Investigation of the mechanism of resistance to third-generation cephalosporins by class C β-lactamases by using chemical complementation

ChemBioChem

Volumn 6, Issue 11, 2005, Pages 2055-2067

  Carter, Brian T ^a,b   Lin, Hening ^a,c   Goldberg, Shalom D ^a,d   Althoff, Eric A ^a,e   Raushel, Jessica ^a,f   Cornish, Virginia W ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Bard High School Early College   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Antibiotic resistance; Chemical complementation; Drug research; High throughput screening; Lactamases

Indexed keywords

BETA LACTAMASE; CEFOTAXIME; CEPHALOSPORIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; BACTERIUM ISOLATE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL BOND; CHEMICAL MUTAGENESIS; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME SUBSTRATE COMPLEX; HIGH THROUGHPUT SCREENING; MICHAELIS CONSTANT; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CEFOTAXIME; CEPHALOSPORINS; CRYSTALLOGRAPHY, X-RAY; DIRECTED MOLECULAR EVOLUTION; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION;

BACTERIA (MICROORGANISMS);

EID: 27744603538     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200500058     Document Type: Article

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