Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis

Future Medicinal Chemistry

Volumn 3, Issue 7, 2011, Pages 803-819

  Nannemann, David P ^a   Birmingham, William R ^a   Scism, Robert A ^a   Bachmann, Brian O ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; ENZYME; MEDIUM CHAIN FATTY ACID; NUCLEOSIDE ANALOG; SITAGLIPTIN; DRUG;

AMINO ACID SEQUENCE; BACTERIAL STRAIN; CELL VIABILITY; CHEMICAL MUTAGENESIS; DIRECTED EVOLUTION; DNA SEQUENCE; DNA SHUFFLING; DRUG SYNTHESIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SYNTHESIS; FLOW CYTOMETRY; GENE LIBRARY; GENETIC RECOMBINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIGAND BINDING; MOLECULAR EVOLUTION; NATURAL SELECTION; PHAGE DISPLAY; PHAGEMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET IRRADIATION; ARTICLE; BIOCATALYSIS; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; ECONOMICS; GENETICS; KINETICS; META ANALYSIS (TOPIC); METABOLISM; MUTAGENESIS; PROTEIN ENGINEERING;

BIOCATALYSIS; DIRECTED MOLECULAR EVOLUTION; ENZYMES; KINETICS; META-ANALYSIS AS TOPIC; MUTAGENESIS; PHARMACEUTICAL PREPARATIONS; PROTEIN ENGINEERING;

EID: 79958708794     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.11.48     Document Type: Review

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