Molecular breeding of carotenoid biosynthetic pathways

Nature Biotechnology

Volumn 18, Issue 7, 2000, Pages 750-753

  Schmidt Dannert, Claudia ^a   Umeno, Daisuke ^b   Arnold, Frances H ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b California Institute of Technology   (United States)

Author keywords

Carotenoid; In vitro evolution; Metabolic engineering; Molecular breeding

Indexed keywords

ACYL COENZYME A DESATURASE; CAROTENOID; LYCOPENE; NATURAL PRODUCT;

ARTICLE; BIOSYNTHESIS; ESCHERICHIA COLI; FATTY ACID DESATURATION; GENE LIBRARY; GENE TARGETING; GENETIC ENGINEERING; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

CAROTENOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; ESCHERICHIA COLI; GENE LIBRARY; GENETIC ENGINEERING; INTRAMOLECULAR LYASES; MODELS, CHEMICAL; OXIDOREDUCTASES; PLASMIDS; TRANSFORMATION, GENETIC;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PROKARYOTA;

EID: 0033941389     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/77319     Document Type: Article

References (32)

1. Altreuter, D.H. & Clark, D.S. Combinatorial biocatalysis: taking the lead from Nature. Curr. Opin. Biotechnol. 10, 130-136 (1999).
2. Reynolds, K.A. Combinatorial biosynthesis: lesson learned from nature. Proc. Natl. Acad. Sci. USA 95, 12744-12746 (1998).
3. Cane, D.E., Walsh, C.T. & Khosla, C. Biochemistry - harnessing the biosynthetic code: combinations, permutations, and mutations. Science 282, 63-68 (1998).
4. Lau, J., Fu, H., Cane, D.E. & Khosla, C. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. Biochemistry 38, 1643-1651 (1999).
5. Stemmer, W.P.C. Rapid evolution of a protein in-vitro by DNA-shuffling. Nature 370, 389-391 (1994).
6. Crameri, A., Raillard, S.A., Bermudez, E. & Stemmer, W.P.C. DNA shuffling of a family of genes from diverse species accelerates directed evolution. Nature 391, 288-291 (1998).
7. Joo, H., Lin, Z.L. & Arnold, F.H. Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation. Nature 399, 670-673 (1999).
8. Arnold, F.H. & Volkov, A.A. Directed evolution of biocatalysts. Curr. Opin. Chem. Biol. 3, 54-59 (1999).
9. Bertram, J.S. Carotenoids and gene regulation. Nutr. Rev. 57, 182-191 (1999).
10. Singh, D.K. & Lippman, S.M. Cancer chemoprevention - Part 1: Retinoids and carotenoids and other classic antioxidants. Oncology NY 12, 1643-1653 (1998).
11. Rock, C.L. Carotenoids: biology and treatment. Pharmacol. Ther. 75, 185-197 (1997).
12. Edge, R., McGarvey, D.J. & Truscott, T.G. The carotenoids as antioxidants - a review. J. Photochem. Photobiol. 41, 189-200 (1997).
13. Johnson, E.A. & Schroeder, W.A. Microbial carotenoids. Adv. Biochem. Eng. Biotechnol. 53, 119-178 (1995).
14. Misawa, N. & Shimada, H. Metabolic engineering for the production of carotenoids in noncarotenogenic bacteria and yeasts. J. Biotechnol. 59, 169-181 (1998).
15. Hirschberg, J. In Carotenoids: biosynthesis and metabolism, Vol. 3 (eds Britton, G., Liaaen-Jensen, S. & Pfander, H.) 148-194 (Birkhauser Verlag, Basel; 1998).
16. Sandmann, G., Albrecht, M., Schnurr, G., Knorzer, O. & Boger, P. The biotechnological potential and design of novel carotenoids by gene combination in Escherichia coli. Trends Biotechnol. 17, 233-237 (1999).
17. Britton, G. In Carotenoids: biosynthesis and metabolism, Vol. 3 (eds Britton, G., Liaaen-Jensen, S. & Pfander, H.) 13-147 (Birkhäuser Verlag, Basel; 1998).
18. Armstrong, G.A. & Hearst, J.E. Carotenoids. 2. Genetics and molecular biology of carotenoid pigment biosynthesis. FASEB J. 10, 228-237 (1996).
19. Sandmann, G. Carotenoid biosynthesis in microorganisms and plants. Eur. J. Biochem. 223, 7-24 (1994).
20. Garcia-Asua, G., Lang, H.P., Cogdell, R.J. & Hunter, C.N. Carotenoid diversity: a modular role for the phytoene desaturase step. Trends Plant Sci. 3, 445-449 (1998).
21. Bartley, G.E., Schmidhauser, T.J., Yanofsky, C. & Scolnik, P.A. Carotenoid desaturases from Rhodobacter capsulatus and Neurospora crassa are structurally and functionally conserved and contain domains homologous to flavoprotein disulfide oxidoreductase. J. Biol. Chem. 265, 16020-16024 (1990).
22. Fraser, P.D. et al. Expression in Escherichia coli, purification, and reactivation of the recombinant Erwinia uredovora phytoene desaturase. J. Biol. Chem. 267, 19891-19895 (1992).
23. Linden, H. et al. Functional complementation in Escherichia coli of different phytoene desaturase genes and analysis of accumulated carotenes. Z. Naturforsch, 46c, 1045-1051 (1991).
24. Armstrong, G.A., Alberti, M., Leach, F. & Hearst, J.E. Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus. Mol. Gen. Genetics 216, 254-268 (1989).
25. Wierenga, R.K., Terpstra, P. & Hol, W.G.J. Prediction of the occurrence of the ADP-binding beta-alpha-beta fold in proteins, using an amino-acid fingerprint. J. Mol. Biol. 187, 101-107 (1986).
26. Ausich, R.L. Production of carotenoids by recombinant DNA-technology. Pure Appl. Chem. 66, 1057-1062 (1994).
27. Hunter, C.N. et al. Introduction of new carotenoids into the bacterial photosynthetic apparatus by combining the carotenoid biosynthetic pahtways of Erwinia herbicola and Rhodobacter sphaeroides. J. Bacteriol. 176, 3692-3697 (1994).
28. Takaichi, S. et al. The carotenoid 7,8-dihydro-psi end group can be cyclized by the lycopene cyclases from the bacterium Erwinia uredovora and the higher plant Capsicum annuum. Eur. J. Biochem. 241, 291-296 (1996).
29. Albrecht, M. et al. Synthesis of atypical cyclic and acyclic hydroxy carotenoids in Escherichia coli transformants. J. Biotechnol. 58, 177-185 (1997).
30. Cunningham, F.X. et al. Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell 8, 1613-1626 (1996).
31. Hugueney, P. et al. Metabolism of cyclic carotenoids - a model for the alteration of this biosynthetic pathway in Capsicum annuum chromoplasts. Plant J. 8, 417-424 (1995).
32. An, G.-H., Cho, M.-H. & Johnson, E.A. Monocyclic carotenoid biosynthetic pathway in the yeast Phaffia rhodozyma (Xanthophyllomyces dendrornous). J. Biosci. Bioeng. 88, 189-193 (1999).