Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function

Journal of Biological Chemistry

Volumn 278, Issue 24, 2003, Pages 22044-22055

  Tsai, Yien Che ^a   Fishman, Paul S ^b,c   Thakor, Nitish V ^a   Oyler, George A ^b,c,d  

^a Johns Hopkins University   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

^d Dept of Neurology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; FLUORESCENCE; GENETIC ENGINEERING; PROTEINS; TOXIC MATERIALS;

CYTOTOXICITY;

ENZYMES;

ALPHA SYNUCLEIN; CELL CYCLE PROTEIN; GREEN FLUORESCENT PROTEIN; PAEL R PROTEIN; PARKIN; POLYGLUTAMINE; PROTEASOME; PROTEIN; PROTEIN P70; SYNPHILIN 1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ANIMALS; BRAIN; CASPASE 12; CASPASES; CELL LINE; CELL SURVIVAL; CYSTEINE ENDOPEPTIDASES; CYTOSOL; GREEN FLUORESCENT PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOBLOTTING; LIGASES; LUMINESCENT PROTEINS; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; PEPTIDES; PLASMIDS; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RATS; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 0038159253     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212235200     Document Type: Article

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