Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 6, 2003, Pages 3143-3148

  Williams, Gavin J ^a   Domann, Silvie ^a   Nelson, Adam ^a   Berry, Alan ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; FRUCTOSE BISPHOSPHATASE; FRUCTOSE BISPHOSPHATE ALDOLASE; TAGATOSE 1,6 DIPHOSPHATE ALDOLASE; UNCLASSIFIED DRUG;

ARTICLE; CARBOHYDRATE SYNTHESIS; DNA BINDING; ENZYME BINDING; ENZYME MECHANISM; ENZYME SUBSTRATE; EVOLUTION; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

ALDEHYDE-LYASES; CATALYTIC DOMAIN; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; FRUCTOSEDIPHOSPHATES; HEXOSEDIPHOSPHATES; KINETICS; MODELS, MOLECULAR; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECOMBINANT PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0037453002     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0635924100     Document Type: Article

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