Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

Biochemical Society Transactions

Volumn 38, Issue 1, 2010, Pages 144-149

  Chin, Lih Shen ^a   Olzmann, James A ^a   Li, Lian ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aggresome; Autophagy; Misfolded protein; Parkin; Parkinson's disease; Ubiquitin protein ligase

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DJ 1 PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; HISTONE DEACETYLASE 6; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSINE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PARKIN; PROTEASOME; PROTEIN P62; TAU PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3;

AGGRESOME; ALZHEIMER DISEASE; ARTICLE; AUTOPHAGY; DEGENERATIVE DISEASE; DRUG MECHANISM; ENDOCYTOSIS; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; HUNTINGTON CHOREA; MICROTUBULE ORGANIZING CENTER; MOTOR NEURON DISEASE; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; SIGNAL TRANSDUCTION; UBIQUITINATION;

AUTOPHAGY; HUMANS; INCLUSION BODIES; LYSINE; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; POLYUBIQUITIN; PROTEIN CONFORMATION; PROTEIN FOLDING; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 76449094465     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0380144     Document Type: Article

References (50)

1. Gregersen, N. (2006) Protein misfolding disorders: pathogenesis and intervention. J. Inherit. Metab. Dis. 29, 456-470
2. Whatley, B.R., Li, L. and Chin, L.S. (2008) The ubiquitin-proteasome system in spongiform degenerative disorders. Biochim. Biophys. Acta 1782, 700-712
3. Olzmann, J.A., Li, L. and Chin, L.S. (2008) Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr. Med. Chem. 15, 47-60
4. Kopito, R.R. (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol. 10, 524-530
5. Xie, Z. and Klionsky, D.J. (2007) Autophagosome formation: core machinery and adaptations. Nat. Cell Biol. 9, 1102-1109
6. Levine, B. and Kroemer, G. (2008) Autophagy in the pathogenesis of disease. Cell 132, 27-42
7. Iwata, A., Christianson, J.C., Bucci, M., Ellerby, L.M., Nukina, N., Forno, L.S. and Kopito, R.R. (2005) Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proc. Natl. Acad. Sci. U.S.A. 102, 13135-13140
8. Ravikumar, B., Duden, R. and Rubinsztein, D.C. (2002) Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum. Mol. Genet. 11, 1107-1117
9. Ravikumar, B., Vacher, C., Berger, Z., Davies, J.E., Luo, S., Oroz, L.G., Scaravilli, F., Easton, D.F., Duden, R., O'Kane, C.J. et al. (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595
10. Iwata, A., Riley, B.E., Johnston, J.A. and Kopito, R.R. (2005) HDAC6 and microtubules are required for autophagic degradation of aggregated Huntingtin. J. Biol. Chem. 280, 40282-40292
11. Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B. and Yuan, J. (2006) Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J. Biol. Chem. 281, 14474-14485
12. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y. and Shimizu, N. (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608
13. Hattori, N. and Mizuno, Y. (2004) Pathogenetic mechanisms of parkin in Parkinson's disease. Lancet 364, 722-724
14. Moore, D.J. (2006) Parkin: a multifaceted ubiquitin ligase. Biochem. Soc. Trans. 34, 749-753
15. Tan, E.K. and Skipper, L.M. (2007) Pathogenic mutations in Parkinson disease. Hum. Mutat. 28, 641-653
16. Goldberg, M.S., Fleming, S.M., Palacino, J.J., Cepeda, C., Lam, H.A., Bhatnagar, A., Meloni, E.G., Wu, N., Ackerson, L.C., Klapstein, G.J. et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 278, 43628-43635
17. Fallon, L., Belanger, C.M., Corera, A.T., Kontogiannea, M., Regan-Klapisz, E., Moreau, F., Voortman, J., Haber, M., Rouleau, G., Thorarinsdottir, T. et al. (2006) A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor traf?cking and PI(3)K-Akt signalling. Nat. Cell Biol. 8, 834-842
18. Henn, I.H., Bouman, L., Schlehe, J.S., Schlierf, A., Schramm, J.E., Wegener, E., Nakaso, K., Culmsee, C., Berninger, B., Krappmann, D. et al. (2007) Parkin mediates neuroprotection through activation of IκB kinase/nuclear factor-κB signaling. J. Neurosci. 27, 1868-1878
19. Clark, I.E., Dodson, M.W., Jiang, C., Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A. and Guo, M. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441, 1162-1166
20. Narendra, D., Tanaka, A., Suen, D.F. and Youle, R.J. (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803
21. Olzmann, J.A., Li, L., Chudaev, M.V., Chen, J., Perez, F.A., Palmiter, R.D. and Chin, L.S. (2007) Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J. Cell Biol. 178, 1025-1038
22. Bonifati, V., Rizzu, P., van Baren, M.J., Schaap, O., Breedveld, G.J., Krieger, E., Dekker, M.C., Squitieri, F., Ibanez, P., Joosse, M. et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299, 256-259
23. Olzmann, J.A., Brown, K., Wilkinson, K.D., Rees, H.D., Huai, Q., Ke, H., Levey, A.I., Li, L. and Chin, L.S. (2004) Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J. Biol. Chem. 279, 8506-8515
24. Huai, Q., Sun, Y., Wang, H., Chin, L.S., Li, L., Robinson, H. and Ke, H. (2003) Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. FEBS Lett. 549, 171-175
25. Kawaguchi, Y., Kovacs, J.J., McLaurin, A., Vance, J.M., Ito, A. and Yao, T.P. (2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115, 727-738
26. Olzmann, J.A. and Chin, L.S. (2008) Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway. Autophagy 4, 85-87
27. Tan, J.M., Wong, E.S., Kirkpatrick, D.S., Pletnikova, O., Ko, H.S., Tay, S.P., Ho, M.W., Troncoso, J., Gygi, S.P., Lee, M.K. et al. (2008) Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum. Mol. Genet. 17, 431-439
28. Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Overvatn, A., Stenmark, H. and Johansen, T. (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on Huntingtin-induced cell death. J. Cell Biol. 171, 603-614
29. Pankiv, S., Clausen, T.H., Lamark, T., Brech, A., Bruun, J.A., Outzen, H., Overvatn, A., Bjørkøy, G. and Johansen, T. (2007) p62 /SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131-24145
30. Seibenhener, M.L., Babu, J.R., Geetha, T., Wong, H.C., Krishna, N.R. and Wooten, M.W. (2004) Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol. Cell. Biol. 24, 8055-8068
31. Wooten, M.W., Geetha, T., Babu, J.R., Seibenhener, M.L., Peng, J., Cox, N., Diaz-Meco, M.T. and Moscat, J. (2008) Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. J. Biol. Chem. 283, 6783-6789
32. Komatsu, M., Waguri, S., Koike, M., Sou, Y.S., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S. et al. (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149-1163
33. Rapoport, S., Dubiel, W. and Muller, M. (1985) Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin-dependent and is accompanied by a high rate of ATP hydrolysis. FEBS Lett. 180, 249-252
34. Sutovsky, P., Moreno, R.D., Ramalho-Santos, J., Dominko, T., Simerly, C. and Schatten, G. (1999) Ubiquitin tag for sperm mitochondria. Nature 402, 371-372
35. Martinez-Vicente, M. and Cuervo, A.M. (2007) Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol. 6, 352-361
36. Nixon, R.A. (2006) Autophagy in neurodegenerative disease: friend, foe or turncoat? Trends Neurosci. 29, 528-535
37. Bennett, E.J., Shaler, T.A., Woodman, B., Ryu, K.Y., Zaitseva, T.S., Becker, C.H., Bates, G.P., Schulman, H. and Kopito, R.R. (2007) Global changes to the ubiquitin system in Huntington's disease. Nature 448, 704-708
38. Laurin, N., Brown, J.P., Morissette, J. and Raymond, V. (2002) Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Am. J. Hum. Genet. 70, 1582-1588
39. Ramesh Babu, J., Lamar Seibenhener, M., Peng, J., Strom, A.L., Kemppainen, R., Cox, N., Zhu, H., Wooten, M.C., Diaz-Meco, M.T., Moscat, J. et al. (2008) Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. J. Neurochem. 106, 107-120
40. Johnston, J.A., Illing, M.E. and Kopito, R.R. (2002) Cytoplasmic dynein/ dynactin mediates the assembly of aggresomes. Cell Motil. Cytoskeleton 53, 26-38
41. Ravikumar, B., Acevedo-Arozena, A., Imarisio, S., Berger, Z., Vacher, C., O'Kane, C.J., Brown, S.D. and Rubinsztein, D.C. (2005) Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat. Genet. 37, 771-776
42. Puls, I., Jonnakuty, C., LaMonte, B.H., Holzbaur, E.L., Tokito, M., Mann, E., Floeter, M.K., Bidus, K., Drayna, D., Oh, S.J. et al. (2003) Mutant dynactin in motor neuron disease. Nat. Genet. 33, 455-456
43. Hafezparast, M., Klocke, R., Ruhrberg, C., Marquardt, A., Ahmad-Annuar, A., Bowen, S., Lalli, G., Witherden, A.S., Hummerich, H., Nicholson, S. et al. (2003) Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 300, 808-812
44. LaMonte, B.H., Wallace, K.E., Holloway, B.A., Shelly, S.S., Ascano, J., Tokito, M., Van Winkle, T., Howland, D.S. and Holzbaur, E.L. (2002) Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron 34, 715-727
45. Skibinski, G., Parkinson, N.J., Brown, J.M., Chakrabarti, L., Lloyd, S.L., Hummerich, H., Nielsen, J.E., Hodges, J.R., Spillantini, M.G., Thusgaard, T. et al. (2005) Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia. Nat. Genet. 37, 806-808
46. Parkinson, N., Ince, P.G., Smith, M.O., Highley, R., Skibinski, G., Andersen, P.M., Morrison, K.E., Pall, H.S., Hardiman, O., Collinge, J. et al. (2006) ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology 67, 1074-1077
47. Filimonenko, M., Stuffers, S., Raiborg, C., Yamamoto, A., Malerod, L., Fisher, E.M., Isaacs, A., Brech, A., Stenmark, H. and Simonsen, A. (2007) Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J. Cell Biol. 179, 485-500
48. Lee, J.A., Beigneux, A., Ahmad, S.T., Young, S.G. and Gao, F.B. (2007) ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr. Biol. 17, 1561-1567
49. Pandey, U.B., Nie, Z., Batlevi, Y., McCray, B.A., Ritson, G.P., Nedelsky, N.B., Schwartz, S.L., DiProspero, N.A., Knight, M.A., Schuldiner, O. et al. (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863
50. Berger, Z., Ravikumar, B., Menzies, F.M., Oroz, L.G., Underwood, B.R., Pangalos, M.N., Schmitt, I., Wullner, U., Evert, B.O., O'Kane, C.J. et al. (2006) Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum. Mol. Genet. 15, 433-442