-
1
-
-
0029044625
-
Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C
-
Meluh, P. B. & Koshland, D. Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol. Biol. Cell 6, 793-807 (1995).
-
(1995)
Mol. Biol. Cell
, vol.6
, pp. 793-807
-
-
Meluh, P.B.1
Koshland, D.2
-
2
-
-
0030249870
-
UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins
-
Shen, Z., Pardington-Purtymun, P. E., Comeaux, J. C., Moyzis, R. K. & Chen, D. J. UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. Genomics 36, 271-279 (1996).
-
(1996)
Genomics
, vol.36
, pp. 271-279
-
-
Shen, Z.1
Pardington-Purtymun, P.E.2
Comeaux, J.C.3
Moyzis, R.K.4
Chen, D.J.5
-
3
-
-
0030588674
-
Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin
-
Okura, T. et al. Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin. J. Immunol. 157, 4277-4281 (1996).
-
(1996)
J. Immunol
, vol.157
, pp. 4277-4281
-
-
Okura, T.1
-
4
-
-
0029736651
-
PIC1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia
-
Boddy, M. N., Howe, K., Etkin, L. D., Solomon, E. & Freemont, P. S. PIC1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. Oncogene 13, 971-982 (1996).
-
(1996)
Oncogene
, vol.13
, pp. 971-982
-
-
Boddy, M.N.1
Howe, K.2
Etkin, L.D.3
Solomon, E.4
Freemont, P.S.5
-
5
-
-
0030455748
-
-
Matunis, M. J., Coutavas, E. & Blobel, G. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J. Cell Biol. 135, 1457-1470 (1996). Identifies SUMO1 as a reversible modifier, together with reference 6, and demonstrates that sumoylation can lead to altered localization.
-
Matunis, M. J., Coutavas, E. & Blobel, G. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J. Cell Biol. 135, 1457-1470 (1996). Identifies SUMO1 as a reversible modifier, together with reference 6, and demonstrates that sumoylation can lead to altered localization.
-
-
-
-
6
-
-
0030932134
-
-
Mahajan, R., Delphin, C., Guan, T., Gerace, L. & Melchior, F. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell 88, 97-107 (1997). Identifies SUMO1 as a reversible modifier, together with reference 5, and demonstrates that sumoylation can lead to novel protein interactions.
-
Mahajan, R., Delphin, C., Guan, T., Gerace, L. & Melchior, F. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell 88, 97-107 (1997). Identifies SUMO1 as a reversible modifier, together with reference 5, and demonstrates that sumoylation can lead to novel protein interactions.
-
-
-
-
7
-
-
24344445216
-
Something about SUMO inhibits transcription
-
Gill, G. Something about SUMO inhibits transcription. Curr. Opin. Genet. Dev. 15, 536-541 (2005).
-
(2005)
Curr. Opin. Genet. Dev
, vol.15
, pp. 536-541
-
-
Gill, G.1
-
8
-
-
33847117566
-
Sumoylation in neurons: Nuclear and synaptic roles?
-
Scheschonka, A., Tang, Z. & Betz, H. Sumoylation in neurons: nuclear and synaptic roles? Trends Neurosci. 30, 85-91 (2007).
-
(2007)
Trends Neurosci
, vol.30
, pp. 85-91
-
-
Scheschonka, A.1
Tang, Z.2
Betz, H.3
-
9
-
-
3943099375
-
Protein modification by SUMO
-
Johnson, E. S. Protein modification by SUMO. Annu. Rev. Biochem. 73, 355-382 (2004).
-
(2004)
Annu. Rev. Biochem
, vol.73
, pp. 355-382
-
-
Johnson, E.S.1
-
10
-
-
1542501958
-
SUMO: Ligases, isopeptidases and nuclear pores
-
Melchior, F., Schergaut, M. & Pichler, A. SUMO: ligases, isopeptidases and nuclear pores. Trends Biochem. Sci. 28, 612-618 (2003).
-
(2003)
Trends Biochem. Sci
, vol.28
, pp. 612-618
-
-
Melchior, F.1
Schergaut, M.2
Pichler, A.3
-
11
-
-
33746305530
-
Viruses and sumoylation: Recent highlights
-
Boggio, R. & Chiocca, S. Viruses and sumoylation: recent highlights. Curr. Opin. Microbiol. 9, 430-436 (2006).
-
(2006)
Curr. Opin. Microbiol
, vol.9
, pp. 430-436
-
-
Boggio, R.1
Chiocca, S.2
-
12
-
-
1342279420
-
SUMO and transcriptional regulation
-
Girdwood, D. W., Tatham, M. H. & Hay, R. T. SUMO and transcriptional regulation. Semin. Cell Dev. Biol. 15, 201-210 (2004).
-
(2004)
Semin. Cell Dev. Biol
, vol.15
, pp. 201-210
-
-
Girdwood, D.W.1
Tatham, M.H.2
Hay, R.T.3
-
14
-
-
0032504021
-
Structure determination of the small ubiquitin-related modifier SUMO-1
-
Bayer, P. et al. Structure determination of the small ubiquitin-related modifier SUMO-1. J. Mol. Biol. 280, 275-286 (1998).
-
(1998)
J. Mol. Biol
, vol.280
, pp. 275-286
-
-
Bayer, P.1
-
15
-
-
0033638223
-
Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast
-
Mossessova, E. & Lima, C. D. Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast. Mol. Cell 5, 865-876 (2000).
-
(2000)
Mol. Cell
, vol.5
, pp. 865-876
-
-
Mossessova, E.1
Lima, C.D.2
-
16
-
-
0036177128
-
-
Bernier-Villamor, V, Sampson, D. A, Matunis, M. J. & Lima, C. D. Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell 108, 345-356 2002, The crystal structure reported in this paper demonstrates how the single E2 conjugating enzyme UBC9 recognizes conventional SUMO-acceptor sites in its targets
-
Bernier-Villamor, V., Sampson, D. A., Matunis, M. J. & Lima, C. D. Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell 108, 345-356 (2002). The crystal structure reported in this paper demonstrates how the single E2 conjugating enzyme UBC9 recognizes conventional SUMO-acceptor sites in its targets.
-
-
-
-
17
-
-
3543046736
-
A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes
-
Guo, D. et al. A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes. Nature Genet. 36, 837-841 (2004).
-
(2004)
Nature Genet
, vol.36
, pp. 837-841
-
-
Guo, D.1
-
18
-
-
0034523266
-
SUMO - nonclassical ubiquitin
-
Melchior, F. SUMO - nonclassical ubiquitin. Annu. Rev. Cell Dev. Biol. 16, 591-626 (2000).
-
(2000)
Annu. Rev. Cell Dev. Biol
, vol.16
, pp. 591-626
-
-
Melchior, F.1
-
19
-
-
0034054669
-
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
-
Saitoh, H. & Hinchey, J. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J. Biol. Chem. 275, 6252-6258 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 6252-6258
-
-
Saitoh, H.1
Hinchey, J.2
-
20
-
-
14644402420
-
A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers
-
Rosas-Acosta, G., Russell, W. K., Deyrieux, A., Russell, D. H. & Wilson, V. G. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. Mol. Cell Proteomics 4, 56-72 (2005).
-
(2005)
Mol. Cell Proteomics
, vol.4
, pp. 56-72
-
-
Rosas-Acosta, G.1
Russell, W.K.2
Deyrieux, A.3
Russell, D.H.4
Wilson, V.G.5
-
21
-
-
33846019234
-
Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics
-
Vertegaal, A. C. et al. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol. Cell Proteomics 5, 2298-2310 (2006).
-
(2006)
Mol. Cell Proteomics
, vol.5
, pp. 2298-2310
-
-
Vertegaal, A.C.1
-
22
-
-
26444494924
-
A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation
-
Owerbach, D., McKay, E. M., Yeh, E. T., Gabbay, K. H. & Bohren, K. M. A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. Biochem. Biophys. Res. Commun. 337, 517-520 (2005).
-
(2005)
Biochem. Biophys. Res. Commun
, vol.337
, pp. 517-520
-
-
Owerbach, D.1
McKay, E.M.2
Yeh, E.T.3
Gabbay, K.H.4
Bohren, K.M.5
-
23
-
-
0030794729
-
The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer
-
Johnson, E. S., Schwienhorst, I., Dohmen, R. J. & Blobel, G. The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J. 16, 5509-5519 (1997).
-
(1997)
EMBO J
, vol.16
, pp. 5509-5519
-
-
Johnson, E.S.1
Schwienhorst, I.2
Dohmen, R.J.3
Blobel, G.4
-
24
-
-
0034676457
-
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
-
Fraser, A. G. et al. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330 (2000).
-
(2000)
Nature
, vol.408
, pp. 325-330
-
-
Fraser, A.G.1
-
25
-
-
34548691835
-
Genetic analysis of sumoylation in Arabidopsis: Heat-induced conjugation of SUMO1 and 2 is essential
-
Saracco, S. A., Miller, M. J., Kurepa, J. & Vierstra, R. D. Genetic analysis of sumoylation in Arabidopsis: heat-induced conjugation of SUMO1 and 2 is essential. Plant Physiol. 145, 119-134 (2007).
-
(2007)
Plant Physiol
, vol.145
, pp. 119-134
-
-
Saracco, S.A.1
Miller, M.J.2
Kurepa, J.3
Vierstra, R.D.4
-
26
-
-
28444448039
-
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
-
Nacerddine, K. et al. The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev. Cell 9, 769-779 (2005).
-
(2005)
Dev. Cell
, vol.9
, pp. 769-779
-
-
Nacerddine, K.1
-
27
-
-
0033508431
-
Characterization of a fission yeast SUMO-1 homologue, Pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation
-
Tanaka, K. et al. Characterization of a fission yeast SUMO-1 homologue, Pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation. Mol. Cell. Biol. 19, 8660-8672 (1999).
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 8660-8672
-
-
Tanaka, K.1
-
28
-
-
33749069523
-
-
Alkuraya, F. S. et al. SUMO1 haploinsufficiency leads to cleft lip and palate. Science 313, 1751 (2006). Finds reduced SUMO1 expression in a patient with cleft lip and shows that mice with one defective SUMO1 allele develop a similar phenotype. Moreover, it shows that SUMO1 is essential in mice.
-
Alkuraya, F. S. et al. SUMO1 haploinsufficiency leads to cleft lip and palate. Science 313, 1751 (2006). Finds reduced SUMO1 expression in a patient with cleft lip and shows that mice with one defective SUMO1 allele develop a similar phenotype. Moreover, it shows that SUMO1 is essential in mice.
-
-
-
-
29
-
-
0033537828
-
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1
-
Desterro, J. M., Rodriguez, M. S., Kemp, G. D. & Hay, R. T. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J. Biol. Chem. 274, 10618-10624 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 10618-10624
-
-
Desterro, J.M.1
Rodriguez, M.S.2
Kemp, G.D.3
Hay, R.T.4
-
30
-
-
0033608252
-
In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2
-
Okuma, T., Honda, R., Ichikawa, G., Tsumagari, N. & Yasuda, H. In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochem. Biophys. Res. Commun. 254, 693-698 (1999).
-
(1999)
Biochem. Biophys. Res. Commun
, vol.254
, pp. 693-698
-
-
Okuma, T.1
Honda, R.2
Ichikawa, G.3
Tsumagari, N.4
Yasuda, H.5
-
31
-
-
0033060826
-
Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex
-
Gong, L., Li, B., Millas, S. & Yeh, E. T. Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. FEBS Lett. 448, 185-189 (1999).
-
(1999)
FEBS Lett
, vol.448
, pp. 185-189
-
-
Gong, L.1
Li, B.2
Millas, S.3
Yeh, E.T.4
-
32
-
-
0030826334
-
Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p
-
Johnson, E. S. & Blobel, G. Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J. Biol. Chem. 272, 26799-26802 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 26799-26802
-
-
Johnson, E.S.1
Blobel, G.2
-
33
-
-
0030728212
-
Ubch9 conjugates SUMO but not ubiquitin
-
Desterro, J. M., Thomson, J. & Hay, R. T. Ubch9 conjugates SUMO but not ubiquitin. FEBS Lett. 417, 297-300 (1997).
-
(1997)
FEBS Lett
, vol.417
, pp. 297-300
-
-
Desterro, J.M.1
Thomson, J.2
Hay, R.T.3
-
34
-
-
0032512922
-
Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue
-
Lee, G. W. et al. Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue. J. Biol. Chem. 273, 6503-6507 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 6503-6507
-
-
Lee, G.W.1
-
35
-
-
0032518581
-
Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2
-
Saitoh, H. et al. Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2. Curr. Biol. 8, 121-124 (1998).
-
(1998)
Curr. Biol
, vol.8
, pp. 121-124
-
-
Saitoh, H.1
-
36
-
-
0035812848
-
new functions bloom for a ubiquitin-like protein
-
for SUMO
-
Hochstrasser, M. SP-RING for SUMO: new functions bloom for a ubiquitin-like protein. Cell 107, 5-8 (2001).
-
(2001)
Cell
, vol.107
, pp. 5-8
-
-
Hochstrasser, M.1
-
37
-
-
33645514646
-
PIAS proteins and transcriptional regulation - more than just SUMO E3 ligases?
-
Sharrocks, A. D. PIAS proteins and transcriptional regulation - more than just SUMO E3 ligases? Genes Dev. 20, 754-758 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 754-758
-
-
Sharrocks, A.D.1
-
38
-
-
0035929279
-
-
Johnson, E. S. & Gupta, A. A. An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell 106, 735-744 (2001). Together with reference 39 describes the first SUMO E3 ligases, Siz1 and Siz2. Identification of their mammalian homologues, the PIAS proteins, as E3 ligases followed shortly thereafter (see references 40 and 45).
-
Johnson, E. S. & Gupta, A. A. An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell 106, 735-744 (2001). Together with reference 39 describes the first SUMO E3 ligases, Siz1 and Siz2. Identification of their mammalian homologues, the PIAS proteins, as E3 ligases followed shortly thereafter (see references 40 and 45).
-
-
-
-
39
-
-
0035966066
-
Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates
-
Takahashi, Y., Kahyo, T., Toh, E. A., Yasuda, H. & Kikuchi, Y. Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. J. Biol. Chem. 276, 48973-48977 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 48973-48977
-
-
Takahashi, Y.1
Kahyo, T.2
Toh, E.A.3
Yasuda, H.4
Kikuchi, Y.5
-
40
-
-
0034789730
-
Involvement of PIAS1 in the sumoylation of tumor suppressor p53
-
Kahyo, T., Nishida, T. & Yasuda, H. Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol. Cell 8, 713-718 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 713-718
-
-
Kahyo, T.1
Nishida, T.2
Yasuda, H.3
-
41
-
-
0037022564
-
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity
-
Schmidt, D. & Muller, S. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Proc. Natl Acad. Sci. USA 99, 2872-2877 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 2872-2877
-
-
Schmidt, D.1
Muller, S.2
-
42
-
-
0036826887
-
PIAS1 and PIASxα function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription
-
Nishida, T. & Yasuda, H. PIAS1 and PIASxα function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. J. Biol. Chem. 277, 41311-41317 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 41311-41317
-
-
Nishida, T.1
Yasuda, H.2
-
43
-
-
0036792683
-
-
Sapetschnig, A. et al. Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO J. 21, 5206-5215 (2002). Provides a clear example for the role of SUMO in inhibiting transcription: PIAS1-dependent sumoylation in the inhibitory domain silences Sp3 without impairing DNA binding.
-
Sapetschnig, A. et al. Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO J. 21, 5206-5215 (2002). Provides a clear example for the role of SUMO in inhibiting transcription: PIAS1-dependent sumoylation in the inhibitory domain silences Sp3 without impairing DNA binding.
-
-
-
-
44
-
-
0037163859
-
PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1
-
Nakagawa, K. & Yokosawa, H. PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1. FEBS Lett. 530, 204-208 (2002).
-
(2002)
FEBS Lett
, vol.530
, pp. 204-208
-
-
Nakagawa, K.1
Yokosawa, H.2
-
45
-
-
0035576878
-
PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
-
Sachdev, S. et al. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 15, 3088-3103 (2001).
-
(2001)
Genes Dev
, vol.15
, pp. 3088-3103
-
-
Sachdev, S.1
-
46
-
-
0036291475
-
PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases
-
Kotaja, N., Karvonen, U., Janne, O. A. & Palvimo, J. J. PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. Mol. Cell. Biol. 22, 5222-5234 (2002).
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 5222-5234
-
-
Kotaja, N.1
Karvonen, U.2
Janne, O.A.3
Palvimo, J.J.4
-
47
-
-
16344370926
-
-
Zhao, X. & Blobel, G. A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc. Natl Acad. Sci. USA 102, 4777-4782 (2005). Together with references 48 and 49 identifies Mms21/Nse2, a component of the Smc5-Smc6 complex, as a novel SP-RING-type SUMO E3 ligase.
-
Zhao, X. & Blobel, G. A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc. Natl Acad. Sci. USA 102, 4777-4782 (2005). Together with references 48 and 49 identifies Mms21/Nse2, a component of the Smc5-Smc6 complex, as a novel SP-RING-type SUMO E3 ligase.
-
-
-
-
48
-
-
11144324990
-
Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage
-
Andrews, E. A. et al. Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Mol. Cell. Biol. 25, 185-196 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 185-196
-
-
Andrews, E.A.1
-
49
-
-
23344442009
-
Human MMS21/NSE2 is a SUMO ligase required for DNA repair
-
Potts, P. R. & Yu, H. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol. Cell. Biol. 25, 7021-7032 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 7021-7032
-
-
Potts, P.R.1
Yu, H.2
-
50
-
-
34447129654
-
-
Potts, P. R. & Yu, H. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nature Struct. Mol. Biol. 14, 581-590 (2007). Links sumoylation to telomerase-independent telomere maintenance in certain cancer cells.
-
Potts, P. R. & Yu, H. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nature Struct. Mol. Biol. 14, 581-590 (2007). Links sumoylation to telomerase-independent telomere maintenance in certain cancer cells.
-
-
-
-
52
-
-
0037059619
-
-
Pichler, A., Gast, A., Seeler, J. S., Dejean, A. & Melchior, F. The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell 108, 109-120 (2002). Identification of the nucleoporin RanBP2 as a unique E3 ligase, the catalytic domain of which is unrelated in sequence to HECT or RING E3 ligases (see also reference 53).
-
Pichler, A., Gast, A., Seeler, J. S., Dejean, A. & Melchior, F. The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell 108, 109-120 (2002). Identification of the nucleoporin RanBP2 as a unique E3 ligase, the catalytic domain of which is unrelated in sequence to HECT or RING E3 ligases (see also reference 53).
-
-
-
-
53
-
-
4744370425
-
The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type
-
Pichler, A., Knipscheer, P., Saitoh, H., Sixma, T. K. & Melchior, F. The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type. Nature Struct. Mol. Biol. 11, 984-991 (2004).
-
(2004)
Nature Struct. Mol. Biol
, vol.11
, pp. 984-991
-
-
Pichler, A.1
Knipscheer, P.2
Saitoh, H.3
Sixma, T.K.4
Melchior, F.5
-
54
-
-
20444384040
-
-
Reverter, D. & Lima, C. D. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature 435, 687-692 (2005). A crystal structure suggests that RanBP2 functions as an E3 ligase by binding both SUMO and UBC9 to position the SUMO-E2 thioester bond in an optimal orientation to enhance conjugation.
-
Reverter, D. & Lima, C. D. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature 435, 687-692 (2005). A crystal structure suggests that RanBP2 functions as an E3 ligase by binding both SUMO and UBC9 to position the SUMO-E2 thioester bond in an optimal orientation to enhance conjugation.
-
-
-
-
55
-
-
11444271001
-
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
-
Tatham, M. H. et al. Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nature Struct. Mol. Biol. 12, 67-74 (2005).
-
(2005)
Nature Struct. Mol. Biol
, vol.12
, pp. 67-74
-
-
Tatham, M.H.1
-
56
-
-
18444370302
-
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
-
Kirsh, O. et al. The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J. 21, 2682-2691 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 2682-2691
-
-
Kirsh, O.1
-
57
-
-
0037418829
-
The polycomb protein Pc2 is a SUMO E3
-
Kagey, M. H., Melhuish, T. A. & Wotton, D. The polycomb protein Pc2 is a SUMO E3. Cell 113, 127-137 (2003).
-
(2003)
Cell
, vol.113
, pp. 127-137
-
-
Kagey, M.H.1
Melhuish, T.A.2
Wotton, D.3
-
58
-
-
13244271351
-
Multiple activities contribute to Pc2 E3 function
-
Kagey, M. H., Melhuish, T. A., Powers, S. E. & Wotton, D. Multiple activities contribute to Pc2 E3 function. EMBO J. 24, 108-119 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 108-119
-
-
Kagey, M.H.1
Melhuish, T.A.2
Powers, S.E.3
Wotton, D.4
-
59
-
-
25444462980
-
Regulation of MEF2 by histone deacetylase 4-and SIRT1 deacetylase-mediated lysine modifications
-
Zhao, X., Sternsdorf, T., Bolger, T. A., Evans, R. M. & Yao, T. P. Regulation of MEF2 by histone deacetylase 4-and SIRT1 deacetylase-mediated lysine modifications. Mol. Cell. Biol. 25, 8456-8464 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 8456-8464
-
-
Zhao, X.1
Sternsdorf, T.2
Bolger, T.A.3
Evans, R.M.4
Yao, T.P.5
-
60
-
-
14844344773
-
Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors
-
Gregoire, S. & Yang, X. J. Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol. Cell. Biol. 25, 2273-2287 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 2273-2287
-
-
Gregoire, S.1
Yang, X.J.2
-
61
-
-
33845970925
-
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ
-
Ghisletti, S. et al. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ. Mol. Cell 25, 57-70 (2007).
-
(2007)
Mol. Cell
, vol.25
, pp. 57-70
-
-
Ghisletti, S.1
-
62
-
-
34147208064
-
An acetylation/deacetylation- SUMOylation switch through a phylogenetically conserved ψKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
-
Stankovic-Valentin, N. et al. An acetylation/deacetylation- SUMOylation switch through a phylogenetically conserved ψKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol. Cell. Biol. 27, 2661-2675 (2007).
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 2661-2675
-
-
Stankovic-Valentin, N.1
-
63
-
-
0035929557
-
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9
-
Tatham, M. H. et al. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J. Biol. Chem. 276, 35368-35374 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 35368-35374
-
-
Tatham, M.H.1
-
64
-
-
0242414786
-
The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast
-
Bylebyl, G. R., Belichenko, I. & Johnson, E. S. The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast. J. Biol. Chem. 278, 44113-44120 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 44113-44120
-
-
Bylebyl, G.R.1
Belichenko, I.2
Johnson, E.S.3
-
65
-
-
33748990136
-
SUSP1 antagonizes formation of highly SUMO2/3-conjugated species
-
Mukhopadhyay, D. et al. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J. Cell Biol. 174, 939-949 (2006).
-
(2006)
J. Cell Biol
, vol.174
, pp. 939-949
-
-
Mukhopadhyay, D.1
-
66
-
-
0034018312
-
The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitinlike Smt3 protein
-
Li, S. J. & Hochstrasser, M. The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitinlike Smt3 protein. Mol. Cell. Biol. 20, 2367-2377 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 2367-2377
-
-
Li, S.J.1
Hochstrasser, M.2
-
67
-
-
0033580444
-
-
Li, S. J. & Hochstrasser, M. A new protease required for cell-cycle progression in yeast. Nature 398, 246-251 (1999). A biochemical screen of an expression library allowed identification of the first SUMO-specific isopeptidase - Ulp1.
-
Li, S. J. & Hochstrasser, M. A new protease required for cell-cycle progression in yeast. Nature 398, 246-251 (1999). A biochemical screen of an expression library allowed identification of the first SUMO-specific isopeptidase - Ulp1.
-
-
-
-
68
-
-
33745049415
-
The SUMO-specific protease SENP5 is required for cell division
-
Di Bacco, A. et al. The SUMO-specific protease SENP5 is required for cell division. Mol. Cell. Biol. 26, 4489-4498 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 4489-4498
-
-
Di Bacco, A.1
-
69
-
-
33744917849
-
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3
-
Gong, L. & Yeh, E. T. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J. Biol. Chem. 281, 15869-15877 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 15869-15877
-
-
Gong, L.1
Yeh, E.T.2
-
70
-
-
0037417333
-
The Ulp1 SUMO isopeptidase: Distinct domains required for viability, nuclear envelope localization, and substrate specificity
-
Li, S. J. & Hochstrasser, M. The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J. Cell Biol. 160, 1069-1081 (2003).
-
(2003)
J. Cell Biol
, vol.160
, pp. 1069-1081
-
-
Li, S.J.1
Hochstrasser, M.2
-
71
-
-
0037205460
-
Association of the human SUMO-1 protease SENP2 with the nuclear pore
-
Hang, J. & Dasso, M. Association of the human SUMO-1 protease SENP2 with the nuclear pore. J. Biol. Chem. 277, 19961-19966 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 19961-19966
-
-
Hang, J.1
Dasso, M.2
-
72
-
-
0036724599
-
Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex
-
Zhang, H., Saitoh, H. & Matunis, M. J. Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol. Cell. Biol. 22, 6498-6508 (2002).
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 6498-6508
-
-
Zhang, H.1
Saitoh, H.2
Matunis, M.J.3
-
73
-
-
0033760171
-
A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase
-
Nishida, T., Tanaka, H. & Yasuda, H. A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase. Eur. J. Biochem. 267, 6423-6427 (2000).
-
(2000)
Eur. J. Biochem
, vol.267
, pp. 6423-6427
-
-
Nishida, T.1
Tanaka, H.2
Yasuda, H.3
-
74
-
-
34248225298
-
The SUMO protease SENP5 is required to maintain mitochondrial morphology and function
-
Zunino, R., Schauss, A., Rippstein, P., Andrade-Navarro, M. & McBride, H. M. The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. J. Cell Sci. 120, 1178-1188 (2007).
-
(2007)
J. Cell Sci
, vol.120
, pp. 1178-1188
-
-
Zunino, R.1
Schauss, A.2
Rippstein, P.3
Andrade-Navarro, M.4
McBride, H.M.5
-
75
-
-
0034603179
-
Differential regulation of sentrinized proteins by a novel sentrin-specific protease
-
Gong, L., Millas, S., Maul, G. G. & Yeh, E. T. Differential regulation of sentrinized proteins by a novel sentrin-specific protease. J. Biol. Chem. 275, 3355-3359 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 3355-3359
-
-
Gong, L.1
Millas, S.2
Maul, G.G.3
Yeh, E.T.4
-
76
-
-
0346422441
-
Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1
-
Bailey, D. & O'Hare, P. Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. J. Biol. Chem. 279, 692-703 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 692-703
-
-
Bailey, D.1
O'Hare, P.2
-
77
-
-
0001720254
-
A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs
-
Kim, K. I. et al. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J. Biol. Chem. 275, 14102-14106 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 14102-14106
-
-
Kim, K.I.1
-
78
-
-
34249880519
-
Modification in reverse: The SUMO proteases
-
Mukhopadhyay, D. & Dasso, M. Modification in reverse: the SUMO proteases. Trends Biochem. Sci. 32, 286-295 (2007).
-
(2007)
Trends Biochem. Sci
, vol.32
, pp. 286-295
-
-
Mukhopadhyay, D.1
Dasso, M.2
-
79
-
-
0032567759
-
Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association
-
Mahajan, R., Gerace, L. & Melchior, F. Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. J. Cell Biol. 140, 259-270 (1998).
-
(1998)
J. Cell Biol
, vol.140
, pp. 259-270
-
-
Mahajan, R.1
Gerace, L.2
Melchior, F.3
-
80
-
-
0032498541
-
SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex
-
Matunis, M. J., Wu, J. & Blobel, G. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J. Cell Biol. 140, 499-509 (1998).
-
(1998)
J. Cell Biol
, vol.140
, pp. 499-509
-
-
Matunis, M.J.1
Wu, J.2
Blobel, G.3
-
81
-
-
0032500634
-
Identification of three major sentrinization sites in PML
-
Kamitani, T. et al. Identification of three major sentrinization sites in PML. J. Biol. Chem. 273, 26675-26682 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 26675-26682
-
-
Kamitani, T.1
-
82
-
-
0033617169
-
The nuclear dot protein Sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers
-
Sternsdorf, T., Jensen, K., Reich, B. & Will, H. The nuclear dot protein Sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers. J. Biol. Chem. 274, 12555-12566 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 12555-12566
-
-
Sternsdorf, T.1
Jensen, K.2
Reich, B.3
Will, H.4
-
83
-
-
0032135131
-
-
Desterro, J. M., Rodriguez, M. S. & Hay, R. T. SUMO-1 modification of IκBα inhibits NF-κB activation. Mol. Cell 2, 233-239 (1998). Provided the first example of a protein that can be sumoylated and ubiquitylated at the same Lys residue.
-
Desterro, J. M., Rodriguez, M. S. & Hay, R. T. SUMO-1 modification of IκBα inhibits NF-κB activation. Mol. Cell 2, 233-239 (1998). Provided the first example of a protein that can be sumoylated and ubiquitylated at the same Lys residue.
-
-
-
-
84
-
-
0034607653
-
c-Jun and p53 activity is modulated by SUMO-1 modification
-
Muller, S. et al. c-Jun and p53 activity is modulated by SUMO-1 modification. J. Biol. Chem. 275, 13321-13329 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 13321-13329
-
-
Muller, S.1
-
85
-
-
33645236037
-
Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence
-
Macauley, M. S. et al. Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. J. Biol. Chem. 281, 4164-4172 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 4164-4172
-
-
Macauley, M.S.1
-
86
-
-
17844401751
-
SUMO modification of the ubiquitinconjugating enzyme E2-25K
-
Pichler, A. et al. SUMO modification of the ubiquitinconjugating enzyme E2-25K. Nature Struct. Mol. Biol. 12, 264-269 (2005).
-
(2005)
Nature Struct. Mol. Biol
, vol.12
, pp. 264-269
-
-
Pichler, A.1
-
87
-
-
30444440554
-
-
Hietakangas, V. et al. PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl Acad. Sci. USA 103, 45-50 (2006). Phosphorylation adjacent to the conventional SUMO-acceptor site enhances modification of several target proteins.
-
Hietakangas, V. et al. PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl Acad. Sci. USA 103, 45-50 (2006). Phosphorylation adjacent to the conventional SUMO-acceptor site enhances modification of several target proteins.
-
-
-
-
88
-
-
0037385213
-
Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1
-
Hietakangas, V. et al. Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol. Cell. Biol. 23, 2953-2968 (2003).
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 2953-2968
-
-
Hietakangas, V.1
-
89
-
-
33750439105
-
An extended consensus motif enhances the specificity of substrate modification by SUMO
-
Yang, S. H., Galanis, A., Witty, J. & Sharrocks, A. D. An extended consensus motif enhances the specificity of substrate modification by SUMO. EMBO J. 25, 5083-5093 (2006).
-
(2006)
EMBO J
, vol.25
, pp. 5083-5093
-
-
Yang, S.H.1
Galanis, A.2
Witty, J.3
Sharrocks, A.D.4
-
90
-
-
0037068455
-
-
Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G. & Jentsch, S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-141 (2002). Demonstrates that monoubiquitylation, polyubiquitylation and sumoylation of the same Lys residue in a non-consensus SUMO-acceptor site of PCNA serve distinct functions in DNA repair and replication (see also references 92 and 93).
-
Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G. & Jentsch, S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-141 (2002). Demonstrates that monoubiquitylation, polyubiquitylation and sumoylation of the same Lys residue in a non-consensus SUMO-acceptor site of PCNA serve distinct functions in DNA repair and replication (see also references 92 and 93).
-
-
-
-
91
-
-
0037961625
-
p300 transcriptional repression is mediated by SUMO modification
-
Girdwood, D. et al. p300 transcriptional repression is mediated by SUMO modification. Mol. Cell 11, 1043-1054 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 1043-1054
-
-
Girdwood, D.1
-
92
-
-
21244449061
-
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p
-
Papouli, E. et al. Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol. Cell 19, 123-133 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 123-133
-
-
Papouli, E.1
-
93
-
-
22944474665
-
SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase
-
Pfander, B., Moldovan, G. L., Sacher, M., Hoege, C. & Jentsch, S. SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature 436, 428-433 (2005).
-
(2005)
Nature
, vol.436
, pp. 428-433
-
-
Pfander, B.1
Moldovan, G.L.2
Sacher, M.3
Hoege, C.4
Jentsch, S.5
-
94
-
-
5644261273
-
ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation
-
Zheng, G. & Yang, Y. C. ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation. J. Biol. Chem. 279, 42410-42421 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 42410-42421
-
-
Zheng, G.1
Yang, Y.C.2
-
95
-
-
0038054467
-
Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding
-
Lin, X. et al. Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol. Cell 11, 1389-1396 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 1389-1396
-
-
Lin, X.1
-
96
-
-
10344252317
-
Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1
-
Macauley, M. S. et al. Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. J. Biol. Chem. 279, 49131-49137 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 49131-49137
-
-
Macauley, M.S.1
-
97
-
-
0037086643
-
-
Hardeland, U., Steinacher, R., Jiricny, J. & Schar, P. Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. EMBO J. 21, 1456-1464 (2002). This work shows that cycles of SUMO modification and demodification of TDG contribute to the enzyme's function, most likely through conformational changes that allow product release and rebinding (see also reference 98).
-
Hardeland, U., Steinacher, R., Jiricny, J. & Schar, P. Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. EMBO J. 21, 1456-1464 (2002). This work shows that cycles of SUMO modification and demodification of TDG contribute to the enzyme's function, most likely through conformational changes that allow product release and rebinding (see also reference 98).
-
-
-
-
98
-
-
20544440797
-
Crystal structure of thymine DNA glycosylase conjugated to SUMO-1
-
Baba, D. et al. Crystal structure of thymine DNA glycosylase conjugated to SUMO-1. Nature 435, 979-982 (2005).
-
(2005)
Nature
, vol.435
, pp. 979-982
-
-
Baba, D.1
-
99
-
-
0034680441
-
Covalent modification of p73α by SUMO-1
-
Minty, A., Dumont, X., Kaghad, M. & Caput, D. Covalent modification of p73α by SUMO-1. J. Biol. Chem. 275, 36316-36323 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 36316-36323
-
-
Minty, A.1
Dumont, X.2
Kaghad, M.3
Caput, D.4
-
100
-
-
5144219680
-
-
Song, J., Durrin, L. K., Wilkinson, T. A., Krontiris, T. G. & Chen, Y. Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc. Natl Acad. Sci. USA 101, 14373-14378 (2004). Through NMR analysis of a PIAS peptide, previously shown to bind SUMO non-covalently (see reference 99), the authors define a minimal SUMO-binding motif.
-
Song, J., Durrin, L. K., Wilkinson, T. A., Krontiris, T. G. & Chen, Y. Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc. Natl Acad. Sci. USA 101, 14373-14378 (2004). Through NMR analysis of a PIAS peptide, previously shown to bind SUMO non-covalently (see reference 99), the authors define a minimal SUMO-binding motif.
-
-
-
-
101
-
-
33744940842
-
Specification of SUMO1- and SUMO2-interacting motifs
-
Hecker, C. M., Rabiller, M., Haglund, K., Bayer, P. & Dikic, I. Specification of SUMO1- and SUMO2-interacting motifs. J. Biol. Chem. 281, 16117-16127 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 16117-16127
-
-
Hecker, C.M.1
Rabiller, M.2
Haglund, K.3
Bayer, P.4
Dikic, I.5
-
102
-
-
14244260623
-
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae
-
Hannich, J. T. et al. Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J. Biol. Chem. 280, 4102-4110 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 4102-4110
-
-
Hannich, J.T.1
-
103
-
-
28844455305
-
Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: A reversal of the bound orientation
-
Song, J., Zhang, Z., Hu, W. & Chen, Y. Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. J. Biol. Chem. 280, 40122-40129 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 40122-40129
-
-
Song, J.1
Zhang, Z.2
Hu, W.3
Chen, Y.4
-
104
-
-
33750447586
-
The mechanisms of PML-nuclear body formation
-
Shen, T. H., Lin, H. K., Scaglioni, P. P., Yung, T. M. & Pandolfi, P. P. The mechanisms of PML-nuclear body formation. Mol. Cell 24, 331-339 (2006).
-
(2006)
Mol. Cell
, vol.24
, pp. 331-339
-
-
Shen, T.H.1
Lin, H.K.2
Scaglioni, P.P.3
Yung, T.M.4
Pandolfi, P.P.5
-
105
-
-
33750491062
-
-
Lin, D. Y. et al. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol. Cell 24, 341-354 (2006). Non-covalent interaction of Daxx with SUMO is required for Daxx-dependent transcriptional repression as well as for Daxx sumoylation.
-
Lin, D. Y. et al. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol. Cell 24, 341-354 (2006). Non-covalent interaction of Daxx with SUMO is required for Daxx-dependent transcriptional repression as well as for Daxx sumoylation.
-
-
-
-
106
-
-
28044437730
-
SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx
-
Kuo, H. Y. et al. SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proc. Natl Acad. Sci. USA 102, 16973-16978 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 16973-16978
-
-
Kuo, H.Y.1
-
107
-
-
34648840192
-
SUMO-targeted ubiquitin ligases in genome stability
-
Prudden, J. et al. SUMO-targeted ubiquitin ligases in genome stability. EMBO J. (2007).
-
(2007)
EMBO J
-
-
Prudden, J.1
-
108
-
-
34648816891
-
-
Sun, H., Leverson, J. D. & Hunter, T. Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J. 26, 4102-4112 (2007). This paper, together with references 107, 109 and 110, suggests that SUMO can serve as a degradation signal by recruiting a ubiquitin E3 ligase via a non-covalent SUMO-SIM/SBM interaction with its targets.
-
Sun, H., Leverson, J. D. & Hunter, T. Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J. 26, 4102-4112 (2007). This paper, together with references 107, 109 and 110, suggests that SUMO can serve as a degradation signal by recruiting a ubiquitin E3 ligase via a non-covalent SUMO-SIM/SBM interaction with its targets.
-
-
-
-
109
-
-
36348977099
-
Ubiquitin-dependent proteolytic control of SUMO conjugates
-
29 Aug, doi:10.1074/jbc.M706505200
-
Uzunova, K. et al. Ubiquitin-dependent proteolytic control of SUMO conjugates. J. Biol. Chem. 29 Aug 2007 (doi:10.1074/jbc.M706505200).
-
(2007)
J. Biol. Chem
-
-
Uzunova, K.1
-
110
-
-
36348964395
-
The yeast HEX3-SLX8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation
-
11 Sep, doi:10.1074/jbc.M706025200
-
Xie, Y. et al. The yeast HEX3-SLX8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J. Biol. Chem. 11 Sep 2007 (doi:10.1074/jbc.M706025200).
-
(2007)
J. Biol. Chem
-
-
Xie, Y.1
-
111
-
-
23144452091
-
Ubiquitin-binding domains
-
Hicke, L., Schubert, H. L. & Hill, C. P. Ubiquitin-binding domains. Nature Rev. Mol. Cell Biol. 6, 610-621 (2005).
-
(2005)
Nature Rev. Mol. Cell Biol
, vol.6
, pp. 610-621
-
-
Hicke, L.1
Schubert, H.L.2
Hill, C.P.3
-
112
-
-
18144404319
-
-
Chupreta, S., Holmstrom, S., Subramanian, L. & Iniguez-Lluhi, J. A. A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties. Mol. Cell. Biol. 25, 4272-4282 (2005). Extensive analysis of SUMO2 mutants revealed a surface in SUMO strictly that is required for transcriptional repression. This surface is now known to interact with SIM/SBM.
-
Chupreta, S., Holmstrom, S., Subramanian, L. & Iniguez-Lluhi, J. A. A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties. Mol. Cell. Biol. 25, 4272-4282 (2005). Extensive analysis of SUMO2 mutants revealed a surface in SUMO strictly that is required for transcriptional repression. This surface is now known to interact with SIM/SBM.
-
-
-
-
113
-
-
1542285164
-
SUMO promotes HDAC-mediated transcriptional repression
-
Yang, S. H. & Sharrocks, A. D. SUMO promotes HDAC-mediated transcriptional repression. Mol. Cell 13, 611-617 (2004).
-
(2004)
Mol. Cell
, vol.13
, pp. 611-617
-
-
Yang, S.H.1
Sharrocks, A.D.2
-
114
-
-
10044264506
-
Negative modulation of androgen receptor transcriptional activity by Daxx
-
Lin, D. Y. et al. Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24, 10529-10541 (2004).
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 10529-10541
-
-
Lin, D.Y.1
-
115
-
-
15944406765
-
SUMO: A history of modification
-
Hay, R. T. SUMO: a history of modification. Mol. Cell 18, 1-12 (2005).
-
(2005)
Mol. Cell
, vol.18
, pp. 1-12
-
-
Hay, R.T.1
-
116
-
-
23344445127
-
Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation
-
Bossis, G. et al. Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol. Cell. Biol. 25, 6964-6979 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 6964-6979
-
-
Bossis, G.1
-
117
-
-
4344685954
-
Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53
-
Lin, J. Y., Ohshima, T. & Shimotohno, K. Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53. FEBS Lett. 573, 15-18 (2004).
-
(2004)
FEBS Lett
, vol.573
, pp. 15-18
-
-
Lin, J.Y.1
Ohshima, T.2
Shimotohno, K.3
-
118
-
-
0036809115
-
SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization
-
Ross, S., Best, J. L., Zon, L. I. & Gill, G. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol. Cell 10, 831-842 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 831-842
-
-
Ross, S.1
Best, J.L.2
Zon, L.I.3
Gill, G.4
-
119
-
-
0141831006
-
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation
-
Stelter, P. & Ulrich, H. D. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature 425, 188-191 (2003).
-
(2003)
Nature
, vol.425
, pp. 188-191
-
-
Stelter, P.1
Ulrich, H.D.2
-
120
-
-
25844437172
-
Mutual interactions between the SUMO and ubiquitin systems: A plea of no contest
-
Ulrich, H. D. Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest. Trends Cell Biol. 15, 525-532 (2005).
-
(2005)
Trends Cell Biol
, vol.15
, pp. 525-532
-
-
Ulrich, H.D.1
-
121
-
-
33748188499
-
PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress
-
Mabb, A. M., Wuerzberger-Davis, S. M. & Miyamoto, S. PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress. Nature Cell Biol. 8, 986-993 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 986-993
-
-
Mabb, A.M.1
Wuerzberger-Davis, S.M.2
Miyamoto, S.3
-
122
-
-
0344305376
-
Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress
-
Huang, T. T., Wuerzberger-Davis, S. M., Wu, Z. H. & Miyamoto, S. Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress. Cell 115, 565-576 (2003).
-
(2003)
Cell
, vol.115
, pp. 565-576
-
-
Huang, T.T.1
Wuerzberger-Davis, S.M.2
Wu, Z.H.3
Miyamoto, S.4
-
123
-
-
33144473786
-
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
-
Shalizi, A. et al. A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science 311, 1012-1017 (2006).
-
(2006)
Science
, vol.311
, pp. 1012-1017
-
-
Shalizi, A.1
-
124
-
-
0033615965
-
Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins
-
Johnson, E. S. & Blobel, G. Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins. J. Cell Biol. 147, 981-994 (1999).
-
(1999)
J. Cell Biol
, vol.147
, pp. 981-994
-
-
Johnson, E.S.1
Blobel, G.2
-
125
-
-
34247538342
-
Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells
-
Lee, Y. J. et al. Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells. J. Cereb. Blood Flow Metab. 27, 950-962 (2007).
-
(2007)
J. Cereb. Blood Flow Metab
, vol.27
, pp. 950-962
-
-
Lee, Y.J.1
-
126
-
-
0037470238
-
The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress
-
Kurepa, J. et al. The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress. J. Biol. Chem. 278, 6862-6872 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 6862-6872
-
-
Kurepa, J.1
-
127
-
-
31544432283
-
-
2 can cause global or local loss of sumoylation due to reversible crosslinking of SUMO E1 and E2 enzymes.
-
2 can cause global or local loss of sumoylation due to reversible crosslinking of SUMO E1 and E2 enzymes.
-
-
-
-
128
-
-
8844219681
-
A mechanism for inhibiting the SUMO pathway
-
Boggio, R., Colombo, R., Hay, R. T., Draetta, G. F. & Chiocca, S. A mechanism for inhibiting the SUMO pathway. Mol. Cell 16, 549-561 (2004).
-
(2004)
Mol. Cell
, vol.16
, pp. 549-561
-
-
Boggio, R.1
Colombo, R.2
Hay, R.T.3
Draetta, G.F.4
Chiocca, S.5
-
129
-
-
34447560073
-
-
Boggio, R., Passafaro, A. & Chiocca, S. Targeting SUMO E1 to ubiquitin ligases: a viral strategy to counteract sumoylation. J. Biol. Chem. 282, 15376-15382 (2007). The viral protein Gam1 abolishes global sumoylation by targeting SUMO E1 for ubiquitin-mediated degradation (together with reference 128).
-
Boggio, R., Passafaro, A. & Chiocca, S. Targeting SUMO E1 to ubiquitin ligases: a viral strategy to counteract sumoylation. J. Biol. Chem. 282, 15376-15382 (2007). The viral protein Gam1 abolishes global sumoylation by targeting SUMO E1 for ubiquitin-mediated degradation (together with reference 128).
-
-
-
-
130
-
-
33748525164
-
Role of desumoylation in the development of prostate cancer
-
Cheng, J., Bawa, T., Lee, P., Gong, L. & Yeh, E. T. Role of desumoylation in the development of prostate cancer. Neoplasia 8, 667-676 (2006).
-
(2006)
Neoplasia
, vol.8
, pp. 667-676
-
-
Cheng, J.1
Bawa, T.2
Lee, P.3
Gong, L.4
Yeh, E.T.5
-
131
-
-
17844401262
-
A role for Ubc9 in tumorigenesis
-
Mo, Y. Y., Yu, Y., Theodosiou, E., Rachel Ee, P. L. & Beck, W. T. A role for Ubc9 in tumorigenesis. Oncogene 24, 2677-2683 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 2677-2683
-
-
Mo, Y.Y.1
Yu, Y.2
Theodosiou, E.3
Rachel Ee, P.L.4
Beck, W.T.5
-
132
-
-
1542380494
-
Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission
-
Harder, Z., Zunino, R. & McBride, H. Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission. Curr. Biol. 14, 340-345 (2004).
-
(2004)
Curr. Biol
, vol.14
, pp. 340-345
-
-
Harder, Z.1
Zunino, R.2
McBride, H.3
-
133
-
-
33845914340
-
-
Dadke, S. et al. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nature Cell Biol. 9, 80-85 (2007). The ER-associated PTP1B is a SUMO target. In vitro assays suggest that sumoylation directly inactivates the enzyme.
-
Dadke, S. et al. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nature Cell Biol. 9, 80-85 (2007). The ER-associated PTP1B is a SUMO target. In vitro assays suggest that sumoylation directly inactivates the enzyme.
-
-
-
-
135
-
-
34547556430
-
+ channels?
-
+ channels? Cell 130, 563-569 (2007).
-
(2007)
Cell
, vol.130
, pp. 563-569
-
-
Feliciangeli, S.1
-
136
-
-
33846914818
-
-
Benson, M. D. et al. SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proc. Natl Acad. Sci. USA 104, 1805-1810 (2007). A voltage-gated potassium channel is a target for reversible sumoylation.
-
Benson, M. D. et al. SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proc. Natl Acad. Sci. USA 104, 1805-1810 (2007). A voltage-gated potassium channel is a target for reversible sumoylation.
-
-
-
-
137
-
-
0032496220
-
+ channel regulatory protein, KChAP
-
+ channel regulatory protein, KChAP. J. Biol. Chem. 273, 11745-11751 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 11745-11751
-
-
Wible, B.A.1
Yang, Q.2
Kuryshev, Y.A.3
Accili, E.A.4
Brown, A.M.5
-
138
-
-
31544477799
-
Pias1 interaction and sumoylation of metabotropic glutamate receptor 8
-
Tang, Z., El Far, O., Betz, H. & Scheschonka, A. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. J. Biol. Chem. 280, 38153-38159 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 38153-38159
-
-
Tang, Z.1
El Far, O.2
Betz, H.3
Scheschonka, A.4
-
139
-
-
34249046463
-
SUMOylation regulates kainate-receptor-mediated synaptic transmission
-
Martin, S., Nishimune, A., Mellor, J. R. & Henley, J. M. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature 447, 321-325 (2007).
-
(2007)
Nature
, vol.447
, pp. 321-325
-
-
Martin, S.1
Nishimune, A.2
Mellor, J.R.3
Henley, J.M.4
-
140
-
-
33846961859
-
SUMO, the three Rs and cancer
-
Seeler, J. S., Bischof, O., Nacerddine, K. & Dejean, A. SUMO, the three Rs and cancer. Curr. Top. Microbiol. Immunol. 313, 49-71 (2007).
-
(2007)
Curr. Top. Microbiol. Immunol
, vol.313
, pp. 49-71
-
-
Seeler, J.S.1
Bischof, O.2
Nacerddine, K.3
Dejean, A.4
-
141
-
-
34249733176
-
SUMO on the road to neurodegeneration
-
Dorval, V. & Fraser, P. E. SUMO on the road to neurodegeneration. Biochim. Biophys. Acta 1773, 694-706 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 694-706
-
-
Dorval, V.1
Fraser, P.E.2
|