Evolutionary potential of (β/α)8-barrels: Functional promiscuity produced by single substitutions in the enolase superfamily

Biochemistry

Volumn 42, Issue 28, 2003, Pages 8387-8393

  Schmidt, Dawn M Z ^a   Mundorff, Emily C ^b   Dojka, Michael ^b   Bermudez, Ericka ^b   Ness, Jon E ^b,d   Govindarajan, Sridhar ^b,d   Babbitt, Patricia C ^c   Minshull, Jeremy ^b,d   Gerlt, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b MAXYGEN INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d DNA20 Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; ENZYMES; ESCHERICHIA COLI; REACTION KINETICS;

MUTANTS;

BIOCHEMISTRY;

ENOLASE; EPIMERASE; LEVO ALANINE DEXTRO LEVO GLUTAMINE EPIMERASE; LYSINE; MUCONATE LACTONINZING ENZYME II; MUCONIC ACID; MUTANT PROTEIN; O SUCCINYLBENZOATE SYNTHASE; UNCLASSIFIED DRUG;

(BETA ALPHA)8 BARREL DOMAIN; AMINO ACID SUBSTITUTION; ARTICLE; AUXOTROPHY; BACTERIUM MUTANT; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; EVOLUTION; EVOLUTIONARY ADAPTATION; GENETIC VARIABILITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; PSEUDOMONAS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CLONING, MOLECULAR; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPYRUVATE HYDRATASE; PROTEIN STRUCTURE, SECONDARY; PSEUDOMONAS; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PSEUDOMONAS; PSEUDOMONAS SP.;

EID: 0037780207     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034769a     Document Type: Article

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