-
1
-
-
9744222883
-
Protein quality control in Alzheimer's disease by the ubiquitin proteasome system
-
de Vrij F.M., Fischer D.F., van Leeuwen F.W., Hol E.M. Protein quality control in Alzheimer's disease by the ubiquitin proteasome system. Prog. Neurobiol. 2004, 74:249-270.
-
(2004)
Prog. Neurobiol.
, vol.74
, pp. 249-270
-
-
de Vrij, F.M.1
Fischer, D.F.2
van Leeuwen, F.W.3
Hol, E.M.4
-
2
-
-
27744451306
-
Ubiquitin-proteasome pathway components as therapeutic targets for CNS maladies
-
Upadhya S.C., Hegde A.N. Ubiquitin-proteasome pathway components as therapeutic targets for CNS maladies. Curr. Pharm. Des. 2005, 11:3807-3828.
-
(2005)
Curr. Pharm. Des.
, vol.11
, pp. 3807-3828
-
-
Upadhya, S.C.1
Hegde, A.N.2
-
3
-
-
33750363298
-
The roles of intracellular protein-degradation pathways in neurodegeneration
-
Rubinsztein D.C. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 2006, 443:780-786.
-
(2006)
Nature
, vol.443
, pp. 780-786
-
-
Rubinsztein, D.C.1
-
4
-
-
38449094180
-
Role of the ubiquitin proteasome system in Alzheimer's disease
-
Upadhya S.C., Hegde A.N. Role of the ubiquitin proteasome system in Alzheimer's disease. BMC Biochem. 2007, 8(Suppl 1):S12.
-
(2007)
BMC Biochem.
, vol.8
, Issue.SUPPL. 1
-
-
Upadhya, S.C.1
Hegde, A.N.2
-
5
-
-
0023140474
-
Ubiquitin is a component of paired helical filaments in Alzheimer's disease
-
Mori H., Kondo J., Ihara Y. Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 1987, 235:1641-1644.
-
(1987)
Science
, vol.235
, pp. 1641-1644
-
-
Mori, H.1
Kondo, J.2
Ihara, Y.3
-
6
-
-
0023927981
-
Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease
-
Lowe J., Blanchard A., Morrell K., Lennox G., Reynolds L., Billett M., Landon M., Mayer R.J. Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease. J. Pathol. 1988, 155:9-15.
-
(1988)
J. Pathol.
, vol.155
, pp. 9-15
-
-
Lowe, J.1
Blanchard, A.2
Morrell, K.3
Lennox, G.4
Reynolds, L.5
Billett, M.6
Landon, M.7
Mayer, R.J.8
-
7
-
-
4143112402
-
Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity
-
Hegde A.N. Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity. Prog. Neurobiol. 2004, 73:311-357.
-
(2004)
Prog. Neurobiol.
, vol.73
, pp. 311-357
-
-
Hegde, A.N.1
-
8
-
-
54249158324
-
Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction
-
Tai H.C., Schuman E.M. Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction. Nat. Rev. Neurosci. 2008, 9:826-838.
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 826-838
-
-
Tai, H.C.1
Schuman, E.M.2
-
9
-
-
0021099710
-
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown
-
Hershko A., Heller H., Elias S., Ciechanover A. Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J. Biol. Chem. 1983, 258:8206-8214.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 8206-8214
-
-
Hershko, A.1
Heller, H.2
Elias, S.3
Ciechanover, A.4
-
10
-
-
0034644474
-
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng L., Wang C., Spencer E., Yang L., Braun A., You J., Slaughter C., Pickart C., Chen Z.J. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000, 103:351-361.
-
(2000)
Cell
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
Yang, L.4
Braun, A.5
You, J.6
Slaughter, C.7
Pickart, C.8
Chen, Z.J.9
-
11
-
-
70350150000
-
The emerging complexity of protein ubiquitination
-
Komander D. The emerging complexity of protein ubiquitination. Biochem. Soc. Trans. 2009, 37:937-953.
-
(2009)
Biochem. Soc. Trans.
, vol.37
, pp. 937-953
-
-
Komander, D.1
-
12
-
-
70350461507
-
Building ubiquitin chains: E2 enzymes at work
-
Ye Y., Rape M. Building ubiquitin chains: E2 enzymes at work. Nat. Rev. Mol. Cell Biol. 2009, 10:755-764.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 755-764
-
-
Ye, Y.1
Rape, M.2
-
13
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction
-
Glickman M.H., Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 2002, 82:373-428.
-
(2002)
Physiol. Rev.
, vol.82
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
15
-
-
65249186662
-
Polyubiquitin binding and disassembly by deubiquitinating enzymes
-
Reyes-Turcu F.E., Wilkinson K.D. Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem. Rev. 2009, 109:1495-1508.
-
(2009)
Chem. Rev.
, vol.109
, pp. 1495-1508
-
-
Reyes-Turcu, F.E.1
Wilkinson, K.D.2
-
16
-
-
77749341438
-
Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity
-
Nagy V., Dikic I. Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity. Biol. Chem. 2010, 391:163-169.
-
(2010)
Biol. Chem.
, vol.391
, pp. 163-169
-
-
Nagy, V.1
Dikic, I.2
-
17
-
-
0031058283
-
Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells
-
Beer-Romero P., Glass S., Rolfe M. Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells. Oncogene 1997, 14:595-602.
-
(1997)
Oncogene
, vol.14
, pp. 595-602
-
-
Beer-Romero, P.1
Glass, S.2
Rolfe, M.3
-
18
-
-
0345119031
-
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression
-
Colledge M., Snyder E.M., Crozier R.A., Soderling J.A., Jin Y., Langeberg L.K., Lu H., Bear M.F., Scott J.D. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 2003, 40:595-607.
-
(2003)
Neuron
, vol.40
, pp. 595-607
-
-
Colledge, M.1
Snyder, E.M.2
Crozier, R.A.3
Soderling, J.A.4
Jin, Y.5
Langeberg, L.K.6
Lu, H.7
Bear, M.F.8
Scott, J.D.9
-
19
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y., Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998, 392:605-608.
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
20
-
-
11244351579
-
Function and regulation of cullin-RING ubiquitin ligases
-
Petroski M.D., Deshaies R.J. Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 2005, 6:9-20.
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 9-20
-
-
Petroski, M.D.1
Deshaies, R.J.2
-
21
-
-
0034745011
-
Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway
-
Tanaka K., Kawakami T., Tateishi K., Yashiroda H., Chiba T. Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway. Biochimie 2001, 83:351-356.
-
(2001)
Biochimie
, vol.83
, pp. 351-356
-
-
Tanaka, K.1
Kawakami, T.2
Tateishi, K.3
Yashiroda, H.4
Chiba, T.5
-
22
-
-
0033615342
-
Mechanisms and regulation of the degradation of cyclin B
-
Hershko A. Mechanisms and regulation of the degradation of cyclin B. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1999, 354:1571-1575.
-
(1999)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.354
, pp. 1571-1575
-
-
Hershko, A.1
-
24
-
-
64549115746
-
Toward an atomic model of the 26S proteasome
-
Cheng Y. Toward an atomic model of the 26S proteasome. Curr. Opin. Struct. Biol. 2009, 19:203-208.
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, pp. 203-208
-
-
Cheng, Y.1
-
25
-
-
65249098267
-
Catalytic mechanism and assembly of the proteasome
-
Marques A.J., Palanimurugan R., Matias A.C., Ramos P.C., Dohmen R.J. Catalytic mechanism and assembly of the proteasome. Chem. Rev. 2009, 109:1509-1536.
-
(2009)
Chem. Rev.
, vol.109
, pp. 1509-1536
-
-
Marques, A.J.1
Palanimurugan, R.2
Matias, A.C.3
Ramos, P.C.4
Dohmen, R.J.5
-
26
-
-
78049264771
-
The 26S proteasome: assembly and function of a destructive machine
-
Epub ahead of print
-
Gallastegui N., Groll M. The 26S proteasome: assembly and function of a destructive machine. Trends Biochem. Sci. 2010, Epub ahead of print.
-
(2010)
Trends Biochem. Sci.
-
-
Gallastegui, N.1
Groll, M.2
-
27
-
-
0036753063
-
Multiple associated proteins regulate proteasome structure and function
-
Leggett D.S., Hanna J., Borodovsky A., Crosas B., Schmidt M., Baker R.T., Walz T., Ploegh H., Finley D. Multiple associated proteins regulate proteasome structure and function. Mol. Cell 2002, 10:495-507.
-
(2002)
Mol. Cell
, vol.10
, pp. 495-507
-
-
Leggett, D.S.1
Hanna, J.2
Borodovsky, A.3
Crosas, B.4
Schmidt, M.5
Baker, R.T.6
Walz, T.7
Ploegh, H.8
Finley, D.9
-
28
-
-
71149107057
-
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening
-
Peth A., Besche H.C., Goldberg A.L. Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening. Mol. Cell 2009, 36:794-804.
-
(2009)
Mol. Cell
, vol.36
, pp. 794-804
-
-
Peth, A.1
Besche, H.C.2
Goldberg, A.L.3
-
29
-
-
0034514655
-
Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome
-
Wilkinson K.D. Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. Semin. Cell Dev. Biol. 2000, 11:141-148.
-
(2000)
Semin. Cell Dev. Biol.
, vol.11
, pp. 141-148
-
-
Wilkinson, K.D.1
-
30
-
-
0023119757
-
The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily
-
Baker R.T., Board P.G. The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily. Nucleic Acids Res. 1987, 15:443-463.
-
(1987)
Nucleic Acids Res.
, vol.15
, pp. 443-463
-
-
Baker, R.T.1
Board, P.G.2
-
31
-
-
0026062590
-
The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes
-
Baker R.T., Board P.G. The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes. Nucleic Acids Res. 1991, 19:1035-1040.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 1035-1040
-
-
Baker, R.T.1
Board, P.G.2
-
32
-
-
0027304239
-
Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity
-
Hegde A.N., Goldberg A.L., Schwartz J.H. Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:7436-7440.
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 7436-7440
-
-
Hegde, A.N.1
Goldberg, A.L.2
Schwartz, J.H.3
-
33
-
-
0023643233
-
A molecular mechanism for long-term sensitization in Aplysia
-
Greenberg S.M., Castellucci V.F., Bayley H., Schwartz J.H. A molecular mechanism for long-term sensitization in Aplysia. Nature 1987, 329:62-65.
-
(1987)
Nature
, vol.329
, pp. 62-65
-
-
Greenberg, S.M.1
Castellucci, V.F.2
Bayley, H.3
Schwartz, J.H.4
-
34
-
-
0030887633
-
Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia
-
Hegde A.N., Inokuchi K., Pei W., Casadio A., Ghirardi M., Chain D.G., Martin K.C., Kandel E.R., Schwartz J.H. Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 1997, 89:115-126.
-
(1997)
Cell
, vol.89
, pp. 115-126
-
-
Hegde, A.N.1
Inokuchi, K.2
Pei, W.3
Casadio, A.4
Ghirardi, M.5
Chain, D.G.6
Martin, K.C.7
Kandel, E.R.8
Schwartz, J.H.9
-
35
-
-
33747199933
-
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
-
Gong B., Cao Z., Zheng P., Vitolo O.V., Liu S., Staniszewski A., Moolman D., Zhang H., Shelanski M., Arancio O. Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell 2006, 126:775-788.
-
(2006)
Cell
, vol.126
, pp. 775-788
-
-
Gong, B.1
Cao, Z.2
Zheng, P.3
Vitolo, O.V.4
Liu, S.5
Staniszewski, A.6
Moolman, D.7
Zhang, H.8
Shelanski, M.9
Arancio, O.10
-
36
-
-
0032911634
-
Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia
-
Chain D.G., Casadio A., Schacher S., Hegde A.N., Valbrun M., Yamamoto N., Goldberg A.L., Bartsch D., Kandel E.R., Schwartz J.H. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 1999, 22:147-156.
-
(1999)
Neuron
, vol.22
, pp. 147-156
-
-
Chain, D.G.1
Casadio, A.2
Schacher, S.3
Hegde, A.N.4
Valbrun, M.5
Yamamoto, N.6
Goldberg, A.L.7
Bartsch, D.8
Kandel, E.R.9
Schwartz, J.H.10
-
37
-
-
0035783657
-
The ubiquitin-proteasome cascade is required for mammalian long-term memory formation
-
The ubiquitin-proteasome cascade is required for mammalian long-term memory formation. Eur. J. Neurosci. 2001, 14:1820-1826.
-
(2001)
Eur. J. Neurosci.
, vol.14
, pp. 1820-1826
-
-
-
38
-
-
40049106834
-
Synaptic protein degradation underlies destabilization of retrieved fear memory
-
Lee S.H., Choi J.H., Lee N., Lee H.R., Kim J.I., Yu N.K., Choi S.L., Lee S.H., Kim H., Kaang B.K. Synaptic protein degradation underlies destabilization of retrieved fear memory. Science 2008, 319:1253-1256.
-
(2008)
Science
, vol.319
, pp. 1253-1256
-
-
Lee, S.H.1
Choi, J.H.2
Lee, N.3
Lee, H.R.4
Kim, J.I.5
Yu, N.K.6
Choi, S.L.7
Lee, S.H.8
Kim, H.9
Kaang, B.K.10
-
39
-
-
77954416653
-
The ubiquitin-proteasome pathway and synaptic plasticity
-
Hegde A.N. The ubiquitin-proteasome pathway and synaptic plasticity. Learn. Mem. 2010, 17:314-327.
-
(2010)
Learn. Mem.
, vol.17
, pp. 314-327
-
-
Hegde, A.N.1
-
40
-
-
0025277205
-
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
-
Dash P.K., Hochner B., Kandel E.R. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature 1990, 345:718-721.
-
(1990)
Nature
, vol.345
, pp. 718-721
-
-
Dash, P.K.1
Hochner, B.2
Kandel, E.R.3
-
41
-
-
0028071507
-
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
-
Bourtchuladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., Silva A.J. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 1994, 79:59-68.
-
(1994)
Cell
, vol.79
, pp. 59-68
-
-
Bourtchuladze, R.1
Frenguelli, B.2
Blendy, J.3
Cioffi, D.4
Schutz, G.5
Silva, A.J.6
-
42
-
-
0027983479
-
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
-
Yin J.C., Wallach J.S., Del V.M., Wilder E.L., Zhou H., Quinn W.G., Tully T. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 1994, 79:49-58.
-
(1994)
Cell
, vol.79
, pp. 49-58
-
-
Yin, J.C.1
Wallach, J.S.2
Del, V.M.3
Wilder, E.L.4
Zhou, H.5
Quinn, W.G.6
Tully, T.7
-
43
-
-
0032538271
-
CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation
-
Bartsch D., Casadio A., Karl K.A., Serodio P., Kandel E.R. CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 1998, 95:211-223.
-
(1998)
Cell
, vol.95
, pp. 211-223
-
-
Bartsch, D.1
Casadio, A.2
Karl, K.A.3
Serodio, P.4
Kandel, E.R.5
-
44
-
-
0029173665
-
CAMP-dependent regulation of gene transcription by cAMP response element-binding protein and cAMP response element modulator
-
Habener J.F., Miller C.P., Vallejo M. cAMP-dependent regulation of gene transcription by cAMP response element-binding protein and cAMP response element modulator. Vitam. Horm. 1995, 51:1-57.
-
(1995)
Vitam. Horm.
, vol.51
, pp. 1-57
-
-
Habener, J.F.1
Miller, C.P.2
Vallejo, M.3
-
45
-
-
0029564149
-
Transcription factors responsive to cAMP
-
Sassone-Corsi P. Transcription factors responsive to cAMP. Annu. Rev. Cell Dev. Biol. 1995, 11:355-377.
-
(1995)
Annu. Rev. Cell Dev. Biol.
, vol.11
, pp. 355-377
-
-
Sassone-Corsi, P.1
-
46
-
-
4143074888
-
Ubiquitin-proteasome-mediated CREB repressor degradation during induction of long-term facilitation
-
Upadhya S.C., Smith T.K., Hegde A.N. Ubiquitin-proteasome-mediated CREB repressor degradation during induction of long-term facilitation. J. Neurochem. 2004, 91:210-219.
-
(2004)
J. Neurochem.
, vol.91
, pp. 210-219
-
-
Upadhya, S.C.1
Smith, T.K.2
Hegde, A.N.3
-
47
-
-
0032732832
-
Activation and degradation of the transcription factor C/EBP during long-term facilitation in Aplysia
-
Yamamoto N., Hegde A.N., Chain D.G., Schwartz J.H. Activation and degradation of the transcription factor C/EBP during long-term facilitation in Aplysia. J. Neurochem. 1999, 73:2415-2423.
-
(1999)
J. Neurochem.
, vol.73
, pp. 2415-2423
-
-
Yamamoto, N.1
Hegde, A.N.2
Chain, D.G.3
Schwartz, J.H.4
-
48
-
-
43049090872
-
Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation
-
Dong C., Upadhya S.C., Ding L., Smith T.K., Hegde A.N. Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation. Learn. Mem. 2008, 15:335-347.
-
(2008)
Learn. Mem.
, vol.15
, pp. 335-347
-
-
Dong, C.1
Upadhya, S.C.2
Ding, L.3
Smith, T.K.4
Hegde, A.N.5
-
49
-
-
0037134015
-
Recruitment of a 19S proteasome subcomplex to an activated promoter
-
Gonzalez F., Delahodde A., Kodadek T., Johnston S.A. Recruitment of a 19S proteasome subcomplex to an activated promoter. Science 2002, 296:548-550.
-
(2002)
Science
, vol.296
, pp. 548-550
-
-
Gonzalez, F.1
Delahodde, A.2
Kodadek, T.3
Johnston, S.A.4
-
50
-
-
33645389088
-
Proteasome and transcription: a destroyer goes into construction
-
Hegde A.N., Upadhya S.C. Proteasome and transcription: a destroyer goes into construction. Bioessays 2006, 28:235-239.
-
(2006)
Bioessays
, vol.28
, pp. 235-239
-
-
Hegde, A.N.1
Upadhya, S.C.2
-
52
-
-
37749021009
-
A role for SUMO modification in transcriptional repression and activation
-
Lyst M.J., Stancheva I. A role for SUMO modification in transcriptional repression and activation. Biochem. Soc. Trans. 2007, 35:1389-1392.
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 1389-1392
-
-
Lyst, M.J.1
Stancheva, I.2
-
53
-
-
0037174622
-
The developing synapse: construction and modulation of synaptic structures and circuits
-
Cohen-Cory S. The developing synapse: construction and modulation of synaptic structures and circuits. Science 2002, 298:770-776.
-
(2002)
Science
, vol.298
, pp. 770-776
-
-
Cohen-Cory, S.1
-
54
-
-
33646125845
-
Cell-intrinsic regulation of axonal morphogenesis by the Cdh1-APC target SnoN
-
Stegmuller J., Konishi Y., Huynh M.A., Yuan Z., Dibacco S., Bonni A. Cell-intrinsic regulation of axonal morphogenesis by the Cdh1-APC target SnoN. Neuron 2006, 50:389-400.
-
(2006)
Neuron
, vol.50
, pp. 389-400
-
-
Stegmuller, J.1
Konishi, Y.2
Huynh, M.A.3
Yuan, Z.4
Dibacco, S.5
Bonni, A.6
-
55
-
-
0141428795
-
Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders
-
Layfield R., Cavey J.R., Lowe J. Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders. Ageing Res. Rev. 2003, 2:343-356.
-
(2003)
Ageing Res. Rev.
, vol.2
, pp. 343-356
-
-
Layfield, R.1
Cavey, J.R.2
Lowe, J.3
-
56
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 2002, 298:789-791.
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
57
-
-
25844512787
-
Synaptic protein degradation by the ubiquitin proteasome system
-
Bingol B., Schuman E.M. Synaptic protein degradation by the ubiquitin proteasome system. Curr. Opin. Neurobiol. 2005, 15:536-541.
-
(2005)
Curr. Opin. Neurobiol.
, vol.15
, pp. 536-541
-
-
Bingol, B.1
Schuman, E.M.2
-
58
-
-
32344440647
-
Synapse formation and plasticity: recent insights from the perspective of the ubiquitin proteasome system
-
Patrick G.N. Synapse formation and plasticity: recent insights from the perspective of the ubiquitin proteasome system. Curr. Opin. Neurobiol. 2006, 16:90-94.
-
(2006)
Curr. Opin. Neurobiol.
, vol.16
, pp. 90-94
-
-
Patrick, G.N.1
-
59
-
-
0019972810
-
The cholinergic hypothesis of geriatric memory dysfunction
-
Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217:408-414.
-
(1982)
Science
, vol.217
, pp. 408-414
-
-
Bartus, R.T.1
Dean, R.L.2
Beer, B.3
Lippa, A.S.4
-
60
-
-
0031128758
-
Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis
-
Graeber M.B., Kosel S., Egensperger R., Banati R.B., Muller U., Bise K., Hoff P., Moller H.J., Fujisawa K., Mehraein P. Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis. Neurogenetics 1997, 1:73-80.
-
(1997)
Neurogenetics
, vol.1
, pp. 73-80
-
-
Graeber, M.B.1
Kosel, S.2
Egensperger, R.3
Banati, R.B.4
Muller, U.5
Bise, K.6
Hoff, P.7
Moller, H.J.8
Fujisawa, K.9
Mehraein, P.10
-
61
-
-
0031855023
-
The case described by Alois Alzheimer in 1911. Historical and conceptual perspectives based on the clinical record and neurohistological sections
-
Moller H.J., Graeber M.B. The case described by Alois Alzheimer in 1911. Historical and conceptual perspectives based on the clinical record and neurohistological sections. Eur. Arch. Psychiatry Clin. Neurosci. 1911, 248(1998):111-122.
-
(1911)
Eur. Arch. Psychiatry Clin. Neurosci.
, vol.248
, Issue.1998
, pp. 111-122
-
-
Moller, H.J.1
Graeber, M.B.2
-
62
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 2004, 430:631-639.
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
63
-
-
0345419152
-
Paired helical filaments from Alzheimer disease patients contain cytoskeletal components
-
Perry G., Rizzuto N., Utilio-Gambetti L., Gambetti P. Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc. Natl. Acad. Sci. U. S. A. 1985, 82:3916-3920.
-
(1985)
Proc. Natl. Acad. Sci. U. S. A.
, vol.82
, pp. 3916-3920
-
-
Perry, G.1
Rizzuto, N.2
Utilio-Gambetti, L.3
Gambetti, P.4
-
64
-
-
0025753852
-
The molecular pathology of Alzheimer's disease
-
Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron 1991, 6:487-498.
-
(1991)
Neuron
, vol.6
, pp. 487-498
-
-
Selkoe, D.J.1
-
66
-
-
27344441173
-
Metabolism of amyloid-beta peptide and Alzheimer's disease
-
Iwata N., Higuchi M., Saido T.C. Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacol. Ther. 2005, 108:129-148.
-
(2005)
Pharmacol. Ther.
, vol.108
, pp. 129-148
-
-
Iwata, N.1
Higuchi, M.2
Saido, T.C.3
-
67
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. U. S. A. 1985, 82:4245-4249.
-
(1985)
Proc. Natl. Acad. Sci. U. S. A.
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
68
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81:741-766.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
69
-
-
0041343303
-
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
-
An W.L., Cowburn R.F., Li L., Braak H., Alafuzoff I., Iqbal K., Iqbal I.G., Winblad B., Pei J.J. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am. J. Pathol. 2003, 163:591-607.
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 591-607
-
-
An, W.L.1
Cowburn, R.F.2
Li, L.3
Braak, H.4
Alafuzoff, I.5
Iqbal, K.6
Iqbal, I.G.7
Winblad, B.8
Pei, J.J.9
-
70
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
71
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
-
Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30:572-580.
-
(1991)
Ann. Neurol.
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
72
-
-
13044287361
-
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
-
Hsia A.Y., Masliah E., McConlogue L., Yu G.Q., Tatsuno G., Hu K., Kholodenko D., Malenka R.C., Nicoll R.A., Mucke L. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:3228-3233.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 3228-3233
-
-
Hsia, A.Y.1
Masliah, E.2
McConlogue, L.3
Yu, G.Q.4
Tatsuno, G.5
Hu, K.6
Kholodenko, D.7
Malenka, R.C.8
Nicoll, R.A.9
Mucke, L.10
-
73
-
-
0034213718
-
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
-
Mucke L., Masliah E., Yu G.Q., Mallory M., Rockenstein E.M., Tatsuno G., Hu K., Kholodenko D., Johnson-Wood K., McConlogue L. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 2000, 20:4050-4058.
-
(2000)
J. Neurosci.
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
74
-
-
0033523480
-
Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice
-
Larson J., Lynch G., Games D., Seubert P. Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Res. 1999, 840:23-35.
-
(1999)
Brain Res.
, vol.840
, pp. 23-35
-
-
Larson, J.1
Lynch, G.2
Games, D.3
Seubert, P.4
-
75
-
-
0033525520
-
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
-
Moechars D., Dewachter I., Lorent K., Reverse D., Baekelandt V., Naidu A., Tesseur I., Spittaels K., Van Den Haute C., Checler F., Godaux E., Cordell B., Van Leuven F. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J. Biol. Chem. 1999, 274:6483-6492.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6483-6492
-
-
Moechars, D.1
Dewachter, I.2
Lorent, K.3
Reverse, D.4
Baekelandt, V.5
Naidu, A.6
Tesseur, I.7
Spittaels, K.8
Van Den Haute, C.9
Checler, F.10
Godaux, E.11
Cordell, B.12
Van Leuven, F.13
-
76
-
-
0036792096
-
Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling
-
Vitolo O.V., Sant'Angelo A., Costanzo V., Battaglia F., Arancio O., Shelanski M. Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:13217-13221.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 13217-13221
-
-
Vitolo, O.V.1
Sant'Angelo, A.2
Costanzo, V.3
Battaglia, F.4
Arancio, O.5
Shelanski, M.6
-
77
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996, 274:99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
78
-
-
0033360356
-
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
-
Chapman P.F., White G.L., Jones M.W., Cooper-Blacketer D., Marshall V.J., Irizarry M., Younkin L., Good M.A., Bliss T.V.P., Hyman B.T., Younkin S.G., Hsiao K.K. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat. Neurosci. 1999, 2:271-276.
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 271-276
-
-
Chapman, P.F.1
White, G.L.2
Jones, M.W.3
Cooper-Blacketer, D.4
Marshall, V.J.5
Irizarry, M.6
Younkin, L.7
Good, M.A.8
Bliss, T.V.P.9
Hyman, B.T.10
Younkin, S.G.11
Hsiao, K.K.12
-
79
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416:535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
80
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar G.M., Li S., Mehta T.H., Garcia-Munoz A., Shepardson N.E., Smith I., Brett F.M., Farrell M.A., Rowan M.J., Lemere C.A., Regan C.M., Walsh D.M., Sabatini B.L., Selkoe D.J. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 2008, 14:837-842.
-
(2008)
Nat. Med.
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
81
-
-
0141987860
-
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg
-
Ciechanover A., Brundin P. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 2003, 40:427-446.
-
(2003)
Neuron
, vol.40
, pp. 427-446
-
-
Ciechanover, A.1
Brundin, P.2
-
82
-
-
0030345833
-
Endosome-lysosomes, ubiquitin and neurodegeneration
-
Mayer R.J., Tipler C., Arnold J., Laszlo L., Al-Khedhairy A., Lowe J., Landon M. Endosome-lysosomes, ubiquitin and neurodegeneration. Adv. Exp. Med. Biol. 1996, 389:261-269.
-
(1996)
Adv. Exp. Med. Biol.
, vol.389
, pp. 261-269
-
-
Mayer, R.J.1
Tipler, C.2
Arnold, J.3
Laszlo, L.4
Al-Khedhairy, A.5
Lowe, J.6
Landon, M.7
-
83
-
-
0031006343
-
Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease
-
Busciglio J., Hartmann H., Lorenzo A., Wong C., Baumann K., Sommer B., Staufenbiel M., Yankner B.A. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J. Neurosci. 1997, 17:5101-5107.
-
(1997)
J. Neurosci.
, vol.17
, pp. 5101-5107
-
-
Busciglio, J.1
Hartmann, H.2
Lorenzo, A.3
Wong, C.4
Baumann, K.5
Sommer, B.6
Staufenbiel, M.7
Yankner, B.A.8
-
84
-
-
0032127320
-
Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease
-
Chui D.H., Shirotani K., Tanahashi H., Akiyama H., Ozawa K., Kunishita T., Takahashi K., Makifuchi T., Tabira T. Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease. J. Neurosci. Res. 1998, 53:99-106.
-
(1998)
J. Neurosci. Res.
, vol.53
, pp. 99-106
-
-
Chui, D.H.1
Shirotani, K.2
Tanahashi, H.3
Akiyama, H.4
Ozawa, K.5
Kunishita, T.6
Takahashi, K.7
Makifuchi, T.8
Tabira, T.9
-
85
-
-
0031922291
-
Establishing a pathological diagnosis in degenerative dementias
-
Lowe J. Establishing a pathological diagnosis in degenerative dementias. Brain Pathol. 1998, 8:403-406.
-
(1998)
Brain Pathol.
, vol.8
, pp. 403-406
-
-
Lowe, J.1
-
86
-
-
0034718208
-
Role of the proteasome in Alzheimer's disease
-
Checler F., da Costa C.A., Ancolio K., Chevallier N., Lopez-Perez E., Marambaud P. Role of the proteasome in Alzheimer's disease. Biochim. Biophys. Acta 2000, 1502:133-138.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 133-138
-
-
Checler, F.1
da Costa, C.A.2
Ancolio, K.3
Chevallier, N.4
Lopez-Perez, E.5
Marambaud, P.6
-
87
-
-
0037312293
-
NEDD8 protein is involved in ubiquitinated inclusion bodies
-
Dil K.A., Kito K., Abe Y., Shin R.W., Kamitani T., Ueda N. NEDD8 protein is involved in ubiquitinated inclusion bodies. J. Pathol. 2003, 199:259-266.
-
(2003)
J. Pathol.
, vol.199
, pp. 259-266
-
-
Dil, K.A.1
Kito, K.2
Abe, Y.3
Shin, R.W.4
Kamitani, T.5
Ueda, N.6
-
88
-
-
67449131894
-
Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration
-
Paine S., Bedford L., Thorpe J.R., Mayer R.J., Cavey J.R., Bajaj N., Sheppard P.W., Lowe J., Layfield R. Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration. Neurosci. Lett. 2009, 460:205-208.
-
(2009)
Neurosci. Lett.
, vol.460
, pp. 205-208
-
-
Paine, S.1
Bedford, L.2
Thorpe, J.R.3
Mayer, R.J.4
Cavey, J.R.5
Bajaj, N.6
Sheppard, P.W.7
Lowe, J.8
Layfield, R.9
-
89
-
-
0001521232
-
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains
-
Perry G., Friedman R., Shaw G., Chau V. Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc. Natl. Acad. Sci. U. S. A. 1987, 84:3033-3036.
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 3033-3036
-
-
Perry, G.1
Friedman, R.2
Shaw, G.3
Chau, V.4
-
90
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl) 1991, 82:239-259.
-
(1991)
Acta Neuropathol. (Berl)
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
91
-
-
33845954777
-
It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease
-
Arnaud L., Robakis N.K., Figueiredo-Pereira M.E. It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease. Neurodegener. Dis. 2006, 3:313-319.
-
(2006)
Neurodegener. Dis.
, vol.3
, pp. 313-319
-
-
Arnaud, L.1
Robakis, N.K.2
Figueiredo-Pereira, M.E.3
-
92
-
-
0032576605
-
Aggresomes: a cellular response to misfolded proteins
-
Johnston J.A., Ward C.L., Kopito R.R. Aggresomes: a cellular response to misfolded proteins. J. Cell Biol. 1998, 143:1883-1898.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 1883-1898
-
-
Johnston, J.A.1
Ward, C.L.2
Kopito, R.R.3
-
93
-
-
3042811126
-
A single amino acid substitution in a proteasome subunit triggers aggregation of ubiquitinated proteins in stressed neuronal cells
-
Li Z., Arnaud L., Rockwell P., Figueiredo-Pereira M.E. A single amino acid substitution in a proteasome subunit triggers aggregation of ubiquitinated proteins in stressed neuronal cells. J. Neurochem. 2004, 90:19-28.
-
(2004)
J. Neurochem.
, vol.90
, pp. 19-28
-
-
Li, Z.1
Arnaud, L.2
Rockwell, P.3
Figueiredo-Pereira, M.E.4
-
94
-
-
70349755717
-
Reversal of long-term dendritic spine alterations in Alzheimer disease models
-
Smith D.L., Pozueta J., Gong B., Arancio O., Shelanski M. Reversal of long-term dendritic spine alterations in Alzheimer disease models. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:16877-16882.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 16877-16882
-
-
Smith, D.L.1
Pozueta, J.2
Gong, B.3
Arancio, O.4
Shelanski, M.5
-
95
-
-
0028811634
-
Axonal degeneration promotes abnormal accumulation of amyloid beta-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse
-
Ichihara N., Wu J., Chui D.H., Yamazaki K., Wakabayashi T., Kikuchi T. Axonal degeneration promotes abnormal accumulation of amyloid beta-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse. Brain Res. 1995, 695:173-178.
-
(1995)
Brain Res.
, vol.695
, pp. 173-178
-
-
Ichihara, N.1
Wu, J.2
Chui, D.H.3
Yamazaki, K.4
Wakabayashi, T.5
Kikuchi, T.6
-
96
-
-
0029133951
-
Ubiquitin immunoreactivity in the central nervous system of gracile axonal dystrophy (GAD) mouse
-
Wu J., Ichihara N., Chui D.H., Yamazaki K., Kikuchi T. Ubiquitin immunoreactivity in the central nervous system of gracile axonal dystrophy (GAD) mouse. No To Shinkei 1995, 47:881-885.
-
(1995)
No To Shinkei
, vol.47
, pp. 881-885
-
-
Wu, J.1
Ichihara, N.2
Chui, D.H.3
Yamazaki, K.4
Kikuchi, T.5
-
97
-
-
10744224825
-
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
-
Osaka H., Wang Y.L., Takada K., Takizawa S., Setsuie R., Li H., Sato Y., Nishikawa K., Sun Y.J., Sakurai M., Harada T., Hara Y., Kimura I., Chiba S., Namikawa K., Kiyama H., Noda M., Aoki S., Wada K. Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum. Mol. Genet. 2003, 12:1945-1958.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1945-1958
-
-
Osaka, H.1
Wang, Y.L.2
Takada, K.3
Takizawa, S.4
Setsuie, R.5
Li, H.6
Sato, Y.7
Nishikawa, K.8
Sun, Y.J.9
Sakurai, M.10
Harada, T.11
Hara, Y.12
Kimura, I.13
Chiba, S.14
Namikawa, K.15
Kiyama, H.16
Noda, M.17
Aoki, S.18
Wada, K.19
-
98
-
-
33646482114
-
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies
-
Barrachina M., Castano E., Dalfo E., Maes T., Buesa C., Ferrer I. Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies. Neurobiol. Dis. 2006, 22:265-273.
-
(2006)
Neurobiol. Dis.
, vol.22
, pp. 265-273
-
-
Barrachina, M.1
Castano, E.2
Dalfo, E.3
Maes, T.4
Buesa, C.5
Ferrer, I.6
-
99
-
-
1842581669
-
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
-
Choi J., Levey A.I., Weintraub S.T., Rees H.D., Gearing M., Chin L.S., Li L. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J. Biol. Chem. 2004, 279:13256-13264.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 13256-13264
-
-
Choi, J.1
Levey, A.I.2
Weintraub, S.T.3
Rees, H.D.4
Gearing, M.5
Chin, L.S.6
Li, L.7
-
100
-
-
33646869931
-
Genetic association between ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population
-
Xue S., Jia J. Genetic association between ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population. Brain Res. 2006, 1087:28-32.
-
(2006)
Brain Res.
, vol.1087
, pp. 28-32
-
-
Xue, S.1
Jia, J.2
-
101
-
-
65049084168
-
Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin
-
Fischer D.F., van D.R., van T.P., Hobo B., Verhage M.C., van der Schors R.C., Li K.W., van M.J., Hol E.M., van Leeuwen F.W. Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin. Neurobiol. Aging 2009, 30:847-863.
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 847-863
-
-
Fischer, D.F.1
van, D.R.2
van, T.P.3
Hobo, B.4
Verhage, M.C.5
van der Schors, R.C.6
Li, K.W.7
van, M.J.8
Hol, E.M.9
van Leeuwen, F.W.10
-
102
-
-
2142645006
-
An analysis of the causes of dementia in 383 elderly autopsied cases
-
Wang L.N., Zhu M.W., Gui Q.P., Li X.H. An analysis of the causes of dementia in 383 elderly autopsied cases. Zhonghua Nei Ke Za Zhi 2003, 42:789-792.
-
(2003)
Zhonghua Nei Ke Za Zhi
, vol.42
, pp. 789-792
-
-
Wang, L.N.1
Zhu, M.W.2
Gui, Q.P.3
Li, X.H.4
-
103
-
-
33644854266
-
Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies
-
van Leeuwen F.W., van T.P., Sonnemans M.A., Hobo B., Mann D.M., van B.C., Kumar-Singh S., Cras P., Leuba G., Savioz A., Maat-Schieman M.L., Yamaguchi H., Kros J.M., Kamphorst W., Hol E.M., de Vos R.A., Fischer D.F. Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies. Neurology 2006, 66:S86-S92.
-
(2006)
Neurology
, vol.66
-
-
van Leeuwen, F.W.1
van, T.P.2
Sonnemans, M.A.3
Hobo, B.4
Mann, D.M.5
van, B.C.6
Kumar-Singh, S.7
Cras, P.8
Leuba, G.9
Savioz, A.10
Maat-Schieman, M.L.11
Yamaguchi, H.12
Kros, J.M.13
Kamphorst, W.14
Hol, E.M.15
de Vos, R.A.16
Fischer, D.F.17
-
104
-
-
33744781515
-
Frontotemporal dementia: clinicopathological correlations
-
Forman M.S., Farmer J., Johnson J.K., Clark C.M., Arnold S.E., Coslett H.B., Chatterjee A., Hurtig H.I., Karlawish J.H., Rosen H.J., Van D., Lee V.V.M., Miller B.L., Trojanowski J.Q., Grossman M. Frontotemporal dementia: clinicopathological correlations. Ann. Neurol. 2006, 59:952-962.
-
(2006)
Ann. Neurol.
, vol.59
, pp. 952-962
-
-
Forman, M.S.1
Farmer, J.2
Johnson, J.K.3
Clark, C.M.4
Arnold, S.E.5
Coslett, H.B.6
Chatterjee, A.7
Hurtig, H.I.8
Karlawish, J.H.9
Rosen, H.J.10
Van, D.11
Lee, V.V.M.12
Miller, B.L.13
Trojanowski, J.Q.14
Grossman, M.15
-
105
-
-
0141638441
-
Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity
-
Song S., Kim S.Y., Hong Y.M., Jo D.G., Lee J.Y., Shim S.M., Chung C.W., Seo S.J., Yoo Y.J., Koh J.Y., Lee M.C., Yates A.J., Ichijo H., Jung Y.K. Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity. Mol. Cell 2003, 12:553-563.
-
(2003)
Mol. Cell
, vol.12
, pp. 553-563
-
-
Song, S.1
Kim, S.Y.2
Hong, Y.M.3
Jo, D.G.4
Lee, J.Y.5
Shim, S.M.6
Chung, C.W.7
Seo, S.J.8
Yoo, Y.J.9
Koh, J.Y.10
Lee, M.C.11
Yates, A.J.12
Ichijo, H.13
Jung, Y.K.14
-
106
-
-
50249163706
-
E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity
-
Song S., Lee H., Kam T.I., Tai M.L., Lee J.Y., Noh J.Y., Shim S.M., Seo S.J., Kong Y.Y., Nakagawa T., Chung C.W., Choi D.Y., Oubrahim H., Jung Y.K. E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. J. Cell Biol. 2008, 182:675-684.
-
(2008)
J. Cell Biol.
, vol.182
, pp. 675-684
-
-
Song, S.1
Lee, H.2
Kam, T.I.3
Tai, M.L.4
Lee, J.Y.5
Noh, J.Y.6
Shim, S.M.7
Seo, S.J.8
Kong, Y.Y.9
Nakagawa, T.10
Chung, C.W.11
Choi, D.Y.12
Oubrahim, H.13
Jung, Y.K.14
-
107
-
-
0033712579
-
4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease
-
Shringarpure R., Grune T., Sitte N., Davies K.J. 4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease. Cell. Mol. Life Sci. 2000, 57:1802-1809.
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 1802-1809
-
-
Shringarpure, R.1
Grune, T.2
Sitte, N.3
Davies, K.J.4
-
108
-
-
0031026231
-
Binding of amyloid beta protein to the 20S proteasome
-
Gregori L., Hainfeld J.F., Simon M.N., Goldgaber D. Binding of amyloid beta protein to the 20S proteasome. J. Biol. Chem. 1997, 272:58-62.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 58-62
-
-
Gregori, L.1
Hainfeld, J.F.2
Simon, M.N.3
Goldgaber, D.4
-
109
-
-
33646461282
-
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
-
Almeida C.G., Takahashi R.H., Gouras G.K. Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J. Neurosci. 2006, 26:4277-4288.
-
(2006)
J. Neurosci.
, vol.26
, pp. 4277-4288
-
-
Almeida, C.G.1
Takahashi, R.H.2
Gouras, G.K.3
-
110
-
-
34548553576
-
Age-dependent axonal degeneration in an Alzheimer mouse model
-
Wirths O., Weis J., Kayed R., Saido T.C., Bayer T.A. Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol. Aging 2007, 28:1689-1699.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1689-1699
-
-
Wirths, O.1
Weis, J.2
Kayed, R.3
Saido, T.C.4
Bayer, T.A.5
-
111
-
-
33645764470
-
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease
-
Wirths O., Weis J., Szczygielski J., Multhaup G., Bayer T.A. Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease. Acta Neuropathol. (Berl) 2006, 111:312-319.
-
(2006)
Acta Neuropathol. (Berl)
, vol.111
, pp. 312-319
-
-
Wirths, O.1
Weis, J.2
Szczygielski, J.3
Multhaup, G.4
Bayer, T.A.5
-
112
-
-
0034131044
-
Impaired proteasome function in Alzheimer's disease
-
Keller J.N., Hanni K.B., Markesbery W.R. Impaired proteasome function in Alzheimer's disease. J. Neurochem. 2000, 75:436-439.
-
(2000)
J. Neurochem.
, vol.75
, pp. 436-439
-
-
Keller, J.N.1
Hanni, K.B.2
Markesbery, W.R.3
-
113
-
-
0037381710
-
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease
-
Keck S., Nitsch R., Grune T., Ullrich O. Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J. Neurochem. 2003, 85:115-122.
-
(2003)
J. Neurochem.
, vol.85
, pp. 115-122
-
-
Keck, S.1
Nitsch, R.2
Grune, T.3
Ullrich, O.4
-
115
-
-
33745959291
-
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species
-
Dickey C.A., Yue M., Lin W.L., Dickson D.W., Dunmore J.H., Lee W.C., Zehr C., West G., Cao S., Clark A.M., Caldwell G.A., Caldwell K.A., Eckman C., Patterson C., Hutton M., Petrucelli L. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J. Neurosci. 2006, 26:6985-6996.
-
(2006)
J. Neurosci.
, vol.26
, pp. 6985-6996
-
-
Dickey, C.A.1
Yue, M.2
Lin, W.L.3
Dickson, D.W.4
Dunmore, J.H.5
Lee, W.C.6
Zehr, C.7
West, G.8
Cao, S.9
Clark, A.M.10
Caldwell, G.A.11
Caldwell, K.A.12
Eckman, C.13
Patterson, C.14
Hutton, M.15
Petrucelli, L.16
-
116
-
-
24144440041
-
In vivo evidence of CHIP up-regulation attenuating tau aggregation
-
Sahara N., Murayama M., Mizoroki T., Urushitani M., Imai Y., Takahashi R., Murata S., Tanaka K., Takashima A. In vivo evidence of CHIP up-regulation attenuating tau aggregation. J. Neurochem. 2005, 94:1254-1263.
-
(2005)
J. Neurochem.
, vol.94
, pp. 1254-1263
-
-
Sahara, N.1
Murayama, M.2
Mizoroki, T.3
Urushitani, M.4
Imai, Y.5
Takahashi, R.6
Murata, S.7
Tanaka, K.8
Takashima, A.9
-
117
-
-
21344463770
-
Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
-
Babu J.R., Geetha T., Wooten M.W. Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation. J. Neurochem. 2005, 94:192-203.
-
(2005)
J. Neurochem.
, vol.94
, pp. 192-203
-
-
Babu, J.R.1
Geetha, T.2
Wooten, M.W.3
-
118
-
-
6844258835
-
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
-
van Leeuwen F.W., de Kleijn D.P., van den Hurk H.H., Neubauer A., Sonnemans M.A., Sluijs J.A., Koycu S., Ramdjielal R.D., Salehi A., Martens G.J., Grosveld F.G., Peter J., Burbach H., Hol E.M. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 1998, 279:242-247.
-
(1998)
Science
, vol.279
, pp. 242-247
-
-
van Leeuwen, F.W.1
de Kleijn, D.P.2
van den Hurk, H.H.3
Neubauer, A.4
Sonnemans, M.A.5
Sluijs, J.A.6
Koycu, S.7
Ramdjielal, R.D.8
Salehi, A.9
Martens, G.J.10
Grosveld, F.G.11
Peter, J.12
Burbach, H.13
Hol, E.M.14
-
119
-
-
0034730172
-
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease
-
Lam Y.A., Pickart C.M., Alban A., Landon M., Jamieson C., Ramage R., Mayer R.J., Layfield R. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:9902-9906.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 9902-9906
-
-
Lam, Y.A.1
Pickart, C.M.2
Alban, A.3
Landon, M.4
Jamieson, C.5
Ramage, R.6
Mayer, R.J.7
Layfield, R.8
-
120
-
-
34249713085
-
Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease
-
van T.P., de Vrij F.M., Schuurman K.G., Dantuma N.P., Fischer D.F., van Leeuwen F.W., Hol E.M. Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease. J. Cell Sci. 2007, 120:1615-1623.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 1615-1623
-
-
van, T.P.1
de Vrij, F.M.2
Schuurman, K.G.3
Dantuma, N.P.4
Fischer, D.F.5
van Leeuwen, F.W.6
Hol, E.M.7
-
121
-
-
4444274236
-
Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases
-
de P.R., Fischer D.F., Maat-Schieman M.L., Hobo B., de Vos R.A., Brunt E.R., Hol E.M., Roos R.A., van Leeuwen F.W. Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases. Hum. Mol. Genet. 2004, 13:1803-1813.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 1803-1813
-
-
de, P.R.1
Fischer, D.F.2
Maat-Schieman, M.L.3
Hobo, B.4
de Vos, R.A.5
Brunt, E.R.6
Hol, E.M.7
Roos, R.A.8
van Leeuwen, F.W.9
-
122
-
-
0037193469
-
Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
-
Lindsten K., de Vrij F.M., Verhoef L.G., Fischer D.F., van Leeuwen F.W., Hol E.M., Masucci M.G., Dantuma N.P. Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation. J. Cell Biol. 2002, 157:417-427.
-
(2002)
J. Cell Biol.
, vol.157
, pp. 417-427
-
-
Lindsten, K.1
de Vrij, F.M.2
Verhoef, L.G.3
Fischer, D.F.4
van Leeuwen, F.W.5
Hol, E.M.6
Masucci, M.G.7
Dantuma, N.P.8
-
123
-
-
0030890399
-
Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
-
Kim T.W., Pettingell W.H., Hallmark O.G., Moir R.D., Wasco W., Tanzi R.E. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J. Biol. Chem. 1997, 272:11006-11010.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11006-11010
-
-
Kim, T.W.1
Pettingell, W.H.2
Hallmark, O.G.3
Moir, R.D.4
Wasco, W.5
Tanzi, R.E.6
-
124
-
-
0030200643
-
Proteasome inhibition enhances the stability of mouse Cu/Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis
-
Hoffman E.K., Wilcox H.M., Scott R.W., Siman R. Proteasome inhibition enhances the stability of mouse Cu/Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis. J. Neurol. Sci. 1996, 139:15-20.
-
(1996)
J. Neurol. Sci.
, vol.139
, pp. 15-20
-
-
Hoffman, E.K.1
Wilcox, H.M.2
Scott, R.W.3
Siman, R.4
-
125
-
-
0033749379
-
Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis
-
Johnston J.A., Dalton M.J., Gurney M.E., Kopito R.R. Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:12571-12576.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 12571-12576
-
-
Johnston, J.A.1
Dalton, M.J.2
Gurney, M.E.3
Kopito, R.R.4
-
126
-
-
0037184063
-
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity
-
Niwa J., Ishigaki S., Hishikawa N., Yamamoto M., Doyu M., Murata S., Tanaka K., Taniguchi N., Sobue G. Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J. Biol. Chem. 2002, 277:36793-36798.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 36793-36798
-
-
Niwa, J.1
Ishigaki, S.2
Hishikawa, N.3
Yamamoto, M.4
Doyu, M.5
Murata, S.6
Tanaka, K.7
Taniguchi, N.8
Sobue, G.9
-
127
-
-
12144286381
-
NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1
-
Miyazaki K., Fujita T., Ozaki T., Kato C., Kurose Y., Sakamoto M., Kato S., Goto T., Itoyama Y., Aoki M., Nakagawara A. NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. J. Biol. Chem. 2004, 279:11327-11335.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 11327-11335
-
-
Miyazaki, K.1
Fujita, T.2
Ozaki, T.3
Kato, C.4
Kurose, Y.5
Sakamoto, M.6
Kato, S.7
Goto, T.8
Itoyama, Y.9
Aoki, M.10
Nakagawara, A.11
-
128
-
-
28844437130
-
Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis
-
Di N.L., Whitson L.J., Cao X., Hart P.J., Levine R.L. Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis. J. Biol. Chem. 2005, 280:39907-39913.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39907-39913
-
-
Di, N.L.1
Whitson, L.J.2
Cao, X.3
Hart, P.J.4
Levine, R.L.5
-
129
-
-
33750089740
-
Degradation of amyotrophic lateral sclerosis-linked mutant Cu, Zn-superoxide dismutase proteins by macroautophagy and the proteasome
-
Kabuta T., Suzuki Y., Wada K. Degradation of amyotrophic lateral sclerosis-linked mutant Cu, Zn-superoxide dismutase proteins by macroautophagy and the proteasome. J. Biol. Chem. 2006, 281:30524-30533.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 30524-30533
-
-
Kabuta, T.1
Suzuki, Y.2
Wada, K.3
-
130
-
-
18744409323
-
Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords-screening by molecular indexing and subsequent cDNA microarray analysis
-
Ishigaki S., Niwa J., Ando Y., Yoshihara T., Sawada K., Doyu M., Yamamoto M., Kato K., Yotsumoto Y., Sobue G. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords-screening by molecular indexing and subsequent cDNA microarray analysis. FEBS Lett. 2002, 531:354-358.
-
(2002)
FEBS Lett.
, vol.531
, pp. 354-358
-
-
Ishigaki, S.1
Niwa, J.2
Ando, Y.3
Yoshihara, T.4
Sawada, K.5
Doyu, M.6
Yamamoto, M.7
Kato, K.8
Yotsumoto, Y.9
Sobue, G.10
-
131
-
-
3042817421
-
CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70
-
Urushitani M., Kurisu J., Tateno M., Hatakeyama S., Nakayama K., Kato S., Takahashi R. CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. J. Neurochem. 2004, 90:231-244.
-
(2004)
J. Neurochem.
, vol.90
, pp. 231-244
-
-
Urushitani, M.1
Kurisu, J.2
Tateno, M.3
Hatakeyama, S.4
Nakayama, K.5
Kato, S.6
Takahashi, R.7
-
132
-
-
0036892683
-
Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis
-
Urushitani M., Kurisu J., Tsukita K., Takahashi R. Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J. Neurochem. 2002, 83:1030-1042.
-
(2002)
J. Neurochem.
, vol.83
, pp. 1030-1042
-
-
Urushitani, M.1
Kurisu, J.2
Tsukita, K.3
Takahashi, R.4
-
133
-
-
0036724314
-
No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis
-
Lee J.P., Gerin C., Bindokas V.P., Miller R., Ghadge G., Roos R.P. No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis. J. Neurochem. 2002, 82:1229-1238.
-
(2002)
J. Neurochem.
, vol.82
, pp. 1229-1238
-
-
Lee, J.P.1
Gerin, C.2
Bindokas, V.P.3
Miller, R.4
Ghadge, G.5
Roos, R.P.6
-
134
-
-
2442436685
-
Long term proteasome inhibition does not preferentially afflict motor neurons in organotypical spinal cord cultures
-
Vlug A.S., Jaarsma D. Long term proteasome inhibition does not preferentially afflict motor neurons in organotypical spinal cord cultures. Amyotroph. Lateral. Scler. 2004, 5:16-21.
-
(2004)
Amyotroph. Lateral. Scler.
, vol.5
, pp. 16-21
-
-
Vlug, A.S.1
Jaarsma, D.2
-
135
-
-
0037565274
-
Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu, Zn superoxide dismutase mutant involved in familial ALS
-
Aquilano K., Rotilio G., Ciriolo M.R. Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu, Zn superoxide dismutase mutant involved in familial ALS. J. Neurochem. 2003, 85:1324-1335.
-
(2003)
J. Neurochem.
, vol.85
, pp. 1324-1335
-
-
Aquilano, K.1
Rotilio, G.2
Ciriolo, M.R.3
-
136
-
-
0038155130
-
Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins
-
Hyun D.H., Lee M., Halliwell B., Jenner P. Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins. J. Neurochem. 2003, 86:363-373.
-
(2003)
J. Neurochem.
, vol.86
, pp. 363-373
-
-
Hyun, D.H.1
Lee, M.2
Halliwell, B.3
Jenner, P.4
-
137
-
-
57649232173
-
Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis
-
Cheroni C., Marino M., Tortarolo M., Veglianese P., De B.S., Fontana E., Zuccarello L.V., Maynard C.J., Dantuma N.P., Bendotti C. Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis. Hum. Mol. Genet. 2009, 18:82-96.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 82-96
-
-
Cheroni, C.1
Marino, M.2
Tortarolo, M.3
Veglianese, P.4
De, B.S.5
Fontana, E.6
Zuccarello, L.V.7
Maynard, C.J.8
Dantuma, N.P.9
Bendotti, C.10
-
138
-
-
54249100481
-
TDP-43: an emerging new player in neurodegenerative diseases
-
Wang I.F., Wu L.S., Shen C.K. TDP-43: an emerging new player in neurodegenerative diseases. Trends Mol. Med. 2008, 14:479-485.
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 479-485
-
-
Wang, I.F.1
Wu, L.S.2
Shen, C.K.3
-
139
-
-
69549114542
-
The molecular links between TDP-43 dysfunction and neurodegeneration
-
Buratti E., Baralle F.E. The molecular links between TDP-43 dysfunction and neurodegeneration. Adv. Genet. 2009, 66:1-34.
-
(2009)
Adv. Genet.
, vol.66
, pp. 1-34
-
-
Buratti, E.1
Baralle, F.E.2
-
140
-
-
12744269033
-
Neurological aspects of the Angelman syndrome
-
Williams C.A. Neurological aspects of the Angelman syndrome. Brain Dev. 2005, 27:88-94.
-
(2005)
Brain Dev.
, vol.27
, pp. 88-94
-
-
Williams, C.A.1
-
141
-
-
0031012849
-
UBE3A/E6-AP mutations cause Angelman syndrome
-
Kishino T., Lalande M., Wagstaff J. UBE3A/E6-AP mutations cause Angelman syndrome. Nat. Genet. 1997, 15:70-73.
-
(1997)
Nat. Genet.
, vol.15
, pp. 70-73
-
-
Kishino, T.1
Lalande, M.2
Wagstaff, J.3
-
142
-
-
0031031570
-
De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome
-
Matsuura T., Sutcliffe J.S., Fang P., Galjaard R.J., Jiang Y.H., Benton C.S., Rommens J.M., Beaudet A.L. De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. Nat. Genet. 1997, 15:74-77.
-
(1997)
Nat. Genet.
, vol.15
, pp. 74-77
-
-
Matsuura, T.1
Sutcliffe, J.S.2
Fang, P.3
Galjaard, R.J.4
Jiang, Y.H.5
Benton, C.S.6
Rommens, J.M.7
Beaudet, A.L.8
-
143
-
-
0032192481
-
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation
-
Jiang Y.H., Armstrong D., Albrecht U., Atkins C.M., Noebels J.L., Eichele G., Sweatt J.D., Beaudet A.L. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 1998, 21:799-811.
-
(1998)
Neuron
, vol.21
, pp. 799-811
-
-
Jiang, Y.H.1
Armstrong, D.2
Albrecht, U.3
Atkins, C.M.4
Noebels, J.L.5
Eichele, G.6
Sweatt, J.D.7
Beaudet, A.L.8
-
144
-
-
0030879482
-
Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons
-
Albrecht U., Sutcliffe J.S., Cattanach B.M., Beechey C.V., Armstrong D., Eichele G., Beaudet A.L. Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons. Nat. Genet. 1997, 17:75-78.
-
(1997)
Nat. Genet.
, vol.17
, pp. 75-78
-
-
Albrecht, U.1
Sutcliffe, J.S.2
Cattanach, B.M.3
Beechey, C.V.4
Armstrong, D.5
Eichele, G.6
Beaudet, A.L.7
-
145
-
-
0031228039
-
The Angelman syndrome candidate gene, UBE3A/E6-AP, is imprinted in brain
-
Rougeulle C., Glatt H., Lalande M. The Angelman syndrome candidate gene, UBE3A/E6-AP, is imprinted in brain. Nat. Genet. 1997, 17:14-15.
-
(1997)
Nat. Genet.
, vol.17
, pp. 14-15
-
-
Rougeulle, C.1
Glatt, H.2
Lalande, M.3
-
146
-
-
0025932933
-
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
-
Huibregtse J.M., Scheffner M., Howley P.M. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J. 1991, 10:4129-4135.
-
(1991)
EMBO J.
, vol.10
, pp. 4129-4135
-
-
Huibregtse, J.M.1
Scheffner, M.2
Howley, P.M.3
-
147
-
-
0033603339
-
Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination
-
Kumar S., Talis A.L., Howley P.M. Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination. J. Biol. Chem. 1999, 274:18785-18792.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18785-18792
-
-
Kumar, S.1
Talis, A.L.2
Howley, P.M.3
-
148
-
-
0032545368
-
E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box
-
Kuhne C., Banks L. E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box. J. Biol. Chem. 1998, 273:34302-34309.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 34302-34309
-
-
Kuhne, C.1
Banks, L.2
-
149
-
-
0032525905
-
The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate
-
Nuber U., Schwarz S.E., Scheffner M. The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate. Eur. J. Biochem. 1998, 254:643-649.
-
(1998)
Eur. J. Biochem.
, vol.254
, pp. 643-649
-
-
Nuber, U.1
Schwarz, S.E.2
Scheffner, M.3
-
150
-
-
0345701252
-
Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome
-
Weeber E.J., Jiang Y.H., Elgersma Y., Varga A.W., Carrasquillo Y., Brown S.E., Christian J.M., Mirnikjoo B., Silva A., Beaudet A.L., Sweatt J.D. Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. J. Neurosci. 2003, 23:2634-2644.
-
(2003)
J. Neurosci.
, vol.23
, pp. 2634-2644
-
-
Weeber, E.J.1
Jiang, Y.H.2
Elgersma, Y.3
Varga, A.W.4
Carrasquillo, Y.5
Brown, S.E.6
Christian, J.M.7
Mirnikjoo, B.8
Silva, A.9
Beaudet, A.L.10
Sweatt, J.D.11
-
151
-
-
33847210262
-
Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation
-
van Woerden G.M., Harris K.D., Hojjati M.R., Gustin R.M., Qiu S., de Avila F.R., Jiang Y.H., Elgersma Y., Weeber E.J. Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. Nat. Neurosci. 2007, 10:280-282.
-
(2007)
Nat. Neurosci.
, vol.10
, pp. 280-282
-
-
van Woerden, G.M.1
Harris, K.D.2
Hojjati, M.R.3
Gustin, R.M.4
Qiu, S.5
de Avila, F.R.6
Jiang, Y.H.7
Elgersma, Y.8
Weeber, E.J.9
-
152
-
-
77649083119
-
The Angelman syndrome protein Ube3A regulates synapse development by ubiquitinating arc
-
Greer P.L., Hanayama R., Bloodgood B.L., Mardinly A.R., Lipton D.M., Flavell S.W., Kim T.K., Griffith E.C., Waldon Z., Maehr R., Ploegh H.L., Chowdhury S., Worley P.F., Steen J., Greenberg M.E. The Angelman syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell 2010, 140:704-716.
-
(2010)
Cell
, vol.140
, pp. 704-716
-
-
Greer, P.L.1
Hanayama, R.2
Bloodgood, B.L.3
Mardinly, A.R.4
Lipton, D.M.5
Flavell, S.W.6
Kim, T.K.7
Griffith, E.C.8
Waldon, Z.9
Maehr, R.10
Ploegh, H.L.11
Chowdhury, S.12
Worley, P.F.13
Steen, J.14
Greenberg, M.E.15
-
153
-
-
0036842130
-
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease
-
Wilson S.M., Bhattacharyya B., Rachel R.A., Coppola V., Tessarollo L., Householder D.B., Fletcher C.F., Miller R.J., Copeland N.G., Jenkins N.A. Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat. Genet. 2002, 32:420-425.
-
(2002)
Nat. Genet.
, vol.32
, pp. 420-425
-
-
Wilson, S.M.1
Bhattacharyya, B.2
Rachel, R.A.3
Coppola, V.4
Tessarollo, L.5
Householder, D.B.6
Fletcher, C.F.7
Miller, R.J.8
Copeland, N.G.9
Jenkins, N.A.10
-
154
-
-
27644477433
-
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice
-
Anderson C., Crimmins S., Wilson J.A., Korbel G.A., Ploegh H.L., Wilson S.M. Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. J. Neurochem. 2005, 95:724-731.
-
(2005)
J. Neurochem.
, vol.95
, pp. 724-731
-
-
Anderson, C.1
Crimmins, S.2
Wilson, J.A.3
Korbel, G.A.4
Ploegh, H.L.5
Wilson, S.M.6
-
155
-
-
33750935146
-
Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14
-
Crimmins S., Jin Y., Wheeler C., Huffman A.K., Chapman C., Dobrunz L.E., Levey A., Roth K.A., Wilson J.A., Wilson S.M. Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14. J. Neurosci. 2006, 26:11423-11431.
-
(2006)
J. Neurosci.
, vol.26
, pp. 11423-11431
-
-
Crimmins, S.1
Jin, Y.2
Wheeler, C.3
Huffman, A.K.4
Chapman, C.5
Dobrunz, L.E.6
Levey, A.7
Roth, K.A.8
Wilson, J.A.9
Wilson, S.M.10
-
156
-
-
69749110327
-
The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions
-
Chen P.C., Qin L.N., Li X.M., Walters B.J., Wilson J.A., Mei L., Wilson S.M. The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. J. Neurosci. 2009, 29:10909-10919.
-
(2009)
J. Neurosci.
, vol.29
, pp. 10909-10919
-
-
Chen, P.C.1
Qin, L.N.2
Li, X.M.3
Walters, B.J.4
Wilson, J.A.5
Mei, L.6
Wilson, S.M.7
-
157
-
-
0025892066
-
Visuospatial cognition in Huntington's disease
-
Mohr E., Brouwers P., Claus J.J., Mann U.M., Fedio P., Chase T.N. Visuospatial cognition in Huntington's disease. Mov Disord. 1991, 6:127-132.
-
(1991)
Mov Disord.
, vol.6
, pp. 127-132
-
-
Mohr, E.1
Brouwers, P.2
Claus, J.J.3
Mann, U.M.4
Fedio, P.5
Chase, T.N.6
-
158
-
-
0029006808
-
Cognitive scores in carriers of Huntington's disease gene compared to noncarriers
-
Foroud T., Siemers E., Kleindorfer D., Bill D.J., Hodes M.E., Norton J.A., Conneally P.M., Christian J.C. Cognitive scores in carriers of Huntington's disease gene compared to noncarriers. Ann. Neurol. 1995, 37:657-664.
-
(1995)
Ann. Neurol.
, vol.37
, pp. 657-664
-
-
Foroud, T.1
Siemers, E.2
Kleindorfer, D.3
Bill, D.J.4
Hodes, M.E.5
Norton, J.A.6
Conneally, P.M.7
Christian, J.C.8
-
159
-
-
0029065482
-
Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia
-
Lange K.W., Sahakian B.J., Quinn N.P., Marsden C.D., Robbins T.W. Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia. J. Neurol. Neurosurg. Psychiatry 1995, 58:598-606.
-
(1995)
J. Neurol. Neurosurg. Psychiatry
, vol.58
, pp. 598-606
-
-
Lange, K.W.1
Sahakian, B.J.2
Quinn, N.P.3
Marsden, C.D.4
Robbins, T.W.5
-
160
-
-
0029906665
-
Executive and mnemonic functions in early Huntington's disease
-
Lawrence A.D., Sahakian B.J., Hodges J.R., Rosser A.E., Lange K.W., Robbins T.W. Executive and mnemonic functions in early Huntington's disease. Brain 1996, 119(Pt 5):1633-1645.
-
(1996)
Brain
, vol.119
, Issue.PART 5
, pp. 1633-1645
-
-
Lawrence, A.D.1
Sahakian, B.J.2
Hodges, J.R.3
Rosser, A.E.4
Lange, K.W.5
Robbins, T.W.6
-
161
-
-
0031814175
-
Evidence for specific cognitive deficits in preclinical Huntington's disease
-
Lawrence A.D., Hodges J.R., Rosser A.E., Kershaw A., ffrench-Constant C., Rubinsztein D.C., Robbins T.W., Sahakian B.J. Evidence for specific cognitive deficits in preclinical Huntington's disease. Brain 1998, 121(Pt 7):1329-1341.
-
(1998)
Brain
, vol.121
, Issue.PART 7
, pp. 1329-1341
-
-
Lawrence, A.D.1
Hodges, J.R.2
Rosser, A.E.3
Kershaw, A.4
ffrench-Constant, C.5
Rubinsztein, D.C.6
Robbins, T.W.7
Sahakian, B.J.8
-
162
-
-
0034234519
-
Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
-
Murphy K.P., Carter R.J., Lione L.A., Mangiarini L., Mahal A., Bates G.P., Dunnett S.B., Morton A.J. Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation. J. Neurosci. 2000, 20:5115-5123.
-
(2000)
J. Neurosci.
, vol.20
, pp. 5115-5123
-
-
Murphy, K.P.1
Carter, R.J.2
Lione, L.A.3
Mangiarini, L.4
Mahal, A.5
Bates, G.P.6
Dunnett, S.B.7
Morton, A.J.8
-
163
-
-
0032949459
-
A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice
-
Shelbourne P.F., Killeen N., Hevner R.F., Johnston H.M., Tecott L., Lewandoski M., Ennis M., Ramirez L., Li Z., Iannicola C., Littman D.R., Myers R.M. A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice. Hum. Mol. Genet. 1999, 8:763-774.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 763-774
-
-
Shelbourne, P.F.1
Killeen, N.2
Hevner, R.F.3
Johnston, H.M.4
Tecott, L.5
Lewandoski, M.6
Ennis, M.7
Ramirez, L.8
Li, Z.9
Iannicola, C.10
Littman, D.R.11
Myers, R.M.12
-
164
-
-
0035883175
-
Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease
-
Morton A.J., Faull R.L., Edwardson J.M. Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease. Brain Res. Bull. 2001, 56:111-117.
-
(2001)
Brain Res. Bull.
, vol.56
, pp. 111-117
-
-
Morton, A.J.1
Faull, R.L.2
Edwardson, J.M.3
-
165
-
-
0037380956
-
Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons
-
Lee J.A., Lim C.S., Lee S.H., Kim H., Nukina N., Kaang B.K. Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons. J. Neurochem. 2003, 85:160-169.
-
(2003)
J. Neurochem.
, vol.85
, pp. 160-169
-
-
Lee, J.A.1
Lim, C.S.2
Lee, S.H.3
Kim, H.4
Nukina, N.5
Kaang, B.K.6
-
166
-
-
0035336658
-
Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
-
Jana N.R., Zemskov E.A., Wang G., Nukina N. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum. Mol. Genet. 2001, 10:1049-1059.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1049-1059
-
-
Jana, N.R.1
Zemskov, E.A.2
Wang, G.3
Nukina, N.4
-
167
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence N.F., Sampat R.M., Kopito R.R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292:1552-1555.
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
168
-
-
34547807613
-
Global changes to the ubiquitin system in Huntington's disease
-
Bennett E.J., Shaler T.A., Woodman B., Ryu K.Y., Zaitseva T.S., Becker C.H., Bates G.P., Schulman H., Kopito R.R. Global changes to the ubiquitin system in Huntington's disease. Nature 2007, 448:704-708.
-
(2007)
Nature
, vol.448
, pp. 704-708
-
-
Bennett, E.J.1
Shaler, T.A.2
Woodman, B.3
Ryu, K.Y.4
Zaitseva, T.S.5
Becker, C.H.6
Bates, G.P.7
Schulman, H.8
Kopito, R.R.9
-
169
-
-
0035889973
-
Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease
-
Martin-Aparicio E., Yamamoto A., Hernandez F., Hen R., Avila J., Lucas J.J. Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease. J. Neurosci. 2001, 21:8772-8781.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8772-8781
-
-
Martin-Aparicio, E.1
Yamamoto, A.2
Hernandez, F.3
Hen, R.4
Avila, J.5
Lucas, J.J.6
-
170
-
-
0037134460
-
Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival
-
Ding Q., Lewis J.J., Strum K.M., Dimayuga E., Bruce-Keller A.J., Dunn J.C., Keller J.N. Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival. J. Biol. Chem. 2002, 277:13935-13942.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13935-13942
-
-
Ding, Q.1
Lewis, J.J.2
Strum, K.M.3
Dimayuga, E.4
Bruce-Keller, A.J.5
Dunn, J.C.6
Keller, J.N.7
-
171
-
-
0032190090
-
The ubiquitin pathway in Parkinson's disease
-
Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., Harta G., Brownstein M.J., Jonnalagada S., Chernova T., Dehejia A., Lavedan C., Gasser T., Steinbach P.J., Wilkinson K.D., Polymeropoulos M.H. The ubiquitin pathway in Parkinson's disease. Nature 1998, 395:451-452.
-
(1998)
Nature
, vol.395
, pp. 451-452
-
-
Leroy, E.1
Boyer, R.2
Auburger, G.3
Leube, B.4
Ulm, G.5
Mezey, E.6
Harta, G.7
Brownstein, M.J.8
Jonnalagada, S.9
Chernova, T.10
Dehejia, A.11
Lavedan, C.12
Gasser, T.13
Steinbach, P.J.14
Wilkinson, K.D.15
Polymeropoulos, M.H.16
-
173
-
-
0037428241
-
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
-
Bonifati V., Rizzu P., van Baren M.J., Schaap O., Breedveld G.J., Krieger E., Dekker M.C., Squitieri F., Ibanez P., Joosse M., van Dongen J.W., Vanacore N., van Swieten J.C., Brice A., Meco G., van Duijn C.M., Oostra B.A., Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 2003, 299:256-259.
-
(2003)
Science
, vol.299
, pp. 256-259
-
-
Bonifati, V.1
Rizzu, P.2
van Baren, M.J.3
Schaap, O.4
Breedveld, G.J.5
Krieger, E.6
Dekker, M.C.7
Squitieri, F.8
Ibanez, P.9
Joosse, M.10
van Dongen, J.W.11
Vanacore, N.12
van Swieten, J.C.13
Brice, A.14
Meco, G.15
van Duijn, C.M.16
Oostra, B.A.17
Heutink, P.18
-
174
-
-
0037426917
-
Pathways to Parkinsonism
-
Cookson M.R. Pathways to Parkinsonism. Neuron 2003, 37:7-10.
-
(2003)
Neuron
, vol.37
, pp. 7-10
-
-
Cookson, M.R.1
-
175
-
-
33645002036
-
Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities
-
Shinbo Y., Niki T., Taira T., Ooe H., Takahashi-Niki K., Maita C., Seino C., Iguchi-Ariga S.M., Ariga H. Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death. Differ. 2006, 13:96-108.
-
(2006)
Cell Death. Differ.
, vol.13
, pp. 96-108
-
-
Shinbo, Y.1
Niki, T.2
Taira, T.3
Ooe, H.4
Takahashi-Niki, K.5
Maita, C.6
Seino, C.7
Iguchi-Ariga, S.M.8
Ariga, H.9
-
176
-
-
0036884733
-
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein
-
Lotharius J., Brundin P. Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat. Rev. Neurosci. 2002, 3:932-942.
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 932-942
-
-
Lotharius, J.1
Brundin, P.2
-
177
-
-
0141891953
-
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
-
Goldberg M.S., Fleming S.M., Palacino J.J., Cepeda C., Lam H.A., Bhatnagar A., Meloni E.G., Wu N., Ackerson L.C., Klapstein G.J., Gajendiran M., Roth B.L., Chesselet M.F., Maidment N.T., Levine M.S., Shen J. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 2003, 278:43628-43635.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 43628-43635
-
-
Goldberg, M.S.1
Fleming, S.M.2
Palacino, J.J.3
Cepeda, C.4
Lam, H.A.5
Bhatnagar, A.6
Meloni, E.G.7
Wu, N.8
Ackerson, L.C.9
Klapstein, G.J.10
Gajendiran, M.11
Roth, B.L.12
Chesselet, M.F.13
Maidment, N.T.14
Levine, M.S.15
Shen, J.16
-
178
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
-
Shimura H., Hattori N., Kubo S., Mizuno Y., Asakawa S., Minoshima S., Shimizu N., Iwai K., Chiba T., Tanaka K., Suzuki T. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 2000, 25:302-305.
-
(2000)
Nat. Genet.
, vol.25
, pp. 302-305
-
-
Shimura, H.1
Hattori, N.2
Kubo, S.3
Mizuno, Y.4
Asakawa, S.5
Minoshima, S.6
Shimizu, N.7
Iwai, K.8
Chiba, T.9
Tanaka, K.10
Suzuki, T.11
-
179
-
-
0141995596
-
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
-
Huynh D.P., Scoles D.R., Nguyen D., Pulst S.M. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. Hum. Mol. Genet. 2003, 12:2587-2597.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2587-2597
-
-
Huynh, D.P.1
Scoles, D.R.2
Nguyen, D.3
Pulst, S.M.4
-
180
-
-
33344456519
-
Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases?
-
Lim K.L., Dawson V.L., Dawson T.M. Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases?. Neurobiol. Aging 2006, 27:524-529.
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 524-529
-
-
Lim, K.L.1
Dawson, V.L.2
Dawson, T.M.3
-
181
-
-
38049014824
-
Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway
-
Olzmann J.A., Chin L.S. Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway. Autophagy 2008, 4:85-87.
-
(2008)
Autophagy
, vol.4
, pp. 85-87
-
-
Olzmann, J.A.1
Chin, L.S.2
-
182
-
-
76449094465
-
Parkin-mediated ubiquitin signalling in aggresome formation and autophagy
-
Chin L.S., Olzmann J.A., Li L. Parkin-mediated ubiquitin signalling in aggresome formation and autophagy. Biochem. Soc. Trans. 2010, 38:144-149.
-
(2010)
Biochem. Soc. Trans.
, vol.38
, pp. 144-149
-
-
Chin, L.S.1
Olzmann, J.A.2
Li, L.3
-
183
-
-
0038159253
-
Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function
-
Tsai Y.C., Fishman P.S., Thakor N.V., Oyler G.A. Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function. J. Biol. Chem. 2003, 278:22044-22055.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22044-22055
-
-
Tsai, Y.C.1
Fishman, P.S.2
Thakor, N.V.3
Oyler, G.A.4
-
184
-
-
57049117002
-
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins
-
Morishima Y., Wang A.M., Yu Z., Pratt W.B., Osawa Y., Lieberman A.P. CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Hum. Mol. Genet. 2008, 17:3942-3952.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 3942-3952
-
-
Morishima, Y.1
Wang, A.M.2
Yu, Z.3
Pratt, W.B.4
Osawa, Y.5
Lieberman, A.P.6
-
185
-
-
55549086868
-
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains
-
Winborn B.J., Travis S.M., Todi S.V., Scaglione K.M., Xu P., Williams A.J., Cohen R.E., Peng J., Paulson H.L. The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J. Biol. Chem. 2008, 283:26436-26443.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 26436-26443
-
-
Winborn, B.J.1
Travis, S.M.2
Todi, S.V.3
Scaglione, K.M.4
Xu, P.5
Williams, A.J.6
Cohen, R.E.7
Peng, J.8
Paulson, H.L.9
-
186
-
-
60549100850
-
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3
-
Todi S.V., Winborn B.J., Scaglione K.M., Blount J.R., Travis S.M., Paulson H.L. Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3. EMBO J. 2009, 28:372-382.
-
(2009)
EMBO J.
, vol.28
, pp. 372-382
-
-
Todi, S.V.1
Winborn, B.J.2
Scaglione, K.M.3
Blount, J.R.4
Travis, S.M.5
Paulson, H.L.6
-
187
-
-
39049148153
-
Aggresome formation and neurodegenerative diseases: therapeutic implications
-
Olzmann J.A., Li L., Chin L.S. Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr. Med. Chem. 2008, 15:47-60.
-
(2008)
Curr. Med. Chem.
, vol.15
, pp. 47-60
-
-
Olzmann, J.A.1
Li, L.2
Chin, L.S.3
-
188
-
-
0037294624
-
Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease
-
Buhmann C., Bussopulos A., Oechsner M. Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease. Mov Disord. 2003, 18:219-221.
-
(2003)
Mov Disord.
, vol.18
, pp. 219-221
-
-
Buhmann, C.1
Bussopulos, A.2
Oechsner, M.3
-
189
-
-
51149121890
-
Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies
-
Bedford L., Hay D., Devoy A., Paine S., Powe D.G., Seth R., Gray T., Topham I., Fone K., Rezvani N., Mee M., Soane T., Layfield R., Sheppard P.W., Ebendal T., Usoskin D., Lowe J., Mayer R.J. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. J. Neurosci. 2008, 28:8189-8198.
-
(2008)
J. Neurosci.
, vol.28
, pp. 8189-8198
-
-
Bedford, L.1
Hay, D.2
Devoy, A.3
Paine, S.4
Powe, D.G.5
Seth, R.6
Gray, T.7
Topham, I.8
Fone, K.9
Rezvani, N.10
Mee, M.11
Soane, T.12
Layfield, R.13
Sheppard, P.W.14
Ebendal, T.15
Usoskin, D.16
Lowe, J.17
Mayer, R.J.18
-
190
-
-
49749112843
-
A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients
-
Wahl C., Kautzmann S., Krebiehl G., Strauss K., Woitalla D., Muller T., Bauer P., Riess O., Kruger R. A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients. J. Neural Transm. 2008, 115:1141-1148.
-
(2008)
J. Neural Transm.
, vol.115
, pp. 1141-1148
-
-
Wahl, C.1
Kautzmann, S.2
Krebiehl, G.3
Strauss, K.4
Woitalla, D.5
Muller, T.6
Bauer, P.7
Riess, O.8
Kruger, R.9
-
191
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu M., Waguri S., Chiba T., Murata S., Iwata J., Tanida I., Ueno T., Koike M., Uchiyama Y., Kominami E., Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441:880-884.
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
Waguri, S.2
Chiba, T.3
Murata, S.4
Iwata, J.5
Tanida, I.6
Ueno, T.7
Koike, M.8
Uchiyama, Y.9
Kominami, E.10
Tanaka, K.11
-
192
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara T., Nakamura K., Matsui M., Yamamoto A., Nakahara Y., Suzuki-Migishima R., Yokoyama M., Mishima K., Saito I., Okano H., Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441:885-889.
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
Yamamoto, A.4
Nakahara, Y.5
Suzuki-Migishima, R.6
Yokoyama, M.7
Mishima, K.8
Saito, I.9
Okano, H.10
Mizushima, N.11
-
193
-
-
34548299555
-
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability
-
Ding W.X., Ni H.M., Gao W., Yoshimori T., Stolz D.B., Ron D., Yin X.M. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am. J. Pathol. 2007, 171:513-524.
-
(2007)
Am. J. Pathol.
, vol.171
, pp. 513-524
-
-
Ding, W.X.1
Ni, H.M.2
Gao, W.3
Yoshimori, T.4
Stolz, D.B.5
Ron, D.6
Yin, X.M.7
-
194
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey U.B., Nie Z., Batlevi Y., McCray B.A., Ritson G.P., Nedelsky N.B., Schwartz S.L., DiProspero N.A., Knight M.A., Schuldiner O., Padmanabhan R., Hild M., Berry D.L., Garza D., Hubbert C.C., Yao T.P., Baehrecke E.H., Taylor J.P. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007, 447:859-863.
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
Schwartz, S.L.7
DiProspero, N.A.8
Knight, M.A.9
Schuldiner, O.10
Padmanabhan, R.11
Hild, M.12
Berry, D.L.13
Garza, D.14
Hubbert, C.C.15
Yao, T.P.16
Baehrecke, E.H.17
Taylor, J.P.18
-
195
-
-
27944504351
-
P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
Bjorkoy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 603-614
-
-
Bjorkoy, G.1
Lamark, T.2
Brech, A.3
Outzen, H.4
Perander, M.5
Overvatn, A.6
Stenmark, H.7
Johansen, T.8
-
196
-
-
0042848910
-
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration
-
Zhai Q., Wang J., Kim A., Liu Q., Watts R., Hoopfer E., Mitchison T., Luo L., He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron 2003, 39:217-225.
-
(2003)
Neuron
, vol.39
, pp. 217-225
-
-
Zhai, Q.1
Wang, J.2
Kim, A.3
Liu, Q.4
Watts, R.5
Hoopfer, E.6
Mitchison, T.7
Luo, L.8
He, Z.9
-
197
-
-
33744922406
-
Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning
-
Hoopfer E.D., McLaughlin T., Watts R.J., Schuldiner O., O'Leary D.D., Luo L. Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron 2006, 50:883-895.
-
(2006)
Neuron
, vol.50
, pp. 883-895
-
-
Hoopfer, E.D.1
McLaughlin, T.2
Watts, R.J.3
Schuldiner, O.4
O'Leary, D.D.5
Luo, L.6
-
198
-
-
27844497059
-
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides
-
Marambaud P., Zhao H., Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J. Biol. Chem. 2005, 280:37377-37382.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37377-37382
-
-
Marambaud, P.1
Zhao, H.2
Davies, P.3
-
199
-
-
6844258835
-
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
-
van Leeuwen F.W., de Kleijn D.P., van den Hurk H.H., Neubauer A., Sonnemans M.A., Sluijs J.A., Koycu S., Ramdjielal R.D., Salehi A., Martens G.J., Grosveld F.G., Peter J., Burbach H., Hol E.M. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 1998, 279:242-247.
-
(1998)
Science
, vol.279
, pp. 242-247
-
-
van Leeuwen, F.W.1
de Kleijn, D.P.2
van den Hurk, H.H.3
Neubauer, A.4
Sonnemans, M.A.5
Sluijs, J.A.6
Koycu, S.7
Ramdjielal, R.D.8
Salehi, A.9
Martens, G.J.10
Grosveld, F.G.11
Peter, J.12
Burbach, H.13
Hol, E.M.14
-
200
-
-
0032846416
-
Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice
-
Saigoh K., Wang Y.L., Suh J.G., Yamanishi T., Sakai Y., Kiyosawa H., Harada T., Ichihara N., Wakana S., Kikuchi T., Wada K. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Nat. Genet. 1999, 23:47-51.
-
(1999)
Nat. Genet.
, vol.23
, pp. 47-51
-
-
Saigoh, K.1
Wang, Y.L.2
Suh, J.G.3
Yamanishi, T.4
Sakai, Y.5
Kiyosawa, H.6
Harada, T.7
Ichihara, N.8
Wakana, S.9
Kikuchi, T.10
Wada, K.11
-
201
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies S.W., Turmaine M., Cozens B.A., DiFiglia M., Sharp A.H., Ross C.A., Scherzinger E., Wanker E.E., Mangiarini L., Bates G.P. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 1997, 90:537-548.
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
DiFiglia, M.4
Sharp, A.H.5
Ross, C.A.6
Scherzinger, E.7
Wanker, E.E.8
Mangiarini, L.9
Bates, G.P.10
-
202
-
-
0035854437
-
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease
-
Shimura H., Schlossmacher M.G., Hattori N., Frosch M.P., Trockenbacher A., Schneider R., Mizuno Y., Kosik K.S., Selkoe D.J. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science 2001, 293:263-269.
-
(2001)
Science
, vol.293
, pp. 263-269
-
-
Shimura, H.1
Schlossmacher, M.G.2
Hattori, N.3
Frosch, M.P.4
Trockenbacher, A.5
Schneider, R.6
Mizuno, Y.7
Kosik, K.S.8
Selkoe, D.J.9
-
203
-
-
0036550998
-
Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia
-
Middleton F.A., Mirnics K., Pierri J.N., Lewis D.A., Levitt P. Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J. Neurosci. 2002, 22:2718-2729.
-
(2002)
J. Neurosci.
, vol.22
, pp. 2718-2729
-
-
Middleton, F.A.1
Mirnics, K.2
Pierri, J.N.3
Lewis, D.A.4
Levitt, P.5
-
204
-
-
22444441576
-
Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts
-
Altar C.A., Jurata L.W., Charles V., Lemire A., Liu P., Bukhman Y., Young T.A., Bullard J., Yokoe H., Webster M.J., Knable M.B., Brockman J.A. Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts. Biol. Psychiatry 2005, 58:85-96.
-
(2005)
Biol. Psychiatry
, vol.58
, pp. 85-96
-
-
Altar, C.A.1
Jurata, L.W.2
Charles, V.3
Lemire, A.4
Liu, P.5
Bukhman, Y.6
Young, T.A.7
Bullard, J.8
Yokoe, H.9
Webster, M.J.10
Knable, M.B.11
Brockman, J.A.12
|