Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and lewy-like inclusions resembling human pale bodies

Journal of Neuroscience

Volumn 28, Issue 33, 2008, Pages 8189-8198

  Bedford, Lynn ^a   Hay, David ^a   Devoy, Anny ^a   Paine, Simon ^a   Powe, Des G ^a   Seth, Rashmi ^a   Gray, Trevor ^a   Topham, Ian ^a   Fone, Kevin ^a   Rezvani, Nooshin ^a   Mee, Maureen ^a   Soane, Tim ^a   Layfield, Robert ^a   Sheppard, Paul W ^b   Ebendal, Ted ^c   Usoskin, Dmitry ^d   Lowe, James ^a   Mayer, R John ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b BIOMOL International LP   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Dementia; Genetics; Neuronal death; Neuropathology; Parkinson's disease; Proteolysis; Transgenic

Indexed keywords

ALPHA SYNUCLEIN; DNA 26S; PROTEASOME; UBIQUITIN; ATP DEPENDENT 26S PROTEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CONTROLLED STUDY; ENZYME SUBUNIT; FEMALE; FOREBRAIN; KNOCKOUT GENE; KNOCKOUT MOUSE; LEWY BODY; MALE; MITOCHONDRION; MOUSE; NERVE DEGENERATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PSMC 1 GENE; ANIMAL; BRAIN; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; HUMAN; MOUSE MUTANT; NERVE CELL; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; BRAIN; FEMALE; HUMANS; INCLUSION BODIES; LEWY BODIES; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE DEGENERATION; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 51149121890     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2218-08.2008     Document Type: Article

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