Designed divergent evolution of enzyme function

Nature

Volumn 440, Issue 7087, 2006, Pages 1078-1082

  Yoshikuni, Yasuo ^a,c   Ferrin, Thomas E ^a,d   Keasling, Jay D ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CATALYSIS; MOLECULAR BIOLOGY; PLASTICITY; SYNTHESIS (CHEMICAL);

BINDING SITE; BIOCHEMICAL ANALYSES; ENZYME FUNCTION; PROMISCUOUS ENZYMES;

ENZYMES;

AMINO ACID; CYSTEINE; GAMMA HUMULENE SYNTHASE; HISTIDINE; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; SERINE; SESQUITERPENE SYNTHASE; SYNTHETASE; TYROSINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID; CATALYSIS; DIVERGENCE; ENZYME ACTIVITY; NUMERICAL MODEL; PLASTICITY; PROTEIN; TERPENE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENETIC VARIABILITY; MATHEMATICAL MODEL; MOLECULAR EVOLUTION; PRIORITY JOURNAL; PROTEIN FUNCTION; REACTION ANALYSIS; SEQUENCE HOMOLOGY;

EID: 33646178621     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04607     Document Type: Article

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