-
2
-
-
50549201557
-
The relation of recombination to mutational advance
-
Muller, H. J. The relation of recombination to mutational advance. Mutat. Res. 1, 2-9 (1964).
-
(1964)
Mutat. Res
, vol.1
, pp. 2-9
-
-
Muller, H.J.1
-
3
-
-
0036500834
-
Reverse engineering of biological complexity
-
Csete, M. E. & Doyle, J. C. Reverse engineering of biological complexity. Science 295, 1664-1669 (2002).
-
(2002)
Science
, vol.295
, pp. 1664-1669
-
-
Csete, M.E.1
Doyle, J.C.2
-
4
-
-
0041989850
-
Challenges in enzyme mechanism and energetics
-
Kraut, D. A., Carroll, K. S. & Herschlag, D. Challenges in enzyme mechanism and energetics. Annu. Rev. Biochem. 72, 517-571 (2003).
-
(2003)
Annu. Rev. Biochem
, vol.72
, pp. 517-571
-
-
Kraut, D.A.1
Carroll, K.S.2
Herschlag, D.3
-
5
-
-
0035807809
-
Enzyme-like proteins by computational design
-
Bolon, D. N. & Mayo, S. L. Enzyme-like proteins by computational design. Proc. Natl Acad. Sci. USA 98, 14274-14279 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 14274-14279
-
-
Bolon, D.N.1
Mayo, S.L.2
-
6
-
-
40449116114
-
De novo computational design of retro-aldol enzymes
-
Jiang, L. et al. De novo computational design of retro-aldol enzymes. Science 319, 1387-1391 (2008).
-
(2008)
Science
, vol.319
, pp. 1387-1391
-
-
Jiang, L.1
-
7
-
-
43449098518
-
Kemp elimination catalysts by computational enzyme design
-
Rothlisberger, D. et al. Kemp elimination catalysts by computational enzyme design. Nature 453, 190-195 (2008).
-
(2008)
Nature
, vol.453
, pp. 190-195
-
-
Rothlisberger, D.1
-
8
-
-
4143131151
-
De novo design of catalytic proteins
-
Kaplan, J. & DeGrado, W. F. De novo design of catalytic proteins. Proc. Natl Acad. Sci. USA 101, 11566-11570 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 11566-11570
-
-
Kaplan, J.1
DeGrado, W.F.2
-
9
-
-
0034625936
-
Peroxidase activity in heme proteins derived from a designed combinatorial library
-
Moffet, D. A. et al. Peroxidase activity in heme proteins derived from a designed combinatorial library. J. Am. Chem. Soc. 122, 7612-7613 (2000).
-
(2000)
J. Am. Chem. Soc
, vol.122
, pp. 7612-7613
-
-
Moffet, D.A.1
-
10
-
-
34447636614
-
Detection of heme oxygenase activity in a library of four-helix bundle proteins: Towards the de novo synthesis of functional heme proteins
-
Monien, B. H. et al. Detection of heme oxygenase activity in a library of four-helix bundle proteins: towards the de novo synthesis of functional heme proteins. J. Mol. Biol. 371, 739-753 (2007).
-
(2007)
J. Mol. Biol
, vol.371
, pp. 739-753
-
-
Monien, B.H.1
-
11
-
-
1542334754
-
Functional analogues of cytochrome c oxidase, myoglobin, and hemoglobin
-
Collman, J. P., Boulatov, R., Sunderland, C. J. & Fu, L. Functional analogues of cytochrome c oxidase, myoglobin, and hemoglobin. Chem. Rev. 104, 561-588 (2004).
-
(2004)
Chem. Rev
, vol.104
, pp. 561-588
-
-
Collman, J.P.1
Boulatov, R.2
Sunderland, C.J.3
Fu, L.4
-
12
-
-
0016624901
-
Binding-energy, specificity, and enzymic catalysis - circe effect
-
Jencks, W. P. Binding-energy, specificity, and enzymic catalysis - circe effect. Adv. Enzymol. 43, 219-410 (1975).
-
(1975)
Adv. Enzymol
, vol.43
, pp. 219-410
-
-
Jencks, W.P.1
-
13
-
-
0017868338
-
Empirical predictions of protein conformation
-
Chou, P. Y. & Fasman, G. D. Empirical predictions of protein conformation. Annu. Rev. Biochem. 47, 251-276 (1978).
-
(1978)
Annu. Rev. Biochem
, vol.47
, pp. 251-276
-
-
Chou, P.Y.1
Fasman, G.D.2
-
14
-
-
0023812695
-
Characterization of a helical protein designed from 1st principles
-
Regan, L. & Degrado, W. F. Characterization of a helical protein designed from 1st principles. Science 241, 976-978 (1988).
-
(1988)
Science
, vol.241
, pp. 976-978
-
-
Regan, L.1
Degrado, W.F.2
-
15
-
-
0028281579
-
Design and synthesis of multi-heme proteins
-
Robertson, D. E. et al. Design and synthesis of multi-heme proteins. Nature 368, 425-431 (1994).
-
(1994)
Nature
, vol.368
, pp. 425-431
-
-
Robertson, D.E.1
-
16
-
-
0033516281
-
Iterative protein redesign
-
Gibney, B. R. et al. Iterative protein redesign. J. Am. Chem. Soc. 121, 4952-4960 (1999).
-
(1999)
J. Am. Chem. Soc
, vol.121
, pp. 4952-4960
-
-
Gibney, B.R.1
-
17
-
-
0037470553
-
X-ray structure of a maquette scaffold
-
Huang, S. S. et al. X-ray structure of a maquette scaffold. J. Mol. Biol. 326, 1219-1225 (2003).
-
(2003)
J. Mol. Biol
, vol.326
, pp. 1219-1225
-
-
Huang, S.S.1
-
18
-
-
1842631425
-
The HP-1 maquette: From an apoprotein structure to a structured hemoprotein designed to promote redox-coupled proton exchange
-
Huang, S. S. et al. The HP-1 maquette: from an apoprotein structure to a structured hemoprotein designed to promote redox-coupled proton exchange. Proc. Natl Acad. Sci. USA 101, 5536-5541 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 5536-5541
-
-
Huang, S.S.1
-
19
-
-
0035910266
-
Achieving stability and conformational specificity in designed proteins via binary patterning
-
Marshall, S. A. & Mayo, S. L. Achieving stability and conformational specificity in designed proteins via binary patterning. J. Mol. Biol. 305, 619-631 (2001).
-
(2001)
J. Mol. Biol
, vol.305
, pp. 619-631
-
-
Marshall, S.A.1
Mayo, S.L.2
-
20
-
-
0014251790
-
Metalloenzymes - entatic nature of their active sites
-
Vallee, B. L. & Williams, R. J. P. Metalloenzymes - entatic nature of their active sites. Proc. Natl Acad. Sci. USA 59, 498-505 (1968).
-
(1968)
Proc. Natl Acad. Sci. USA
, vol.59
, pp. 498-505
-
-
Vallee, B.L.1
Williams, R.J.P.2
-
21
-
-
0032564310
-
Functionalized de novo designed proteins: Mechanism of proton coupling to oxidation/reduction in heme protein maquettes
-
Shifman, J. M. et al. Functionalized de novo designed proteins: mechanism of proton coupling to oxidation/reduction in heme protein maquettes. Biochemistry 37, 16815-16827 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 16815-16827
-
-
Shifman, J.M.1
-
22
-
-
33750968485
-
Native-like structure in designed four helix bundles driven by buried polar interactions
-
Koder, R. L. et al. Native-like structure in designed four helix bundles driven by buried polar interactions. J. Am. Chem. Soc. 128, 14450-14451 (2006).
-
(2006)
J. Am. Chem. Soc
, vol.128
, pp. 14450-14451
-
-
Koder, R.L.1
-
23
-
-
0033535980
-
Design and synthesis of a globin fold
-
Isogai, Y. et al. Design and synthesis of a globin fold. Biochemistry 38, 7431-7443 (1999).
-
(1999)
Biochemistry
, vol.38
, pp. 7431-7443
-
-
Isogai, Y.1
-
24
-
-
0034641675
-
Self-assembly of heme A and heme B in a designed four-helix bundle: Implications for a cytochrome c oxidase maquette
-
Gibney, B. R. et al. Self-assembly of heme A and heme B in a designed four-helix bundle: implications for a cytochrome c oxidase maquette. Biochemistry 39, 11041-11049 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 11041-11049
-
-
Gibney, B.R.1
-
25
-
-
11144288653
-
Design of a five-coordinate heme protein maquette: A spectroscopic model of deoxymyoglobin
-
Zhuang, J. Y. et al. Design of a five-coordinate heme protein maquette: a spectroscopic model of deoxymyoglobin. Inorg. Chem. 43, 8218-8220 (2004).
-
(2004)
Inorg. Chem
, vol.43
, pp. 8218-8220
-
-
Zhuang, J.Y.1
-
26
-
-
0011062898
-
Functional intermediates in reaction of cytochrome-oxidase with oxygen
-
Chance, B., Saronio, C. & Leigh, J. S. Functional intermediates in reaction of cytochrome-oxidase with oxygen. Proc. Natl Acad. Sci. USA 72, 1635-1640 (1975).
-
(1975)
Proc. Natl Acad. Sci. USA
, vol.72
, pp. 1635-1640
-
-
Chance, B.1
Saronio, C.2
Leigh, J.S.3
-
27
-
-
0001023291
-
The molecular mechanism of autoxidation for myoglobin and hemoglobin: A venerable puzzle
-
Shikama, K. The molecular mechanism of autoxidation for myoglobin and hemoglobin: a venerable puzzle. Chem. Rev. 98, 1357-1373 (1998).
-
(1998)
Chem. Rev
, vol.98
, pp. 1357-1373
-
-
Shikama, K.1
-
28
-
-
0041801437
-
Hemoglobin studies. 2. A synthetic material with hemoglobin-like property
-
Wang, J. H. Hemoglobin studies. 2. A synthetic material with hemoglobin-like property. J. Am. Chem. Soc. 80, 3168-3169 (1958).
-
(1958)
J. Am. Chem. Soc
, vol.80
, pp. 3168-3169
-
-
Wang, J.H.1
-
29
-
-
0035826571
-
Proof of principle in a de novo designed protein maquette: An allosterically regulated, charge-activated conformational switch in a tetra-alpha-helix bundle
-
Grosset, A. M. et al. Proof of principle in a de novo designed protein maquette: an allosterically regulated, charge-activated conformational switch in a tetra-alpha-helix bundle. Biochemistry 40, 5474-5487 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 5474-5487
-
-
Grosset, A.M.1
-
30
-
-
0035918528
-
A model for ligand binding to hexacoordinate hemoglobins
-
Trent, J. T., Hvitved, A. N. & Hargrove, M. S. A model for ligand binding to hexacoordinate hemoglobins. Biochemistry 40, 6155-6163 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 6155-6163
-
-
Trent, J.T.1
Hvitved, A.N.2
Hargrove, M.S.3
-
31
-
-
0035914459
-
Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family
-
Dewilde, S. et al. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J. Biol. Chem. 276, 38949-38955 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 38949-38955
-
-
Dewilde, S.1
-
32
-
-
0041833723
-
Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity
-
Pesce, A. et al. Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Structure 11, 1087-1095 (2003).
-
(2003)
Structure
, vol.11
, pp. 1087-1095
-
-
Pesce, A.1
-
33
-
-
0030681291
-
A comparison of functional and structural consequences of the tyrosine B10 and glutamine E7 motifs in two invertebrate hemoglobins (Ascaris suum and Lucina pectinata)
-
Peterson, E. S. et al. A comparison of functional and structural consequences of the tyrosine B10 and glutamine E7 motifs in two invertebrate hemoglobins (Ascaris suum and Lucina pectinata). Biochemistry 36, 13110-13121 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 13110-13121
-
-
Peterson, E.S.1
-
34
-
-
12344311264
-
Bioinspired hydrogen bond motifs in ligand design: The role of noncovalent interactions in metal ion mediated activation of dioxygen
-
Borovik, A. S. Bioinspired hydrogen bond motifs in ligand design: the role of noncovalent interactions in metal ion mediated activation of dioxygen. Acc. Chem. Res. 38, 54-61 (2005).
-
(2005)
Acc. Chem. Res
, vol.38
, pp. 54-61
-
-
Borovik, A.S.1
-
35
-
-
0001256538
-
Control of biological electron-transport via molecular recognition and binding - the velcro model
-
Mclendon, G. Control of biological electron-transport via molecular recognition and binding - the velcro model. Struct. Bond. 75, 159-174 (1991).
-
(1991)
Struct. Bond
, vol.75
, pp. 159-174
-
-
Mclendon, G.1
-
36
-
-
0142231009
-
Mechanism for electron transfer within and between proteins
-
Page, C. C., Moser, C. C. & Dutton, P. L. Mechanism for electron transfer within and between proteins. Curr. Opin. Chem. Biol. 7, 551-556 (2003).
-
(2003)
Curr. Opin. Chem. Biol
, vol.7
, pp. 551-556
-
-
Page, C.C.1
Moser, C.C.2
Dutton, P.L.3
-
38
-
-
0033791659
-
Critical analysis of antibody catalysis
-
Hilvert, D. Critical analysis of antibody catalysis. Annu. Rev. Biochem. 69, 751-793 (2000).
-
(2000)
Annu. Rev. Biochem
, vol.69
, pp. 751-793
-
-
Hilvert, D.1
-
39
-
-
34548858708
-
Engineering by homologous recombination: Exploring sequence and function within a conserved fold
-
Carbone, M. N. & Arnold, F. H. Engineering by homologous recombination: exploring sequence and function within a conserved fold. Curr. Opin. Struct. Biol. 17, 454-459 (2007).
-
(2007)
Curr. Opin. Struct. Biol
, vol.17
, pp. 454-459
-
-
Carbone, M.N.1
Arnold, F.H.2
-
40
-
-
0026513046
-
Nature of biological electron-transfer
-
Moser, C. C. et al. Nature of biological electron-transfer. Nature 355, 796-802 (1992).
-
(1992)
Nature
, vol.355
, pp. 796-802
-
-
Moser, C.C.1
-
41
-
-
0041821836
-
A perspective on enzyme catalysis
-
Benkovic, S. J. & Hammes-Schiffer, S. A perspective on enzyme catalysis. Science 301, 1196-1202 (2003).
-
(2003)
Science
, vol.301
, pp. 1196-1202
-
-
Benkovic, S.J.1
Hammes-Schiffer, S.2
-
42
-
-
0041876227
-
Computer simulations of enzyme catalysis: Methods, progress, and insights
-
Warshel, A. Computer simulations of enzyme catalysis: methods, progress, and insights. Annu. Rev. Biophys. Biomol. Struct. 32, 425-443 (2003).
-
(2003)
Annu. Rev. Biophys. Biomol. Struct
, vol.32
, pp. 425-443
-
-
Warshel, A.1
-
43
-
-
0041806720
-
Myoglobin: The hydrogen atom of biology and a paradigm of complexity
-
Frauenfelder, H., McMahon, B. H. & Fenimore, P. W. Myoglobin: the hydrogen atom of biology and a paradigm of complexity. Proc. Natl Acad. Sci. USA 100, 8615-8617 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 8615-8617
-
-
Frauenfelder, H.1
McMahon, B.H.2
Fenimore, P.W.3
-
44
-
-
0034801533
-
Carbon monoxide binding by de novo heme proteins derived from designed combinatorial libraries
-
Moffet, D. A. et al. Carbon monoxide binding by de novo heme proteins derived from designed combinatorial libraries. J. Am. Chem. Soc. 123, 2109-2115 (2001).
-
(2001)
J. Am. Chem. Soc
, vol.123
, pp. 2109-2115
-
-
Moffet, D.A.1
-
45
-
-
0033729233
-
A flash photolysis method to characterize hexacoordinate hemoglobin kinetics
-
Hargrove, M. S. A flash photolysis method to characterize hexacoordinate hemoglobin kinetics. Biophys. J. 79, 2733-2738 (2000).
-
(2000)
Biophys. J
, vol.79
, pp. 2733-2738
-
-
Hargrove, M.S.1
-
46
-
-
0026636807
-
The role of solvent viscosity in the dynamics of protein conformational-changes
-
Ansari, A. et al. The role of solvent viscosity in the dynamics of protein conformational-changes. Science 256, 1796-1798 (1992).
-
(1992)
Science
, vol.256
, pp. 1796-1798
-
-
Ansari, A.1
-
47
-
-
0001306148
-
Mechanisms of ligand recognition in myoglobin
-
Springer, B. A., Sligar, S. G., Olson, J. S. & Phillips, G. N. Mechanisms of ligand recognition in myoglobin. Chem. Rev. 94, 699-714 (1994).
-
(1994)
Chem. Rev
, vol.94
, pp. 699-714
-
-
Springer, B.A.1
Sligar, S.G.2
Olson, J.S.3
Phillips, G.N.4
-
48
-
-
0024468312
-
The effects of E7 and E11 mutations on the kinetics of ligand-binding to R-state human-hemoglobin
-
Mathews, A. J. et al. The effects of E7 and E11 mutations on the kinetics of ligand-binding to R-state human-hemoglobin. J. Biol. Chem. 264, 16573-16583 (1989).
-
(1989)
J. Biol. Chem
, vol.264
, pp. 16573-16583
-
-
Mathews, A.J.1
-
49
-
-
0345761151
-
Oxygen-avid hemoglobin of Ascaris
-
Goldberg, D. E. Oxygen-avid hemoglobin of Ascaris. Chem. Rev. 99, 3371-3378 (1999).
-
(1999)
Chem. Rev
, vol.99
, pp. 3371-3378
-
-
Goldberg, D.E.1
-
50
-
-
0017113593
-
Dissociation of CO from carboxyhemoglobin
-
Sharma, V. S., Schmidt, M. R. & Ranney, H. M. Dissociation of CO from carboxyhemoglobin. J. Biol. Chem. 251, 4267-4272 (1976).
-
(1976)
J. Biol. Chem
, vol.251
, pp. 4267-4272
-
-
Sharma, V.S.1
Schmidt, M.R.2
Ranney, H.M.3
-
51
-
-
0000056206
-
Methyl deuteration reactions in vinylporphyrins: Protoporphyrins IX, III, and XIII
-
Smith, K. M., Parish, D. W. & Inouye, W. S. Methyl deuteration reactions in vinylporphyrins: protoporphyrins IX, III, and XIII. J. Org. Chem. 51, 666-671 (1986).
-
(1986)
J. Org. Chem
, vol.51
, pp. 666-671
-
-
Smith, K.M.1
Parish, D.W.2
Inouye, W.S.3
-
52
-
-
0027491210
-
Contributing software to the internet: The amplify program
-
Engels, W. R. Contributing software to the internet: the amplify program. Trends Biochem. Sci. 18, 448-450 (1993).
-
(1993)
Trends Biochem. Sci
, vol.18
, pp. 448-450
-
-
Engels, W.R.1
-
53
-
-
0028784138
-
Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides
-
Stemmer, W. P. C., Crameri, A., Ha, K. D., Brennan, T. M. & Heyneker, H. L. Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides. Gene 164, 49-53 (1995).
-
(1995)
Gene
, vol.164
, pp. 49-53
-
-
Stemmer, W.P.C.1
Crameri, A.2
Ha, K.D.3
Brennan, T.M.4
Heyneker, H.L.5
-
54
-
-
0027584038
-
Overcoming inclusion body formation in a high-level expression system
-
Moore, J. T., Uppal, A., Maley, F. & Maley, G. F. Overcoming inclusion body formation in a high-level expression system. Protein Expr. Purif. 4, 160-163 (1993).
-
(1993)
Protein Expr. Purif
, vol.4
, pp. 160-163
-
-
Moore, J.T.1
Uppal, A.2
Maley, F.3
Maley, G.F.4
|