Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease

Journal of Neuroscience

Volumn 17, Issue 13, 1997, Pages 5101-5107

  Busciglio, Jorge ^a,c   Hartmann, Henrike ^a   Lorenzo, Alfredo ^a   Wong, Caine ^a   Baumann, Karlheinz ^b   Sommer, Bernd ^b   Staufenbiel, Matthias ^b   Yankner, Bruce A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b Preclinical Research   (Switzerland)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Alzheimer's disease; Cytoskeleton; Degeneration; Dendritic; Differentiation; Presenilin

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; ANTIBODY; PROTEIN;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN CORTEX; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DENDRITE; DISEASE ASSOCIATION; EMBRYO; ENDOPLASMIC RETICULUM; FETUS; GENE; GENE MUTATION; GROWTH CONE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE MICROSCOPY; NERVE CELL DIFFERENTIATION; NEUROFIBRILLARY TANGLE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SENILE PLAQUE;

EID: 0031006343     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-13-05101.1997     Document Type: Article

References (21)

1. Busciglio J, Yankner BA (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378:776-779.
2. Busciglio J, Gabuzda DH, Matsudaira P, Yankner BA (1993) Generation of β-amyloid in the secretory pathway in neuronal and non-neuronal cells. Proc Natl Acad Sci USA 90:2092-2096.
3. Cook DG, Sung JC, Golde TE, Felsenstein KM, Wolczyk BS, Tanzi RE, Trojanowski JQ, Lee VM-Y, Doms RW (1996) Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc Natl Acad Sci USA 93:9223-9226.
4. Cribbs DH, Chen LS, Bende SM, LaFerla FM (1996) Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in murine brain. Am J Pathol 148:1797-1806.
5. Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS (1996) Protein topology of presenilin 1. Neuron 17:1023-1030.
6. Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA (1994) Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 269:13623-13628.
7. Gorman CM, Gies DR, McCray G (1990) Transient production of proteins using an Adenovirus transformed cell line. DNA Prot Eng Techn 2:3-10.
8. Greenberg SG, Davies P (1990) A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci USA 87:5827-5831.
9. Harlow E, Lane D (1988) Antibodies: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
10. Hartmann H, Busciglio J, Baumann K-H, Staufenbiel M, Yankner BA (1997) Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem, in press.
11. Kovacs DM, Fausett HJ, Page KJ, Kim T-W, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W (1996) Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med 2:224-229.
12. Lorenzo A, Yankner BA (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc Natl Acad Sci USA 91:12243-12247.
13. Murphy GM, Forno LS, Ellis WG, Nochlin D, Levy-Lahad E, Poorkaj P, Bird TD, Jiang Z, Cordell B (1996) Antibodies to presenilin proteins degect neurofibrillary tangles in Alzheimer's disease. Am J Pathol 149:1839-1846.
14. Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, Mar L, Sorbi S, Nacmias B, Placentini S, Amaducci L, Chumakov I, Cohen D, Lannfelt L, Fraser PE, Rommens JM, St. George-Hyslop PH (1995) Familial Alzheimer's disease in kindred with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-778.
15. Scheuner D, Eckman M, Jensen X, Song M, Citron N, Suzuki TD, Bird J, Hardy M, Hutton W, Kukull E, Larson E, Leyy-Lahad M, Viitanen E, Peskind P, Poorkaj G, Schellenberg R, Tanzi W, Wasco L, Lanfelt Selkoe D, Younkin S (1996) Secreted amyloid β-protein similar to that in the senile plagues of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature 2:864-870.
16. Schrader-Fischer G, Paganetti P (1996) Effect of alkalinizing agents on the processing of the β-amyloid precursor protein. Brain Res 716:91-100.
17. Sherrington R, Rogaev El, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Li G, Holman K, Tsuda T, Mar L, Foncin J-F, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Pericak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St. George-Hyslop PH (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.
18. Terasaki M, Traverse Slater N, Fein A, Schmidek A, Reese TS (1994) Continuous network of endoplasmic reticulum in cerebellar Purkinje neurons. Proc Natl Acad Sci USA 91:7510-7514.
19. Thinakaran G, Borcheit DR, Lee MK, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey A, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17:181-190.
20. Wisniewski T, Palha JA, Ghiso J, Frangione B (1995) S182 protein in Alzheimer's disease neuritic plaques. Lancet 346:1366.
21. Yankner BA (1996) Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16:921-932.