Bioremediation meets biomedicine: therapeutic translation of microbial catabolism to the lysosome. Trends Biotechnol 20: 452-455, 2002.
    • (2002) Trends Biotechnol , vol.20 , pp. 452-455
    • De Grey, A.D.1
  • 28
    • 0035984192 scopus 로고    scopus 로고
    • HO2*: The forgotten radical
    • De Grey AD. HO2*: the forgotten radical. DNA Cell Biol 21: 251-257, 2002.
    • (2002) DNA Cell Biol , vol.21 , pp. 251-257
    • De Grey, A.D.1
  • 29
    • 0025636261 scopus 로고
    • Spontaneous activity level and life span in rotifers: Lack of support for the rate of living theory
    • Enesco HE, McTavish A, and Garberi R. Spontaneous activity level and life span in rotifers: lack of support for the rate of living theory. Gerontology 36: 256-261, 1990.
    • (1990) Gerontology , vol.36 , pp. 256-261
    • Enesco, H.E.1    McTavish, A.2    Garberi, R.3
  • 31
    • 0036372751 scopus 로고    scopus 로고
    • Aging of proteins and the proteasome
    • Friguet B. Aging of proteins and the proteasome. Prog Molec Subcell Biol 29: 17-33, 2002.
    • (2002) Prog Molec Subcell Biol , vol.29 , pp. 17-33
    • Friguet, B.1
  • 32
    • 0033606902 scopus 로고    scopus 로고
    • Nematode ageing: Putting metabolic theories to the test
    • Gems D. Nematode ageing: Putting metabolic theories to the test. Curr Biol 9: R614-616, 1999.
    • (1999) Curr Biol , vol.9
    • Gems, D.1
  • 34
    • 4344677922 scopus 로고    scopus 로고
    • Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease
    • Grune T, Jung T, Merker K, and Davies KJ. Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int J Biochem Cell Biol 36: 2519-2530, 2004.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2519-2530
    • Grune, T.1    Jung, T.2    Merker, K.3    Davies, K.J.4
  • 36
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J and Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356, 2002.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 37
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 211: 298-300, 1956.
    • (1956) J Gerontol , vol.211 , pp. 298-300
    • Harman, D.1
  • 38
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 20: 145-147, 1972.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 39
    • 0025074187 scopus 로고
    • Lipofuscin and ceroid formation: The cellular recycling system
    • Harman D. Lipofuscin and ceroid formation: the cellular recycling system. Adv Exp Med Biol 266: 3-15, 1989.
    • (1989) Adv Exp Med Biol , vol.266 , pp. 3-15
    • Harman, D.1
  • 40
    • 0028223426 scopus 로고
    • Free-radical theory of aging. Increasing the functional life span
    • Harman D. Free-radical theory of aging. Increasing the functional life span. Ann NY Acad Sci 717: 1-15, 1994.
    • (1994) Ann NY Acad Sci , vol.717 , pp. 1-15
    • Harman, D.1
  • 41
    • 4344661620 scopus 로고    scopus 로고
    • Non-oxidative modification of DNA and proteins
    • von Zglinicki T, ed. Dordrecht: Kluwer
    • Hipkiss AR. Non-oxidative modification of DNA and proteins. In: Aging at the Molecular Level, von Zglinicki T, ed. Dordrecht: Kluwer, 2003; 145-177.
    • (2003) Aging at the Molecular Level , pp. 145-177
    • Hipkiss, A.R.1
  • 42
    • 0023550044 scopus 로고
    • Ultrastructural changes in the frontal cortex and hippocampus in the ageing marmoset
    • Honavar M and Lantos PL. Ultrastructural changes in the frontal cortex and hippocampus in the ageing marmoset. Mech Ageing Dev 41: 161-175, 1987.
    • (1987) Mech Ageing Dev , vol.41 , pp. 161-175
    • Honavar, M.1    Lantos, P.L.2
  • 43
    • 0029563691 scopus 로고
    • Lipofuscin in bovine muscle and brain: A model for studying age pigment
    • Jolly RD, Douglas BV, Davey PM, and Roiri JE. Lipofuscin in bovine muscle and brain: a model for studying age pigment. Gerontology 41: 283-295, 1995.
    • (1995) Gerontology , vol.41 , pp. 283-295
    • Jolly, R.D.1    Douglas, B.V.2    Davey, P.M.3    Roiri, J.E.4
  • 44
    • 0033151863 scopus 로고    scopus 로고
    • Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions
    • Khrapko K, Bodyak N, Thilly WG, van Orsouw NJ, Zhang X, Coller HA, Perls TT, Upton M, Vijg J, and Wei JY. Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res 27: 2434-2441, 1999.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2434-2441
    • Khrapko, K.1    Bodyak, N.2    Thilly, W.G.3    Van Orsouw, N.J.4    Zhang, X.5    Coller, H.A.6    Perls, T.T.7    Upton, M.8    Vijg, J.9    Wei, J.Y.10
  • 45
    • 0024546310 scopus 로고
    • DNA, mutations and aging
    • Kirkwood TB. DNA, mutations and aging. Mutat Res 219: 1-7, 1989.
    • (1989) Mutat Res , vol.219 , pp. 1-7
    • Kirkwood, T.B.1
  • 46
    • 0029890534 scopus 로고    scopus 로고
    • A network theory of ageing: The interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process
    • Kowald A and Kirkwood TB. A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat Res 316: 209-236, 1996.
    • (1996) Mutat Res , vol.316 , pp. 209-236
    • Kowald, A.1    Kirkwood, T.B.2
  • 47
    • 0027097908 scopus 로고
    • Role of glycation in aging
    • Lee AT and Cerami A. Role of glycation in aging. Ann N Y Acad Sci 663: 63-70, 1992.
    • (1992) Ann N Y Acad Sci , vol.663 , pp. 63-70
    • Lee, A.T.1    Cerami, A.2
  • 48
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine B and Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477, 2004.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 49
    • 0344734108 scopus 로고    scopus 로고
    • Mortality patterns suggest lack of senescence in hydra
    • Martinez DE. Mortality patterns suggest lack of senescence in hydra. Exp Gerontol 33: 217-225, 1998.
    • (1998) Exp Gerontol , vol.33 , pp. 217-225
    • Martinez, D.E.1
  • 50
    • 0025044090 scopus 로고
    • Effect of alpha-tocopherol and some metal chelators on lipofuscin accumulation in cultured neonatal rat cardiac myocytes
    • Marzabadi MR, Sohal RS, and Brunk UT. Effect of alpha-tocopherol and some metal chelators on lipofuscin accumulation in cultured neonatal rat cardiac myocytes. Anal Cell Pathol 2: 333-346, 1990.
    • (1990) Anal Cell Pathol , vol.2 , pp. 333-346
    • Marzabadi, M.R.1    Sohal, R.S.2    Brunk, U.T.3
  • 51
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, and Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301: 1387-1391, 2003.
    • (2003) Science , vol.301 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.L.4    Hall, D.H.5    Levine, B.6
  • 52
    • 0034967925 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway and proteasome inhibitors
    • Myung J, Kim KB, and Crews CM. The ubiquitin-proteasome pathway and proteasome inhibitors. Med Res Rev 21: 245-273, 2001.
    • (2001) Med Res Rev , vol.21 , pp. 245-273
    • Myung, J.1    Kim, K.B.2    Crews, C.M.3
  • 53
    • 0029564967 scopus 로고
    • Age-related changes in the lipofuscin accumulation of brain and heart
    • Nakano M, Oenzil F, Mizuno T, and Gotoh S. Age-related changes in the lipofuscin accumulation of brain and heart. Gerontology 41: 69-79, 1995.
    • (1995) Gerontology , vol.41 , pp. 69-79
    • Nakano, M.1    Oenzil, F.2    Mizuno, T.3    Gotoh, S.4
  • 54
    • 0037233423 scopus 로고    scopus 로고
    • Aging of cultured retinal pigment epithelial cells: Oxidative reactions, lipofuscin formation and blue light damage
    • Nilsson SE, Sundelin SP, Wihlmark U, and Brunk UT. Aging of cultured retinal pigment epithelial cells: oxidative reactions, lipofuscin formation and blue light damage. Doc Ophthalmol 106: 13-16, 2003.
    • (2003) Doc Ophthalmol , vol.106 , pp. 13-16
    • Nilsson, S.E.1    Sundelin, S.P.2    Wihlmark, U.3    Brunk, U.T.4
  • 56
    • 0015932795 scopus 로고
    • Ageing of clones of mammalian cells
    • Orgel LE. Ageing of clones of mammalian cells. Nature 243: 441-445, 1973.
    • (1973) Nature , vol.243 , pp. 441-445
    • Orgel, L.E.1
  • 57
    • 0030897739 scopus 로고    scopus 로고
    • Genetic and functional changes in mitochondria associated with aging
    • Ozawa T. Genetic and functional changes in mitochondria associated with aging. Physiol Rev 77: 425-464, 1997.
    • (1997) Physiol Rev , vol.77 , pp. 425-464
    • Ozawa, T.1
  • 58
    • 0037448064 scopus 로고    scopus 로고
    • Prevention of oxidant-induced cell death by lysosomotropic iron chelators
    • Persson HL, Yu Z, Tirosh O, Eaton JW, and Brunk UT. Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic Biol Med 34: 1295-1305, 2003.
    • (2003) Free Radic Biol Med , vol.34 , pp. 1295-1305
    • Persson, H.L.1    Yu, Z.2    Tirosh, O.3    Eaton, J.W.4    Brunk, U.T.5
  • 59
    • 0041885207 scopus 로고    scopus 로고
    • Linking oxidative stress and genetics of aging with p66Shc signaling and forkhead transcription factors
    • Purdom S and Chen QM. Linking oxidative stress and genetics of aging with p66Shc signaling and forkhead transcription factors. Biogerontology 4: 181-191, 2003.
    • (2003) Biogerontology , vol.4 , pp. 181-191
    • Purdom, S.1    Chen, Q.M.2
  • 60
    • 0036345047 scopus 로고    scopus 로고
    • Role of heme oxygenase-1 in the biogenesis of corpora amylacea
    • Sahlas DJ, Liberman A, and Schipper HM. Role of heme oxygenase-1 in the biogenesis of corpora amylacea. Biogerontology 3: 223-231, 2002.
    • (2002) Biogerontology , vol.3 , pp. 223-231
    • Sahlas, D.J.1    Liberman, A.2    Schipper, H.M.3
  • 61
    • 0024597761 scopus 로고
    • Lysosomal integral membrane glycoproteins are expressed at high levels in the inclusion bodies of 1-cell disease fibroblasts
    • Sandoval IV, Chen JW, Yuan L, and August JT. Lysosomal integral membrane glycoproteins are expressed at high levels in the inclusion bodies of 1-cell disease fibroblasts. Arch Biochem Biophys 271: 157-167, 1989.
    • (1989) Arch Biochem Biophys , vol.271 , pp. 157-167
    • Sandoval, I.V.1    Chen, J.W.2    Yuan, L.3    August, J.T.4
  • 62
    • 0032874037 scopus 로고    scopus 로고
    • The effect of aging on pars compacta of the substantia nigra in rhesus monkey
    • Siddiqi ZA and Peters A. The effect of aging on pars compacta of the substantia nigra in rhesus monkey. J Neuropathol Exp Neurol 58: 903-920, 1999.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 903-920
    • Siddiqi, Z.A.1    Peters, A.2
  • 63
    • 0036628724 scopus 로고    scopus 로고
    • Role of oxidative stress and protein oxidation in the aging process
    • Sohal RS. Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med 33: 37-44, 2002.
    • (2002) Free Radic Biol Med , vol.33 , pp. 37-44
    • Sohal, R.S.1
  • 64
    • 0031452173 scopus 로고    scopus 로고
    • Structure and physiological function of calpains
    • Sorimachi H, Ishiura S, and Suzuki K. Structure and physiological function of calpains. Biochem J 328: 721-732, 1997.
    • (1997) Biochem J , vol.328 , pp. 721-732
    • Sorimachi, H.1    Ishiura, S.2    Suzuki, K.3
  • 65
    • 0034881033 scopus 로고    scopus 로고
    • Oxidative stress and protein aggregation during biological aging
    • Squier TC. Oxidative stress and protein aggregation during biological aging. Exp Gerontol 36: 1539-1550, 2001.
    • (2001) Exp Gerontol , vol.36 , pp. 1539-1550
    • Squier, T.C.1
  • 66
    • 0035039021 scopus 로고    scopus 로고
    • Protein oxidation in aging and age-related diseases
    • Stadtman ER. Protein oxidation in aging and age-related diseases. Ann NY Acad Sci 928: 22-38, 2001.
    • (2001) Ann NY Acad Sci , vol.928 , pp. 22-38
    • Stadtman, E.R.1
  • 68
    • 12344251782 scopus 로고    scopus 로고
    • Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material
    • Stroikin Y, Dalen H, Lööf S, and Terman A. Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material. Eur J Cell Biol 83: 583-590, 2004.
    • (2004) Eur J Cell Biol , vol.83 , pp. 583-590
    • Stroikin, Y.1    Dalen, H.2    Lööf, S.3    Terman, A.4
  • 69
    • 0031812476 scopus 로고    scopus 로고
    • Lipofuscin accumulation of cultured retinal pigment epithelial cells reduces their phagocytic capacity
    • Sundelin S, Wihlmark U, Nilsson SEG, and Brunk UT. Lipofuscin accumulation of cultured retinal pigment epithelial cells reduces their phagocytic capacity. Curr Eye Res 17: 851-857, 1998.
    • (1998) Curr Eye Res , vol.17 , pp. 851-857
    • Sundelin, S.1    Wihlmark, U.2    Seg, N.3    Brunk, U.T.4
  • 70
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • Tatar M, Bartke A, and Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299: 1346-1351, 2003.
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 71
    • 0017233986 scopus 로고
    • A morphometric study of the density of mitochondrial cristae in heart and liver of aging mice
    • Tate EL and Herbener GH. A morphometric study of the density of mitochondrial cristae in heart and liver of aging mice. J Gerontol 31: 129-134, 1976.
    • (1976) J Gerontol , vol.31 , pp. 129-134
    • Tate, E.L.1    Herbener, G.H.2
  • 73
    • 18844425714 scopus 로고    scopus 로고
    • Role of compartmentalized redox-active iron on hydrogen peroxide-induced DNA damage and apoptosis
    • Tenopoulou M, Doulias PT, Barbouti A, Brunk UT, and Galaris D. Role of compartmentalized redox-active iron on hydrogen peroxide-induced DNA damage and apoptosis. Biochem J 387: 703-710, 2005.
    • (2005) Biochem J , vol.387 , pp. 703-710
    • Tenopoulou, M.1    Doulias, P.T.2    Barbouti, A.3    Brunk, U.T.4    Galaris, D.5
  • 74
    • 0035063178 scopus 로고    scopus 로고
    • Garbage catastrophe theory of aging: Imperfect removal of oxidative damage?
    • Terman A. Garbage catastrophe theory of aging: imperfect removal of oxidative damage? Redox Rep 6: 15-26, 2001.
    • (2001) Redox Rep , vol.6 , pp. 15-26
    • Terman, A.1
  • 75
    • 0032821609 scopus 로고    scopus 로고
    • Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress
    • Terman A, Abrahamsson N, and Brunk UT. Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress. Exp Gerontol 34: 755-770, 1999.
    • (1999) Exp Gerontol , vol.34 , pp. 755-770
    • Terman, A.1    Abrahamsson, N.2    Brunk, U.T.3
  • 76
    • 0032169551 scopus 로고    scopus 로고
    • Ceroid/lipofuscin formation in cultured human fibroblasts: The role of oxidative stress and lysosomal proteolysis
    • Terman A and Brunk UT. Ceroid/lipofuscin formation in cultured human fibroblasts: The role of oxidative stress and lysosomal proteolysis. Mech Ageing Dev 104: 277-291, 1998.
    • (1998) Mech Ageing Dev , vol.104 , pp. 277-291
    • Terman, A.1    Brunk, U.T.2
  • 77
    • 0032579473 scopus 로고    scopus 로고
    • On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes
    • Terman A and Brunk UT. On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes. Mech Ageing Dev 100: 145-156, 1998.
    • (1998) Mech Ageing Dev , vol.100 , pp. 145-156
    • Terman, A.1    Brunk, U.T.2
  • 79
    • 2342457124 scopus 로고    scopus 로고
    • Myocyte aging and mitochondrial turnover
    • Terman A and Brunk UT. Myocyte aging and mitochondrial turnover. Exp Gerontol 39: 701-705, 2004.
    • (2004) Exp Gerontol , vol.39 , pp. 701-705
    • Terman, A.1    Brunk, U.T.2
  • 80
    • 0032730787 scopus 로고    scopus 로고
    • Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation
    • Terman A, Dalen H, and Brunk UT. Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation. Exp Gerontol 34: 943-957, 1999.
    • (1999) Exp Gerontol , vol.34 , pp. 943-957
    • Terman, A.1    Dalen, H.2    Brunk, U.T.3
  • 81
    • 0042707790 scopus 로고    scopus 로고
    • Mitochondrial recycling and aging of cardiac myocytes: The role of autophagocytosis
    • Terman A, Dalen H, Eaton JW, Neuzil J, and Brunk UT. Mitochondrial recycling and aging of cardiac myocytes: The role of autophagocytosis. Exp Gerontol 38: 863-876, 2003.
    • (2003) Exp Gerontol , vol.38 , pp. 863-876
    • Terman, A.1    Dalen, H.2    Eaton, J.W.3    Neuzil, J.4    Brunk, U.T.5
  • 82
    • 3242715838 scopus 로고    scopus 로고
    • Aging of cardiac myocytes in culture: Oxidative stress, lipofuscin accumulation, and mitochondrial turnover
    • Terman A, Dalen H, Eaton JW, Neuzil J, and Brunk UT. Aging of cardiac myocytes in culture: Oxidative stress, lipofuscin accumulation, and mitochondrial turnover. Ann NY Acad Sci 1019: 70-77, 2004.
    • (2004) Ann NY Acad Sci , vol.1019 , pp. 70-77
    • Terman, A.1    Dalen, H.2    Eaton, J.W.3    Neuzil, J.4    Brunk, U.T.5
  • 84
    • 10844254688 scopus 로고    scopus 로고
    • Argyrophilic grain disease: A late-onset dementia with distinctive features among tauopathies
    • Tolnay M and Clavaguera F. Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. Neuropathology 24: 269-283, 2004.
    • (2004) Neuropathology , vol.24 , pp. 269-283
    • Tolnay, M.1    Clavaguera, F.2
  • 85
    • 0034663419 scopus 로고    scopus 로고
    • Somatic cell mutations: Can they provide a link between aging and cancer?
    • Turker MS. Somatic cell mutations: can they provide a link between aging and cancer? Mech Ageing Dev 117: 1-19, 2000.
    • (2000) Mech Ageing Dev , vol.117 , pp. 1-19
    • Turker, M.S.1
  • 86
    • 0030943224 scopus 로고    scopus 로고
    • Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation
    • Wihlmark U, Wrigstad A, Roberg K, Nilsson SE, and Brunk UT. Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation. Free Radic Biol Med 22: 1229-1234, 1997.
    • (1997) Free Radic Biol Med , vol.22 , pp. 1229-1234
    • Wihlmark, U.1    Wrigstad, A.2    Roberg, K.3    Nilsson, S.E.4    Brunk, U.T.5
  • 87
    • 0021867392 scopus 로고
    • Lipofuscin accumulation and its prevention by vitamin e in nervous tissue: Quantitative analysis using snail buccal ganglia as a simple model system
    • Winstanley EK and Pentreath VW. Lipofuscin accumulation and its prevention by vitamin E in nervous tissue: quantitative analysis using snail buccal ganglia as a simple model system. Mech Ageing Dev 29: 299-307, 1985.
    • (1985) Mech Ageing Dev , vol.29 , pp. 299-307
    • Winstanley, E.K.1    Pentreath, V.W.2
  • 88
    • 0037401916 scopus 로고    scopus 로고
    • Intracellular localization of proteasomes
    • Wojcik C and DeMartino GN. Intracellular localization of proteasomes. Int J Biochem Cell Biol 35: 579-589, 2003.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 579-589
    • Wojcik, C.1    Demartino, G.N.2
  • 89
    • 0029587510 scopus 로고
    • Early appearance of age-associated deterioration in mitochondrial function of diaphragm and heart in rats treated with doxorubicin
    • Yamada K, Sugiyama S, Kosaka K, Hayakawa M, and Ozawa T. Early appearance of age-associated deterioration in mitochondrial function of diaphragm and heart in rats treated with doxorubicin. Exp Gerontol 30: 581-593, 1995.
    • (1995) Exp Gerontol , vol.30 , pp. 581-593
    • Yamada, K.1    Sugiyama, S.2    Kosaka, K.3    Hayakawa, M.4    Ozawa, T.5
  • 92
    • 0037010295 scopus 로고    scopus 로고
    • Age-related decline in neurogenesis: Old cells or old environment?
    • Zitnik G and Martin GM. Age-related decline in neurogenesis: old cells or old environment? J Neurosci Res 70: 258-263, 2002.
    • (2002) J Neurosci Res , vol.70 , pp. 258-263
    • Zitnik, G.1    Martin, G.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.