Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

Journal of Neurochemistry

Volumn 83, Issue 5, 2002, Pages 1030-1042

  Urushitani, Makoto ^a   Kurisu, Junko ^a   Tsukita, Kayoko ^a   Takahashi, Ryosuke ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Amyotrophic lateral sclerosis; Motor neuron death; Oxidative stress; Proteasome; Protein misfolding; Ubiquitin

Indexed keywords

COMPLEMENTARY DNA; HYDROGEN PEROXIDE; PROTEASOME; RECOMBINANT PROTEIN; SUPEROXIDE DISMUTASE; UBIQUITIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; EMBRYO; GENE MUTATION; GENE OVEREXPRESSION; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; MOTOR NEURON DISEASE; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING; TRANSGENIC MOUSE;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENE EXPRESSION; HUMANS; KIDNEY; MACROMOLECULAR SUBSTANCES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; MULTIENZYME COMPLEXES; NEUROBLASTOMA; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN DENATURATION; PROTEIN FOLDING; SOLUBILITY; SUPEROXIDE DISMUTASE; UBIQUITIN;

ANIMALIA; MUS MUSCULUS;

EID: 0036892683     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01211.x     Document Type: Article

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